Article
Endocrinology & Metabolism
Maria Ramos-Caceres, Itziar Lamiquiz-Moneo, Ana Cenarro, Pilar Calmarza, Victoria Marco-Benedi, Ana M. Bea, Rocio Mateo-Gallego, Jose Puzo, Jose M. Ordovas, Fernando Civeira, Martin Laclaustra
Summary: This study analyzes the relationship between triglycerides (TGs) and lipoprotein(a) (Lp(a)) concentrations. It found an inverse relationship between TG and Lp(a). Larger VLDL size, VLDLs enriched in apoE, and the apoE2/E2 genotype were associated with lower levels of Lp(a).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Brynne E. Whitacre, Philip Howles, Scott Street, Jamie Morris, Debi Swertfeger, W. Sean Davidson
Summary: High levels of circulating triglycerides are associated with metabolic diseases. This study found that APOE on VLDL modulates LPL activity, which may be relevant to the pathogenesis of metabolic diseases.
JOURNAL OF LIPID RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Late Tokgozoglu, Peter Libby
Summary: Lipid risk factors for cardiovascular disease depend on both lifestyle and additional measures for optimum control. Recent genetic findings have identified novel targets for lipid-lowering therapy, providing new avenues for management. New treatments targeting triglyceride-rich lipoproteins and lipoprotein(a) have emerged and shown improved efficacy and tolerability. Gene-editing approaches are also being explored in lipid management.
EUROPEAN HEART JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Iva Klobucar, Lucija Klobucar, Margarete Lechleitner, Matias Trbusic, Gudrun Pregartner, Andrea Berghold, Hansjoerg Habisch, Tobias Madl, Sasa Frank, Vesna Degoricija
Summary: This study found that the serum levels of endothelial lipase (EL) were associated with the serum levels and composition of apolipoprotein B (apoB)-containing lipoproteins, and these associations were different between metabolic syndrome (MS) patients and healthy volunteers (HVs). In MS patients, EL levels were negatively correlated with cholesterol levels in large very low-density lipoprotein (VLDL) particles, as well as with total-cholesterol, free-cholesterol, triglyceride, and phospholipid contents of VLDL and intermediate-density lipoprotein particles. In HVs, EL levels were positively correlated with the serum levels of apoB, triglycerides, and phospholipids in large low-density lipoprotein particles. These findings suggest that EL levels are influenced by MS and may play a role in lipid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Alexia Rouland, David Masson, Laurent Lagrost, Bruno Verges, Thomas Gautier, Benjamin Bouillet
Summary: ApoC1 is a small apolipoprotein with significant roles in lipoprotein metabolism. It affects the metabolism of triglycerides and cholesterol and is involved in inflammation regulation. However, further studies are needed to fully understand its precise functions and its relationship with cardiometabolic diseases.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rebecca Grueneis, Hansi Weissensteiner, Claudia Lamina, Sebastian Schoenherr, Lukas Forer, Silvia Di Maio, Gertraud Streiter, Annette Peters, Christian Gieger, Florian Kronenberg, Stefan Coassin
Summary: This study investigated the effects of PNR10 and PNR11 alleles on Lp(a) concentrations, and found that their association with decreased Lp(a) is influenced by a linkage disequilibrium with the common splicing mutation KIV-2 4925G>A.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Multidisciplinary Sciences
Kevin A. Guttenplan, Maya K. Weigel, Priya Prakash, Prageeth R. Wijewardhane, Philip Hasel, Uriel Rufen-Blanchette, Alexandra E. Munch, Jacob A. Blum, Jonathan Fine, Mikaela C. Neal, Kimberley D. Bruce, Aaron D. Gitler, Gaurav Chopra, Shane A. Liddelow, Ben A. Barres
Summary: Astrocytes respond to diseases and injuries in the central nervous system by releasing long-chain saturated fatty acids contained in lipoparticles, leading to the death of neurons and mature oligodendrocytes. The elimination of saturated lipids produced by astrocytes can mitigate astrocyte-induced toxicity, suggesting a mechanism by which astrocytes kill cells in the central nervous system.
Article
Biochemistry & Molecular Biology
Masashi Muramatsu, Tsuyoshi Osawa, Yuri Miyamura, Suguru Nakagawa, Toshiya Tanaka, Tatsuhiko Kodama, Hiroyuki Aburatani, Juro Sakai, Sandra Ryeom, Takashi Minami
Summary: DSCR-1 serves as a feedback modulator for NFAT signals crucial for cell proliferation and inflammation, and plays a critical role in vascular wall remodeling and macrophage phenotypic switch. Loss of both Dscr-1 and ApoE causes metabolic dysfunction in the liver but reduces atherosclerotic plaques, resulting in increased serum cholesterol and vasculopathy.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Cell Biology
Guoyuan Qi, Yashi Mi, Xiaojian Shi, Haiwei Gu, Roberta Diaz Brinton, Fei Yin
Summary: This study reveals the detrimental effects of ApoE4 on fatty acid metabolism in neurons and astrocytes, leading to lipid accumulation and energy imbalance. ApoE4 decreases the transport efficiency of neuronal lipids, compromising metabolic and synaptic support from astrocytes to neurons.
Review
Pharmacology & Pharmacy
Waqas A. Malick, Ron Do, Robert S. Rosenson
Summary: Severe hypertriglyceridemia (sHTG) is an important risk factor for acute pancreatitis and is caused by genetic defects. Novel pathway-specific therapeutics targeting LPL modulating proteins offer better efficacy in treating sHTG and reducing the risk of acute pancreatitis and atherosclerotic cardiovascular disease events.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Sandeep Bansal, Andrea Ruzza, Jps Sawhney, Govind Kulkarni, Shammana Iyengar, Vimal Mehta, Andrew Hamer, You Wu, Frederick J. Raal
Summary: The RAMAN study evaluated the safety and tolerability of evolocumab in patients with HoFH in India, showing that the drug was safe and well tolerated in this population with smaller reductions in LDL-C and other lipids than previous studies.
JOURNAL OF CLINICAL LIPIDOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Maryam Darabi, Anatol Kontush
Summary: Recent research has shown that raising agents for high-density lipoprotein (HDL) have failed to reduce cardiovascular disease, while individuals with extremely high HDL-cholesterol levels have increased cardiovascular mortality. This has led to the expansion of the concept of HDL function to include its role in the lipolysis of triglyceride-rich lipoproteins (TGRLs) by lipoprotein lipase. This new perspective presents opportunities for novel therapeutic applications aimed at reducing cardiovascular disease by accelerating cholesterol flux through the lipolysis process.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Biochemistry & Molecular Biology
Jonathan S. Rink, Adam Yuh Lin, Kaylin M. McMahon, Andrea E. Calvert, Shuo Yang, Tim Taxter, Jonathan Moreira, Amy Chadburn, Amir Behdad, Reem Karmali, C. Shad Thaxton, Leo Gordon
Summary: Recent research suggests that malignant cells dependent on cholesterol uptake from lipoproteins are susceptible to ferroptosis, a type of cell death triggered by accumulation of oxidized lipids in cell membranes. Treatment of these cells with HDL NPs activates a compensatory metabolic response, leading to increased de novo cholesterol synthesis and downregulation of GPX4 expression, resulting in ferroptosis-mediated cell death. In vivo studies in mouse lymphoma xenografts and patient samples further support the potential of targeting SCARB1 with HDL NPs for cholesterol uptake-addicted lymphoma cells.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Shuang Yao, Fan Zheng, Yang Yu, Yuxia Zhan, Ning Xu, Guanghua Luo, Lu Zheng
Summary: This study showed that ApoM is expressed in mouse macrophages and is involved in cholesterol uptake, similar to SR-BI. ApoM-enriched HDL facilitated cholesterol efflux from macrophages, while recombinant human ApoM protein inhibited this ability.
Article
Cardiac & Cardiovascular Systems
Ghaleb Khirfan, Manshi Li, Xiaofeng Wang, Joseph A. DiDonato, Raed A. Dweik, Gustavo A. Heresi
Summary: Recent studies have shown that Apolipoprotein A-I (ApoA-I) may be a more sensitive biomarker than high-density lipoprotein cholesterol (HDL-C) in chronic thromboembolic pulmonary hypertension (CTEPH), and may be associated with right heart dysfunction.
PULMONARY CIRCULATION
(2021)
Article
Neurosciences
Keishi Kisoh, Hideki Hayashi, Miho Arai, Maiko Orita, Bo Yuan, Norio Takagi
MOLECULAR NEUROBIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Ichiro Horinokita, Hideki Hayashi, Rika Oteki, Risa Mizumura, Tatsuaki Yamaguchi, Akane Usui, Bo Yuan, Norio Takagi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Multidisciplinary Sciences
Mariko Yamada, Hideki Hayashi, Kaori Suzuki, Shoko Sato, Daisuke Inoue, Yui Iwatani, Meiko Ohata, Bo Yuan, Norio Takagi
SCIENTIFIC REPORTS
(2019)
Article
Medicine, Research & Experimental
Qiuyan Guo, Koji Mizuno, Katsuki Okuyama, Na Lin, Yanqiong Zhang, Hideki Hayashi, Norio Takagi, Takashi Sato
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Article
Pharmacology & Pharmacy
Bowen Yu, Bo Yuan, JingZhe Li, Anna Kiyomi, Hidetomo Kikuchi, Hideki Hayashi, Xiaomei Hu, Mari Okazaki, Munetoshi Sugiura, Toshihiko Hirano, Yingyi Fan, Xiaohua Pei, Norio Takagi
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Neurosciences
Mayumi Asada, Hideki Hayashi, Kenjiro Murakami, Kento Kikuiri, Ryotaro Kaneko, Bo Yuan, Norio Takagi
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Oncology
Hideki Hayashi, Ichiro Horinokita, Yuji Yamada, Keisuke Hamada, Norio Takagi, Motoyoshi Nomizu
Summary: Peptides derived from laminin, specifically AG73 and C16, show superior cell attachment and neurite extension activities for rat neural stem/progenitor cells (NPCs) compared to other peptides. They support the growth of neurons and astrocytes differentiated from NPCs, with C16 also promoting the expression of neuronal markers. These peptides have potential as valuable biomaterials for NPC research.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Oncology
Bo Yuan, Kang Xu, Ryota Shimada, JingZhe Li, Hideki Hayashi, Mari Okazaki, Norio Takagi
Summary: Glioblastoma is a fatal primary malignant brain tumor with a low survival rate, and there is an urgent need for novel therapeutic approaches. Trivalent arsenic derivative and gamabufotalin show cytotoxic effects against glioblastoma cells, with synergistic cytotoxicity when combined. The study suggests that G(2)/M cell cycle arrest, necrosis, and autophagy contribute to the cytotoxicity, and a possible strategy of combining these compounds with a p38 MAPK inhibitor may provide new insights into combating glioblastoma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Min Wang, Hideki Hayashi, Ichiro Horinokita, Mayumi Asada, Yui Iwatani, Jian-xun Liu, Norio Takagi
Summary: The study demonstrated that SEI protected Neuro2a cells against glutamate-induced toxicity by modulating the JNK/caspase-3 pathway and apoptosis, suggesting SEI as a promising candidate for neuroprotection.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Neurosciences
Ichiro Horinokita, Hideki Hayashi, Rihona Yoshizawa, Mika Ichiyanagi, Yui Imamura, Yui Iwatani, Norio Takagi
Summary: The study found that the inhibition of PGRN cleavage, rather than direct action, can suppress post-ischemic inflammation, potentially establishing a new approach for cerebral ischemia treatment.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ichiro Horinokita, Hideki Hayashi, Takamasa Nagatomo, Yuna Fushiki, Yui Iwatani, Norio Takagi
Summary: In this study, the researchers investigated the effects of sivelestat and progranulin (PGRN) on neural stem cells under ischemic conditions. They found that treatment with recombinant PGRN (rPGRN) increased cell proliferation and phosphorylation of Akt and GSK-3 beta, while sivelestat had no effect. Additionally, rPGRN enhanced neurite outgrowth of differentiated neurons. These findings suggest that PGRN could be a potential therapeutic approach for cerebral ischemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Correction
Oncology
Bo Yuan, Kang Xu, Ryota Shimada, JingZhe Li, Hideki Hayashi, Mari Okazaki, Norio Takagi
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mayumi Asada, Hideki Hayashi, Norio Takagi
Summary: Neuronal cell death after cerebral ischemia is mainly caused by excessive Ca2+ influx through NMDA receptors. DNA methylation plays an important role in this process, and inhibition of DNMTs can protect cells from injury. Pharmacological inhibition of DNMTs is effective in protecting against glutamate excitotoxicity.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Ophthalmology
Hideki Hayashi, Misuzu Mori, Mina Harashima, Tatsuya Hashizume, Miho Furiya, Chihaya Mukaigaito, Emi Takemura, Mariko Yamada, Kanako Mise, Bo Yuan, Norio Takagi
Summary: The study found that E-LPs can protect the optic nerve from degeneration and reduce the increase of alpha-2-macroglobulin in the aqueous humor and retina of rats. E-LPs directly decreased the expression and secretion of alpha-2-macroglobulin in primary cultures of Muller glia, which was blocked by knockdown of LRP1. E-LPs promoted the phosphorylation of STAT3 and inhibited the expression of alpha-2-macroglobulin, suggesting a potential protective mechanism against excitotoxicity in the retina.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Oncology
Bowen Yu, Bo Yuan, Anna Kiyomi, Hidetomo Kikuchi, Hideki Hayashi, Xiaomei Hu, Mari Okazaki, Munetoshi Sugiura, Toshihiko Hirano, Xiaohua Pei, Norio Takagi
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2019)