Activity of ADAM17 (a Disintegrin and Metalloprotease 17) Is Regulated by Its Noncatalytic Domains and Secondary Structure of its Substrates

Discovery of Novel Inhibitors of a Disintegrin and Metalloprotease 17 (ADAM17) Using Glycosylated and Non-glycosylated Substrates

(2012) Dmitriy Minond et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds

(2011) Joshua Roth et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Elucidation of the Contribution of Active Site and Exosite Interactions to Affinity and Specificity of Peptidylic Serine Protease Inhibitors Using Non-Natural Arginine Analogs

(2011) M. Hosseini et al.   MOLECULAR PHARMACOLOGY

Cross-domain inhibition of TACE ectodomain

(2011) C. J. Tape et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluorescent Substrates Useful as High Throughput Screening Tools for ADAM9

(2010) Marcia L. Moss et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

ADAM8 substrate specificity: Influence of pH on pre-processing and proteoglycan degradation

(2009) Troii Hall et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models

(2009) Vijaykumar M. Baragi et al.   ARTHRITIS AND RHEUMATISM

Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10

(2009) Cristina I. Caescu et al.   BIOCHEMICAL JOURNAL

EGFR ligands and their signaling scissors, ADAMs, as new molecular targets for anticancer treatments

(2009) Hiromi Kataoka   JOURNAL OF DERMATOLOGICAL SCIENCE

Specific targeting of metzincin family members with small-molecule inhibitors: Progress toward a multifarious challenge

(2008) Dimitris Georgiadis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate

(2008) Janelle L. Lauer-Fields et al.   BIOORGANIC & MEDICINAL CHEMISTRY

ADAM10 as a Target for Anti-Cancer Therapy

(2008) Marcia Moss et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Engineering Functional Antithrombin Exosites in α1-Proteinase Inhibitor That Specifically Promote the Inhibition of Factor Xa and Factor IXa

(2008) Gonzalo Izaguirre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ADAM metalloproteinases

(2008) D EDWARDS et al.   MOLECULAR ASPECTS OF MEDICINE

Three-dimensional domain architecture of the ADAM family proteinases

(2008) Soichi Takeda   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Drug Insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis

(2008) Marcia L Moss et al.   Nature clinical practice. Rheumatology