Article
Biochemistry & Molecular Biology
Junjuan Wang, Ruolin Song, Ruoxi Lan, Mengzhen Hao, Guirong Liu, Manman Liu, Shanfeng Sun, Cheng Chen, Huilian Che
Summary: There is no universally accepted classification of the severity of allergic reactions triggered by different food allergens. A food allergy model was established to study the severity of allergies caused by peanut, egg, milk, and soybean proteins. It was found that peanut allergy was the most severe and soybean allergy was the least severe. Peanut allergy was associated with the regulation of asthma genes through the MAPK signaling pathway, leading to more severe allergic reactions.
Article
Pharmacology & Pharmacy
Brandon W. Lewis, Maria L. Ford, Aiman Q. Khan, Joshua Walum, Rodney D. Britt
Summary: Type 2-high severe asthma is a distinct subtype characterized by Th2 inflammation, high eosinophil lung infiltration, impaired lung function, and reduced corticosteroid sensitivity. Acute and chronic allergen models induce type 2 inflammation, but the differences in corticosteroid sensitivity remain unclear. This study found that chronic allergen exposure is associated with more persistent type 2 immune responses and corticosteroid insensitivity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Ainara Velez-del-Burgo, Patricia Sanchez, Ester Sunen, Jorge Martinez, Idoia Postigo
Summary: The study describes a mouse model of asthma induced by only Alt a 1, the major allergen of Alternaria alternata. It demonstrates that Alt a 1 alone can induce lung inflammatory response and mimic the immune response of allergic asthma. This model allows the evaluation of molecules for targeted immunotherapy for fungal allergic asthma.
Article
Pharmacology & Pharmacy
Lloyd Tanner, Jesper Bergwik, Ravi K. Bhongir, Lang Pan, Caijuan Dong, Olov Wallner, Christina Kalderen, Thomas Helleday, Istvan Boldogh, Mikael Adner, Arne Egesten
Summary: This study investigates the potential of OGG1 as a clinically relevant pharmacological target for the treatment of allergic inflammation. The results show that TH5487 treatment decreases goblet cell hyperplasia and mucus production, reduces NF-κB activation, and decreases the expression of proinflammatory cytokines and chemokines, resulting in lower recruitment of immune cells to the lungs. The findings suggest that OGG1 inhibition may have therapeutic effects on allergic asthma.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Jack T. Womble, Mark D. Ihrie, Victoria L. McQuade, Akhil Hegde, Matthew S. McCravy, Sanat Phatak, Robert M. Tighe, Loretta G. Que, David D'Alessio, Julia K. L. Walker, Jennifer L. Ingram
Summary: Asthma is a chronic airway inflammatory disease, and patients with comorbid obesity may experience resistance to currently available therapeutics. Bariatric surgery has been shown to improve asthma control and airway hyperresponsiveness, but the underlying mechanisms are still unclear.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Yu-Qin He, Yue-Long Qiao, Shan Xu, Wo-Er Jiao, Rui Yang, Yong-Gang Kong, Ze-Zhang Tao, Shi-Ming Chen
Summary: This study found that allergens can induce autophagy in CD11c+ dendritic cells in a dose dependent manner, and promote immune imbalance of downstream T cells towards a proinflammatory phenotype. Autophagy plays an important regulatory role in allergic inflammatory response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Zhidan Li, Wei Zhang, Fang Luo, Jian Li, Wenbin Yang, Bingkuan Zhu, Qunfeng Wu, Xiaoling Wang, Chengsong Sun, Yuxiang Xie, Bin Xu, Zhaojun Wang, Feng Qian, Jiaxu Chen, Yanmin Wan, Wei Hu
Summary: Lung-stage Schistosoma japonicum infection protects against OVA-induced asthma by upregulating Treg cells in lung tissue to suppress IgE production.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiuru Li, Ruitao Hou, Hao Ding, Xiang Gao, Zichen Wei, Ting Qi, Lei Fang
Summary: Mollugin, derived from Rubia cordifolia L, has been found to possess anti-inflammatory properties. This study aimed to investigate the protective effects of mollugin against shrimp tropomyosin (ST)-induced allergic airway inflammation in mice. The results showed that mollugin reduced eosinophil infiltration, mucus secretion, and lung eosinophil peroxidase activity, as well as the production of Th2 cytokines IL-4 and IL-5. It also inhibited the expression of various genes related to inflammation in the lung tissues. Furthermore, the molecular docking study suggested that mollugin may exert its effects through the inhibition of p38 MAPK and PARP1. Immunohistochemistry analysis revealed that mollugin mitigated arginase-1 expression and macrophage levels in the lungs, supporting its role in inhibiting macrophage polarization.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Laura Hesse, J. N. G. Oude Elberink, Antoon J. M. van Oosterhout, Martijn C. Nawijn
Summary: Allergic respiratory diseases are chronic inflammatory diseases with diverse symptoms. Traditional pharmacological intervention only suppresses symptoms, while allergen immunotherapy (AIT) has the potential to induce long-term tolerance. However, AIT is not effective for all allergic disorders and requires years of treatment. Extensive research has been conducted to improve the safety and efficacy of AIT by studying its mechanisms.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Respiratory System
Maria Weitoft, Mans Kadefors, Henning Stenberg, Ellen Tufvesson, Zuzana Diamant, Sara Rolandsson Enes, Leif Bjermer, Oskar Rosmark, Gunilla Westergren-Thorsson
Summary: This study aimed to investigate the changes in plasma proteome and circulating hematopoietic progenitor cells associated with the late phase response (LPR) to inhaled allergens in asthmatic individuals. The results showed that LPR was associated with significant changes in a large proportion of plasma proteome, especially in protease inhibitors, which may influence the inflammatory response. Additionally, alterations in multiple coagulation-related proteins were found to be associated with LPR.
RESPIRATORY RESEARCH
(2022)
Article
Immunology
Katarzyna Wojcik-Pszczola, Krzysztof Pociecha, Grazyna Chlon-Rzepa, Monika Zadrozna, Barbara Nowak, Hanna Plutecka, Paulina Koczurkiewicz-Adamczyk, Katarzyna Przejczowska-Pomierny, Elzbieta Pekala, Reinoud Gosens, Elzbieta Wyska
Summary: This study investigated the effects of two pan-phosphodiesterase (PDE) inhibitors on a murine model of allergic asthma. The results showed that these inhibitors reduced airway inflammation and remodeling, and alleviated the symptoms of asthma by inhibiting the TGF-β/Smad signaling pathway. Therefore, these inhibitors may serve as potential anti-asthmatic drug candidates.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kevin Looi, Alexander N. Larcombe, Kara L. Perks, Luke J. Berry, Graeme R. Zosky, Paul Rigby, Darryl A. Knight, Anthony Kicic, Stephen M. Stick
Summary: This study found that challenge with ovalbumin or house dust mite in mice resulted in bronchoalveolar inflammation, with previously infected mice showing higher levels of OVA-specific IgE in serum. Mice previously infected, sensitized, and challenged with OVA were most responsive to methacholine, while HDM challenge caused significant increases in tissue damping and tissue elastance. Influenza infection was associated with decreased claudin-1 expression and occludin expression in OVA or HDM-challenged mice, demonstrating the importance of respiratory epithelium in pre-sensitized individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Allergy
Punyada Suchiva, Toshiro Takai, Seiji Kamijo, Natsuko Maruyama, Takehiko Yokomizo, Yukihiko Sugimoto, Ko Okumura, Shigaku Ikeda, Hideoki Ogawa
Summary: Inhibition of COX can enhance sensitization to protease allergens, increase Th2 and Th17 cytokine production, and lead to allergic airway inflammation. Co-treatment with COX-1 selective and COX-2 selective inhibitors can more efficiently promote Th cell responses and airway inflammation.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Eva Conde, Romain Bertrand, Bianca Balbino, Jonathan Bonnefoy, Julien Stackowicz, Noemie Caillot, Fabien Colaone, Samir Hamdi, Raissa Houmadi, Alexia Loste, Jasper B. J. Kamphuis, Francois Huetz, Laurent Guilleminault, Nicolas Gaudenzio, Aurelie Mougel, David Hardy, John N. Snouwaert, Beverly H. Koller, Vincent Serra, Pierre Bruhns, Geraldine Grouard-Vogel, Laurent L. Reber
Summary: The study developed vaccines targeting IL-4 and IL-13, demonstrating promising prophylactic and therapeutic effects in mouse models of asthma. Vaccines specific for human IL-4 and IL-13 also showed efficient neutralization of these cytokines in mice, suggesting a potential long-term therapeutic strategy for allergic asthma.
NATURE COMMUNICATIONS
(2021)
Article
Environmental Sciences
Xihua Wang, Shuyuan Guan, Lingbin Sun, Zhongliang Dai
Summary: Simultaneous exposure to both BaP and house dust mites (HDM) exacerbates pulmonary inflammation and hyperresponsiveness in a murine asthma model. This study provides insights into the potential epigenetic basis for BaP-induced asthma exacerbation through RNA sequencing and DNA methylation assessment.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Ya-Wen Yang, Chien-Chia Chen, Ching-Yao Yang, Chih-Yuan Lee, Hung-Chih Yang, Bor-Luen Chiang, Ya-Hui Chuang, Tiffany E. Wu, Hong-Shiee Lai, Meng-Kun Tsai
Summary: This study investigated the cellular immune responses of HBsAg-positive renal transplantation recipients taking immunosuppressants and nucleotide analogues (NAs). The results showed that Groups 2 and 3 had higher cellular immune responses, possibly inducing liver pathology due to uncontrolled viral replication.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Medicine, General & Internal
Chin-An Yang, Ya-Ling Huang, Bor-Luen Chiang
Summary: The study found shared innate immune response pathways between COVID-19 and KD transcriptomes, indicating that genetic polymorphisms associated with innate immune dysregulation and KD susceptibility, along with variants in STING and STAT3, may predict the severity of COVID-19 and potential susceptibility to COVID-19 related MIS-C.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Yung-Sen Chang, Chih-Chen Tsai, Pang-Yan Yang, Chih-Yu Tang, Bor-Luen Chiang
Summary: Oral melatonin supplement has been shown to improve dermatitis severity in children with AD. This study investigated the mechanism and immunomodulatory effect of topical melatonin treatment in mice and cell models of AD. The results suggest that melatonin may have a direct immunomodulatory effect on AD and could be a potential treatment for patients with AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Ting-Wei Lin, Ya-Chiao Hu, Yao-Hsu Yang, Yin-Hsiu Chien, Ni-Chung Lee, Hsin-Hui Yu, Bor-Luen Chiang, Li-Chieh Wang
Summary: We reported a case of a patient with multiple disorders, including autoimmune disease, immunodeficiency, enteropathy, organomegaly and lymphocytic infiltration. The patient showed excellent response to abatacept treatment.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Allergy
Li-Chieh Wang, Yen-Ming Huang, Chieh Lu, Bor-Luen Chiang, Ying-Rou Shen, Hsun-Yi Huang, Chien-Chang Lee, Nan-Wei Su, Bi-Fong Lin
Summary: This study aimed to investigate the influence of fatty acid compositions in breast milk (BM) on the development of atopic dermatitis (AD) in exclusively breastfed infants. The results showed that the levels of caprylate and acetate in breast milk were negatively associated with objSCORAD in AD infants.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Pediatrics
Jyh-Hong Lee, Yu-Tsan Lin, Ai-Lin Chu, Shu-Ya Hsiao, Kuei-Ying Chang, Yao-Hsu Yang, Li-Chieh Wang, Hsin-Hui Yu, Ya-Chiao Hu, Bor-Luen Chiang
Summary: This study examines the impact of total IgE, blood eosinophil, allergen sensitization, and inhaled corticosteroid (ICS) on longitudinal outcomes in childhood asthma patients. It finds that blood eosinophil percentage and mold sensitization are significantly associated with increased asthma severity. Characteristics including sensitization status and ICS dosage demonstrate an improved capability for predicting clinical outcomes.
PEDIATRIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Chiao-Juno Chiu, Chien-Chia Liao, Yu-Hsiang Hsu, Bor-Luen Chiang
Summary: Endogenous adult lung SSEA-1(+) cells almost disappear in asthmatic mice, but a unique population of circulating SSEA-1(+) cells is enriched after the challenge phase. These cells play a beneficial role in lung inflammation and structural damage by homing to the lung and inhibiting inflammatory cell infiltration.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Immunology
Ting-Sheng Lin, Jyh-Hong Lee, Li-Chieh Wang, Yao-Hsu Yang, Yu-Lung Lau, Wen- Lee, Yu-Tsan Lin, Bor-Luen Chiang, Hsin-Hui Yu
Summary: This study aimed to investigate the clinical features, genetic characteristics, treatment, and prognosis of patients with chronic granulomatous disease (CGD). Results showed that there were six patients with X-linked CGD and three patients with autosomal recessive CGD. Patients with X-linked CGD had earlier onset and diagnosis ages compared to those with autosomal recessive CGD. Prophylactic use of antibiotics, antifungal agents, and interferon-gamma might alleviate infection episodes in CGD patients. Rating: 7 out of 10.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Editorial Material
Rheumatology
Hsin-Hui Yu, Bor-Luen Chiang
CLINICAL RHEUMATOLOGY
(2023)
Letter
Immunology
Yu-Chia Chen, Shiann-Tarng Jou, Ni-Chung Lee, Bor-Luen Chiang, Hsin-Hui Yu
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Ting -Wei Lin, Ya-Chiao Hu, Bor-Luen Chiang
Summary: This study aimed to evaluate the clinical characteristics of children diagnosed with juvenile dermatomyositis (JDM) in Taiwan and identify biomarkers for predicting the disease course and outcomes. The study included 47 patients, with a mean age of 7.5 years at disease onset. The most common initial presentations were Gottron's sign, muscle weakness, and facial rash. The results identified factors associated with complete clinical remission and the chronic continuous course, highlighting the importance of aggressive treatment for the latter.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Cell Biology
Jing-Hui Huang, Yu-Li Lin, Li-Chieh Wang, Bor-Luen Chiang
Summary: Our study demonstrated that splenic B cells can convert CD4(+)CD25(-) naive T cells into CD4(+)CD25(+)Foxp3(-) regulatory T cells without adding cytokines, termed Treg-of-B cells. These Treg-of-B cells are potent suppressors of adaptive immunity. We investigated whether Treg-of-B cells could promote M2 macrophage polarization and alleviate psoriasis. Our results showed that Treg-of-B cells can induce M2 macrophage polarization and attenuate the clinical manifestations of psoriasis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Pediatrics
Tzu-Chuan Hsu, Yao-Hsu Yang, Li-Chieh Wang, Jyh-Hong Lee, Hsin-Hui Yu, Yu-Tsan Lin, Ya-Chiao Hu, Bor-Luen Chiang
Summary: This study aimed to determine the risk factors for subsequent lupus nephritis (LN) development in patients with juvenile-onset systemic lupus erythematosus (jSLE). A retrospective cohort study found that out of 48 jSLE patients without initial LN, 20 developed subsequent LN. Persistently high levels of anti-double-stranded DNA antibody and erythrocyte sedimentation rate were identified as risk factors for subsequent LN in jSLE patients.
PEDIATRIC RHEUMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Jyh-Hong Lee, Li-Chieh Wang, Yu-Tsan Lin, Yao-Hsu Yang, Hsin-Hui Yu, Ya-Chiao Hu, Bor-Luen Chiang
Summary: Childhood asthma is a heterogeneous disease characterized by chronic airway inflammation. We aimed to compare the clinical features between nonallergic and allergic childhood asthma and apply microRNA to explore the underlying mechanism of nonallergic childhood asthma.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Yu-Li Lin, Pei-Yun Cheng, Chiao-Li Chin, Kuan-Ting Chuang, Jing-Yi Lin, Ning Chang, Chun-Kei Pan, Cheng-Sheng Lin, Siao-Cian Pan, Bor-Luen Chiang
Summary: This study found that the polysaccharide PS-G from Ganoderma lucidum can be used as a potential adjuvant for developing mucosal bivalent vaccines against EV-A71 and EV-D68. The vaccines induced strong immune responses, producing specific antibodies that neutralized the viruses and provided protection.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)