Article
Pharmacology & Pharmacy
Zhong-hua Wu, Hua Fan, Shang-yan Gao, Yan-fei Jin, Bo Jiang, Jian Shen
Summary: Depression is a mood disorder with a significant economic burden. Oroxylin A, an active component from Scutellariae radix, has potential antidepressant effects by increasing hippocampal brain-derived neurotrophic factor (BDNF) levels and neurogenesis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Ling Liu, Chun-Hui Ji, Yuan Wang, Jie Zhao, Yue Liu, Wen-Qian Tang, Jiang-Hong Gu, Bo Jiang
Summary: The study found that L-701,324 has antidepressant effects in mice, possibly by promoting the hippocampal BDNF system, which can prevent stress-induced depressive-like behaviors.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Kohei Hayashi, Takaomi Shimokawa, Masayo Yamagata, Kozo Yoneda
Summary: The study showed that long-term treatment with yohimbine can be an effective therapeutic option to prevent the progression of chronic kidney disease, by reducing renal dysfunction, lowering blood pressure, and suppressing renal fibrosis.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Review
Medicine, General & Internal
Anna Mosiolek, Jadwiga Mosiolek, Slawomir Jakima, Aleksandra Pieta, Agata Szulc
Summary: Major depressive disorder (MDD) is a multifactorial disease with ongoing research on the role of neurotrophic factors in its pathophysiology. Antidepressant treatment can modify serum levels of neurotrophins, such as BDNF, leading to clinical improvement of MDD. Further research is needed to understand the correlation between different antidepressant drugs and neurotrophic factor serum levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Hanan H. Ahmed, Reham M. Essam, Muhammed F. El-Yamany, Kawkab A. Ahmed, Ayman E. El-Sahar
Summary: This study found that lactoferrin improves depressive behavior and biochemical abnormalities induced by chronic restraint stress in rats. Additionally, lactoferrin restores balance and plays an antidepressant role by inhibiting oxidative stress and inflammatory cascades.
Article
Immunology
Samuel C. Woodburn, Helina S. Asrat, James K. Flurer, Hana C. Schwierling, Justin L. Bollinger, Lauren L. Vollmer, Eric S. Wohleb
Summary: Chronic stress reduces synaptic expression of glutamate receptors in the PFC, leading to working memory deficits. Recent studies suggest that microglia are an important source of BDNF. Mice with deficient microglial BDNF showed increased susceptibility to the behavioral and cognitive consequences of stress.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Physiology
Yuki Tomiga, Yasuki Higaki, Keizo Anzai, Hirokazu Takahashi
Summary: Evidence suggests a link between diabetes and mood disorders, but TGF-beta 2 does not seem to improve diabetes-related mood behaviors.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Behavioral Sciences
Daniele Cavaleri, Federico Moretti, Alessandra Bartoccetti, Stefano Mauro, Cristina Crocamo, Giuseppe Carra, Francesco Bartoli
Summary: Based on meta-analyses, this overview suggests that the brain-derived neurotrophic factor (BDNF) may serve as a potential biomarker for major depressive disorder (MDD) and antidepressant response. People with MDD show lower peripheral and central BDNF levels compared to non-depressed individuals, and blood BDNF levels are negatively correlated with symptom severity. Antidepressant treatment can lead to increased blood BDNF levels, proportional to symptom improvement, while non-pharmacological interventions do not affect BDNF concentrations.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Behavioral Sciences
Mingxiu Chang, Li Zhang, Huiyu Dai, Ling Sun
Summary: The study found that genistein has anti-depression effects by increasing activity levels, improving sucrose preference, reducing cortisol levels, and enhancing the expression of BDNF in the brain tissue of rats.
BRAIN AND BEHAVIOR
(2021)
Article
Pharmacology & Pharmacy
Yan-Mei Chen, Hua Fan, Jie Huang, Tian-Shun Shi, Wei-Yu Li, Cheng-Niu Wang, Bo Jiang, Jian-Feng Liu
Summary: Depression is a prevalent psychiatric disorder associated with chronic stress, monoaminergic dysfunction, impaired neurogenesis, and decreased BDNF-CREB signaling. The study suggests that F3/Contactin, a cell-adhesion molecule, may be implicated in depression and could serve as a novel antidepressant target. Over-expression of hippocampal F3/Contactin prevents depressive-like behaviors and dysfunction in neurogenesis and signaling, while administration of vortioxetine, an antidepressant, ameliorates the inhibitory effects on F3/Contactin expression.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Arwin Hajmirzaeyian, Mohsen Chamanara, Amir Rashidian, Saied Shakyba, Ehsan Nassireslami, Reza Akhavan-Sigari
Summary: The study demonstrated the antidepressant-like effect of melatonin on neurogenic stress-induced depression in mice using acute foot-shock stress. Melatonin significantly improved depressant-like behavior and NMDA receptors may be involved in this effect.
Article
Neurosciences
Jie Zhao, Yin Zhang, Yue Liu, Wen-Qian Tang, Chun-Hui Ji, Jiang-Hong Gu, Bo Jiang
Summary: The study found that MNA has antidepressant-like potential in mice, at least partially mediated through promoting the hippocampal BDNF signaling pathway. A single injection of MNA (100 and 200 mg/kg) displayed notable antidepressant-like effects in the FST and TST.
NEUROSCIENCE LETTERS
(2021)
Article
Pharmacology & Pharmacy
Maria Salud Garcia-Gutierrez, Daniela Navarro, Amaya Austrich-Olivares, Jorge Manzanares
Summary: This study aims to characterize the pharmacological and molecular profile of cannabidiol (CBD) as an antidepressant. The effects of CBD, alone or combined with sertraline (STR), were evaluated in mice exposed to chronic stress. CBD showed faster and more significant antidepressant-like effects compared to STR, but the combination of CBD and STR had a negative impact on treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Hueih Ling Ong, I-Ni Chiang, Lin-Nei Hsu, Cheih-Wen Chin, I-Hung Shao, Mei-Yu Jang, Yung-Shun Juan, Chung-Cheng Wang, Hann-Chorng Kuo
Summary: This article reviews the available data on non-surgical management for neurogenic lower urinary tract dysfunction (NLUTD) in patients with chronic spinal cord injury (SCI) and provides the most updated knowledge for readers. The bladder management approaches for storage and voiding dysfunction are minimally invasive, safe, and efficacious procedures. The main goals for NLUTD management are urinary continence, improved quality of life, prevention of urinary tract infections, and preservation of upper urinary tract function. However, there is a lack of high-quality evidence and new minimally invasive treatments for NLUTD, requiring collaboration between urologists, nephrologists, and physiatrists to ensure the health of SCI patients in the future.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Yoshiki Matsuda, Nobuyuki Ozawa, Takiko Shinozaki, Kazuhisa Aoki, Naomi Nihonmatsu-Kikuchi, Toshikazu Shinba, Yoshitaka Tatebayashi
Summary: Chronic antidepressant treatment can significantly alleviate social avoidance, sleep disturbances, and EEG abnormalities in rodent chronic stress models. Additionally, reduced REM sleep theta power may be a core sleep symptom in socially defeated rats.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Lidia Madrid, Javier Jimenez-Martin, Elizabeth J. Coulson, Dhanisha J. Jhaveri
Summary: The production and circuit integration of new neurons in the adult mammalian hippocampus are highly sensitive to neuronal activity, with acetylcholine playing a key role in regulating neurogenesis. Further research is needed to gain a deeper understanding of the mechanisms and translational potential of acetylcholine and its receptors in this process of cellular neuroplasticity.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Clinical Neurology
M. J. Nishanth, Shanker Jha
Summary: Suicidal behavior is a globally prevalent psychiatric disorder with high mortality rates, causing psychological and economic burdens to families and societies, thus requiring the development of effective prevention and treatment approaches. However, despite neurobiological studies on genetic and epigenetic factors, brain regions, and neurotransmitters involved in suicide, a clear understanding of the origins of self-destructive tendencies is lacking.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Neurosciences
Garima Virmani, Priyal D'almeida, Arnab Nandi, Swananda Marathe
Summary: Major depressive disorder is a debilitating neuropsychiatric illness affecting over 20% of the global population. Recent research has shown that astrocytes play a significant role in the pathophysiology and potentially the pathogenesis of major depression. Chronic stress has differential effects on astrocyte subpopulations within the hippocampus.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Cell Biology
Parul Sethi, Garima Virmani, Kushaan Gupta, Surya Chandra Rao Thumu, Narendrakumar Ramanan, Swananda Marathe
Summary: Development and plasticity of the nervous system involve changes in cellular morphology. Researchers have developed a software tool called SMorph to analyze the morphology of nervous system cells quickly and automatically. SMorph was tested on neurons, astrocytes, and microglia, revealing subtle changes in cell morphology and showing structural remodeling in hippocampal astrocytes after chronic antidepressant treatment.
JOURNAL OF CELL SCIENCE
(2021)
Editorial Material
Neurosciences
Jacinta N. Conroy, Dhanisha J. Jhaveri, Elizabeth J. Coulson
Summary: The direct interaction between antidepressants and TrkB revealed in a recent study sheds light on synaptic remodeling mechanisms, potentially enhancing the development of improved antidepressant therapeutics.
Article
Psychiatry
Kelly J. Heard, Maxim N. Shokhirev, Caroline Becronis, Callie Fredlender, Nadia Zahid, Amy T. Le, Yuan Ji, Michelle Skime, Timothy Nelson, Daniel Hall-Flavin, Richard Weinshilboum, Fred H. Gage, Krishna C. Vadodaria
Summary: The study explores the impact of chronic stress on cortisol-induced neuropathology, finding unique differences at the transcriptomic level between chronic and acute cortisol treatment, and investigates the stress response transcriptome of astrocytes from MDD patient iPSCs. These data emphasize the unique role of astrocytes in the central nervous system and present potential genes for further research on the relationship between chronic stress and MDD.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Daniel G. Blackmore, Frederik J. Steyn, Alison Carlisle, Imogen O'Keeffe, King-Year Vien, Xiaoqing Zhou, Odette Leiter, Dhanisha Jhaveri, Jana Vukovic, Michael J. Waters, Perry F. Bartlett
Summary: The study demonstrates that appropriate exercise can improve learning ability in aged mice, but only when it occurs for a specific duration. The spike in growth hormone levels and increase in neurogenesis play a crucial role in mediating this effect.
Article
Neurosciences
Praachi Tiwari, Darshana Kapri, Amartya Pradhan, Angarika Balakrishnan, Pratik R. Chaudhari, Vidita A. Vaidya
Summary: This study investigates the impact of enhanced G(i) signaling during postnatal and juvenile periods on adult anxiety and depression behaviors. The results indicate that inhibiting CaMKII alpha-positive forebrain excitatory neurons during these developmental windows does not affect the programming of anxiodepressive behaviors in adulthood.
Article
Neurosciences
Darshana Kapri, Krishna C. Vadodaria, Karen S. Rommelfanger, Yvonne E. Ogbonmwan, L. Cameron Liles, Kimberly A. Fernandes-Thomas, Sonali S. Salvi, Basma F. A. Husain, David Weinshenker, Vidita A. Vaidya
Summary: Pharmacological lesioning of noradrenergic afferents impairs adult hippocampal neurogenesis in mice, while the complete genetic loss of NE from birth has no effect.
IBRO NEUROSCIENCE REPORTS
(2022)
Review
Neurosciences
Katherine Bassil, Anthi C. Krontira, Thomas Leroy, Alana I. H. Escoto, Clara Snijders, Cameron D. Pernia, R. Jeroen Pasterkamp, Laurence de Nijs, Daniel van den Hove, Gunter Kenis, Marco P. Boks, Krishna Vadodaria, Nikolaos P. Daskalakis, Elisabeth B. Binder, Bart P. F. Rutten
Summary: HPA axis dysregulation is implicated in stress-related disorders and the release of glucocorticoids is associated with neurobiological changes that contribute to negative consequences of chronic stress and psychiatric disorders. In vitro studies investigating the effects of glucocorticoids on various neuronal processes provide insights into the pathophysiology of stress-related psychiatric disorders.
NEUROBIOLOGY OF STRESS
(2023)
Review
Neurosciences
Dhanisha J. Jhaveri, Aileen McGonigal, Christel Becker, Jean-Jacques Benoliel, L. Sanjay Nandam, Lisa Soncin, Iliana Kotwas, Christophe Bernard, Fabrice Bartolomei
Summary: Stress is identified as a major contributor to human disease, including epilepsy. This review explores the complex relationship between stress and epilepsy, highlighting key neurobiological mechanisms. It discusses current clinical management approaches and proposes the development of new treatments that target shared mechanisms of stress and epilepsy. The integration of data from genetics to systems biology is emphasized, with the potential for personalized interventions using machine learning and neuromodulation strategies.
Meeting Abstract
Neurosciences
Jordi Serrats, Krishna Vadodaria, Kimberly Vanover, Eve Taylor, Stephen Cunningham
NEUROPSYCHOPHARMACOLOGY
(2022)
Meeting Abstract
Neurosciences
Krishna Vadodaria, Brian D. Kangas, David S. Garvey, William Brubaker, Diego A. Pizzagalli, Vikram Sudarsan, Kimberly E. Vanover, Jordi Serrats
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biology
Toshali Banerjee, Sthitapranjya Pati, Praachi Tiwari, Vidita A. Vaidya
Summary: The study found that altering neuronal activity within PV-positive interneurons during the critical postnatal developmental window can shape the emergence of anxio-depressive behaviors in adulthood, with sex playing a key role in determining behavioral outcomes.
JOURNAL OF BIOSCIENCES
(2022)
Review
Education & Educational Research
Katherine L. Jones, Mei Zhou, Dhanisha J. Jhaveri
Summary: Adult hippocampal neurogenesis plays a crucial role in generating and integrating new neurons in the hippocampus during adulthood, and has the potential to modulate neural circuit function and behavior. Dysregulation of this process is linked to stress-related neuropsychiatric conditions, but the exact role of adult hippocampal neurogenesis in regulating stress response and mood disorders is still controversial.
NPJ SCIENCE OF LEARNING
(2022)