Endorepellin, the Angiostatic Module of Perlecan, Interacts with Both the α2β1 Integrin and Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)

An Antibody Targeted to VEGFR-2 Ig Domains 4-7 Inhibits VEGFR-2 Activation and VEGFR-2-Dependent Angiogenesis without Affecting Ligand Binding

(2011) J. Kendrew et al.   MOLECULAR CANCER THERAPEUTICS

Heparan Sulfate-Dependent Signaling of Fibroblast Growth Factor 18 by Chondrocyte-Derived Perlecan

(2010) Christine Y. Chuang et al.   BIOCHEMISTRY

Soluble Perlecan Domain I Enhances Vascular Endothelial Growth Factor-165 Activity and Receptor Phosphorylation in Human Bone Marrow Endothelial Cells

(2010) Arivalagan Muthusamy et al.   BMC BIOCHEMISTRY

Effective Suppression of Vascular Network Formation by Combination of Antibodies Blocking VEGFR Ligand Binding and Receptor Dimerization

(2010) Denis Tvorogov et al.   CANCER CELL

Integrin affinity modulation in angiogenesis

(2010) Ganapati H. Mahabeleshwar et al.   CELL CYCLE

Activin A Binds to Perlecan through Its Pro-region That Has Heparin/Heparan Sulfate Binding Activity

(2010) Shaoliang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin α1β1 Promotes Caveolin-1 Dephosphorylation by Activating T Cell Protein-tyrosine Phosphatase

(2010) Corina M. Borza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decorin Antagonizes Met Receptor Activity and Down-regulates β-Catenin and Myc Levels

(2010) Simone Buraschi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulfate Regulates VEGF165- and VEGF121-mediated Vascular Hyperpermeability

(2010) Ding Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vascular Endothelial Growth Factor A (VEGF-A) Induces Endothelial and Cancer Cell Migration through Direct Binding to Integrin α9β1

(2010) Saji Oommen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells

(2010) Tom T. Chen et al.   JOURNAL OF CELL BIOLOGY

Proteoglycans in cancer biology, tumour microenvironment and angiogenesis

(2010) Renato V. Iozzo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TIMP-2 modulates VEGFR-2 phosphorylation and enhances phosphodiesterase activity in endothelial cells

(2010) Seo-Jin Lee et al.   LABORATORY INVESTIGATION

Vascular Endothelial Growth Factor: Much More than an Angiogenesis Factor

(2010) Donald R. Senger   MOLECULAR BIOLOGY OF THE CELL

Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling

(2010) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Key Role for the Integrin α2β1 in Experimental and Developmental Angiogenesis

(2009) James D. San Antonio et al.   AMERICAN JOURNAL OF PATHOLOGY

Cooperation between integrin ανβ3 and VEGFR2 in angiogenesis

(2009) Payaningal R. Somanath et al.   ANGIOGENESIS

Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity

(2009) A. Nystrom et al.   BLOOD

Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level

(2009) Xuefeng Zhang et al.   FASEB JOURNAL

Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis

(2009) Jason J. Zoeller et al.   MATRIX BIOLOGY

Basement membrane proteoglycans: Modulators Par Excellence of cancer growth and angiogenesis

(2009) Renato V. Iozzo et al.   MOLECULES AND CELLS

Diverse Cell Signaling Events Modulated by Perlecan†

(2008) John M. Whitelock et al.   BIOCHEMISTRY

Heparan Sulfate in Perlecan Promotes Mouse Atherosclerosis

(2008) Karin Tran-Lundmark et al.   CIRCULATION RESEARCH

Endothelial Cells Provide Feedback Control for Vascular Remodeling Through a Mechanosensitive Autocrine TGF-β Signaling Pathway

(2008) Aaron B. Baker et al.   CIRCULATION RESEARCH

Extracellular matrix mediates a molecular balance between vascular morphogenesis and regression

(2008) George E Davis et al.   CURRENT OPINION IN HEMATOLOGY

Caspase-3 Activation Triggers Extracellular Cathepsin L Release and Endorepellin Proteolysis

(2008) Jean-François Cailhier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A central function for perlecan in skeletal muscle and cardiovascular development

(2008) Jason J. Zoeller et al.   JOURNAL OF CELL BIOLOGY

The protein tyrosine phosphatase TCPTP controls VEGFR2 signalling

(2008) E. Mattila et al.   JOURNAL OF CELL SCIENCE

Sustained VEGF Blockade Results in Microenvironmental Sequestration of VEGF by Tumors and Persistent VEGF Receptor-2 Activation

(2008) A. Kadenhe-Chiweshe et al.   MOLECULAR CANCER RESEARCH

Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma

(2008) Masatoshi Jinnin et al.   NATURE MEDICINE

Identification of circulating endorepellin LG3 fragment: Potential use as a serological biomarker for breast cancer

(2007) Jong Wook Chang et al.   Proteomics Clinical Applications