The Extended Transmembrane Orai1 N-terminal (ETON) Region Combines Binding Interface and Gate for Orai1 Activation by STIM1

Differential Roles of the C and N Termini of Orai1 Protein in Interacting with Stromal Interaction Molecule 1 (STIM1) for Ca2+Release-activated Ca2+(CRAC) Channel Activation

(2013) Hongying Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The C- and N-terminal STIM1 binding sites on Orai1 are required for both trapping and gating CRAC channels

(2013) Beth A. McNally et al.   JOURNAL OF PHYSIOLOGY-LONDON

Orai Channel Pore Properties and Gating by STIM: Implications from the Orai Crystal Structure

(2013) B. S. Rothberg et al.   Science Signaling

Understanding the importance of the aromatic amino-acid residues as hot-spots

(2012) I.S. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Plucking the high hanging fruit: A systematic approach for targeting protein–protein interactions

(2012) Monika Raj et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Crystal Structure of Calmodulin Binding Domain of Orai1 in Complex with Ca2+•Calmodulin Displays a Unique Binding Mode

(2012) Yanshun Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Canonical Transient Receptor Potential (TRPC) 1 Acts as a Negative Regulator for Vanilloid TRPV6-mediated Ca2+Influx

(2012) Rainer Schindl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gated regulation of CRAC channel ion selectivity by STIM1

(2012) Beth A. McNally et al.   NATURE

Crystal Structure of the Calcium Release-Activated Calcium Channel Orai

(2012) X. Hou et al.   SCIENCE

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation

(2011) Martin Muik et al.   EMBO JOURNAL

Molecular Determinants within N Terminus of Orai3 Protein That Control Channel Activation and Gating

(2011) Judith Bergsmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91

(2011) S. L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient protein-protein interactions

(2011) S. E. Acuner Ozbabacan et al.   PROTEIN ENGINEERING DESIGN & SELECTION

The STIM/Orai coupling machinery

(2010) Irene Frischauf et al.   Channels

A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating

(2010) Annette Lis et al.   JOURNAL OF GENERAL PHYSIOLOGY

Activation of STIM1-Orai1 Involves an Intramolecular Switching Mechanism

(2010) M. K. Korzeniowski et al.   Science Signaling

Transient Protein-Protein Interactions: Structural, Functional, and Network Properties

(2010) James R. Perkins et al.   STRUCTURE

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

Mechanistic view on domains mediating STIM1-Orai coupling

(2009) Marc Fahrner et al.   IMMUNOLOGICAL REVIEWS

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels

(2009) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Hydrophobicity at the N Terminus/Membrane Interface Impairs Gating of the Severe Combined Immunodeficiency-related ORAI1 Mutant

(2009) Isabella Derler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Determinants of the Coupling between STIM1 and Orai Channels

(2009) Irene Frischauf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation

(2008) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy

(2008) Laura Navarro-Borelly et al.   JOURNAL OF PHYSIOLOGY-LONDON

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

(2008) Riina M. Luik et al.   NATURE