Article
Infectious Diseases
Sofia C. Santamarina, Daniel A. Heredia, Andres M. Durantini, Edgardo N. Durantini
Summary: The widespread use of antibiotics has led to an increase in microbial resistance, necessitating the development of new strategies to combat pathogens. Photoactive polymers offer an interesting approach to kill microbes and maintain aseptic surfaces.
Article
Engineering, Biomedical
Yamin Liu, Ze-Kun Wang, Zhong-Zheng Gao, Yang Zong, Jian-Da Sun, Wei Zhou, Hui Wang, Da Ma, Zhan-Ting Li, Dan -Wei Zhang
Summary: In this study, a biocompatible porous organic polymer (POP) was found to suppress the skin phototoxicity caused by clinically used photodynamic agents (PDAs). In vivo experiments showed that POP can significantly alleviate the phototoxicity without reducing the efficacy of the PDAs.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Applied
Bingjie Hou, Wenyuan Zhang, Cuili Li, Xueqin Sun, Xiaoxia Feng, Jiacheng Liu
Summary: This study reports the synthesis and evaluation of four cationic porphyrins as potential photodynamic therapeutic agents. The results show that ZnP2 exhibits high phototoxicity towards cancer cells and low toxicity towards normal cells, making it a promising candidate for photodynamic therapy.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Bruno L. Raposo, Sueden Souza, Gleyciane S. Santana, Max T. A. Lima, Jose F. Sarmento-Neto, Julio S. Reboucas, Goreti Pereira, Beate S. Santos, Paulo E. Cabral Filho, Martha S. Ribeiro, Adriana Fontes
Summary: Researchers proposed a novel method of using polyvinylpyrro-lidone (PVP) coated silver nanoparticles (AgNPs) in combination with cationic Zn(II) porphyrins (ZnPs) for photodynamic inactivation (PDI) of Candida albicans infections. The AgNPs-ZnPs system achieved complete eradication of Candida albicans at lower porphyrin concentrations, reducing the risk of antifungal drug resistance.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Mafalda Laranjo, Nelson A. M. Pereira, Andreia S. R. Oliveira, Marcia Campos Aguiar, Goncalo Brites, Bruno F. O. Nascimento, Beatriz Serambeque, Bruna D. P. Costa, Joao Pina, J. Sergio Seixas de Melo, Marta Pineiro, M. Filomena Botelho, Teresa M. V. D. Pinho e Melo
Summary: Novel meso-tetraarylchlorins with different degrees of hydrophilicity were synthesized and their photophysical characterization was studied. The chlorins with specific structures exhibited high photocytotoxicity against human melanoma and esophageal and bladder carcinomas.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Physical
Boyang Sun, Sanjana Ghosh, Xuedan He, Wei-Chiao Huang, Breandan Quinn, Meiling Tian, Dushyant Jahagirdar, Moustafa T. Mabrouk, Joaquin Ortega, Yumiao Zhang, Shuai Shao, Jonathan F. Lovell
Summary: This study explores the potential of photodynamic therapy (PDT) combined with chemotherapy for tumor ablation. Liposomes loaded with a photosensitizer and a potent anti-cancer drug were successfully developed and demonstrated effective tumor ablation in in vivo experiments. This liposome delivery system shows versatility and potential for achieving enhanced tumor treatment.
Article
Oncology
Gislaine Patricia de Andrade, Thaiza Ferreira Menegassi de Souza, Giselle Cerchiaro, Maria Aparecida da Silva Pinhal, Anderson Orzari Ribeiro, Manoel Joao Batista Castello Girao
Summary: Hypericin is a potent photosensitizer used in antitumor and antimicrobial photodynamic therapy, with different levels of phototoxicity observed according to specific light dose and concentration. The localization and cell death mechanisms of hypericin are dependent on cell type, as revealed by in vitro studies highlighting the efficiency of photodynamic treatment in various applications.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Oncology
Man Yi Li, Le Mi, Gennady Meerovich, Thin Wut Soe, Ting Chen, Ni Ni Than, Yi Jia Yan, Zhi Long Chen
Summary: Esophageal cancer, the most common gastrointestinal tumor, is challenging to treat with conventional methods. Porphyrin-based photosensitizers in photodynamic therapy show promise in targeting tumor cells with limited damage to normal cells. Novel 5,15-diaryl-10,20-dihalogeno porphyrin derivatives, particularly II4, demonstrate superior antitumor efficacy in both in vitro and in vivo studies, indicating potential for future clinical applications.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jia Tian, Baoxuan Huang, Lei Xia, Yucheng Zhu, Weian Zhang
Summary: Photodynamic therapy (PDT) is a promising treatment for bacterial infections. Researchers have developed a supramolecular photosensitizer that not only produces reactive oxygen species (ROS) for sterilization, but also exhibits anti-inflammatory and cell protection capabilities. In vitro and in vivo experiments have demonstrated the excellent antibacterial and anti-inflammatory effects of this photosensitizer.
Article
Chemistry, Multidisciplinary
Tiffany Ho, Keegan Guidolin, Ali Makky, Michael Valic, Lili Ding, Jiachuan Bu, Mark Zheng, Miffy H. Y. Cheng, Jeremy Yau, Juan Chen, Gang Zheng
Summary: The inclusion of aminopolycarboxylic acid conjugated lipids in liposome-like porphyrin nanoparticles enhanced their intracellular uptake by 25-fold. This new uptake strategy, which fluidizes the cell membrane, improves photodynamic therapy cell killing and tumor delineation. It offers a potential solution to challenges in conventional drug delivery.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Yanyan Li, Guichen Li, Qian Zhang, Yuxia Li, Qifan Jia, Wenyuan Zhang, Xiaoxia Feng, Weibing Xu, Jiacheng Liu
Summary: Three water-soluble porphyrins containing halogen atoms (F, Cl, Br) were synthesized, with P3 showing the highest singlet oxygen generation capacity. MTT assay confirmed good phototoxicity and high selectivity of P1-P3, while fluorescence imaging and intracellular reactive oxygen species demonstrated cell apoptosis and ROS production. The high ROS production and excellent phototoxicity make the photosensitizers potential candidates for PDT drugs.
CHEMICAL PHYSICS LETTERS
(2021)
Article
Chemistry, Applied
C. Pontremoli, G. Chinigo, S. Galliano, M. J. Moran Plata, D. M. Dereje, E. Sansone, A. Gilardino, C. Barolo, A. Fiorio Pla, S. Visentin, N. Barbero
Summary: A new series of pentamethine indolenine cyanine dyes were designed and synthesized to investigate the structure-activity relationship on their photodynamic activity. The effect of different functionalizations on the heteroaromatic indolenine ring (no substituents, bromine, iodine, and carboxylic acid) on ROS production, cytotoxicity, photodynamic activity, and cellular uptake was determined. A statistical multivariate design, such as Design of Experiments (DoE), was used to evaluate the factors that greatly affect the cyanine photoactive behavior while minimizing the number of experiments. The synthesized dyes showed low cytotoxicity in the dark, but only some of them exhibited phototoxic effects upon irradiation in MCF-7 cell lines, confirming a structure-activity relationship.
Article
Biochemistry & Molecular Biology
Tayana Mazin Tsubone, Waleska Kerllen Martins, Marcia S. F. Franco, Maryana N. Silva, Rosangela Itri, Mauricio S. Baptista
Summary: The lipid composition plays a crucial role in the structure and function of cellular and organelle membranes, impacting membrane proteins and various biochemical events. Photochemical reactions in biological membranes, while essential for processes like photosynthesis, can also lead to cell damage and disease, but may also be harnessed for therapeutic purposes in Photodynamic Therapy.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Pharmacology & Pharmacy
Jose Garces-Garces, Miguel Sanchez-Martos, Gema Martinez-Navarrete, Eduardo Fernandez-Jover, Mirela Encheva, Martin Leon, Javier Ortiz, Angela Sastre-Santos, Fernando Fernandez-Lazaro
Summary: The synthesis and characterization of two new water soluble perylenediimides, PDI-1 and PDI-2, with potential applications in anticancer activities were described. These compounds demonstrated high fluorescence quantum yield in water and showed selective cytotoxicity toward cancer cells when exposed to specific light wavelength. The findings provide a strong foundation for the future exploration of PDI-1 and PDI-2 as effective photosensitizers in photodynamic therapy.
Article
Biochemistry & Molecular Biology
Aleksandra Kaczorowska, Malgorzata Malinga-Drozd, Wojciech Kalas, Marta Kopaczynska, Stanislaw Wolowiec, Katarzyna Borowska
Summary: In this study, Polyamidoamine PAMAM dendrimer generation 3 (G3) was modified with biotin and glucoheptoamidated to obtain a series of conjugates with different numbers of biotin residues, which were used as host molecules to encapsulate 5-aminolevulinic acid. The interaction between host and guest molecules was characterized by NMR, revealing an increase in solubility of 5-aminolevulinic acid in water. Moreover, the encapsulates showed potential for delivering 5-aminolevulinic acid to cells without cytotoxic effects, and aqueous encapsulates were found to be more effective in this regard.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Waleed M. Renno, Ludmil Benov, Khalid M. Khan
JOURNAL OF NEUROSURGERY-SPINE
(2017)
Article
Biochemistry & Molecular Biology
Sara Moghnie, Artak Tovmasyan, James Craik, Ines Batinic-Haberle, Ludmil Benov
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2017)
Article
Oncology
Khazna Alenezi, Artak Tovmasyan, Ines Batinic-Haberle, Ludmil T. Benov
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2017)
Article
Biochemistry & Molecular Biology
Artak Tovmasyan, Jacqueline C. Bueno-Janice, Melba C. Jaramillo, Romulo S. Sampaio, Julio S. Reboucas, Natalia Kyui, Ludmil Benov, Brian Deng, Ting-Ting Huang, Margaret E. Tome, Ivan Spasojevic, Ines Batinic-Haberle
ANTIOXIDANTS & REDOX SIGNALING
(2018)
Article
Biochemistry & Molecular Biology
Sebastian Carballal, Valeria Valez, Damian Alvarez-Paggi, Artak Tovmasyan, Ines Batinic-Haberle, Gerardo Ferrer-Sueta, Daniel H. Murgida, Rafael Radi
FREE RADICAL BIOLOGY AND MEDICINE
(2018)
Article
Multidisciplinary Sciences
Malak Charara, Artak Tovmasyan, Ines Batinic-Haberle, James Craik, Ludmil Benov
Article
Microbiology
Rawan Al-Mutairi, Artak Tovmasyan, Ines Batinic-Haberle, Ludmil Benov
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Multidisciplinary Sciences
Ludmil Benov
Article
Biochemistry & Molecular Biology
Artak Tovmasyan, Ines Batinic-Haberle, Ludmil Benov
Review
Cell Biology
Ines Batinic-Haberle, Artak Tovmasyan, Zhiqing Huang, Weina Duan, Li Du, Sharareh Siamakpour-Reihani, Zhipeng Cao, Huaxin Sheng, Ivan Spasojevic, Angeles Alvarez Secord
Summary: MnPs were initially developed as SOD mimics but later found to react with various reactive species and modify protein activities through oxidation, affecting both normal and cancer cells. Lead Mn porphyrins have been tested in various injury and cancer models, with some progressing to clinical trials for glioma, head and neck cancer, anal cancer, and other conditions.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cell Biology
Luksana Chaiswing, Chontida Yarana, William St Clair, Artak Tovmasyan, Ines Batinic-Haberle, Ivan Spasojevic, Daret St Clair
Summary: This study used a redox-active MnP compound to investigate the redox status of ovarian cancer cells. The results showed that chemotherapy-resistant cells were under higher oxidative stress and had increased glycolysis activity and mitochondrial respiration. Altering the redox state could effectively inhibit the growth and metabolic activity of these cells.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Pharmacology & Pharmacy
Tigran Margaryan, Mackenna Elliott, Nader Sanai, Artak Tovmasyan
Summary: A sensitive and rapid LC-MS/MS method was developed for quantifying LY3214996, abemaciclib, and their metabolites in human samples. The method was successfully applied in a clinical trial.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Katherine L. Houlihan, Petros P. Keoseyan, Amber N. Juba, Tigran Margaryan, Max E. Voss, Alexander M. Babaoghli, Justin M. Norris, Greg J. Adrian, Artak Tovmasyan, Lori M. Buhlman
Summary: Loss-of-function parkin mutations lead to oxidative stress and degeneration of dopaminergic neurons. In this study, the researchers found that the absence of parkin in fruit flies resulted in sustained increase of mitochondrial hydrogen peroxide levels in vulnerable neurons, as well as dysregulation of glutathione redox equilibrium. Supplementation of folic acid improved these abnormalities but did not mitigate whole-brain oxidative stress.
Article
Biochemistry & Molecular Biology
Milini Thomas, Ludmil Benov
BIOLOGICAL TRACE ELEMENT RESEARCH
(2018)