Amyloid beta 42 peptide (A 42)-lowering compounds directly bind to A  and interfere with amyloid precursor protein (APP) transmembrane dimerization

Aberrant Amyloid Precursor Protein (APP) Processing in Hereditary Forms of Alzheimer Disease Caused by APP Familial Alzheimer Disease Mutations Can Be Rescued by Mutations in the APP GxxxG Motif

(2010) Lisa-Marie Munter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The secretases: enzymes with therapeutic potential in Alzheimer disease

(2010) Bart De Strooper et al.   Nature Reviews Neurology

An NSAID-like Compound, FT-9, Preferentially Inhibits γ-Secretase Cleavage of the Amyloid Precursor Protein Compared to Its Effect on Amyloid Precursor-like Protein 1

(2009) Carlo Sala Frigerio et al.   BIOCHEMISTRY

Nonspecificity of Binding of γ-Secretase Modulators to the Amyloid Precursor Protein

(2009) Andrew J. Beel et al.   BIOCHEMISTRY

Role of Amyloid-  Glycine 33 in Oligomerization, Toxicity, and Neuronal Plasticity

(2009) A. Harmeier et al.   JOURNAL OF NEUROSCIENCE

 -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of  -Carboxyl Terminal Fragment

(2009) M. Takami et al.   JOURNAL OF NEUROSCIENCE

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

Substrate specificity of γ-secretase and other intramembrane proteases

(2008) A. J. Beel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Homophilic Interactions of the Amyloid Precursor Protein (APP) Ectodomain Are Regulated by the Loop Region and Affect β-Secretase Cleavage of APP

(2008) Daniela Kaden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate-targeting γ-secretase modulators

(2008) Thomas L. Kukar et al.   NATURE