Phospholipase D and the Maintenance of Phosphatidic Acid Levels for Regulation of Mammalian Target of Rapamycin (mTOR)

Molecular damage in cancer: an argument for mTOR-driven aging

(2016) Mikhail V. Blagosklonny   Aging-US

Mutant Ras Elevates Dependence on Serum Lipids and Creates a Synthetic Lethality for Rapamycin

(2014) D. Salloum et al.   MOLECULAR CANCER THERAPEUTICS

Enrichment of phosphatidylinositols with specific acyl chains

(2013) Kenneth D'Souza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The role of phospholipids in the biological activity and structure of the endoplasmic reticulum

(2013) Thomas A. Lagace et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress

(2013) R. M. Young et al.   GENES & DEVELOPMENT

Glutamine and cancer: cell biology, physiology, and clinical opportunities

(2013) Christopher T. Hensley et al.   JOURNAL OF CLINICAL INVESTIGATION

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Amino Acids and mTOR Mediate Distinct Metabolic Checkpoints in Mammalian G1 Cell Cycle

(2013) Mahesh Saqcena et al.   PLoS One

Lysophosphatidic Acid Acyltransferase Beta Regulates mTOR Signaling

(2013) Michelle A. Blaskovich et al.   PLoS One

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

(2013) J. J. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphatidic acid and lipid-sensing by mTOR

(2013) David A. Foster   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Diacylglycerol Kinase   Is a Critical Signaling Node and Novel Therapeutic Target in Glioblastoma and Other Cancers

(2013) C. L. Dominguez et al.   Cancer Discovery

Phosphatidate phosphatase, a key regulator of lipid homeostasis

(2012) Florencia Pascual et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Regulation of TOR by small GTPases

(2012) Raúl V Durán et al.   EMBO REPORTS

The hydrophobic amino acids involved in the interdomain association of phospholipase D1 regulate the shuttling of phospholipase D1 from vesicular organelles into the nucleus

(2012) Young Hoon Jang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Redundant functions of phospholipases D1 and D2 in platelet α-granule release

(2012) I. THIELMANN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

PERK Utilizes Intrinsic Lipid Kinase Activity To Generate Phosphatidic Acid, Mediate Akt Activation, and Promote Adipocyte Differentiation

(2012) E. Bobrovnikova-Marjon et al.   MOLECULAR AND CELLULAR BIOLOGY

Protein kinase C, an elusive therapeutic target?

(2012) Daria Mochly-Rosen et al.   NATURE REVIEWS DRUG DISCOVERY

Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling

(2012) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phospholipase D and mTORC1: Nutrients Are What Bring Them Together

(2012) B. M. Wiczer et al.   Science Signaling

Amino acids and mTORC1: from lysosomes to disease

(2012) Alejo Efeyan et al.   TRENDS IN MOLECULAR MEDICINE

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

(2011) Robbie Loewith et al.   GENETICS

Phospholipase D Mediates Nutrient Input to Mammalian Target of Rapamycin Complex 1 (mTORC1)

(2011) Limei Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Class III PI-3-kinase activates phospholipase D in an amino acid–sensing mTORC1 pathway

(2011) Mee-Sup Yoon et al.   JOURNAL OF CELL BIOLOGY

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Phosphatidic Acid Plays a Regulatory Role in Clathrin-mediated Endocytosis

(2010) Costin N. Antonescu et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The phospholipase D1 pathway modulates macroautophagy

(2010) Claudia Dall'Armi et al.   Nature Communications

Phosphatidate degradation: Phosphatidate phosphatases (lipins) and lipid phosphate phosphatases

(2009) David N. Brindley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Phosphatidic acid signaling to mTOR: Signals for the survival of human cancer cells

(2009) David A. Foster   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Albumin as Fatty Acid Transporter

(2009) Ger J. van der Vusse   Drug Metabolism and Pharmacokinetics

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

(2009) R J DeBerardinis et al.   ONCOGENE

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Honokiol Suppresses Survival Signals Mediated by Ras-Dependent Phospholipase D Activity in Human Cancer Cells

(2008) A. Garcia et al.   CLINICAL CANCER RESEARCH

Role of Phosphatidic Acid in the Coupling of the ERK Cascade

(2008) Catherine A. Kraft et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acyl-CoA:Lysophospholipid Acyltransferases

(2008) Hideo Shindou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of mTORC1 and mTORC2 Complex Assembly by Phosphatidic Acid: Competition with Rapamycin

(2008) A. Toschi et al.   MOLECULAR AND CELLULAR BIOLOGY

Phospholipase D1 is an effector of Rheb in the mTOR pathway

(2008) Y. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

Diacylglycerol kinases: at the hub of cell signalling

(2007) Isabel Mérida et al.   BIOCHEMICAL JOURNAL