A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer’s mouse model via an HSF1-mediated mechanism

Why Do So Many Drugs for Alzheimer's Disease Fail in Development? Time for New Methods and New Practices?

(2017) Robert E. Becker et al.   JOURNAL OF ALZHEIMERS DISEASE

NEDD4-mediated HSF1 degradation underlies α-synucleinopathy

(2015) Eunhee Kim et al.   HUMAN MOLECULAR GENETICS

Frequency power and coherence of electroencephalography are correlated with the severity of Alzheimer's disease: A multicenter analysis in Taiwan

(2015) Chih-Chung Chen et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Hippocampal–prefrontal input supports spatial encoding in working memory

(2015) Timothy Spellman et al.   NATURE

Frequency-specific hippocampal-prefrontal interactions during associative learning

(2015) Scott L Brincat et al.   NATURE NEUROSCIENCE

What does gamma coherence tell us about inter-regional neural communication?

(2015) György Buzsáki et al.   NATURE NEUROSCIENCE

Hippocampal–cortical interaction in decision making

(2015) Jai Y. Yu et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Visual Areas Exert Feedforward and Feedback Influences through Distinct Frequency Channels

(2015) André Moraes Bastos et al.   NEURON

Rhythms for Cognition: Communication through Coherence

(2015) Pascal Fries   NEURON

In Vivo Profiling Reveals a Competent Heat Shock Response in Adult Neurons: Implications for Neurodegenerative Disorders

(2015) Alisia Carnemolla et al.   PLoS One

Hsp90 Chaperone Inhibitor 17-AAG Attenuates A -Induced Synaptic Toxicity and Memory Impairment

(2014) Y. Chen et al.   JOURNAL OF NEUROSCIENCE

The Systemic Amyloid Precursor Transthyretin (TTR) Behaves as a Neuronal Stress Protein Regulated by HSF1 in SH-SY5Y Human Neuroblastoma Cells and APP23 Alzheimer's Disease Model Mice

(2014) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Increased heat shock transcription factor 1 in the cerebellum reverses the deficiency of Purkinje cells in Alzheimer's disease

(2013) Yu-Qing Jiang et al.   BRAIN RESEARCH

Metabolic Stress Modulates Alzheimer’s β-Secretase Gene Transcription via SIRT1-PPARγ-PGC-1 in Neurons

(2013) Ruishan Wang et al.   Cell Metabolism

A novel small molecule HSP90 inhibitor, NXD30001, differentially induces heat shock proteins in nervous tissue in culture and in vivo

(2013) Jieun R. C. Cha et al.   CELL STRESS & CHAPERONES

Decreased coherence between the two olfactory bulbs in Alzheimer's disease model mice

(2013) Qing Liu et al.   NEUROSCIENCE LETTERS

Altered Oscillation and Synchronization of Default-Mode Network Activity in Mild Alzheimer’s Disease Compared to Mild Cognitive Impairment: An Electrophysiological Study

(2013) Fu-Jung Hsiao et al.   PLoS One

Suppression of protein aggregation by chaperone modification of high molecular weight complexes

(2012) John Labbadia et al.   BRAIN

Wavelet Coherence Model for Diagnosis of Alzheimer Disease

(2012) Ziad Sankari et al.   CLINICAL EEG AND NEUROSCIENCE

In vivo imaging of induction of heat-shock protein-70 gene expression with fluorescence reflectance imaging and intravital confocal microscopy following brain ischaemia in reporter mice

(2012) Xavier de la Rosa et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Heat shock protein 90 in neurodegenerative diseases

(2012) Wenjie Luo et al.   Molecular Neurodegeneration

Oscillations in the prefrontal cortex: a gateway to memory and attention

(2011) Karim Benchenane et al.   CURRENT OPINION IN NEUROBIOLOGY

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

(2011) John Labbadia et al.   JOURNAL OF CLINICAL INVESTIGATION

Suppression of Alzheimer's Disease-Related Phenotypes by Expression of Heat Shock Protein 70 in Mice

(2011) T. Hoshino et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease: synapses gone cold

(2011) Robert M Koffie et al.   Molecular Neurodegeneration

Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases

(2011) Daniel W. Neef et al.   NATURE REVIEWS DRUG DISCOVERY

Chronic Stress-induced Hippocampal Vulnerability: The Glucocorticoid Vulnerability Hypothesis

(2011) Cheryl D. Conrad   REVIEWS IN THE NEUROSCIENCES

KRIBB11 Inhibits HSP70 Synthesis through Inhibition of Heat Shock Factor 1 Function by Impairing the Recruitment of Positive Transcription Elongation Factor b to thehsp70Promoter

(2010) Young Ju Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Novel Hsp90 Inhibitor NXD30001 Induces Tumor Regression in a Genetically Engineered Mouse Model of Glioblastoma Multiforme

(2010) H. Zhu et al.   MOLECULAR CANCER THERAPEUTICS

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

Thinned-skull cranial window technique for long-term imaging of the cortex in live mice

(2010) Guang Yang et al.   Nature Protocols

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Heat shock proteins: Cellular and molecular mechanisms in the central nervous system

(2010) R. Anne Stetler et al.   PROGRESS IN NEUROBIOLOGY

Structural dynamics of dendritic spines in memory and cognition

(2010) Haruo Kasai et al.   TRENDS IN NEUROSCIENCES

Synthesis of pochoxime prodrugs as potent HSP90 inhibitors

(2009) Cuihua Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of HSP90 with Pochoximes: SAR and Structure-Based Insights

(2009) Sofia Barluenga et al.   CHEMBIOCHEM

Brain-Permeable Small-Molecule Inhibitors of Hsp90 Prevent  -Synuclein Oligomer Formation and Rescue  -Synuclein-Induced Toxicity

(2009) P. Putcha et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Stably maintained dendritic spines are associated with lifelong memories

(2009) Guang Yang et al.   NATURE

Neuroprotective activity and evaluation of Hsp90 inhibitors in an immortalized neuronal cell line

(2008) Yuanming Lu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

HSP70 and Constitutively Active HSF1 Mediate Protection Against CDCrel-1-mediated Toxicity

(2008) Alisha E Jung et al.   MOLECULAR THERAPY