Cyclic Nucleotide-gated Channel α-3 (CNGA3) Interacts with Stereocilia Tip-Link Cadherin 23 + Exon 68 or Alternatively with Myosin VIIa, Two Proteins Required for Hair Cell Mechanotransduction

CNGA3 is expressed in inner ear hair cells and binds to an intracellular C-terminus domain of EMILIN1

(2012) Dakshnamurthy Selvakumar et al.   BIOCHEMICAL JOURNAL

Endoplasmic Reticulum Stress-associated Cone Photoreceptor Degeneration in Cyclic Nucleotide-gated Channel Deficiency

(2012) Arjun Thapa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HCN1 and HCN2 Proteins Are Expressed in Cochlear Hair Cells

(2012) Neeliyath A. Ramakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Whole-exome sequencing identifiesALMS1, IQCB1, CNGA3, andMYO7Amutations in patients with leber congenital amaurosis

(2011) Xia Wang et al.   HUMAN MUTATION

Allelic hierarchy of CDH23 mutations causing non-syndromic deafness DFNB12 or Usher syndrome USH1D in compound heterozygotes

(2011) J. M. Schultz et al.   JOURNAL OF MEDICAL GENETICS

Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A

(2011) A. J. Ehrlicher et al.   NATURE

Mutations in Protocadherin 15 and Cadherin 23 Affect Tip Links and Mechanotransduction in Mammalian Sensory Hair Cells

(2011) Kumar N. Alagramam et al.   PLoS One

Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction

(2011) M. Grati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gating of Two Mechanoelectrical Transducer Channels Associated with a Single Tip Link

(2010) Bora Sul et al.   BIOPHYSICAL JOURNAL

PIST regulates the intracellular trafficking and plasma membrane expression of Cadherin 23

(2010) Zhigang Xu et al.   BMC CELL BIOLOGY

Linking molecular motors to membrane cargo

(2010) Anna Akhmanova et al.   CURRENT OPINION IN CELL BIOLOGY

Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids

(2010) Amel Bahloul et al.   HUMAN MOLECULAR GENETICS

The cell biology of hearing

(2010) Martin Schwander et al.   JOURNAL OF CELL BIOLOGY

Targeting of the Hair Cell Proteins Cadherin 23, Harmonin, Myosin XVa, Espin, and Prestin in an Epithelial Cell Model

(2010) L. Zheng et al.   JOURNAL OF NEUROSCIENCE

Structural Determinants of Cadherin-23 Function in Hearing and Deafness

(2010) Marcos Sotomayor et al.   NEURON

EHD4 and CDH23 Are Interacting Partners in Cochlear Hair Cells

(2009) Soma Sengupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Localization of inner hair cell mechanotransducer channels using high-speed calcium imaging

(2009) Maryline Beurg et al.   NATURE NEUROSCIENCE

Defining features of the hair cell mechanoelectrical transducer channel

(2009) Robert Fettiplace   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Mutations in CNGA3 impair trafficking or function of cone cyclic nucleotide-gated channels, resulting in achromatopsia

(2008) Peggy Reuter et al.   HUMAN MUTATION

Calcium-dependent Binding of HCN1 Channel Protein to Hair Cell Stereociliary Tip Link Protein Protocadherin 15 CD3

(2008) Neeliyath A. Ramakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic Nucleotide-regulated Cation Channels

(2008) Martin Biel   JOURNAL OF BIOLOGICAL CHEMISTRY

MAGI-1, A Candidate Stereociliary Scaffolding Protein, Associates with the Tip-Link Component Cadherin 23

(2008) Z. Xu et al.   JOURNAL OF NEUROSCIENCE

Pairwise coupling of hair cell transducer channels links auditory sensitivity and dynamic range

(2008) Sietse M. van Netten et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY