Article
Biochemistry & Molecular Biology
Xin Wen, Geng Hu, Xue Xiao, Xinzhi Zhang, Qiang Zhang, Hengjun Guo, Xianyao Li, Qingxin Liu, Haifang Li
Summary: FGF2 inhibits mineralization of bone marrow stromal cells by up-regulating osteoclastogenesis gene expression, while enhancing osteoclast development through the ERK-CREB pathway. This highlights the potential of FGF2/ERK/CREB inhibitors in treating bone-related disorders like osteoporosis.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Review
Pharmacology & Pharmacy
Zechao Qu, Bo Zhang, Lingbo Kong, Yining Gong, Mingzhe Feng, Xiangcheng Gao, Dong Wang, Liang Yan
Summary: This paper provides an overview of the molecular mechanisms of osteoclasts in osteolysis-related diseases and the potential of natural plant derivatives and compounds for treating these diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Yan Yang, Xiangxin Li
Summary: This study revealed the effects of SIRT1 on the OPG/RANKL signaling pathway and periodontitis progression. The results showed that overexpression of SIRT1 can activate the OPG/RANKL pathway, inhibit osteoclastogenesis, and attenuate periodontitis progression.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Pharmacology & Pharmacy
Jing Sun, Wugui Chen, Songtao Li, Sizhen Yang, Ying Zhang, Xu Hu, Hao Qiu, Jigong Wu, Shangcheng Xu, Tongwei Chu
Summary: This study revealed that Nox4 promotes RANKL-induced autophagy and osteoclastogenesis by activating the ROS/PERK/eIF-2α/ATF4 pathway. Inhibition of this pathway significantly suppresses autophagy, providing a novel therapeutic target for osteoclastogenesis-related diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Hong Ki Min, Se Hee Kim, Ji-Yeon Lee, Sang-Heon Lee, Hae-Rim Kim
Summary: In this study, the effect of DJ-1 on helper T cell differentiation, fibroblast-like synoviocyte (FLS) activation, and osteoclastogenesis in rheumatoid arthritis was investigated. The results demonstrated that DJ-1 inhibits the production of pro-inflammatory cytokines and activation of RA-FLS, as well as osteoclast formation. Therefore, DJ-1 holds potential importance in the treatment of rheumatoid arthritis.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Liping Liu, Xiaodong Sun, Yunliang Guo, Keli Ge
Summary: Evodiamine (EVO) from Evodiae fructus has antitumor effects on gastric cancer cells, mainly through cytotoxicity, including inhibition of proliferation, cell cycle arrest, apoptosis, and metastasis. This study aimed to investigate the role of TRPV1/Ca2+ in EVO-induced cytotoxicity in human gastric cancer cells. The results showed that EVO exposure led to ROS generation and apoptotic cell death, which could be ameliorated by pretreatment with EUK134. EVO exposure also induced ROS generation and mitochondrial dysfunction, mainly through mitochondrial ROS generation, which could be attenuated by rotenone pretreatment. Moreover, EVO-induced cytotoxicity could be significantly ameliorated by chelation of intracellular Ca2+, confirming that EVO induces cell death through Ca2+ overload. Inhibition of TRPV1 attenuated Ca2+ influx, ROS generation, and apoptotic cell death induced by EVO exposure, while overexpression of TRPV1 augmented EVO-induced cytotoxicity. Furthermore, inhibition of mitochondrial calcium uniporter (MCU) attenuated EVO-induced cell death and mitochondrial dysfunction. EVO exposure also induced endoplasmic reticulum stress, which was depleted by EUK134 pretreatment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Wenqiang Zhang, Ruonan Ning, Ting Ran, Qi Peng, Yong Liu, Tao Lu, Yadong Chen, Min Jiang, Yu Jiao
Summary: In this study, a novel 3-acetylindole compound was identified as a bone antiresorptive agent with selective inhibitory activity against BRPF1B. It showed outstanding inhibitory activity against osteoclastogenesis and differentiation, and demonstrated a strong bone antiresorptive effect by modulating the RANKL/RANK/NFATc1 pathway.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Wei Wei, Chenjian Peng, Renjun Gu, Xiwu Yan, Jiapeng Ye, Zhuicheng Xu, Xianjie Sheng, Guicheng Huang, Yang Guo
Summary: Urolithin A can attenuate RANKL-induced osteoclastogenesis by suppressing inflammation and activating the Nrf2 signaling pathway, thereby alleviating bone loss.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Hai-Wei Chen, Chi-Fen Chen, Pei-Rong Lee, Shuenn-Jium Yiin, Jia-Yun Liang, Jue-Liang Hsu, Chi- Chang, Chi-Liang Chern
Summary: 2,5-dihydroxyacetophenone (DHAP), a phenolic compound in Ganoderma bambusicola, inhibits osteoclastogenesis by inhibiting the NFATc1 signaling pathway.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Minglong Qiu, Changwei Li, Zhengwei Cai, Cuidi Li, Kai Yang, Nijiati Tulufu, Bo Chen, Liang Cheng, Chengyu Zhuang, Zhihong Liu, Jin Qi, Wenguo Cui, Lianfu Deng
Summary: A 3D biomimetic calcified cartilaginous callus (CACC) scaffold is developed using 3D printing technology. The scaffold mimics the porous structure of the cartilaginous matrix and promotes angiogenesis and osteogenesis while inhibiting the resorption of the calcified matrix. In vivo experiments demonstrate that the scaffold significantly enhances angiogenesis and osteogenesis, ultimately improving the regeneration of large-segment bone defects.
Article
Biochemistry & Molecular Biology
Yinglong Xu, Dezhi Song, Xixi Lin, Hui Peng, Yuangang Su, Jiamin Liang, Na Hai, Jinmin Zhao, Qian Liu
Summary: Corylifol A can prevent estrogen-deficiency-induced bone loss by inhibiting osteoclastogenesis and intracellular ROS levels. This study also found that Corylifol A has no effect on cortical bone in ovariectomized mice.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Multidisciplinary Sciences
Paula B. Donate, Kalil Alves de Lima, Raphael S. Peres, Fausto Almeida, Sandra Y. Fukada, Tarcilia A. Silva, Daniele C. Nascimento, Nerry T. Cecilio, Jhimmy Talbot, Rene D. Oliveira, Geraldo A. Passos, Jose Carlos Alves-Filho, Thiago M. Cunha, Paulo Louzada-Junior, Foo Y. Liew, Fernando Q. Cunha
Summary: Transcriptomic analysis revealed that microRNA-132 is induced specifically in Th17 cells in the presence of AhR agonist or CS-enriched medium. This induced miRNA132 acts as a proinflammatory mediator by promoting osteoclastogenesis through down-regulating COX2, exacerbating the development of RA.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Xiang Li, Yuxin Wang, Liangping Li, Shengji Zhou, Fengchao Zhao
Summary: Osteoclasts are crucial for bone health but can cause problems like osteoporosis. Sclareol, a natural compound, has various biological activities including anti-tumor, anti-inflammatory, antibacterial, and immunomodulatory functions. This study found that Sclareol inhibited osteoclastogenesis and promoted osteoblastogenesis by regulating the expression of CCN1 via the MAPK pathway, offering a potential treatment option for osteoclast-related disorders.
CELL BIOLOGY AND TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Meipeng Zhu, Qian Guo, Honglei Kang, Renpeng Peng, Yimin Dong, Yayun Zhang, Sibo Wang, Haiyang Liu, Hongjian Zhao, Zijian Dong, Kehan Song, Shimeng Xu, Pengju Wang, Liangxi Chen, Jian Liu, Feng Li
Summary: Fatty amide hydrolase (FAAH) is involved in various biological processes and may play an important role in osteoclastogenesis. Inhibition of FAAH in bone marrow-derived macrophages (BMMs) suppressed osteoclastogenesis and bone resorption. The FAAH inhibitor PF-04457845 improved bone loss in mice, and its effects were mediated through the NF-kappa B and MAPK pathways. Targeting FAAH may be a promising strategy for treating osteoclast-related diseases, particularly osteoporosis.
Article
Oncology
P. A. N. CA, S. H. I. C. H. A. N. G. YAN, Y. A. N. LU, X. I. A. O. X. I. A. O. ZHOU, X. I. U. H. U. I. WANG, M. I. N. G. H. U. I. WANG, Z. H. I. F. E. N. G. YIN
Summary: The study found that carnosol can suppress osteoclastogenesis by inhibiting the activation of the NF-kappa B signaling pathway. In both in vitro and in vivo experiments, carnosol significantly inhibited osteoclast differentiation and function, and attenuated postmenopausal bone loss.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Endocrinology & Metabolism
Dong Hwee Son, Khanh Doan, Dong Joo Yang, Ji Su Sun, Seul Ki Kim, Namju Kang, Jung Yun Kang, Ji-Hye Paik, Ronald A. DePinho, Yun-Hee Choi, Dong Min Shin, Ki Woo Kim
METABOLISM-CLINICAL AND EXPERIMENTAL
(2019)
Article
Endocrinology & Metabolism
Aran Son, Namju Kang, Sue Young Oh, Ki Woo Kim, Shmuel Muallem, Yu-Mi Yang, Dong Min Shin
JOURNAL OF ENDOCRINOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Soyoung Hwang, Dong Min Shin, Jeong Hee Hong
Review
Biochemistry & Molecular Biology
Jung Yun Kang, Namju Kang, Yu-Mi Yang, Jeong Hee Hong, Dong Min Shin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Pharmacology & Pharmacy
Soyoung Hwang, Dong Min Shin, Jeong Hee Hong
Article
Medicine, Research & Experimental
Ji Su Sun, Dong Joo Yang, Ann W. Kinyua, Seul Gi Yoon, Je Kyung Seong, Juwon Kim, Seok Jun Moon, Dong Min Shin, Yun-Hee Choi, Ki Woo Kim
Summary: The dysfunction of primary cilia in the ventromedial hypothalamus is linked to impaired energy and skeletal homeostasis, resulting in obesity and increased bone density. Dysfunction of VMH primary cilia leads to decreased sympathetic activation and central leptin resistance, impacting energy expenditure and bone metabolism.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Soyoung Hwang, Peter Chang-Whan Lee, Dong Min Shin, Jeong Hee Hong
Summary: Spinophilin plays a crucial role in modulating the junctional network and cellular migration in lung cancer cells, affecting invasive ability and transporter activity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Sue Young Oh, Namju Kang, Jung Yun Kang, Ki Woo Kim, Jong-Hoon Choi, Yu-Mi Yang, Dong Min Shin
Summary: This study revealed that Sestrin2 plays a crucial role in bone homeostasis and osteoclast differentiation by regulating NFATc1 and the TRAF6/p62 interaction in the RANKL-RANK-TRAF6 signaling pathway. The deletion of Sestrin2 led to a decrease in osteoclast differentiation and function, as well as reduced bone mass, suggesting its novel role in bone metabolism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Hyun Jin Kim, Jiae Lee, Gong-Rak Lee, Narae Kim, Hye In Lee, Minjeong Kwon, Nam Young Kim, Jin Ha Park, Ye Hee Kang, Hyeong Ju Song, TaeSoo Kim, Dong Min Shin, Woojin Jeong
Summary: FN inhibits osteoclastogenesis by blocking CaMKIV and calcineurin, reducing the risk of bone diseases like osteoporosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Sukjoon Lee, Dongzi Chen, Munsu Park, Sunil Kim, Yoon Jeong Choi, Seok Jun Moon, Dong Min Shin, Ji Hyun Lee, Euiseong Kim
Summary: Single-cell RNA sequencing revealed distinct gene expression patterns in specific clusters of human dental pulp stem cells (hDPSCs) and human periodontal ligament stem cells (hPDLSCs). hDPSCs exhibited osteogenic and neurogenic cell populations, while hPDLSCs mainly comprised osteogenic and myofibroblastic populations. The results can serve as valuable resources for further research in dental therapeutics.
JOURNAL OF ENDODONTICS
(2022)
Article
Toxicology
Dongun Lee, Peter Chang-Whan Lee, Jeong Hee Hong, Dong Min Shin
Summary: The study found that 8-estradiol treatment attenuated the oxalate or bicarbonate transporting activities through SLC26A6 and enhanced cancer cell migration. Even in the presence of 8-estradiol treatment, increased SLC26A6 expression weakened cellular migration. These results suggest that 8-estradiol treatment enhances cancer cell migration by inhibiting SLC26A6 activity.
TOXICOLOGY IN VITRO
(2022)
Article
Multidisciplinary Sciences
Seul Ki Kim, Le Trung Tran, Cherl NamKoong, Hyung Jin Choi, Hye Jin Chun, Yong-ho Lee, MyungHyun Cheon, ChiHye Chung, Junmo Hwang, Hyun-Ho Lim, Dong Min Shin, Yun-Hee Choi, Ki Woo Kim
Summary: Small humanin-like peptide 2 (SHLP2), a mitochondrial-derived peptide, plays a crucial role in energy homeostasis. The study demonstrates that SHLP2 can protect mice from high-fat diet-induced obesity and improve insulin sensitivity. It activates pro-opiomelanocortin (POMC) neurons in the hypothalamus, which suppresses food intake and promotes thermogenesis. The researchers also discover that SHLP2 binds to and activates chemokine receptor 7 (CXCR7).
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Minjeong Ji, Hee Jung Ryu, Hyeon-Man Baek, Dong Min Shin, Jeong Hee Hong
Summary: The study found that modulation of the migratory module of fibroblast-like synoviocytes (FLSs) can attenuate the severity of rheumatoid arthritis (RA). The sodium bicarbonate cotransporter n1 (NBCn1) was identified in RA-FLSs and inhibiting NBCs reduced FLS migration and RA symptoms.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Soyoung Hwang, Dong Min Shin, Jeong Hee Hong
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Pharmacology & Pharmacy
Namju Kang, Ki Woo Kim, Dong Min Shin
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2019)