Article
Multidisciplinary Sciences
Xi-zhi J. Guo, Stephen J. Elledge
Summary: T cells play a crucial role in battling cancer and infectious diseases, but can also be involved in autoimmune reactions. This study introduces a new approach using virus-pseudotyped peptides loaded on MHC to modify disease-relevant T cells, allowing for antigen discovery and T cell engineering in a selective manner.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Immunology
Edgar Angelats, Pere Santamaria
Summary: TR1 cells are an immunosuppressive T cell subset that produces high levels of IL-10. Recent studies suggest that TR1 cells have potential therapeutic applications in immune-mediated diseases. However, the developmental biology of TR1 cells remains unclear.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Keunok Jung, Min-Jeong Son, Se-Young Lee, Jeong-Ah Kim, Deok-Han Ko, Sojung Yoo, Chul-Ho Kim, Yong-Sung Kim
Summary: A new antibody technology has been developed to deliver viral epitopes into tumor cells, aiding immune cells to more effectively attack tumor cells.
Article
Immunology
Katharina Zoldan, Sabine Ehrlich, Saskia Killmer, Katharina Wild, Maike Smits, Marissa Russ, Anna-Maria Globig, Maike Hofmann, Robert Thimme, Tobias Boettler
Summary: The study revealed that HCV-specific CD4 T cells exhibit a Tfh1 phenotype with superior B cell helper capacity despite a Th1 bias. Moreover, chronic exposure to type I IFN was found to support the enrichment of highly functional HCV-specific Tfh-like cells during HCV infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu Gao, Curtis Cai, Alba Grifoni, Thomas R. Muller, Julia Niessl, Anna Olofsson, Marion Humbert, Lotta Hansson, Anders Osterborg, Peter Bergman, Puran Chen, Annika Olsson, Johan K. Sandberg, Daniela Weiskopf, David A. Price, Hans-Gustaf Ljunggren, Annika C. Karlsson, Alessandro Sette, Soo Aleman, Marcus Buggert
Summary: This study found that SARS-CoV-2 spike-specific CD4(+) and CD8(+) T cells induced by prior infection or BNT162b2 vaccination provide extensive immune coverage against the Omicron variant. Additionally, T cells induced by BNT162b2 vaccination exhibit higher cross-reactivity to the Omicron variant compared to T cells induced by prior SARS-CoV-2 infection.
Review
Immunology
Ning Jiang, Michael Malone, Shahab Chizari
Summary: Human T cells have a diverse T-cell receptor repertoire that allows them to identify and defend against a wide range of antigens. The T-cell repertoire must possess a high degree of cross-reactivity to effectively surveil the vast universe of possible antigens. Antigen-specific and cross-reactive T-cell responses are crucial in immune responses associated with infections, neurodegeneration, and cancer. This review explores the implications of these responses and highlights recent technological advancements in profiling T-cell responses experimentally and through computational biology.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Medicine, Research & Experimental
Aixian Zheng, Yanlin Du, Yiru Wang, Youshi Zheng, Zhaoyu Ning, Ming Wu, Cuilin Zhang, Da Zhang, Jingfeng Liu, Xiaolong Liu
Summary: This study introduces a highly stable CD16/PDL1 bi-specific aptamer (CP-bi-apt) that enhances the immune response of NK cells against tumors and reduces the negative impact of PD-L1 over-expression.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Clinical Neurology
Le-Minh Dao, Marie-Luise Machule, Petra Bacher, Julius Hoffmann, Lam-Thanh Ly, Florian Wegner, Alexander Scheffold, Harald Pruess
Summary: NMDAR encephalitis patients have lower frequencies of NR1-reactive CD4(+) T helper cells and produce significantly less inflammatory cytokines, indicating disease-specific functional alterations compared to healthy controls, not influenced by therapeutic immunosuppression.
JOURNAL OF NEUROLOGY
(2021)
Article
Immunology
Hanspeter Pircher, Daniel D. Pinschewer, Thomas Boehm
Summary: Previous studies have questioned the effectiveness of thymic-negative selection in identifying self-specific T cells using peptide-MHC tetramers. In this study, we used pMHCI tet to enumerate CD8 T cells specific for the gp33 epitope of lymphocytic choriomeningitis virus in a mouse model. We found that the gp33-tet staining profiles of polyclonal T cells from GP(+) and GP(-) mice were overlapping, but cells from GP(+) mice had lower mean fluorescence intensities.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Julien Subburayalu, Sebastian Dolff, Shilei Xu, Ming Sun, Monika Lindemann, Andreas Heinold, Falko M. Heinemann, Jan Willem Cohen Tervaert, Ute Eisenberger, Johannes Korth, Alexandra Brinkhoff, Andreas Kribben, Oliver Witzke, Benjamin Wilde
Summary: TFH cells and TFR cells play important roles in the formation of dnDSA after renal transplant. Activation of TFH cells is associated with the development of dnDSA, while TFR cells have an inhibitory effect on TFH cells.
CLINICAL IMMUNOLOGY
(2021)
Article
Biology
Cilia R. Pothast, Romy C. Dijkland, Melissa Thaler, Renate S. Hagedoorn, Michel G. D. Kester, Anne K. Wouters, Pieter S. Hiemstra, Martijn J. van Hemert, Stephanie Gras, J. H. Frederik Falkenburg, Mirjam H. M. Heemskerk
Summary: CMV-specific T cells cross react with SARS-CoV-2, despite low sequence homology between the two viruses, and may contribute to the pre-existing immunity against SARS-CoV-2.
Article
Microbiology
Nicole L. Grant, Kristen Kelly, Pauline Maiello, Helena Abbott, Shelby O'Connor, Philana Ling Lin, Charles A. Scanga, JoAnne L. Flynn
Summary: Despite research focus on CD4 T cells in Mtb infections, little is known about Mtb-specific T cells within lung granulomas. We identified immunodominant epitopes for two Mtb proteins using a macaque model, facilitating the identification of Mtb-specific cells. Granulomas were found to be enriched sites for Mtb-specific cells, which expressed activation markers and transcription factors. Our data highlighted the importance of activated, polarized Mtb-specific cells for controlling Mtb in lung granulomas.
Article
Immunology
Katie E. Lineburg, Emma J. Grant, Srividhya Swaminathan, Demetra S. M. Chatzileontiadou, Christopher Szeto, Hannah Sloane, Archana Panikkar, Jyothy Raju, Pauline Crooks, Sweera Rehan, Andrea T. Nguyen, Lea Lekieffre, Michelle A. Neller, Zhen Wei Marcus Tong, Dhilshan Jayasinghe, Keng Yih Chew, Christian A. Lobos, Hanim Halim, Jacqueline M. Burrows, Alan Riboldi-Tunnicliffe, Weisan Chen, Lloyd D'Orsogna, Rajiv Khanna, Kirsty R. Short, Corey Smith, Stephanie Gras
Summary: Efforts are being made to understand the immune response to SARS-CoV-2, with a focus on T cell immunity and cross-recognition with seasonal coronaviruses. Research has shown that the N protein of SARS-CoV-2 induces an immunodominant response and T cells demonstrate cross-reactivity towards certain coronaviruses through specific peptide conformations.
Review
Medicine, Research & Experimental
Tingting Zhang, Adila Aipire, Yijie Li, Changying Guo, Jinyao Li
Summary: This review summarizes the mechanisms of cross-presentation (XPT) and its application in tumor immunotherapy. Dendritic cells enhance their antigen presentation capacity through receptor-mediated internalization of exogenous antigens, endosome escape, engagement of other XPT-related proteins, and the use of adjuvants, thereby improving the outcomes of DC-based therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Editorial Material
Oncology
James Reading, Kane Foster, Kroopa Joshi, Benny Chain
Summary: This article discusses two papers published in Cancer Cell (Zheng et al., 2022 and Veatch et al., 2022) that demonstrate the application of single-cell sequencing in defining a molecular phenotype to identify tumor-specific T cells.
Article
Virology
Eric R. Weiss, Susanna L. Lamers, Jennifer L. Henderson, Alexandre Melnikov, Mohan Somasundaran, Manuel Garber, Liisa Selin, Chad Nusbaum, Katherine Luzuriaga
JOURNAL OF VIROLOGY
(2018)
Article
Biochemistry & Molecular Biology
Minan Wang, Li-Chin Yao, Mingshan Cheng, Danying Cai, Jan Martinek, Chong-Xian Pan, Wei Shi, Ai-Hong Ma, Ralph W. De Vere White, Susan Airhart, Edison T. Liu, Jacques Banchereau, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, Karolina Palucka, James G. Keck
Article
Biochemistry & Molecular Biology
Michael A. Brehm, Laurie L. Kenney, Michael V. Wiles, Benjamin E. Low, Roland M. Tisch, Lisa Burzenski, Christian Mueller, Dale L. Greiner, Leonard D. Shultz
Article
Immunology
Sonal Jangalwe, Varun N. Kapoor, Jia Xu, Nomeda Girnius, Norman J. Kennedy, Yvonne J. K. Edwards, Raymond M. Welsh, Roger J. Davis, Michael A. Brehm
JOURNAL OF IMMUNOLOGY
(2019)
Article
Immunology
Melissa A. Gawron, Mark Duval, Claudia Carbone, Smita Jaiswal, Aaron Wallace, Joseph C. Martin, Ann Dauphin, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, Jeremy Luban, Lisa A. Cavacini
JOURNAL OF IMMUNOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Leonard D. Shultz, James Keck, Lisa Burzenski, Sonal Jangalwe, Shantashri Vaidya, Dale L. Greiner
Article
Virology
Murali Muniraju, Lorraine Z. Mutsvunguma, Joslyn Foley, Gabriela M. Escalante, Esther Rodriguez, Romina Nabiee, Jennifer Totonchy, David H. Mulama, Joshua Nyagol, Felix Wussow, Anne K. Barasa, Michael Brehm, Javier Gordon Ogembo
JOURNAL OF VIROLOGY
(2019)
Article
Multidisciplinary Sciences
Leyuan Ma, Magnolia L. Pak, Jianhong Ou, Jun Yu, Pamela St Louis, Yi Shan, Lloyd Hutchinson, Shaoguang Li, Michael A. Brehm, Lihua Julie Zhu, Michael R. Green
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Immunology
Todd M. Allen, Michael A. Brehm, Sandra Bridges, Stacy Ferguson, Priti Kumar, Oleg Mirochnitchenko, Karolina Palucka, Roberta Pelanda, Brigitte Sanders-Beer, Leonard D. Shultz, Lishan Su, Mercy PrabhuDas
Article
Microbiology
Joyce E. Karlinsey, Taylor A. Stepien, Matthew Mayho, Larissa A. Singletary, Lacey K. Bingham-Ramos, Michael A. Brehm, Dale L. Greiner, Leonard D. Shultz, Larry A. Gallagher, Matt Bawn, Robert A. Kingsley, Stephen J. Libby, Ferric C. Fang
CELL HOST & MICROBE
(2019)
Article
Rheumatology
Sudesh Pawaria, Kerstin Nundel, Kevin M. Gao, Stephanie Moses, Patricia Busto, Kevin Holt, Rohit B. Sharma, Michael A. Brehm, Ellen M. Gravallese, Merav Socolovsky, Anette Christ, Ann Marshak-Rothstein
ARTHRITIS & RHEUMATOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Terrin L. Manes, Ari Simenauer, Jason L. Geohring, Juliana Flemming, Michael Brehm, Adela Cota-Gomez
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Review
Oncology
Jane Chuprin, Hannah Buettner, Mina O. Seedhom, Dale L. Greiner, James G. Keck, Fumihiko Ishikawa, Leonard D. Shultz, Michael A. Brehm
Summary: Immunotherapy has shown promise in treating various cancers, but there is still much to learn about its mechanisms of action and biomarkers of response. Humanized mice, which are mice engrafted with human tumors and immune components, offer several advantages for immuno-oncology research. This Review discusses the benefits and challenges of humanized mice and highlights the latest advances in their generation for potential clinical translation.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yetao Wang, Lawrence Lifshitz, Noah J. Silverstein, Esther Mintzer, Kevin Luk, Pamela StLouis, Michael A. Brehm, Scot A. Wolfe, Steven G. Deeks, Jeremy Luban
Summary: Innate lymphoid cells (ILCs) are a diverse population of cells that include NK cells and play important roles in tissue homeostasis and repair, inflammation, and protection from infection. This study used transcriptional and chromatin profiling to investigate the interplay between human blood ILCs and their responses to HIV-1 infection. The findings reveal the existence of four main ILC subsets in human blood and provide insights into how HIV-1 infection disrupts NK cells and their homeostatic function.
Article
Allergy
Bradford A. Youngblood, Emily C. Brock, John Leung, Rustom Falahati, Paul J. Bryce, Jessica Bright, Jason Williams, Leonard D. Shultz, Dale L. Greiner, Michael A. Brehm, Christopher Bebbington, Nenad Tomasevic
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2019)