First and Second Generation γ-Secretase Modulators (GSMs) Modulate Amyloid-β (Aβ) Peptide Production through Different Mechanisms

Acute Effect on the Aβ Isoform Pattern in CSF in Response to γ-Secretase Modulator and Inhibitor Treatment in Dogs

(2017) Erik Portelius et al.   JOURNAL OF ALZHEIMERS DISEASE

Tritium labeling of a γ-secretase inhibitor and two modulators as in vitro imaging agents

(2012) Jonas Malmquist et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Piperidine Acetic Acid Based γ-Secretase Modulators Directly Bind to Presenilin-1

(2011) Christina J. Crump et al.   ACS Chemical Neuroscience

Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1

(2011) Yu Ohki et al.   EMBO JOURNAL

Novel γ-Secretase Enzyme Modulators Directly Target Presenilin Protein

(2011) Amelie Ebke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Attenuated Aβ42Responses to Low Potency γ-Secretase Modulators Can Be Overcome for Many Pathogenic Presenilin Mutants by Second-generation Compounds

(2011) Benedikt Kretner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

γ-Secretase Modulators as Potential Disease Modifying Anti-Alzheimer’s Drugs

(2010) Daniel Oehlrich et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of AZD4694, a novel fluorinated Aβ plaque neuroimaging PET radioligand

(2010) Anders Juréus et al.   JOURNAL OF NEUROCHEMISTRY

Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease

(2010) Gen He et al.   NATURE

Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease

(2010) Maria Z. Kounnas et al.   NEURON

Amyloid beta 42 peptide (A 42)-lowering compounds directly bind to A  and interfere with amyloid precursor protein (APP) transmembrane dimerization

(2010) L. Richter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translational Medicine Lessons from Flurizan's Failure in Alzheimer's Disease (AD) Trial: Implication for Future Drug Discovery and Development for AD

(2009) Hong I. Wan et al.   CTS-Clinical and Translational Science

Synaptic activity prompts γ-secretase–mediated cleavage of EphA4 and dendritic spine formation

(2009) Eiji Inoue et al.   JOURNAL OF CELL BIOLOGY

 -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of  -Carboxyl Terminal Fragment

(2009) M. Takami et al.   JOURNAL OF NEUROSCIENCE

Substrate-targeting γ-secretase modulators

(2008) Thomas L. Kukar et al.   NATURE