期刊
FRONTIERS IN GENETICS
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2022.820442
关键词
melatonin biosynthesis; arylalkylamine N-acetyltransferase (AANAT); phylogeny; physiological function; fish
Melatonin, an important hormone, plays a role in endocrine regulation in vertebrates. Fish have the most diverse aanat genes compared to other vertebrates, potentially contributing to seasonal migration, amphibious aerial vision, and adaptation to cave or deep-sea environments. Advances in genetic sequencing will enhance our understanding of AANAT function in various fish species.
As an important hormone, melatonin participates in endocrine regulation of diverse functions in vertebrates. Its biosynthesis is catalyzed by four cascaded enzymes, among them, arylalkylamine N-acetyltransferase (AANAT) is the most critical one. Although only single aanat gene has been identified in most groups of vertebrates, researchers including us have determined that fish have the most diverse of aanat genes (aanat1a, aanat1b, and aanat2), playing various potential roles such as seasonal migration, amphibious aerial vision, and cave or deep-sea adaptation. With the rapid development of genome and transcriptome sequencing, more and more putative sequences of fish aanat genes are going to be available. Related phylogeny and functional investigations will enrich our understanding of AANAT functions in various fish species.
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