Article
Oncology
Liangzi Cao, Hao Li, Xiaofang Liu, Yubang Wang, Bowen Zheng, Chengzhong Xing, Naijin Zhang, Jingwei Liu
Summary: This study investigated the molecular alterations and clinical relevance of NEDD4 E3 ligase family genes in 33 cancer types. The findings revealed increased expression of NEDD4 members in pancreatic cancer and decreased expression in thyroid cancer. NEDD4 family genes exhibited a range of mutation frequencies, with HECW1 and HECW2 showing relatively high mutation rates. Breast cancer presented with a high frequency of NEDD4 copy number amplification. Additionally, NEDD4 family members were involved in various pathways such as p53, Akt, apoptosis, and autophagy, and their expression correlated with the survival of cancer patients.
Article
Biochemistry & Molecular Biology
Hao-Yu Chuang, Li-Yun Hsu, Chih-Ming Pan, Narpati Wesa Pikatan, Vijesh Kumar Yadav, Iat-Hang Fong, Chao-Hsuan Chen, Chi-Tai Yeh, Shao-Chih Chiu
Summary: The overexpression of NEDD4-1 in GBM and TMZ-resistant cells is associated with oncogenicity, tumorigenesis, and chemoresistance. Mechanistically, NEDD4-1 mediates the degradation of PTEN and upregulation of the AKT/NRF2/HO-1 signaling pathway, leading to increased defense against reactive oxygen species and higher resistance against TMZ treatment. Targeting this regulatory axis may help eliminate TMZ-resistant glioblastoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ke Wang, Yanping Yu, Wei Wang, Yu Jiang, Yunlong Li, Xunliang Jiang, Yihuan Qiao, Le Chen, Xinhui Zhao, Jun Liu, Angang Yang, Jipeng Li, Rui Zhang
Summary: This study found different levels of IGF1R dependency in gastric cancer cells. Knockdown of NEDD4 significantly suppressed tumor growth in IGF1R-dependent gastric cancer cells, while it had no effect on IGF1R-independent cells. Additionally, high expression of NEDD4 and IGF1 predicted a worse prognosis in gastric cancer patients. Targeting NEDD4 may be a promising therapeutic strategy for IGF1 signal pathway-driven gastric cancer.
Article
Biology
Lu Zhu, Qing Zhang, Ciro D. Cordeiro, Sudeep Banjade, Richa Sardana, Yuxin Mao, Scott D. Emr
Summary: The study reveals a novel ubiquitination modification implemented by Rsp5 adaptor proteins, which controls the recruitment and activity of Rsp5 to facilitate the turnover of membrane proteins.
Review
Biochemistry & Molecular Biology
Rui Zhang, Shaoqing Shi
Summary: HECT-type E3 ubiquitin ligases play a vital role in controlling protein function and stability, and members of the NEDD4 family have critical roles in dysregulation of autophagy in cancer cells. This review focuses on the role of NEDD4 E3 ligases in defective autophagy in cancer cells, discussing their function, substrates, and signaling pathways, providing a basis for cancer treatment through modulation of these ligases.
MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Amanda B. Chai, Richard Callaghan, Ingrid C. Gelissen
Summary: The study demonstrates that NEDD4-1 regulates the expression and activity of P-gp, thereby facilitating the clearance of Aβ peptides from the brain. This finding offers a potential approach for the treatment of Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Min Sup Song, Pier Paolo Pandolfi
Summary: Members of the HECT family of E3 ubiquitin ligases have significant regulatory roles in PTEN function, subcellular localization, and levels, enabling the identification of genes involved in tumorigenesis and cancer susceptibility. These findings hold promise for the development of novel therapeutic approaches for cancer prevention and treatment, as well as other diseases.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Fang Cheng, Yi Cheng, Xiaoling Zhao, Lihui An, Linfang Yang, Zihan Li, Lei Zhang, Runzhi He
Summary: The study investigates the role of NEDD4 in cutaneous melanoma, revealing that NEDD4 knockdown suppresses cellular proliferation and invasion while increasing apoptosis rate. It is suggested that NEDD4 regulates biological activity through the Notch1/PTEN pathway in melanoma cells.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Genetics & Heredity
James A. Conway, Grant Kinsman, Edgar R. Kramer
Summary: Parkinson's disease is a neurodegenerative disease with unclear molecular pathologies. Enhancing the clearance of alpha-synuclein, a proposed causative protein, is a central idea for PD research. NEDD4 ligases have been shown to influence the degradation of alpha-synuclein and may be potential therapeutic targets for PD. Understanding the expression and function of NEDD4 ligases in the brain is crucial for uncovering the mechanisms of PD.
Article
Biochemistry & Molecular Biology
Kai Li, Yi Niu, Yichuan Yuan, Jiliang Qiu, Yunxing Shi, Chengrui Zhong, Zhiyu Qiu, Keren Li, Zhu Lin, Zhenkun Huang, Chao Zhang, Dinglan Zuo, Wei He, Yunfei Yuan, Binkui Li
Summary: Insufficient thermal ablation can promote the progression of hepatocellular carcinoma (HCC) and upregulate the E3 ligase Nedd4. Nedd4 enhances the TGF-beta signal transduction, promoting tumor growth and metastasis. High Nedd4 expression correlates with aggressive tumor phenotypes and poor prognosis in HCC patients.
Article
Multidisciplinary Sciences
Iman Lohraseb, Peter McCarthy, Genevieve Secker, Ceilidh Marchant, Jianmin Wu, Naveid Ali, Sharad Kumar, Roger J. Daly, Natasha L. Harvey, Hiroshi Kawabe, Oded Kleifeld, Sophie Wiszniak, Quenten Schwarz
Summary: This study uncovers the important role of NEDD4-mediated ubiquitination in neural crest cell development, regulating the ubiquitination and turnover of Profilin 1 to modulate actin polymerization.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Jiayi Huang, Chunshuai Wu, Guanhua Xu, Yue Sun, Chao Gui, Jiawei Fu, Zhiming Cui, Haiming Huang
Summary: The study revealed that the decreased expression of miR-429 in SCI rat plasma exosomes promotes neuronal apoptosis, possibly through the interaction of miR-429 with the downstream target gene PTEN, thereby affecting the PI3K/Akt pathway.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Andrew G. Manford, Elijah L. Mena, Karen Y. Shih, Christine L. Gee, Rachael McMinimy, Brenda Martinez-Gonzalez, Rumi Sherriff, Brandon Lew, Madeline Zoltek, Fernando Rodriguez-Perez, Makda Woldesenbet, John Kuriyan, Michael Rape
Summary: Oxidative phosphorylation not only produces ATP, but also generates reactive oxygen species. Cells alleviate reductive stress by ubiquitylating and degrading FNIP1, which relies on zinc as a molecular glue during this process.
Article
Engineering, Mechanical
Nan Liu, Hongli Yang, Shasha Li, Danni Wang, Liangui Yang
Summary: The team constructed a coupling model involving p53-Mdm2 negative feedback loop and p53-PTEN-Mdm2 positive feedback loop, finding that PTEN is crucial for p53 oscillation or bistable switching dynamic behaviors, and the positive feedback loop may enrich the dynamic behaviors of the p53 system.
ACTA MECHANICA SINICA
(2021)
Article
Biotechnology & Applied Microbiology
Liuzhong Wang, Jianzhong Sang, Yamin Zhang, Ling Gao, Dongli Zhao, Hua Cao
Summary: The study revealed that circular RNA itchy E3 ubiquitin protein ligase (circ-ITCH) suppresses nasopharyngeal carcinoma (NPC) tumorigenesis by interacting with microRNA-214 (miR-214) and upregulating the expression of phosphatase and tensin homolog (PTEN). This proposed a novel mechanism for NPC inhibition.
JOURNAL OF GENE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Eunhee Kim, Bin Wang, Namratha Sastry, Eliezer Masliah, Peter T. Nelson, Huaibin Cai, Francesca-Fang Liao
HUMAN MOLECULAR GENETICS
(2016)
Article
Neurosciences
Yupin Chen, Dong-qi Zhang, Zhong Liao, Bin Wang, Suzhen Gong, Chuang Wang, Ming-zi Zhang, Guo-hua Wang, Huaibin Cai, Francesca-Fang Liao, Jiang-ping Xu
MOLECULAR NEURODEGENERATION
(2015)
Article
Biochemistry & Molecular Biology
B. Wang, Y. Liu, L. Huang, J. Chen, J. J. Li, R. Wang, E. Kim, Y. Chen, C. Justicia, K. Sakata, H. Chen, A. Planas, R. S. Ostrom, W. Li, G. Yang, M. P. McDonald, R. Chen, D. H. Heck, F-F Liao
MOLECULAR PSYCHIATRY
(2017)
Article
Peripheral Vascular Disease
Chi Young Song, Nayaab S. Khan, Francesca-Fang Liao, Bin Wang, Ji Soo Shin, Joseph V. Bonventre, Kafait U. Malik
AMERICAN JOURNAL OF HYPERTENSION
(2018)
Article
Immunology
Jing Jing Li, Bin Wang, Mahesh Chandra Kodali, Chao Chen, Eunhee Kim, Benjamin John Patters, Lubin Lan, Santosh Kumar, Xinjun Wang, Junming Yue, Francesca-Fang Liao
JOURNAL OF NEUROINFLAMMATION
(2018)
Article
Neurosciences
Young-Don Kwak, Bin Wang, Jing Jing Li, Ruishan Wang, Qiyue Deng, Shiyong Diao, Yaomin Chen, Raymond Xu, Eliezer Masliah, Huaxi Xu, Jung-Joon Sung, Francesca-Fang Liao
JOURNAL OF NEUROSCIENCE
(2012)
Article
Neurosciences
Yaomin Chen, Bin Wang, Dan Liu, Jing Jing Li, Yueqiang Xue, Kazuko Sakata, Ling-qiang Zhu, Scott A. Heldt, Huaxi Xu, Francesca-Fang Liao
JOURNAL OF NEUROSCIENCE
(2014)
Article
Neurosciences
Wen-Lei Li, Hui-Hui Cai, Bin Wang, Ling Chen, Qi-Gang Zhou, Chun-Xia Luo, Na Liu, Xin-Sheng Ding, Dong-Ya Zhu
JOURNAL OF NEUROSCIENCE RESEARCH
(2009)
Article
Cell & Tissue Engineering
Chun-Xia Luo, Xing Jin, Chang-Chun Cao, Ming-Mei Zhu, Bin Wang, Lei Chang, Qi-Gang Zhou, Hai-Yin Wu, Dong-Ya Zhu
Meeting Abstract
Peripheral Vascular Disease
Chi Young Song, Nayaab S. Khan, Xiao R. Fang, Francesca-Fang Liao, Bin Wang, Joseph V. Bonventre, Kafait U. Malik
Article
Biochemistry & Molecular Biology
Chun Xia Luo, Xin Jian Zhu, Qi Gang Zhou, Bin Wang, Wei Wang, Hui Hui Cai, Yong Jun Sun, Mei Hu, Jun Jiang, Yao Hua, Xiao Han, Dong Ya Zhu
JOURNAL OF NEUROCHEMISTRY
(2007)
Article
Biochemistry & Molecular Biology
Qi-Gang Zhou, Yao Hu, Yao Hua, Mei Hu, Chun-Xia Luo, Xiao Han, Xin-Jian Zhu, Bin Wang, Jin-Shu Xu, Dong-Ya Zhu
JOURNAL OF NEUROCHEMISTRY
(2007)