New Insights on the Mechanism of Quinoline-based DNA Methyltransferase Inhibitors

Design, Synthesis and Biological Evaluation of 4-Amino-N-(4-aminophenyl)benzamide Analogues of Quinoline-Based SGI-1027 as Inhibitors of DNA Methylation

(2014) Elodie Rilova et al.   ChemMedChem

Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells

(2014) Sergio Valente et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure–activity relationships for 4-anilinoquinoline derivatives as inhibitors of the DNA methyltransferase enzyme DNMT1

(2013) Swarna A. Gamage et al.   BIOORGANIC & MEDICINAL CHEMISTRY

DNA Methyltransferase-1 Inhibitors as Epigenetic Therapy for Cancer

(2013) Varinder Singh et al.   CURRENT CANCER DRUG TARGETS

New anticancer active and selective phenylene-bisbenzothiazoles: Synthesis, antiproliferative evaluation and DNA binding

(2013) Livio Racané et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Laccaic Acid A Is a Direct, DNA-competitive Inhibitor of DNA Methyltransferase 1

(2013) Rebecca L. Fagan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The future of epigenetic therapy in solid tumours—lessons from the past

(2013) Nilofer Azad et al.   Nature Reviews Clinical Oncology

Development of a universal radioactive DNA methyltransferase inhibition test for high-throughput screening and mechanistic studies

(2013) Christina Gros et al.   NUCLEIC ACIDS RESEARCH

Clinical outcome of treatment with a combined regimen of decitabine and aclacinomycin/cytarabine for patients with refractory acute myeloid leukemia

(2012) Lu Xi Song et al.   ANNALS OF HEMATOLOGY

DNA methylation inhibitors in cancer: Recent and future approaches

(2012) Christina Gros et al.   BIOCHIMIE

Towards the Chemoinformatic-Based Identification of DNA Methyltransferase Inhibitors: 2D- and 3D-Similarity Profile of Screening Libraries

(2012) Jakyung Yoo et al.   Current Computer-Aided Drug Design

DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies

(2012) Jacques Fahy et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The Replication Focus Targeting Sequence (RFTS) Domain Is a DNA-competitive Inhibitor of Dnmt1

(2011) Farisa Syeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1)

(2011) K. Takeshita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non-Small Cell Lung Cancer

(2011) R. A. Juergens et al.   Cancer Discovery

Structure and Function of Mammalian DNA Methyltransferases

(2010) Renata Zofia Jurkowska et al.   CHEMBIOCHEM

Targeting DNA methylation for epigenetic therapy

(2010) Xiaojing Yang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation

(2009) J. Datta et al.   CANCER RESEARCH

Photochemical electrocyclisation of 3-vinylindoles to pyrido[2,3-a]-, pyrido[4,3-a]- and thieno[2,3-a]-carbazoles: Design, synthesis, DNA binding and antitumor cell cytotoxicity

(2009) Thomas Lemster et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY