In VitroResistance Selections forPlasmodium falciparumDihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-binding Site and Altered Growth

Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance

(2014) A. K. Lukens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antimalarial drug discovery — approaches and progress towards new medicines

(2013) Erika L. Flannery et al.   NATURE REVIEWS MICROBIOLOGY

Asexual Populations of the Human Malaria Parasite, Plasmodium falciparum, Use a Two-Step Genomic Strategy to Acquire Accurate, Beneficial DNA Amplifications

(2013) Jennifer L. Guler et al.   PLoS Pathogens

Outwitting Evolution: Fighting Drug-Resistant TB, Malaria, and HIV

(2012) Daniel E. Goldberg et al.   CELL

Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc 1 Catalytic Turnover and Protein Expression

(2012) Nicholas Fisher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Factors Influencing the Specificity of Inhibitor Binding to the Human and Malaria Parasite Dihydroorotate Dehydrogenases

(2012) Paul T. P. Bedingfield et al.   JOURNAL OF MEDICINAL CHEMISTRY

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

(2012) Y. Yuthavong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presenting your structures: theCCP4mgmolecular-graphics software

(2011) S. McNicholas et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The evolutionary landscape of antifolate resistance in Plasmodium falciparum

(2011) MARNA S. COSTANZO et al.   JOURNAL OF GENETICS

A framework for variation discovery and genotyping using next-generation DNA sequencing data

(2011) Mark A DePristo et al.   NATURE GENETICS

Novel Inhibitors ofPlasmodium falciparumDihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model

(2010) Michael L. Booker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Compensatory Mutations Restore Fitness during the Evolution of Dihydrofolate Reductase

(2010) K. M. Brown et al.   MOLECULAR BIOLOGY AND EVOLUTION

How can we identify parasite genes that underlie antimalarial drug resistance?

(2010) Tim Anderson et al.   PHARMACOGENOMICS

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Resistance to antimalarial compounds: Methods and applications

(2009) Benoit Witkowski et al.   DRUG RESISTANCE UPDATES

In vitro selection of Plasmodium falciparum drug-resistant parasite lines

(2009) A. Nzila et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds

(2009) Xiaoyi Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vivo Selection ofPlasmodium falciparumParasites Carrying the Chloroquine-SusceptiblepfcrtK76 Allele after Treatment with Artemether-Lumefantrine in Africa

(2009) Christin Sisowath et al.   JOURNAL OF INFECTIOUS DISEASES

Identification of a Metabolically Stable Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Antimalarial Activity in Mice

(2009) Ramesh Gujjar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Analysis of Flavin Oxidation and Electron-Transfer Inhibition inPlasmodium falciparumDihydroorotate Dehydrogenase†

(2008) Nicholas A. Malmquist et al.   BIOCHEMISTRY

In vitro evaluations of antimalarial drugs and their relevance to clinical outcomes

(2008) Eric H. Ekland et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitors with Potent and Selective Activity against the Malaria ParasitePlasmodium falciparum

(2008) Margaret A. Phillips et al.   JOURNAL OF MEDICINAL CHEMISTRY

PlasmoDB: a functional genomic database for malaria parasites

(2008) C. Aurrecoechea et al.   NUCLEIC ACIDS RESEARCH