Modulation of Nuclear Factor E2-related Factor-2 (Nrf2) Activation by the Stress Response GeneImmediate Early Response-3(IER3) in Colonic Epithelial Cells

Immediate early response gene X-1, a potential prognostic biomarker in cancers

(2013) Mei X Wu et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Immunohistochemical Study of the Nrf2 Pathway in Colorectal Cancer

(2013) Liang-Che Chang et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

The high Nrf2 expression in human acute myeloid leukemia is driven by NF- B and underlies its chemo-resistance

(2012) S. A. Rushworth et al.   BLOOD

Somatic mutations of the KEAP1 gene in common solid cancers

(2012) Nam Jin Yoo et al.   HISTOPATHOLOGY

Enhanced Th17 Differentiation and Aggravated Arthritis in IEX-1-Deficient Mice by Mitochondrial Reactive Oxygen Species-Mediated Signaling

(2012) L. Zhi et al.   JOURNAL OF IMMUNOLOGY

Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity

(2012) A Arlt et al.   ONCOGENE

Emerging Role of IEX-1 in Tumor Pathogenesis and Prognosis

(2012) Shailendra Kapoor   ULTRASTRUCTURAL PATHOLOGY

The ‘N-factors’ in pancreatic cancer: functional relevance of NF-κB, NFAT and Nrf2 in pancreatic cancer

(2012) A Arlt et al.   Oncogenesis

Succination of Keap1 and Activation of Nrf2-Dependent Antioxidant Pathways in FH-Deficient Papillary Renal Cell Carcinoma Type 2

(2011) Lisa Kinch et al.   CANCER CELL

An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma

(2011) Aikseng Ooi et al.   CANCER CELL

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

(2011) Julie Adam et al.   CANCER CELL

NRF2 Blockade Suppresses Colon Tumor Angiogenesis by Inhibiting Hypoxia-Induced Activation of HIF-1 

(2011) T.-H. Kim et al.   CANCER RESEARCH

Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway

(2011) Miao Yu et al.   CELLULAR SIGNALLING

Reciprocal Regulation of The Survival and Apoptosis of Th17 and Th1 Cells in The Colon

(2011) Irina V. Ustyugova et al.   INFLAMMATORY BOWEL DISEASES

miR-200a Regulates Nrf2 Activation by TargetingKeap1mRNA in Breast Cancer Cells

(2011) Gabriel Eades et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory Macrophages Induce Nrf2 Transcription Factor-dependent Proteasome Activity in Colonic NCM460 Cells and Thereby Confer Anti-apoptotic Protection

(2011) Susanne Sebens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cruciferous Vegetable Phytochemical Sulforaphane Affects Phase II Enzyme Expression and Activity in Rat Cardiomyocytes through Modulation of Akt Signaling Pathway

(2011) Emanuela Leoncini et al.   JOURNAL OF FOOD SCIENCE

Genome-Wide Expression Profiling Identifies an Impairment of Negative Feedback Signals in the Crohn’s Disease-Associated NOD2 Variant L1007fsinsC

(2011) Susanne Billmann-Born et al.   JOURNAL OF IMMUNOLOGY

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Clinical Significance of IEX-1 Expression in Ovarian Carcinoma

(2011) Liping Han et al.   ULTRASTRUCTURAL PATHOLOGY

The Nrf2-Keap1-ARE Signaling Pathway: The Regulation and Dual Function of Nrf2 in Cancer

(2010) Donna D. Zhang   ANTIOXIDANTS & REDOX SIGNALING

Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

(2010) John D. Hayes et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of the immediate early response 3 (IER3) gene in cellular stress response, inflammation and tumorigenesis

(2010) Alexander Arlt et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression

(2010) James W. Kaspar et al.   FASEB JOURNAL

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases

(2010) Shruti Singh et al.   FREE RADICAL RESEARCH

Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease

(2010) Pamela M. OʼConnor et al.   INFLAMMATORY BOWEL DISEASES

Nuclear Factor (Erythroid-Derived 2)-Like 2 Regulates Drug Resistance in Pancreatic Cancer Cells

(2010) Young Bin Hong et al.   PANCREAS

Nrf2: friend or foe for chemoprevention?

(2009) T. W. Kensler et al.   CARCINOGENESIS

Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells

(2009) Hanane Akhdar et al.   EUROPEAN JOURNAL OF CANCER

Ablation of gly96/immediate early gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: Role for gly96/iex-1 in the regulation of NF-κB

(2009) Christian Sina et al.   INFLAMMATORY BOWEL DISEASES

A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders

(2009) Jiyoung Kim et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2)

(2009) A Arlt et al.   ONCOGENE

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues

(2008) Rui Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increased Susceptibility of Nrf2 Knockout Mice to Colitis-Associated Colorectal Cancer

(2008) T. O. Khor et al.   Cancer Prevention Research

IEX-1 targets mitochondrial F1Fo-ATPase inhibitor for degradation

(2008) L Shen et al.   CELL DEATH AND DIFFERENTIATION

Dual roles of Nrf2 in cancer

(2008) A LAU et al.   PHARMACOLOGICAL RESEARCH

IEX-1 directly interferes with RelA/p65 dependent transactivation and regulation of apoptosis

(2007) Alexander Arlt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nrf2 signaling: An adaptive response pathway for protection against environmental toxic insults

(2007) W OSBURN et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH