Preservation of Protein Dynamics in Dihydrofolate Reductase Evolution

Hydrogen Tunneling Links Protein Dynamics to Enzyme Catalysis

(2013) Judith P. Klinman et al.   Annual Review of Biochemistry

Connecting Protein Conformational Dynamics with Catalytic Function As Illustrated in Dihydrofolate Reductase

(2013) Yao Fan et al.   BIOCHEMISTRY

Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans

(2013) C. T. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogen Donor–Acceptor Fluctuations from Kinetic Isotope Effects: A Phenomenological Model

(2012) Daniel Roston et al.   BIOCHEMISTRY

Two Pyrenylalanines in Dihydrofolate Reductase Form an Excimer Enabling the Study of Protein Dynamics

(2012) Shengxi Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Remote Mutation Affects the Hydride Transfer by Disrupting Concerted Protein Motions in Thymidylate Synthase

(2012) Zhen Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Barrier crossing in dihydrofolate reductase does not involve a rate-promoting vibration

(2012) Mariangela Dametto et al.   MOLECULAR PHYSICS

Evidence that a ‘dynamic knockout’ in Escherichia coli dihydrofolate reductase does not affect the chemical step of catalysis

(2012) E. Joel Loveridge et al.   Nature Chemistry

Good vibrations in enzyme-catalysed reactions

(2012) Sam Hay et al.   Nature Chemistry

Taking Ockham's razor to enzyme dynamics and catalysis

(2012) David R. Glowacki et al.   Nature Chemistry

Triple Isotopic Labeling and Kinetic Isotope Effects: Exposing H-Transfer Steps in Enzymatic Systems

(2011) Arundhuti Sen et al.   BIOCHEMISTRY

Temperature Dependence of the Kinetic Isotope Effects in Thymidylate Synthase. A Theoretical Study

(2011) Natalia Kanaan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effects of the Donor–Acceptor Distance and Dynamics on Hydride Tunneling in the Dihydrofolate Reductase Catalyzed Reaction

(2011) Vanja Stojković et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions

(2011) A. J. Adamczyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics and dissipation in enzyme catalysis

(2011) N. Boekelheide et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Dynamic Knockout Reveals That Conformational Fluctuations Influence the Chemical Step of Enzyme Catalysis

(2011) G. Bhabha et al.   SCIENCE

Update 1 of: Tunneling and Dynamics in Enzymatic Hydride Transfer

(2010) Zachary D. Nagel et al.   CHEMICAL REVIEWS

Different Reaction Mechanisms for Mesophilic and Thermophilic Dihydrofolate Reductases

(2009) E. Joel Loveridge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY