Article
Biochemistry & Molecular Biology
Atsushi Kaida, Satomi Yamamoto, Alejandro Parrales, Eric D. Young, Atul Ranjan, Mohamed A. Alalem, Kei-ichi Morita, Yu Oikawa, Hiroyuki Harada, Tohru Ikeda, Sufi M. Thomas, Francisco J. Diaz, Tomoo Iwakuma
Summary: DNAJA1 promotes tumor metastasis in head and neck squamous cell carcinoma by accumulating unfolded mutant p53, suggesting it as a potential therapeutic target for this type of cancer.
Article
Neurosciences
Uroos Akber, Heeji Jo, Seungje Jeon, Seung-Joo Yang, Sunhwa Bong, Sungsu Lim, Yun Kyung Kim, Zee-Yong Park, Chul-Seung Park
Summary: Protein aggregation-induced neurotoxicity in neurodegenerative disorders can be mitigated by the protective role of molecular chaperones, while the substrate-recruiting subunit CRBN of cullin4-RING-E3-ligase can influence phosphorylation and aggregation of tau protein through ubiquitin-mediated degradation, reducing pathological tau accumulation in the brain.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Antonella Marino Gammazza, Vincenzo Restivo, Roberta Baschi, Celeste Caruso Bavisotto, Angelo B. Cefalu, Giulia Accardi, Everly Conway de Macario, Alberto J. L. Macario, Francesco Cappello, Roberto Monastero
Summary: Molecular chaperones play key roles in neurodegenerative diseases, with higher levels of Hsp60 and Hsp70 found in AD patients, while lower levels of Hsp90 were observed in both aMCI and AD. However, these findings lost significance after adjustment for multiple comparisons, indicating the need for further studies with larger populations.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Cell Biology
Shweta Kishor Sonawane, Vladimir N. Uversky, Subashchandrabose Chinnathambi
Summary: The study demonstrated the potential neuroprotective effect of Baicalein in inhibiting aggregation of human Tau protein, dissolving pre-formed fibrils, and being non-toxic to neuronal cells. Baicalein could be considered a lead molecule in combating Tau pathology in Alzheimer's disease.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Filippa Lo Cascio, Paola Marzullo, Rakez Kayed, Antonio Palumbo Piccionello
Summary: This review highlights recent research on modifying the structure of curcumin to search for new effective therapeutic agents against neurodegenerative diseases, with a particular focus on Alzheimer's disease.
Review
Biochemistry & Molecular Biology
Vasileios Papaliagkas, Kallirhoe Kalinderi, Patroklos Vareltzis, Despoina Moraitou, Theodora Papamitsou, Maria Chatzidimitriou
Summary: Alzheimer's disease (AD) is a rapidly growing disease that urgently requires early diagnosis and treatment. Cerebrospinal fluid (CSF), which directly contacts the brain's extracellular space, is the most useful biological fluid for reflecting molecular events in the brain. Proteins and molecules that reflect the pathogenesis of AD, including neurodegeneration, accumulation of Abeta, hyperphosphorylation of tau protein, and apoptosis, can be used as biomarkers. The most commonly used CSF biomarkers for AD are total tau, phospho-tau, and Abeta42.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Batbayar Tumurbaatar, Anna Fracassi, Pietro Scaduto, Jutatip Guptarak, Randall Woltjer, Daniel Jupiter, Giulio Taglialatela
Summary: This study investigates the association of autophagy with cognitive integrity in individuals with Alzheimer's disease neuropathology but without dementia. The results suggest that preserved autophagy may protect against cognitive decline in these individuals.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Longfei Li, Jin Miao, Dandan Chu, Nana Jin, Yunn Chyn Tung, Chun-Ling Dai, Wen Hu, Cheng-Xin Gong, Khalid Iqbal, Fei Liu
Summary: Findings from this study suggest that the monoclonal tau antibody 77G7 effectively suppresses the seeding activity of AD O-tau and could potentially be developed as an immunotherapeutic drug to inhibit the propagation of tau pathology in AD and related tauopathies.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Clinical Neurology
Shuai Zhao, Ziqi Fan, Xinyi Zhang, Zheyu Li, Ting Shen, Kaicheng Li, Yaping Yan, Yunfeng Yuan, Jiali Pu, Jun Tian, Zhirong Liu, Yanxing Chen, Baorong Zhang
Summary: This study found that metformin can inhibit the propagation of tau protein in Alzheimer's disease and reduce its hyperphosphorylation. It also improves learning and memory deficits, suggesting that metformin could be a promising drug for the prevention and early treatment of AD.
Article
Biochemistry & Molecular Biology
Lei Liu, Yuqi Cai, Bianca M. Lauro, Angela L. Meunier, Jasmeer Chhatwal, Dennis J. Selkoe
Summary: This study aimed to establish a method for generating accurate calibrators as biomarkers for Alzheimer's disease. A semi-synthetic p-Tau181 calibrator was produced by coupling a recombinant tau fragment with a synthetic peptide containing a phosphorylated residue. The calibrator showed a low limit of quantification of 0.14 pg/ml when tested on multiple platforms. This simple and cost-effective method can be used to generate tau pT181 calibrators suitable for different immunoassay platforms and can be easily adapted for other phosphorylated epitopes relevant to Alzheimer's disease.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Billie J. Matchett, Sarah J. Lincoln, Matt Baker, Nikoleta Tamvaka, Sydney A. Labuzan, Tiffany Hicks N. Sirmans, Christina M. Moloney, Jacqueline Helminger, Kelly M. Hinkle, Janisse Cabrera-Rodriguez, Daniel P. Wickland, Patrick W. Johnson, Michael G. Heckman, Joseph S. Reddy, Steven G. Younkin, Minerva M. Carrasquillo, Ranjan Duara, Neill R. Graff-Radford, Cyril Pottier, Niluefer Ertekin-Taner, Owen A. Ross, Rosa Rademakers, Dennis W. Dickson, Melissa E. Murray
Summary: We investigated the involvement of genetic variants in the SERPINA5 gene in Alzheimer's disease (AD) and found a rare missense variant (p.E228Q) that was present in a small percentage of AD cases. However, there was no significant difference in demographic or clinicopathologic characteristics between carriers and noncarriers of this variant. Moreover, our findings suggest that SERPINA5 genetic variants may not play a major role in clinicopathologic differences in AD.
Article
Clinical Neurology
Madeline S. Morrison, Hugo J. Aparicio, Kaj Blennow, Henrik Zetterberg, Nicholas J. Ashton, Thomas K. Karikari, Yorghos Tripodis, Brett Martin, Joseph N. Palmisano, Michael A. Sugarman, Brandon Frank, Eric G. Steinberg, Katherine W. Turk, Andrew E. Budson, Rhoda Au, Lee E. Goldstein, Gyungah R. Jun, Neil W. Kowall, Ronald Killiany, Wei Qiao Qiu, Robert A. Stern, Jesse Mez, Ann C. McKee, Thor D. Stein, Michael L. Alosco
Summary: In one of the largest studies of its kind, researchers found that ante-mortem plasma phosphorylated-tau(181) concentrations can accurately differentiate brain donors with and without Alzheimer's disease. This blood test could serve as a minimally invasive and cost-effective tool for the detection and monitoring of Alzheimer's disease.
Article
Clinical Neurology
Emma M. Coomans, Jori Tomassen, Rik Ossenkoppele, Sandeep S. Golla, Marijke den Hollander, Lyduine E. Collij, Emma Weltings, Sophie M. van der Landen, Emma E. Wolters, Albert D. Windhorst, Frederik Barkhof, Eco J. C. de Geus, Philip Scheltens, Pieter Jelle Visser, Bart N. M. van Berckel, Anouk den Braber
Summary: Coomans et al. found substantial similarities in tau load and spatial distribution among identical twins, indicating a significant role of genetic factors in tau pathology. However, differences between twin pairs suggest the influence of environmental factors in tau accumulation. This study provides insights into factors associated with tau pathology and may be important for preventive strategies against Alzheimer's disease.
Article
Clinical Neurology
Alfonso Martinisi, Martin Flach, Frederik Sprenger, Stephan Frank, Markus Tolnay, David T. Winkler
Summary: The study showed that toxic tau species causing neuronal dysfunction can be cleared without inducing seeding effects, suggesting an effective therapeutic intervention in tauopathies. Moreover, recovered mice did not develop more motor impairment or tau pathology in the long term compared to control groups.
Article
Cell Biology
Xing Jun Jiang, Yan Qing Wu, Rong Ma, Yan Min Chang, Lu Lu Li, Jia Hui Zhu, Gong Ping Liu, Gang Li
Summary: This study found that overexpression of PINK1 can promote the degradation of accumulated tau proteins in patients with AD, improving cognitive abilities and rescuing damaged neurons and synapses. Furthermore, PINK1 also improves mitochondrial dysfunction caused by tau proteins. This suggests that PINK1 may be a potential target for AD treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Shelby Meier, Michelle Bell, Danielle N. Lyons, Jennifer Rodriguez-Rivera, Alexandria Ingram, Sarah N. Fontaine, Elizabeth Mechas, Jing Chen, Benjamin Wolozin, Harry LeVine, Haining Zhu, Jose F. Abisambra
JOURNAL OF NEUROSCIENCE
(2016)
Article
Cell Biology
Tara Vanderweyde, Daniel J. Apicco, Katherine Youmans-Kidder, Peter E. A. Ash, Casey Cook, Edroaldo Lummertz da Rocha, Karen Jansen-West, Alissa A. Frame, Allison Citro, John D. Leszyk, Pavel Ivanov, Jose F. Abisambra, Martin Steffen, Hu Li, Leonard Petrucelli, Benjamin Wolozin
Article
Geriatrics & Gerontology
Sarah N. Fontaine, Alexandria Ingram, Ryan A. Cloyd, Shelby E. Meier, Emily Miller, Danielle Lyons, Grant K. Nation, Elizabeth Mechas, Blaine Weiss, Chiara Lanzillotta, Fabio Di Domenico, Frederick Schmitt, David K. Powell, Moriel Vandsburger, Jose F. Abisambra
NEUROBIOLOGY OF AGING
(2017)
Article
Geriatrics & Gerontology
Diana L. Castillo-Carranza, Ashley N. Nilson, Candice E. Van Skike, Jordan B. Jahrling, Kishan Patel, Prajesh Garach, Julia E. Gerson, Urmi Sengupta, Jose Abisambra, Peter Nelson, Juan Troncoso, Zoltan Ungvari, Veronica Galvan, Rakez Kayed
Article
Neurosciences
Chiara Lanzillotta, Antonella Tramutola, Shelby Meier, Frederick Schmitt, Eugenio Barone, Marzia Perluigi, Fabio Di Domenico, Jose F. Abisambra
JOURNAL OF ALZHEIMERS DISEASE
(2018)
Article
Multidisciplinary Sciences
Shelby Meier, Assaf A. Gilad, J. Anthony Brandon, Chenghao Qian, Erhe Gao, Jose F. Abisambra, Moriel Vandsburger
SCIENTIFIC REPORTS
(2018)
Article
Geriatrics & Gerontology
Elena S. Gusareva, Jean-Claude Twizere, Kristel Sleegers, Pierre Dourlen, Jose F. Abisambra, Shelby Meier, Ryan Cloyd, Blaine Weiss, Bart Dermaut, Kyrylo Bessonov, Sven J. van der Lee, Minerva M. Carrasquillo, Yuriko Katsumata, Majid Cherkaoui, Bob Asselbergh, M. Arfan Ikram, Richard Mayeux, Lindsay A. Farrer, Jonathan L. Haines, Margaret A. Pericak-Vance, Gerard D. Schellenberg, Rebecca Sims, Julie Williams, Philippe Amouyel, Cornelia M. van Duijn, Nilufer Ertekin-Taner, Christine Van Broeckhoven, Franck Dequiedt, David W. Fardo, Jean-Charles Lambert, Kristel Van Steen
NEUROBIOLOGY OF AGING
(2018)
Article
Neurosciences
Brandon F. Maziuk, Daniel J. Apicco, Anna Lourdes Cruz, Lulu Jiang, Peter E. A. Ash, Edroaldo Lummertz da Rocha, Cheng Zhang, Wai Haung Yu, John Leszyk, Jose F. Abisambra, Hu Li, Benjamin Wolozin
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Mychael V. Lourenco, Rudimar L. Frozza, Guilherme B. de Freitas, Hong Zhang, Grasielle C. Kincheski, Felipe C. Ribeiro, Rafaella A. Goncalves, Julia R. Clarke, Danielle Beckman, Agnieszka Staniszewski, Hanna Berman, Lorena A. Guerra, Leticia Forny-Germano, Shelby Meier, Donna M. Wilcock, Jorge M. de Souza, Soniza Alves-Leon, Vania F. Prado, Marco A. M. Prado, Jose F. Abisambra, Fernanda Tovar-Moll, Paulo Mattos, Ottavio Arancio, Sergio T. Ferreira, Fernanda G. De Felice
Review
Geriatrics & Gerontology
Ryan A. Cloyd, Shon A. Koren, Jose F. Abisambra
FRONTIERS IN AGING NEUROSCIENCE
(2018)
Article
Clinical Neurology
Shon A. Koren, Matthew J. Hamm, Shelby E. Meier, Blaine E. Weiss, Grant K. Nation, Emad A. Chishti, Juan Pablo Arango, Jing Chen, Haining Zhu, Eric M. Blalock, Jose F. Abisambra
ACTA NEUROPATHOLOGICA
(2019)
Review
Biochemistry & Molecular Biology
Shon A. Koren, Drew A. Gillett, Simon V. D'Alton, Matthew J. Hamm, Jose F. Abisambra
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Shon A. Koren, Matthew J. Hamm, Ryan Cloyd, Sarah N. Fontaine, Emad Chishti, Chiara Lanzillotta, Jennifer Rodriguez-Rivera, Alexandria Ingram, Michelle Bell, Sara M. Galvis-Escobar, Nicholas Zulia, Fabio Di Domenico, Duc Duong, Nicholas T. Seyfried, David Powell, Moriel Vandsburger, Tal Frolinger, Anika M. S. Hartz, John Koren, Jeffrey M. Axten, Nicholas J. Laping, Jose F. Abisambra
Summary: Tauopathies are a group of disorders involving neurodegeneration and cognitive decline, with limited therapeutic options due to lack of understanding of molecular mechanisms. Treating early stage tau transgenic mice with a multi-target kinase inhibitor improved brain atrophy and cognitive function, despite unchanged levels of hyperphosphorylated tau. Proteomics data identified potential therapeutic targets for tauopathy treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Pradoldej Sompol, Jenna L. Gollihue, Susan D. Kraner, Irina A. Artiushin, Ryan A. Cloyd, Emad A. Chishti, Shon A. Koren, Grant K. Nation, Jose F. Abisambra, Orsolya Huzian, Lajos I. Nagy, Miklos Santha, Laszlo Hackler, Laszlo G. Puskas, Christopher M. Norris
Summary: Inhibition of the protein phosphatase calcineurin (CN) can improve pathophysiological and cognitive changes in aging rodents and mice with aging-related Alzheimer's disease (AD)-like pathology. A newly developed neuroprotective hydroxyquinoline derivative (Q134R) that suppresses NFAT signaling, without inhibiting CN activity, shows promising results in improving cognitive performance and potentially increasing longevity in mice. These findings suggest that Q134R could be a valuable drug for treating AD and aging-related disorders.
Review
Neurosciences
Ariel Walker, Ben Chapin, Jose Abisambra, Steven T. DeKosky
Summary: This literature review investigated whether a single moderate to severe head injury leads to long-term development of tauopathy. The results of most human and animal studies suggest that a single moderate to severe head injury is associated with greater chronic development of tauopathy, but caution is needed due to limitations in the studies.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Ankita Chadda, Alexander G. Kozlov, Binh Nguyen, Timothy M. Lohman, Eric A. Galburt
Summary: In this study, it was found that the DNA damage response in Mycobacterium tuberculosis differs from well-studied model bacteria. The DNA repair helicase UvrD1 in Mtb is activated through a redox-dependent process and is closely associated with the homo-dimeric Ku protein. Additionally, Ku protein is shown to stimulate the helicase activity of UvrD1.
JOURNAL OF MOLECULAR BIOLOGY
(2024)