Leucine Stimulates Insulin Secretion via Down-regulation of Surface Expression of Adrenergic α2A Receptor through the mTOR (Mammalian Target of Rapamycin) Pathway

Hypertension After Kidney Transplant

(2011) Mahendra Mangray et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

An amino acid mixture improves glucose tolerance and insulin signaling in Sprague-Dawley rats

(2011) Jeffrey R. Bernard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

α2-Adrenoceptor Regulation of Blood Glucose Homeostasis

(2011) Veronica Fagerholm et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

The Antidepressant Desipramine Is an Arrestin-biased Ligand at the α2A-Adrenergic Receptor Driving Receptor Down-regulationin Vitroandin Vivo

(2011) Christopher Cottingham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New-Onset Diabetes After Renal Transplantation: Diagnosis, Incidence, Risk Factors, Impact on Outcomes, and Novel Implications

(2011) Z. Kaposztas et al.   TRANSPLANTATION PROCEEDINGS

Sirolimus Therapy Predisposes to New-Onset Diabetes Mellitus After Renal Transplantation: A Long-Term Analysis of Various Treatment Regimens

(2011) E. Gyurus et al.   TRANSPLANTATION PROCEEDINGS

Risk factors for new-onset diabetes after kidney transplantation

(2010) Adnan Sharif et al.   Nature Reviews Nephrology

Leucine metabolism in regulation of insulin secretion from pancreatic beta cells

(2010) Jichun Yang et al.   NUTRITION REVIEWS

Rapamycin impairs metabolism-secretion coupling in rat pancreatic islets by suppressing carbohydrate metabolism

(2009) Makiko Shimodahira et al.   JOURNAL OF ENDOCRINOLOGY

Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes

(2009) A. H. Rosengren et al.   SCIENCE

Amino acid regulation of TOR complex 1

(2008) Joseph Avruch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Amino Acids Activate mTOR Complex 1 via Ca2+/CaM Signaling to hVps34

(2008) Pawan Gulati et al.   Cell Metabolism

mTOR Inhibition by Rapamycin Prevents  -Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes

(2008) M. Fraenkel et al.   DIABETES

Sirolimus Is Associated with New-Onset Diabetes in Kidney Transplant Recipients

(2008) O. Johnston et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Leucine, when ingested with glucose, synergistically stimulates insulin secretion and lowers blood glucose

(2008) Dionysia Kalogeropoulou et al.   METABOLISM-CLINICAL AND EXPERIMENTAL