The Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Active Site and Cleavage Sequence Differentially Regulate Protein Secretion from Proteolysis
出版年份 2014 全文链接
标题
The Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Active Site and Cleavage Sequence Differentially Regulate Protein Secretion from Proteolysis
作者
关键词
-
出版物
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 289, Issue 42, Pages 29030-29043
出版商
American Society for Biochemistry & Molecular Biology (ASBMB)
发表日期
2014-09-11
DOI
10.1074/jbc.m114.594861
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The Hypercholesterolemia-Risk Gene SORT1 Facilitates PCSK9 Secretion
- (2014) Camilla Gustafsen et al. Cell Metabolism
- PCSK9
- (2014) Nabil G. Seidah et al. CIRCULATION RESEARCH
- A 52-Week Placebo-Controlled Trial of Evolocumab in Hyperlipidemia
- (2014) Dirk J. Blom et al. NEW ENGLAND JOURNAL OF MEDICINE
- PCSK9 acts as a chaperone for the LDL receptor in the endoplasmic reticulum
- (2013) Thea Bismo Strøm et al. BIOCHEMICAL JOURNAL
- The Multifaceted Proprotein Convertases: Their Unique, Redundant, Complementary, and Opposite Functions
- (2013) Nabil G. Seidah et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial
- (2013) Kevin Fitzgerald et al. LANCET
- PCSK9 Prosegment Chimera as Novel Inhibitors of LDLR Degradation
- (2013) Yascara Grisel Luna Saavedra et al. PLoS One
- SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion
- (2013) Xiao-Wei Chen et al. eLife
- Loss- and Gain-of-function PCSK9 Variants
- (2012) Suzanne Benjannet et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The biology and therapeutic targeting of the proprotein convertases
- (2012) Nabil G. Seidah et al. NATURE REVIEWS DRUG DISCOVERY
- Effect of a Monoclonal Antibody to PCSK9 on LDL Cholesterol
- (2012) Evan A. Stein et al. NEW ENGLAND JOURNAL OF MEDICINE
- Novel Loss-of-Function PCSK9 Variant Is Associated with Low Plasma LDL Cholesterol in a French-Canadian Family and with Impaired Processing and Secretion in Cell Culture
- (2011) J. Mayne et al. CLINICAL CHEMISTRY
- Novel Domain Interaction Regulates Secretion of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Protein
- (2011) Fen Du et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cellular and secreted pro-protein convertase subtilisin/kexin type 9 catalytic activity in hepatocytes
- (2009) Sanae Kourimate et al. ATHEROSCLEROSIS
- An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol
- (2009) Huanting Liu et al. BMC BIOTECHNOLOGY
- Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells
- (2009) Markey C. McNutt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation
- (2009) Steve Poirier et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Enzymatic assembly of DNA molecules up to several hundred kilobases
- (2009) Daniel G Gibson et al. NATURE METHODS
- Mutation S462P in the PCSK9 gene reduces secretion of mutant PCSK9 without affecting the autocatalytic cleavage
- (2008) Jamie Cameron et al. ATHEROSCLEROSIS
- Molecular basis for LDL receptor recognition by PCSK9
- (2008) H. J. Kwon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now