Deoxyhypusine Synthase Promotes Differentiation and Proliferation of T Helper Type 1 (Th1) Cells in Autoimmune Diabetes

The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis

(2013) Lindsey E. Padgett et al.   Annals of the New York Academy of Sciences

T cell–derived inducible nitric oxide synthase switches off TH17 cell differentiation

(2013) Jianjun Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Dynamic Dual Role of IL-2 Signaling in the Two-Step Differentiation Process of Adaptive Regulatory T Cells

(2013) Z. Guo et al.   JOURNAL OF IMMUNOLOGY

Targeting Regulatory T Cells in the Treatment of Type 1 Diabetes Mellitus

(2012) S.M. Cabrera et al.   CURRENT MOLECULAR MEDICINE

ER Stress as a Trigger for  -Cell Dysfunction and Autoimmunity in Type 1 Diabetes

(2012) B. O'Sullivan-Murphy et al.   DIABETES

Islet  -Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

(2012) S. A. Tersey et al.   DIABETES

Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes

(2012) I. Marhfour et al.   DIABETOLOGIA

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Translational Control of Inducible Nitric Oxide Synthase by p38 MAPK in Islet β-Cells

(2012) Yurika Nishiki et al.   MOLECULAR ENDOCRINOLOGY

eIF5A interacts functionally with eEF2

(2011) Camila A. O. Dias et al.   AMINO ACIDS

Progressive Erosion of  -Cell Function Precedes the Onset of Hyperglycemia in the NOD Mouse Model of Type 1 Diabetes

(2011) D. Ize-Ludlow et al.   DIABETES

How Does Type 1 Diabetes Develop?: The Notion of Homicide or  -Cell Suicide Revisited

(2011) M. A. Atkinson et al.   DIABETES

A role for interleukin-2 trans-presentation in dendritic cell–mediated T cell activation in humans, as revealed by daclizumab therapy

(2011) Simone C Wuest et al.   NATURE MEDICINE

Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group

(2010) J. B. Matthews et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Inhibition of Deoxyhypusine Synthase Enhances Islet β Cell Function and Survival in the Setting of Endoplasmic Reticulum Stress and Type 2 Diabetes

(2010) Reiesha D. Robbins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Polyamines in Supporting Growth of Mammalian Cells Is Mediated through Their Requirement for Translation Initiation and Elongation

(2010) Guy Landau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The unique hypusine modification of eIF5A promotes islet β cell inflammation and dysfunction in mice

(2010) Bernhard Maier et al.   JOURNAL OF CLINICAL INVESTIGATION

eIF5A Promotes Translation Elongation, Polysome Disassembly and Stress Granule Assembly

(2010) Chi Ho Li et al.   PLoS One

Functional significance of eIF5A and its hypusine modification in eukaryotes

(2009) M. H. Park et al.   AMINO ACIDS

eIF5A has a function in the elongation step of translation in yeast

(2009) Ana P.B. Gregio et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Progression to Diabetes in Relatives of Type 1 Diabetic Patients: Mechanisms and Mode of Onset

(2009) E. Ferrannini et al.   DIABETES

Peroxisome Proliferator-Activated Receptor   Activation Restores Islet Function in Diabetic Mice through Reduction of Endoplasmic Reticulum Stress and Maintenance of Euchromatin Structure

(2009) C. Evans-Molina et al.   MOLECULAR AND CELLULAR BIOLOGY

Hypusine-containing protein eIF5A promotes translation elongation

(2009) Preeti Saini et al.   NATURE