Article
Cell Biology
Salla Mattola, Elina Mantyla, Vesa Aho, Sami Salminen, Simon Leclerc, Mikko Oittinen, Kari Salokas, Jani Jarvensivu, Satu Hakanen, Teemu O. Ihalainen, Keijo Viiri, Maija Vihinen-Ranta
Summary: This study suggests that canine parvovirus capsids may use additional routes for nuclear escape, and the nuclear envelope permeability increases at the late stages of infection. Inhibition of cell cycle regulatory protein Cdk1 and pro-apoptotic protein caspase 3 can prevent the leakage of nuclear envelope, indicating the involvement of G2/M checkpoint regulation in this process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Siobhan O'Brien, Susan Kelso, Zachary Steinhart, Stephen Orlicky, Monika Mis, Yunhye Kim, Sichun Lin, Frank Sicheri, Stephane Angers
Summary: This study reports a novel synthetic lethal genetic interaction between FBXW7 and CCNL1 and identifies CCNL1 as a substrate of the SCF-FBXW7 E3 ligase. Defective CCNL1 accumulation resulting from FBXW7 mutation leads to shorter mitotic time. Cells with FBXW7 loss-of-function mutations are highly sensitive to treatment with a CDK11 inhibitor, suggesting a potential genetic vulnerability for cancer treatment.
Article
Oncology
Yuandong Cao, Aidi Gao, Xiaoqing Li, Han Min, Chao He, Xinchen Sun, Wei-Qun Ding, Jundong Zhou
Summary: TAB182 is identified as a key regulator of radiation sensitivity in ESCC cells, with its downregulation sensitizing cancer cells to ionizing radiation and overcoming radioresistance by interacting with FHL2 to modulate the G2-M checkpoint.
Article
Dermatology
Kun Ren, Meng Zhou, Lingjun Li, Cheng Wang, Shengtao Yuan, Hongyang Li
Summary: C118P, a novel tubulin polymerization inhibitor, has shown strong anticancer effects in melanoma cells by inhibiting cell proliferation and inducing apoptosis. Mechanistically, C118P induces G2/M arrest through downregulation of BUB1B expression, providing a potential strategy for the clinical treatment of melanoma.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Changyin Zhou, Xue Zhang, Yilong Miao, Yu Zhang, Yu Li, Bo Xiong
Summary: Sororin functions as a regulator of meiotic G(2)-M transition and spindle assembly in mammalian oocytes, with its interactions with Cyclin B2 playing a crucial role in driving M phase entry and bipolar spindle formation in meiosis.
Article
Oncology
Christina Hassiepen, Aashish Soni, Ines Rudolf, Vivian Boron, Sebastian Oeck, George Iliakis, Alexander Schramm
Summary: Neuroblastoma with high expression of TrkA/NTRK1 is associated with better prognosis, but the impact of TrkA/NTRK1 on radiation response is not well understood. This study found that TrkA/NTRK1-expressing cells fail to activate the G2/M cell cycle checkpoint after irradiation, leading to increased short-term cell viability. The deficient G2/M-checkpoint upon DNA damage induced by ionizing radiation in TrkA/NTRK1-activated cells suggests a potential role of NTRK signaling in checkpoint regulation and response to radiation.
Article
Oncology
Ruixuan Wang, Tang Li, Guangren Li, Sheng-Xiang Lin
Summary: The upregulation of 17 beta-HSD7 in epithelial ovarian cancer cells leads to increased proliferation, which can be significantly reduced by knocking down the enzyme. Inhibition of 17 beta-HSD7 also results in negative feedback, lowering estradiol levels and increasing dihydrotestosterone levels, ultimately suppressing cell proliferation. Therefore, targeting 17 beta-HSD7 shows promise as a therapeutic strategy against malignant ovarian cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Cell Biology
Ying Shao, Wenming Zhang, Dongnian Du, Yi Yu, Qing Li, Xiaogang Peng
Summary: This study revealed that FAT10 promotes renal fibrosis by prolonging CHK1-mediated G2/M arrest via USP7. Inhibition of the FAT10/USP7/CHK1 axis may be a potential therapeutic approach for chronic kidney disease.
Article
Oncology
Hae-Ahm Lee, Ki-Back Chu, Eun-Kyung Moon, Fu-Shi Quan
Summary: HDACi sensitizes HCC cells to oxidative stress by inducing CDK inhibitor expression, leading to inhibition of CDK4/6, FOXM1, and downstream target genes phosphorylation, ultimately causing G2/M cell cycle arrest.
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Oncology
Lili Du, Jiexian Jing, Yan Wang, Xiaoqin Xu, Ting Sun, Yanchun Shi, Weigang Wang, Baoguo Tian, Cunzhi Han, Xianwen Zhao, Huibo Chang
Summary: The present study demonstrated the important role of SASS6 in promoting MDA-MB-231 cell growth, regulating cell cycle progression, and downregulating the CDK1/cyclin B1 signaling pathway in TNBC. SASS6 knockdown resulted in inhibited cell growth, G2/M phase arrest, and decreased expression of key cell cycle regulators and signaling molecules. These findings suggest the potential therapeutic target of SASS6 in TNBC treatment, warranting further investigation in preclinical and clinical studies.
Article
Cell Biology
Martina Galli, Laura Diani, Roberto Quadri, Alessandro Nespoli, Elena Galati, Davide Panigada, Paolo Plevani, Marco Muzi-Falconi
Summary: Symmetry breaking by cellular polarization is crucial for the cell-cycle of Saccharomyces cerevisiae cells, allowing bud emergence and growth. The morphogenesis checkpoint coordinates bud formation and cell cycle progression, with the novel role of the kinase haspin in regulating this process. Haspin monitors polarity establishment and links bud emergence to the G2/M cell cycle transition in yeast.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Yujie Huang, Yonghao Tian, Wenhao Zhang, Ruijuan Liu, Weifang Zhang
Summary: Rab12 was up-regulated in cervical cancer tissues and HPV+ cervical cancer cells. Knockdown of Rab12 enhanced radiosensitivity while overexpression of Rab12 promotes radioresistance. Rab12 regulates DNA double-strand breaks and DNA homologous recombination repair, affecting the radioresistance of cervical cancer cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shigeaki Sunada, Hiroko Saito, Doudou Zhang, Zeyu Xu, Yoshio Miki
Summary: CDK1 inhibitors regulate cellular sensitivity to DNA damage by controlling cell cycle progression and DNA repair inhibition, providing insights for developing clinical strategies targeting CDK1 inhibition in tumor cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Jihong Lin, Lei Zhang, Zhiwei Wang, Qi Guan, Kai Bao, Lan Wu
Summary: COH-203 was found to have notable time- and dose-dependent antiproliferative effects on the human acute promyelocytic leukemia HL-60 cell line, resulting in cell cycle arrest at G(2)/M phase and induction of apoptosis. Western blot analysis revealed that upregulation of cyclin B was associated with G(2)/M arrest, while downregulated expression of Bcl-2 indicated that COH-203 may induce apoptosis in HL-60 cells via the mitochondrial pathway in a caspase-dependent manner.
Article
Oncology
Maike Zimmermann, Si-Si Wang, Hongyong Zhang, Tzu-yin Lin, Michael Malfatti, Kurt Haack, Ted Ognibene, Hongyuan Yang, Susan Airhart, Kenneth W. Turteltaub, George D. Cimino, Clifford G. Tepper, Alexandra Drakaki, Karim Chamie, Ralph de Vere White, Chong-xian Pan, Paul T. Henderson
MOLECULAR CANCER THERAPEUTICS
(2017)
Article
Oncology
Si-Si Wang, Maike Zimmermann, Hongyong Zhang, Tzu-yin Lin, Michael Malfatti, Kurt Haack, Kenneth W. Turteltaub, George D. Cimino, Ralph de Vere White, Chong-xian Pan, Paul T. Henderson
INTERNATIONAL JOURNAL OF CANCER
(2017)
Editorial Material
Neurosciences
Mary C. Horne, Johannes W. Hell
JOURNAL OF PHYSIOLOGY-LONDON
(2017)
Article
Oncology
Fuli Wang, Hongyong Zhang, Ai-Hong Ma, Weimin Yu, Maike Zimmermann, Jun Yang, Sung Hee Hwang, Daniel Zhu, Tzu-yin Lin, Michael Malfatti, Kenneth W. Turteltaub, Paul T. Henderson, Susan Airhart, Bruce D. Hammock, Jianlin Yuan, Ralph W. de Vere White, Chong-Xian Pan
MOLECULAR CANCER THERAPEUTICS
(2018)
Article
Biochemistry & Molecular Biology
Debapriya Ghosh, Madeline Nieves-Cintron, Sendoa Tajada, Ingrid Brust-Mascher, Mary C. Horne, Johannes W. Hell, Rose E. Dixon, Luis F. Santana, Manuel F. Navedo
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2018)
Article
Neurosciences
Lucas Matt, Karam Kim, Anne C. Hergarden, Tommaso Patriarchi, Zulfiqar A. Malik, Deborah K. Park, Dhrubajyoti Chowdhury, Olivia R. Buonarati, Peter B. Henderson, Cigdem Gokcek Sarac, Yonghong Zhang, Durga Mohapatra, Mary C. Home, James B. Ames, Johannes W. Hell
Article
Chemistry, Medicinal
Sisi Wang, Tiffany M. Scharadin, Maike Zimmermann, Michael A. Malfatti, Kenneth W. Turteltaub, Ralph de Vere White, Chong-Xian Pan, Paul T. Henderson
CHEMICAL RESEARCH IN TOXICOLOGY
(2018)
Review
Pharmacology & Pharmacy
Kwun Nok Mimi Man, Manuel F. Navedo, Mary C. Horne, Johannes W. Hell
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 60
(2020)
Article
Oncology
Maike Zimmermann, Tao Li, Thomas J. Semrad, Chun-Yi Wu, Aiming Yu, George Cimino, Michael Malfatti, Kurt Haack, Kenneth W. Turteltaub, Chong-xian Pan, May Cho, Edward J. Kim, Paul T. Henderson
MOLECULAR CANCER THERAPEUTICS
(2020)
Article
Oncology
Robson Amaral, Maike Zimmermann, Ai-Hong Ma, Hongyong Zhang, Kamilla Swiech, Chong-Xian Pan
Review
Biochemistry & Molecular Biology
Kwun Nok Mimi Man, Peter Bartels, Mary C. Horne, Johannes W. Hell
Article
Multidisciplinary Sciences
Taylor L. Voelker, Silvia G. del Villar, Maartje Westhoff, Alexandre D. Costa, Andrea M. Coleman, Johannes W. Hell, Mary C. Horne, Eamonn J. Dickson, Rose E. Dixon
Summary: CaV1.2 channels in the heart are affected by angiotensin II, a therapeutic target of heart failure drugs and regulator of blood pressure. Angiotensin II causes a decrease in PIP2, which leads to the suppression of CaV1.2 currents. This study found that PIP2 depletion destabilizes CaV1.2 channels and reduces their expression and function. The results suggest that PIP2 plays a crucial role in maintaining cardiac excitability and that angiotensin II-induced PIP2 depletion impairs excitation-contraction coupling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Environmental Sciences
Michael A. Malfatti, Bruce A. Buchholz, Heather A. Enright, Benjamin J. Stewart, Ted J. Ognibene, A. Daniel McCartt, Gabriela G. Loots, Maike Zimmermann, Tiffany M. Scharadin, George D. Cimino, Brian A. Jonas, Chong-Xian Pan, Graham Bench, Paul T. Henderson, Kenneth W. Turteltaub
Article
Biochemistry & Molecular Biology
Pang-Yen Tseng, Peter B. Henderson, Anne C. Hergarden, Tommaso Patriarchi, Andrea M. Coleman, Mark W. Lillya, Carlota Montagut-Bordas, Boram Lee, Johannes W. Hell, Mary C. Horne
Article
Chemistry, Medicinal
Alessia Stornetta, Maike Zimmermann, George D. Cimino, Paul T. Henderson, Shana J. Sturla
CHEMICAL RESEARCH IN TOXICOLOGY
(2017)