期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 20, 期 2, 页码 146-152出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2008.07.009
关键词
ADAM; ADAMTS; Disintegrin metalloproteinases; MDC proteins; Ectodomain shedding
资金
- Ministry of Education, Science, Sports and Culture, and Health and Labour Sciences Research [19370047]
A disintegrin and metalloproteinase (ADAM) family of proteins constitutes a major class of mammalian membrane-bound sheddases that are responsible for the processing of cell-surface-protein ectodomains, including the latent forms of growth factors, cytokines and their receptors. However, the molecular mechanism by which ADAMs recognize and process their substrates is largely unknown. Recent crystallographic studies on phylogenically related snake venom metalloproteinases (SVMPs) and mammalian ADAM with thrombospondin type-1 motif (ADAMTS) family proteins have shed light on the structure-function properties of ADAMs. This review will highlight these recent structures, particularly the non-catalytic ancillary domains, which might be important for substrate recognition. (C) 2008 Elsevier Ltd. All rights reserved.
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