Article
Cell Biology
Yi-Ting Liu, Danielle A. Sliter, Mario K. Shammas, Xiaoping Huang, Chunxin Wang, Hannah Calvelli, Dragan S. Maric, Derek P. Narendra
Summary: PINK1 and PRKN, known to cause Parkinson's disease when mutated, form a quality control mitophagy pathway studied mainly in cultured cells. However, the contribution of the PINK1-PRKN pathway to mitophagy in vivo is disputed, with conflicting results from studies using mitophagy reporters mt-Keima and mito-QC. This study compared the performance of the two reporters in cell culture and mice under PINK1-PRKN activating stress, finding that mito-QC was less sensitive than mt-Keima, particularly for PINK1-PRKN mitophagy. These results indicate that the differences in sensitivity may explain conflicting reports and caution against using mito-QC as a reporter for PINK1-PRKN mitophagy.
Article
Multidisciplinary Sciences
Fredrik Trulsson, Vyacheslav Akimov, Mihaela Robu, Nila van Overbeek, David Aureliano Perez Berrocal, Rashmi G. Shah, Juergen Cox, Girish M. Shah, Blagoy Blagoev, Alfred C. O. Vertegaal
Summary: This study compares the regulatory effects of the proteasome and deubiquitinating enzymes (DUBs) on the ubiquitinated proteome. The authors find preferential sets of substrates regulated by DUBs or by the proteasome. Moreover, they find that PARP1 is hyper-ubiquitinated in response to DUB inhibition, which increases its enzymatic activity.
NATURE COMMUNICATIONS
(2022)
Review
Pharmacology & Pharmacy
Komal Latif, Aman Ullah, Anastasiia D. Shkodina, Dmytro I. Boiko, Zakia Rafique, Badrah S. Alghamdi, Mohamed A. Alfaleh, Ghulam Md. Ashraf
Summary: Drug repurposing is an attractive approach for pharmaceutical development, as it allows the use of existing drugs to treat different diseases. In the case of Parkinson's disease, a neurodegenerative condition, drug repurposing strategies can be applied effectively.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Veterinary Sciences
Elsayed Metwally, Hatim A. Al-Abbadi, Tarique Hussain, Ghulam Murtaza, Ahmed M. Abdellatif, Mahmoud F. Ahmed
Summary: Neurodegenerative disorders pose a major healthcare challenge globally, and calpain signaling plays a crucial role in neuronal dysfunction and cell death. Understanding the structure and activity of calpains is essential for unraveling their roles in cellular physiology and pathology, and the inhibition of calpain activity could be a potential therapeutic approach for treating neurodegenerative diseases.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Neurosciences
Xiaoyi Xu, Xin He, Zeyan Zhang, Yanyi Chen, Junyu Li, Shanshan Ma, Qiaoying Huang, Mingtao Li
Summary: This study identified that the inactivation of CREB and decreased expression of NURR1 are associated with nigral dopaminergic neurodegeneration in Parkinson's disease (PD). The mechanism underlying CREB inactivation involves the interaction between HDAC1/PP1y complex and CREB, and disrupting this interaction can restore CREB activity and protect dopaminergic neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
David Seynnaeve, Daniel P. Mulvihill, Joris Winderickx, Vanessa Franssens
Summary: Our study demonstrates that the lack of Glo2 and Gre3 activity leads to increased formation of large Synphilin-1 inclusions in S. cerevisiae, correlating with enhanced oxidative stress levels and inhibitory effects on growth. Similarly, polar-localised inclusions were observed in S. pombe, but no growth defects were observed upon expression of SNCAIP. Overall, yeasts, especially S. cerevisiae, serve as valuable models for understanding the mechanisms underlying Synphilin-1 pathology in neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ping Liu, Xiaoji Cong, Shengjie Liao, Xinglong Jia, Xiaomin Wang, Wei Dai, Linhui Zhai, Lei Zhao, Jing Ji, Duan Ni, Zhiwei Liu, Yulu Chen, Lulu Pan, Wei Liu, Jian Zhang, Min Huang, Bin Liu, Minjia Tan
Summary: This study identified phosphorylation-dependent SCF substrates using a quantitative phosphoproteome approach, demonstrating the mechanism by which SCFFBXO22 recognizes a phosphodegron. FBXO22 was shown to mediate BAG3 ubiquitination and degradation, impacting tumor growth, apoptosis, and cell cycle progression.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Cell Biology
Ursula Kern, Klemens Froehlich, Johanna Bedacht, Nico Schmidt, Martin L. Biniossek, Nicole Gensch, Katja Baerenfaller, Oliver Schilling
Summary: DJ-1 is a crucial component of cellular proteomes, with its C-terminal helix 8 playing a key role in deglycation activity. The presence or absence of helix 8 in DJ-1 significantly impacts mitochondrial and lysosomal biology. The pleiotropic nature of DJ-1 is further demonstrated by its indirect modulation of lysosomal protease activity.
Article
Pharmacology & Pharmacy
Rana E. Kamal, Esther Menze, Amgad Albohy, Hebatalla I. Ahmed, Samar S. Azab
Summary: This study evaluated the potential of carvedilol as an anti-Parkinson's drug and anti-tau protein target through computational simulation and in vivo experiments. The results suggest that carvedilol has neuro-protective effects and may be a candidate for the management of Parkinson's disease.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Anthony R. Braun, Elly E. Liao, Mian Horvath, Prakriti Kalra, Karen Acosta, Malaney C. Young, Noah Nathan Kochen, Chih Hung Lo, Roland Brown, Michael D. Evans, William C. K. Pomerantz, Elizabeth Rhoades, Kelvin Luk, Razvan L. Cornea, David D. Thomas, Jonathan N. Sachs
Summary: A research team developed a high-throughput drug discovery platform using fluorescence resonance energy transfer (FRET) and fluorescent alpha-synuclein biosensors to detect pre-fibrillar oligomers in living cells, leading to the discovery of new compounds that could improve the success rate of Parkinson's disease treatment drug discovery campaigns.
NPJ PARKINSONS DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Alejandro Quintero-Villegas, Sergio Ivan Valdes-Ferrer
Summary: 5-HT7 receptors are the most recently identified among serotonin receptors, and their role in neurodegenerative diseases is not fully understood. This review discusses the signaling pathways and cellular mechanisms involved in 5-HT7R activation, as well as the potential therapeutic implications of pharmacological interventions for 5-HT7R signaling in neurodegeneration.
MOLECULAR MEDICINE
(2022)
Article
Neurosciences
Sahil H. Shah, Lucio M. Schiapparelli, Satoshi Yokota, Yuanhui Ma, Xin Xia, Sahana Shankar, Sarah Saturday, Michael Nahmou, Catalina Sun, John Yates, Hollis T. Cline, Jeffrey L. Goldberg
Summary: In this study, a new in vivo quantitative measure of newly synthesized proteins was developed and applied to examine the changes in the retina after optic nerve injury. The results revealed a dynamic translational response within broader proteostasis regulation, enhancing our understanding of the cellular response to injury.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Jennifer R. Pinnell, Mei Cui, Kim Tieu
Summary: Exosomes play a potential role in the propagation of pathological alpha-synuclein in Parkinson's disease. They have the ability to transport proteins and genetic material between cells, and may serve as biomarkers and delivery vectors for therapeutics in PD.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Food Science & Technology
Zhiwei Zhang, Pingping Liu, Xiaorong Deng, Xin Guo, Xiaoying Mao, Xiaobing Guo, Jian Zhang
Summary: In this study, it was found that oxidants can alter the structure of myofibrillar protein, increasing its susceptibility to proteolysis. Oxidation also affects protein cross-linking and aggregation, leading to inhibition of specific proteins' resistance to degradation.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Cell Biology
Sokhna M. S. Yakhine-Diop, Mario Rodriguez-Arribas, Saray Canales-Cortes, Guadalupe Martinez-Chacon, Elisabet Uribe-Carretero, Mercedes Blanco-Benitez, Gema Duque-Gonzalez, Marta Paredes-Barquero, Eva Alegre-Cortes, Vicente Climent, Ana Aiastui, Adolfo Lopez de Munain, Jose M. Bravo-San Pedro, Mireia Niso-Santano, Jose M. Fuentes, Rosa A. Gonzalez-Polo
Summary: Autophagy is a cellular mechanism responsible for maintaining internal balance by degrading cellular components, but it can be altered in various diseases, including Parkinson's disease. Parkinson's disease is a multifactorial disease, with mutations in the LRRK2 gene affecting the autophagy mechanism and compromising cell viability.
CELL BIOLOGY AND TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
C. Kim, N. Yun, J. Lee, M. B. H. Youdim, C. Ju, W-K Kim, P-L Han, Y. J. Oh
CELL DEATH AND DIFFERENTIATION
(2016)
Article
Biochemistry & Molecular Biology
Hyoeun Kim, Nuri Yun, Dasom Mun, Ji-Young Kang, Seung-Hyun Lee, Hyelim Park, Hyewon Park, Boyoung Joung
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Medicine, General & Internal
Shanyu Cui, Hyewon Park, Hyelim Park, Dasom Mun, Seung-Hyun Lee, Hyoeun Kim, Nuri Yun, Hail Kim, Michael Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung
YONSEI MEDICAL JOURNAL
(2018)
Article
Biochemistry & Molecular Biology
Juhyung Lee, Nuri Yun, Chiho Kim, Min-Young Song, Kang-Sik Park, Young J. Oh
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2014)
Article
Biochemistry & Molecular Biology
Nuri Yun, Young Mook Lee, Chiho Kim, Hirohiko Shibayama, Akira Tanimura, Yuri Hamanaka, Yuzuru Kanakura, Il-Seon Park, Areum Jo, Joo-Ho Shin, Chung Ju, Won-Ki Kim, Young J. Oh
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Multidisciplinary Sciences
Juhyung Lee, Yeon Uk Ko, Yuhyun Chung, Nuri Yun, Myungjin Kim, Kyungjin Kim, Young J. Oh
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Dasom Mun, Hyoeun Kim, Ji-Young Kang, Hyelim Park, Hyewon Park, Seung-Hyun Lee, Nuri Yun, Boyoung Joung
Article
Medicine, Research & Experimental
Ji-Young Kang, Hyewon Park, Hyoeun Kim, Dasom Mun, Hyelim Park, Nuri Yun, Boyoung Joung
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2019)
Article
Multidisciplinary Sciences
Hyoeun Kim, Ji-Young Kong, Dasom Mun, Nuri Yun, Boyoung Joung
Article
Biochemistry & Molecular Biology
Kyung-Ah Park, Nuri Yun, Young J. Oh
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Cell Biology
Yeon Uk Ko, Chiho Kim, Juhyung Lee, Dana Kim, Yoonkyung Kim, Nuri Yun, Young J. Oh
CELL DEATH & DISEASE
(2019)
Article
Medicine, Research & Experimental
Ji-Young Kang, Hyoeun Kim, Dasom Mun, Nuri Yun, Boyoung Joung
Article
Neurosciences
Yeon Uk Ko, Hwa Young Song, Won-Ki Kim, Tae Young Yune, Nuri Yun, Young J. Oh
NEUROSCIENCE LETTERS
(2020)
Article
Chemistry, Multidisciplinary
Ji-Young Kang, Hyoeun Kim, Dasom Mun, Nuri Yun, Boyoung Joung
Summary: By functionalizing extracellular vesicles (EVs) with a cardiac-targeting peptide (CTP) and loading curcumin and miR144-3p simultaneously, enhanced targeting ability, bioavailability, and cardioprotective effects of therapeutic molecules can be achieved, providing a promising nanomedicine strategy for MI therapy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Cell Biology
Chang-Ki Oh, Young Ki Choi, Ih-Yeon Hwang, Yeon Uk Ko, In Kwon Chung, Nuri Yun, Young J. Oh
CELL DEATH & DISEASE
(2020)