Article
Biology
Simona Moravcova, Eva Filipovska, Veronika Spisska, Irena Svobodova, Jiri Novotny, Zdenka Bendova
Summary: Systemic or in vitro lipopolysaccharide (LPS) administration did not significantly affect AANAT expression or activity, but simultaneous LPS administration and Stat3 silencing enhanced aa-nat transcription and AANAT activity to a similar extent as Stat3 inhibition alone.
Article
Endocrinology & Metabolism
A. S. M. Kamruzzaman, Susumu Hiragaki, Yasuhiko Watari, Takashi Natsukawa, Akie Yasuhara, Naoyuki Ichihara, Amr A. Mohamed, Azza M. Elgendy, Makio Takeda
Summary: Melatonin plays a role in orchestrating daily and seasonal rhythms in organisms, impacting locomotor activity. The enzyme aaNAT is a key regulator of the circadian system in cockroaches, influencing the synchronization of locomotor rhythms. Additionally, the receptor mediating Melatonin function in cockroaches is likely similar to the mammalian MT2, with Melatonin and aaNAT constituting a circadian output pathway for locomotor activity.
JOURNAL OF PINEAL RESEARCH
(2021)
Review
Medicine, Research & Experimental
Amira Mohamed Taha, Abdelrahman Mohamed Mahmoud, Mohamed M. Ghonaim, Ateeba Kamran, Jehad Feras Alsamhori, Majd M. Albarakat, Abhigan Babu Shrestha, Vikash Jaiswal, Russel J. Reiter
Summary: Septic cardiomyopathy is a complication of sepsis with high mortality rates. Despite extensive research, there is currently no effective pharmacological agent for this condition. Melatonin, with its diverse functions in the body, has emerged as a potential treatment for sepsis-induced cardiomyopathy due to its anti-oxidant, anti-inflammatory, anti-apoptotic, and cardioprotective roles.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pathology
Mehran Sharifi, Nesa Rajabpoor Nikoo, Bita Badehnoosh, Rana Shafabakhsh, Reza Asemi, Russel J. Reiter, Zatollah Asemi
Summary: Endometriosis is a serious disease in women that has a significant financial burden similar to diabetes mellitus globally. It is associated with pelvic pain, decreased quality of life, and reduced work efficiency, as well as various clinical consequences including mood complaints and increased risks of inflammation, metabolic impairments, immunologic problems, and malignancies. Melatonin, a natural molecule with antioxidant and anti-inflammatory properties, has shown potential in limiting endometriosis by inhibiting proliferation, reducing oxidative stress and inflammation, inducing apoptosis, and inhibiting the growth of endometriotic tissue. However, further clinical trials are needed to confirm its efficacy.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Multidisciplinary Sciences
Kousuke Okimura, Yusuke Nakane, Taeko Nishiwaki-Ohkawa, Takashi Yoshimura
Summary: The study found that the photoperiodic regulation of dopamine signaling and its pharmacological intervention can improve the attenuation of retinal photosensitivity caused by short photoperiod in mice. Dynamic seasonal changes in retinal photosensitivity were revealed by electroretinograms. Transcriptome analysis identified the short-day mediated suppression of the Th gene, which encodes tyrosine hydroxylase, a key enzyme in dopamine biosynthesis.
SCIENTIFIC REPORTS
(2021)
Review
Endocrinology & Metabolism
Yan Meng, Zhengbo Tao, Siming Zhou, Wacili Da, Lin Tao
Summary: This study conducted a quantitative and qualitative analysis of melatonin research over the past 20 years using bibliometric methods, predicting future research trends. Findings showed that the United States had the highest number of publications in melatonin research, and future research hot spots are likely to focus on the structure and function of melatonin, clinical applications, and target-based drug design.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rehab T. Oshiba, Ehab Touson, Yasser M. Elsherbini, Mohamed E. Abdraboh
Summary: This study demonstrates the significant impact of melatonin in counteracting tumor growth through scavenging free radicals, regulating lipid peroxidation, and affecting cell cycle and apoptosis. The signaling pathways of melatonin in adenocarcinoma have been highlighted, emphasizing the novel role of M./P53/miR215/CD44 and M./miR96//foxO1 cascades in diminishing cancer cell growth, survival, and metastasis.
Review
Genetics & Heredity
Yu Huang, Jia Li, Chao Bian, Ruihan Li, Xinxin You, Qiong Shi
Summary: Melatonin, an important hormone, plays a role in endocrine regulation in vertebrates. Fish have the most diverse aanat genes compared to other vertebrates, potentially contributing to seasonal migration, amphibious aerial vision, and adaptation to cave or deep-sea environments. Advances in genetic sequencing will enhance our understanding of AANAT function in various fish species.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Jing Wang, Man Li, Meigui Wang, Jing Yang, Deguang Li, Yunxia Hao
Summary: Accumulating evidence suggests that miRNAs play a crucial role in lung adenocarcinoma. The specific contributions and mechanisms of miR-181c-5p in lung adenocarcinoma are not well understood. This study aimed to clarify the potential mechanism by which miR-181c-5p regulates the progression of lung adenocarcinoma. The results showed that miR-181c-5p was up-regulated in lung adenocarcinoma tissues and cells. Inhibition of miR-181c-5p suppressed the viability, migration, and invasion of lung adenocarcinoma cells. It was also found that miR-181c-5p targeted the PRKN gene and mediated its functions in lung adenocarcinoma progression. These findings suggest that miR-181c-5p could be a potential diagnostic and predictive marker for lung adenocarcinoma, offering new insights into the development of treatment strategies.
BIOCHEMICAL GENETICS
(2023)
Article
Environmental Sciences
Wenbo Jiang, Huanyu Wu, Rui Guo, Xiaoqing Xu, Yue Wang, XiTao Jiang, Yu Wang, Xuemin Yan, Wenbo Gu, Xin Liu, Fengyu Cao, Ying Li, Tianshu Han, Changhao Sun
Summary: This study found that Dibromoacetic acid (DBA) can induce neurotoxicity in the pineal gland and disrupt melatonin rhythm by inhibiting the p-CREB1-AANAT signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Physiology
Natalia Ziolkowska, Bogdan Lewczuk
Summary: This study demonstrated the significant impact of norepinephrine and light exposure on melatonin secretion in goose pineal explants. It was found that norepinephrine played a key role in regulating pineal secretory activity, especially in maintaining the rhythmicity of melatonin. Additionally, the levels of VMA and HMV in the pineal glands provided precise information about the activity of sympathetic nerve fibers in geese.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hai-Xiang Guo, Yi Zheng, Guo-Kun Zhao, Hao-Qi Wang, Song Yu, Fei Gao, Jia-Bao Zhang, Yong-Hong Zhang, Bao Yuan
Summary: This study revealed that circ-ERC2 can participate in the synthesis of melatonin in the pineal gland through the miR-125a-5p/MAT2A axis, providing a new basis for the research on the circadian rhythm of noncoding RNA in pineal melatonin secretion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Aurea S. Blancas-Velazquez, Tenna Bering, Signe Bille, Martin F. Rath
Summary: This study aims to investigate the role of clock genes on pineal gland endocrine function, particularly on the enzyme Aanat involved in melatonin synthesis. It was found that rhythmic clock gene expression in the pineal gland largely depends on the suprachiasmatic nucleus (SCN) and pineal cells house a slave oscillator controlled by adrenergic signaling. Histological analysis revealed that clock genes are expressed in pinealocytes and colocalize with Aanat transcripts, suggesting their involvement in cellular melatonin production. Knockdown of the clock gene Clock led to an overexpression of Aanat in pinealocytes, indicating that SCN-dependent rhythmic expression of Clock gene regulates the daily profile of Aanat expression.
JOURNAL OF PINEAL RESEARCH
(2023)
Review
Medicine, General & Internal
Daniel Gashaneh Belay, Misganaw Gebrie Worku
Summary: This study aimed to assess the pooled prevalence of pineal gland calcification. The pooled prevalence of pineal gland calcification was found to be 61.65%, with age, male sex, and white ethnicity being the major socio-demographic characteristics that increase the prevalence of this condition.
SYSTEMATIC REVIEWS
(2023)
Article
Medicine, General & Internal
Yi Zheng, Hao Jiang, Hao-Qi Wang, Hai-Xiang Guo, Dong-Xu Han, Yi-Jie Huang, Yan Gao, Bao Yuan, Jia-Bao Zhang
Summary: In this study, a large number of circRNAs and miRNAs were identified in the rat pineal gland through transcriptome analysis, with differential expression patterns during the day and night. A ceRNA regulatory network was constructed to predict interactions among circRNAs, miRNAs, and mRNAs with differential expression, providing insights into the role of circRNA in regulating changes in melatonin circadian rhythms. The analyzed data presented in this study will serve as a valuable resource for future investigations on the altered physiology of circRNAs in diurnal rhythms.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Martin F. Rath, Steven L. Coon, Fernanda G. Amaral, Joan L. Weller, Morten Moller, David C. Klein
Article
Biochemistry & Molecular Biology
Michael Parks, Samantha Court, Benjamin Bowns, Siobhan Cleary, Samuel Clokie, Julie Hewitt, Denise Williams, Trevor Cole, Fiona MacDonald, Mike Griffiths, Stephanie Allen
EUROPEAN JOURNAL OF HUMAN GENETICS
(2017)
Article
Biology
Peter S. Backlund, Henryk F. Urbanski, Mark A. Doll, David W. Hein, Marjan Bozinoski, Christopher E. Mason, Steven L. Coon, David C. Klein
JOURNAL OF BIOLOGICAL RHYTHMS
(2017)
Article
Genetics & Heredity
Christopher M. Watson, Nick Camm, Laura A. Crinnion, Samuel Clokie, Rachel L. Robinson, Julian Adlard, Ruth Charlton, Alexander F. Markham, Ian M. Carr, David T. Bonthron
MOLECULAR DIAGNOSIS & THERAPY
(2017)
Letter
Oncology
Ceri E. Oldreive, Philip J. Byrd, Grant S. Stewart, Alexander J. Taylor, Sana Farhat, Anna Skowronska, Edward Smith, Manoj Raghavan, Dragana Janic, Lidija Dokmanovic, Sam Clokie, Nicholas Davies, Marwan Kwok, Guy Pratt, Shankara Paneesha, Paul Moss, Tatjana Stankovic, Malcolm Taylor
LEUKEMIA & LYMPHOMA
(2019)
Article
Genetics & Heredity
Salam A. Assi, Maria Rosaria Imperato, Daniel J. L. Coleman, Anna Pickin, Sandeep Potluri, Anetta Ptasinska, Paulynn Suyin Chin, Helen Blair, Pierre Cauchy, Sally R. James, Joaquin Zacarias-Cabeza, L. Niall Gilding, Andrew Beggs, Sam Clokie, Justin C. Loke, Phil Jenkin, Ash Uddin, Ruud Delwel, Stephen J. Richards, Manoj Raghavan, Michael J. Griffiths, Olaf Heidenreich, Peter N. Cockerill, Constanze Bonifer
Article
Endocrinology & Metabolism
L. A. Hughes, K. McKay-Bounford, E. A. Webb, P. Dasani, S. Clokie, H. Chandran, L. McCarthy, Z. Mohamed, J. M. W. Kirk, N. P. Krone, S. Allen, T. R. P. Cole
ENDOCRINE CONNECTIONS
(2019)
Review
Ophthalmology
Amy Gerrish, Edward Stone, Samuel Clokie, John R. Ainsworth, Helen Jenkinson, Maureen McCalla, Carol Hitchcott, Isabel Colmenero, Stephanie Allen, Manoj Parulekar, Trevor Cole
BRITISH JOURNAL OF OPHTHALMOLOGY
(2019)
Article
Genetics & Heredity
Richard J. Holt, Rodrigo M. Young, Berta Crespo, Fabiola Ceroni, Cynthia J. Curry, Emanuele Bellacchio, Dorine A. Bax, Andrea Ciolfi, Marleen Simon, Christina R. Fagerberg, Ellen van Binsbergen, Alessandro De Luca, Luigi Memo, William B. Dobyns, Alaa Afif Mohammed, Samuel J. H. Clokie, Celia Zazo Seco, Yong-Hui Jiang, Kristina P. Sorensen, Helle Andersen, Jennifer Sullivan, Zoe Powis, Anna Chassevent, Constance Smith-Hicks, Slave Petrovski, Thalia Antoniadi, Vandana Shashi, Bruce D. Gelb, Stephen W. Wilson, Dianne Gerrelli, Marco Tartaglia, Nicolas Chassaing, Patrick Calvas, Nicola K. Ragge
AMERICAN JOURNAL OF HUMAN GENETICS
(2019)
Article
Pathology
Elizabeth Young, Benjamin Bowns, Amy Gerrish, Michael Parks, Samantha Court, Samuel Clokie, Chipo Mashayamombe-Wolfgarten, Julie Hewitt, Denise Williams, Trevor Cole, Stephanie Allen
JOURNAL OF MOLECULAR DIAGNOSTICS
(2020)
Article
Endocrinology & Metabolism
Eric Chang, Cong Fu, Steven L. Coon, Shahar Alon, Marjan Bozinoski, Matthew Breymaier, Diego M. Bustos, Samuel J. Clokie, Yoav Gothilf, Caroline Esnault, P. Michael Iuvone, Christopher E. Mason, Margaret J. Ochocinska, Adi Tovin, Charles Wang, Pinxian Xu, Jinhan Zhu, Ryan Dale, David C. Klein
JOURNAL OF PINEAL RESEARCH
(2020)
Article
Oncology
Hannah J. Gleneadie, Amy H. Baker, Nikolaos Batis, Jennifer Bryant, Yao Jiang, Samuel J. H. Clokie, Hisham Mehanna, Paloma Garcia, Deena M. A. Gendoo, Sally Roberts, Megan Burley, Alfredo A. Molinolo, J. Silvio Gutkind, Ben A. Scheven, Paul R. Cooper, Joanna L. Parish, Farhat L. Khanim, Malgorzata Wiench
Summary: DAC upregulates the COX-2-PGE-2 pathway in cancer cells, providing survival potential, which is offset by the addition of paracetamol. Paracetamol supplementation leads to glutathione depletion and accumulation of ROS/superoxide, restricting tumor growth.
Article
Medicine, General & Internal
Amy Gerrish, Benjamin Bowns, Chipo Mashayamombe-Wolfgarten, Elizabeth Young, Samantha Court, Joshua Bott, Maureen McCalla, Simon Ramsden, Michael Parks, David Goudie, Sue Carless, Samuel Clokie, Trevor Cole, Stephanie Allen
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Endocrinology & Metabolism
Youn Hee Jee, Jinhee Wang, Shanna Yue, Melissa Jennings, Samuel J. Clokie, Ola Nilsson, Julian C. Lui, Jeffrey Baron
Article
Genetics & Heredity
Lauren M. Watson, Elizabeth Bamber, Ricardo Parolin Schnekenberg, Jonathan Williams, Conceicao Bettencourt, Jennifer Lickiss, Katherine Fawcett, Samuel Clokie, Yvonne Wallis, Penny Clouston, David Sims, Henry Houlden, Esther B. E. Becker, Andrea H. Nemeth
AMERICAN JOURNAL OF HUMAN GENETICS
(2017)