Apolipoprotein E3 (ApoE3) but Not ApoE4 Protects against Synaptic Loss through Increased Expression of Protein Kinase Cϵ

α, β-DCP-LA Selectively Activates PKC-ε and Stimulates Neurotransmitter Release with the Highest Potency among 4 Diastereomers

(2017) Tadashi Shimizu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

High ability of apolipoprotein E4 to stabilize amyloid-β peptide oligomers, the pathological entities responsible for Alzheimer's disease

(2011) Emilie Cerf et al.   FASEB JOURNAL

PKC   Activation Prevents Synaptic Loss, A  Elevation, and Cognitive Deficits in Alzheimer's Disease Transgenic Mice

(2011) J. Hongpaisan et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Amyloid oligomers: formation and toxicity of Aβ oligomers

(2010) Masafumi Sakono et al.   FEBS Journal

Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Mediates Neuronal Aβ42 Uptake and Lysosomal Trafficking

(2010) Rodrigo A. Fuentealba et al.   PLoS One

Protein Kinase C Activators as Synaptogenic and Memory Therapeutics

(2009) Miao-Kun Sun et al.   ARCHIV DER PHARMAZIE

Isolation and Characterization of Patient-derived, Toxic, High Mass Amyloid β-Protein (Aβ) Assembly from Alzheimer Disease Brains

(2009) Akihiko Noguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduction of β-Amyloid Levels by Novel Protein Kinase Cϵ Activators

(2009) Thomas J. Nelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protection of Neurons from Apoptosis by Apolipoprotein E-containing Lipoproteins Does Not Require Lipoprotein Uptake and Involves Activation of Phospholipase Cγ1 and Inhibition of Calcineurin

(2009) Hideki Hayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DCP-LA stimulates AMPA receptor exocytosis through CaMKII activation due to PP-1 inhibition

(2009) Takeshi Kanno et al.   JOURNAL OF CELLULAR PHYSIOLOGY

ApoE4 Decreases Spine Density and Dendritic Complexity in Cortical Neurons In Vivo

(2009) S. B. Dumanis et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance

(2009) Jungsu Kim et al.   NEURON

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

Neuroprotective versus tumorigenic protein kinase C activators

(2009) T.J. Nelson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks

(2008) Alexandra Bour et al.   BEHAVIOURAL BRAIN RESEARCH

Amyloid   Oligomers (A 1-42 Globulomer) Suppress Spontaneous Synaptic Activity by Inhibition of P/Q-Type Calcium Currents

(2008) V. Nimmrich et al.   JOURNAL OF NEUROSCIENCE

ApoE Promotes the Proteolytic Degradation of Aβ

(2008) Qingguang Jiang et al.   NEURON