Article
Pharmacology & Pharmacy
Guoju Hong, Lin Zhou, Guanqiang Zheng, Xiaoxia Zheng, Zhenqiu Chen, Wei He, Qiushi Wei
Summary: Liquiritin (LIQ) has the ability to inhibit osteoclast formation and bone-resorbing activity induced by RANKL, and it exerts its effects by reducing ROS levels and suppressing the Ca2+/MAPK-NFATc1 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Cong Xu, Shu-Qing Jin, Chen Jin, Zi-Han Dai, Yu-Hao Wu, Gao-Lu He, Hai-Wei Ma, Chao-Yi Xu, Wen-Lai Fang
Summary: The study aimed to investigate the effect and mechanism of Cedrol (Ced) in estrogen-deficient osteoporosis. The results demonstrated that Ced mitigated RANKL-induced osteoclastogenesis by reducing ROS content and inhibiting NFATc1, NF-KB, and MAPK signaling pathways. Additionally, Ced-mediated anti-osteolytic property was observed in ovariectomized mice. Thus, this study revealed the anti-osteoporotic potential of Cedrol in Ginger and provided more pharmacological evidence for Ginger as a food or medicine for bone metabolic disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Guoju Hong, Zhenqiu Chen, Xiaorui Han, Lin Zhou, Fengxiang Pang, Rishana Wu, Yingshan Shen, Xiaoming He, Zhinan Hong, Ziqi Li, Wei He, Qiushi Wei
Summary: The study revealed that Robinin could prevent bone resorption by inhibiting osteoclastogenesis mediated by RANKL, reducing ROS production, and regulating molecular signaling pathways, making it a potential drug for treating osteoporosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Mengbo Zhu, Wenbin Xu, Jiuzhou Jiang, Yining Wang, Yanjing Guo, Ruijia Yang, Yaqiong Chang, Bin Zhao, Zhenyu Wang, Jianfeng Zhang, Te Wang, Liqin Shangguan, Shaowei Wang
Summary: The study found that peiminine can inhibit the differentiation and function of OCs by regulating the levels of specific genes and proteins, with potential targets including NF-kappa B and ERK1/2 signaling pathways. In an animal model, peiminine can alleviate bone loss in ovariectomized mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Medicinal
Shuan-Jing Wang, Jiahui Zhang, Jing-Zan Zhang, Ruo-Nan Ning, Chen-Chen Li, Xing Xu, Min Jiang, Wen-Wei Qiu
Summary: A series of heterocyclic ring-fused derivatives of 20(S)-protopanaxadiol (PPD) were synthesized and evaluated for their inhibitory effects on RANKL-induced osteoclastogenesis. Compound 33 (SH491) showed the highest potency with 100% inhibition at 0.1 μM and 44.4% inhibition at 0.01 μM, surpassing the lead compound PPD. Cytotoxicity tests indicated that the inhibitory effect was not due to cytotoxicity, and SH491 also affected osteoblastogenesis.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Immunology
Delong Chen, Feifan Chu, Gangyu Zhang, Qingqing Wang, Ying Li, Meng Zhang, Qi He, Junzheng Yang, Haibin Wang, Ping Sun, Jiake Xu, Peng Chen
Summary: The natural compound 12-deoxyphorbol 13-acetate (DPA) was found to inhibit osteoclast differentiation and function, potentially serving as a promising treatment for osteoporosis. Mechanistically, DPA suppressed RANKL-induced downstream signaling pathways and showed efficacy in an osteoporosis mice model.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mina Ding, Zhihao Chen, Eunjin Cho, Sang-Wook Park, Tae-Hoon Lee
Summary: This study identifies GSK2879552, a LSD1 inhibitor, as a potential treatment for osteoporosis by inhibiting osteoclast differentiation. LSD1 inhibitors effectively inhibit RANKL-induced osteoclastogenesis and prevent the expression of osteoclast-specific genes. Inhibition of LSD1 activities may be a potential target for preventing bone diseases characterized by excessive osteoclast activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Mi Hye Kim, Haesu Lee, In Jin Ha, Woong Mo Yang
Summary: ZP administration in osteoporotic mice resulted in increased bone mineral density, restoration of serum bone biomarker levels, decreased osteoclast counts, and inhibition of osteoclast formation. These findings suggest that ZP may be a potential therapeutic agent for osteoporosis.
Article
Biochemistry & Molecular Biology
Yinglong Xu, Dezhi Song, Xixi Lin, Hui Peng, Yuangang Su, Jiamin Liang, Na Hai, Jinmin Zhao, Qian Liu
Summary: Corylifol A can prevent estrogen-deficiency-induced bone loss by inhibiting osteoclastogenesis and intracellular ROS levels. This study also found that Corylifol A has no effect on cortical bone in ovariectomized mice.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cell & Tissue Engineering
M. H. Kim, L. Y. Choi, J. Y. Chung, E-J Kim, W. M. Yang
Summary: In this study, the potential therapeutic effect of auraptene on osteoporosis and its underlying mechanism were investigated using network pharmacology and experimental osteoporotic mice. The results showed that auraptene could ameliorate bone loss in osteoporosis by downregulating the RANKL/NFATc1 pathway and inhibiting osteoclastic activity. This study contributes to the identification of potential therapeutic agents for the treatment of osteoporosis.
BONE & JOINT RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Gang Wang, Chao Ma, Kai Chen, Ziyi Wang, Heng Qiu, Delong Chen, Jianbo He, Cheng Zhang, Ding Guo, Boyong Lai, Shuangxiao Zhang, Linfeng Huang, Fan Yang, Jinbo Yuan, Leilei Chen, Wei He, Jiake Xu
Summary: This study demonstrates that cycloastragenol (CAG) inhibits the formation and function of osteoclasts by regulating intracellular signaling pathways. It has potential as an alternative treatment for osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Lichan Yuan, Na Zhao, Junyi Wang, Yuying Liu, Li Meng, Shuyu Guo, Erik A. C. Wiemer, Qi Chen, Yelin Mao, Jingjing Ben, Junqing Ma
Summary: The study revealed that MVP acts as a negative regulator of osteoclastogenesis, inhibiting bone resorption and potentially serving as a therapeutic target for preventing bone loss.
Article
Biochemistry & Molecular Biology
Zhenhua Feng, Siyue Tao, Zhaobo Huang, Bingjie Zheng, Xiangxi Kong, Yufeng Xiang, Qibin Zhang, Haixin Song, Zhikun Xu, Xiaoan Wei, Fengdong Zhao, Jian Chen
Summary: It has been found that the deubiquitinase UCHL1 serves as a negative regulator in bone resorption. UCHL1 deubiquitinates and stabilizes TAZ protein, inhibiting osteoclastogenesis. Additionally, UCHL1 competes with CNA for binding to NFATC1, inhibiting NFATC1 dephosphorylation and nuclear transport and impeding osteoclastogenesis. Therefore, activating UCHL1 may be a potential therapeutic strategy for various bone diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Endocrinology & Metabolism
Wu Jianwei, Tian Ye, Wang Hongwei, Li Dachuan, Zou Fei, Jiang Jianyuan, Wang Hongli
Summary: Bone remodelling is a dynamic process involving bone-resorbing osteoclasts and bone-forming osteoblasts. Excessive osteoclastogenesis can lead to osteolytic diseases, and the receptor activator of NF-kappa B ligand (RANKL) is considered to be an important regulator of osteoclastogenesis. Transforming growth factor beta-activated kinase 1 (TAK1) plays a significant role in RANKL-induced osteoclastogenesis by regulating multiple signaling pathways. Understanding the mechanisms of TAK1 in this process has potential implications for the treatment of osteolytic diseases.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Mingchao Jin, Jiangbo Nie, Juli Zhu, Jing Li, Tianshun Fang, Juntao Xu, Xuesheng Jiang, Zhuo Chen, Jianyou Li, Fengfeng Wu
Summary: This study demonstrated for the first time that acacetin inhibited osteoclastogenesis, bone resorption activity, and related gene expression by modulating multiple signaling pathways, suggesting its potential therapeutic effects for preventing osteoporosis and other osteolytic disorders.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Ji Su Sun, Dong Joo Yang, Ann W. Kinyua, Seul Gi Yoon, Je Kyung Seong, Juwon Kim, Seok Jun Moon, Dong Min Shin, Yun-Hee Choi, Ki Woo Kim
Summary: The dysfunction of primary cilia in the ventromedial hypothalamus is linked to impaired energy and skeletal homeostasis, resulting in obesity and increased bone density. Dysfunction of VMH primary cilia leads to decreased sympathetic activation and central leptin resistance, impacting energy expenditure and bone metabolism.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Linh V. Nguyen, Khoa D. A. Nguyen, Chi-Thanh Ma, Quoc-Thai Nguyen, Huong T. H. Nguyen, Dong-Joo Yang, Trung Le Tran, Ki Woo Kim, Khanh V. Doan
Summary: p-Coumaric acid potentially activates peripheral AMPK and improves glucose metabolism, while showing inhibitory effects on central AMPK activity. This differential effect enhances hypothalamic leptin sensitivity and improves whole-body glucose homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Soyoung Hwang, Peter Chang-Whan Lee, Dong Min Shin, Jeong Hee Hong
Summary: Spinophilin plays a crucial role in modulating the junctional network and cellular migration in lung cancer cells, affecting invasive ability and transporter activity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Sue Young Oh, Namju Kang, Jung Yun Kang, Ki Woo Kim, Jong-Hoon Choi, Yu-Mi Yang, Dong Min Shin
Summary: This study revealed that Sestrin2 plays a crucial role in bone homeostasis and osteoclast differentiation by regulating NFATc1 and the TRAF6/p62 interaction in the RANKL-RANK-TRAF6 signaling pathway. The deletion of Sestrin2 led to a decrease in osteoclast differentiation and function, as well as reduced bone mass, suggesting its novel role in bone metabolism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Hyun Jin Kim, Jiae Lee, Gong-Rak Lee, Narae Kim, Hye In Lee, Minjeong Kwon, Nam Young Kim, Jin Ha Park, Ye Hee Kang, Hyeong Ju Song, TaeSoo Kim, Dong Min Shin, Woojin Jeong
Summary: FN inhibits osteoclastogenesis by blocking CaMKIV and calcineurin, reducing the risk of bone diseases like osteoporosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Sukjoon Lee, Dongzi Chen, Munsu Park, Sunil Kim, Yoon Jeong Choi, Seok Jun Moon, Dong Min Shin, Ji Hyun Lee, Euiseong Kim
Summary: Single-cell RNA sequencing revealed distinct gene expression patterns in specific clusters of human dental pulp stem cells (hDPSCs) and human periodontal ligament stem cells (hPDLSCs). hDPSCs exhibited osteogenic and neurogenic cell populations, while hPDLSCs mainly comprised osteogenic and myofibroblastic populations. The results can serve as valuable resources for further research in dental therapeutics.
JOURNAL OF ENDODONTICS
(2022)
Article
Biochemistry & Molecular Biology
Anish Ashok Adpaikar, Sushan Zhang, Hyun-Yi Kim, Ki Woo Kim, Seok Jun Moon, Jong-Min Lee, Han-Sung Jung
Summary: In this study, a suspension-culture method was established to fine-tune taste bud organoids by altering their apicobasal polarity, enabling the accessible localization of taste receptor cells. These suspension-cultured organoids showed comparable differentiation and renewal rates to those of taste buds in vivo, and exhibited functional taste receptor cells and cycling progenitor cells. This method provides an efficient model for taste research, including taste bud development, regeneration, and transplantation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Toxicology
Dongun Lee, Peter Chang-Whan Lee, Jeong Hee Hong, Dong Min Shin
Summary: The study found that 8-estradiol treatment attenuated the oxalate or bicarbonate transporting activities through SLC26A6 and enhanced cancer cell migration. Even in the presence of 8-estradiol treatment, increased SLC26A6 expression weakened cellular migration. These results suggest that 8-estradiol treatment enhances cancer cell migration by inhibiting SLC26A6 activity.
TOXICOLOGY IN VITRO
(2022)
Article
Biochemistry & Molecular Biology
Hong Phuong Nguyen, Seungheon Shin, Kyung-Ju Shin, Phuong Hoa Tran, Hyungsun Park, Quang De Tran, Mi-Hyun No, Ji Su Sun, Ki Woo Kim, Hyo-Bum Kwak, Seongju Lee, Steve K. Cho, Su-Geun Yang
Summary: This study investigated the effects of microgravity on retinal function in ARPE19 cells. The findings showed that microgravity conditions led to the formation of multicellular spheroids and significantly decreased cell migration in ARPE19 cells. It was also observed that microgravity increased intracellular reactive oxygen species and caused mitochondrial dysfunction. Activation of autophagic pathways and ciliogenesis were also observed under microgravity conditions. Furthermore, it was demonstrated that mitophagy activation was triggered via the mTOR-ULK1-BNIP3 signaling axis. TPP-Niacin was shown to effectively mitigate microgravity-induced oxidative stress and mitochondrial dysfunction in vitro. Further investigations are needed to understand the physiological functions and biological efficacies of TPP-Niacin in primary human retinal cells, in vivo models, and target identification.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Jimin Jeon, Hyemi Lee, Min-Seung Jeon, Seok-Jung Kim, Cham Choi, Ki Woo Kim, Dong Joo Yang, Sangho Lee, Yong-Soo Bae, Won Il Choi, Juyeon Jung, Seong-il Eyun, Siyoung Yang
Summary: The upregulation of ACVR2B and its assembly play a role in osteoarthritic cartilage destruction. Activin A, the ligand for ACVR2B, regulates catabolic factor expression in OA development. The ACVR2B assembly, consisting of Activin A, ACVR2B, ACVR1B, Nox4, and AP-1-induced HIF-2 alpha, accelerates OA development.
Article
Multidisciplinary Sciences
Seul Ki Kim, Le Trung Tran, Cherl NamKoong, Hyung Jin Choi, Hye Jin Chun, Yong-ho Lee, MyungHyun Cheon, ChiHye Chung, Junmo Hwang, Hyun-Ho Lim, Dong Min Shin, Yun-Hee Choi, Ki Woo Kim
Summary: Small humanin-like peptide 2 (SHLP2), a mitochondrial-derived peptide, plays a crucial role in energy homeostasis. The study demonstrates that SHLP2 can protect mice from high-fat diet-induced obesity and improve insulin sensitivity. It activates pro-opiomelanocortin (POMC) neurons in the hypothalamus, which suppresses food intake and promotes thermogenesis. The researchers also discover that SHLP2 binds to and activates chemokine receptor 7 (CXCR7).
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Minjeong Ji, Hee Jung Ryu, Hyeon-Man Baek, Dong Min Shin, Jeong Hee Hong
Summary: The study found that modulation of the migratory module of fibroblast-like synoviocytes (FLSs) can attenuate the severity of rheumatoid arthritis (RA). The sodium bicarbonate cotransporter n1 (NBCn1) was identified in RA-FLSs and inhibiting NBCs reduced FLS migration and RA symptoms.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Le Trung Tran, Sohee Park, Seul Ki Kim, Jin Sun Lee, Ki Woo Kim, Obin Kwon
Summary: The hypothalamus plays a crucial role in controlling energy expenditure and metabolism, influencing lean to fatty tissue ratio, gender-based metabolic differences, activity levels, and weight gain in response to food intake. Further research is needed to unravel cause-and-effect relationships and genetic factors involved in metabolic regulation.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)