Review
Pharmacology & Pharmacy
Valentina Carotti, Juan P. Rigalli, Jenny van Asbeck-van der Wijst, Joost G. J. Hoenderop
Summary: Purinergic signalling is a process mediated by purinergic receptors, where extracellular nucleotides and nucleosides bind to the receptors, resulting in changes in cell physiology. This signalling is involved in important physiological processes and pathophysiological situations such as cancer and inflammation. Extracellular vesicles (EVs) play a crucial role in modulating purinergic signalling and can affect target cells and tissues located at distant locations. The regulation of extracellular ATP levels and adenosine by EVs has significant impact on processes like inflammation, immune response, and cancer pathogenesis.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Fisheries
Shuo Li, Tongtong Zhang, Yu Feng, Jinsheng Sun
Summary: Extracellular nucleotides, such as ATP and ADP, released during inflammation or infection, play a crucial role in regulating immune responses in fish by activating specific purinergic receptors on immune cells.
Article
Medicine, Research & Experimental
Yanesko Fernandes Bella, Carlos Rocha Oliveira, Jose Roberto Mateus-Silva, Maysa Alves Rodrigues Brandao-Rangel, Anamei Silva-Reis, Juliana de Melo Batista Santos, Regiane Albertini, Rodrigo Alvaro Brandao Lopes-Martins, Luis Vicente Franco de Oliveira, Rodolfo P. Vieira
Summary: In this study, the effects of Immunity-6TM, a phytocomplex, on leukemia cells were investigated. The results showed that Immunity-6TM can inhibit the release of proinflammatory cytokines and induce the release of anti-inflammatory cytokines, suggesting its potential as an adjuvant in leukemia treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
R. O. Leite, P. O. de Souza, C. B. Haas, F. da Silveira, K. R. Mohr, A. P. S. Bertoni, M. S. Soares, J. H. Azambuja, M. Dal Pra, L. L. P. da Cruz, N. E. Gelsleichter, K. Begnini, G. Hasko, M. R. Wink, R. M. Spanevello, E. Braganhol
Summary: Sepsis is a life-threatening organ dysfunction caused by a dysregulated inflammatory response to infection. Purinergic signaling, mediated by purines such as ATP and adenosine, plays a crucial role in the immune and inflammatory responses during sepsis. Sepsis disrupts the balance of ATP and adenosine levels, leading to dysregulation of immune responses. The measurement of serum levels and activities of purinergic pathway markers may serve as potential biomarkers for sepsis diagnosis and treatment.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Medicine, Research & Experimental
Karine Paula Reichert, Milagros Fanny Vera Castro, Charles Elias Assmann, Nathieli Bianchin Bottari, Vanessa Valeria Miron, Andreia Cardoso, Naiara Stefanello, Vera Maria Melchiors Morsch, Maria Rosa Chitolina Schetinger
Summary: This review focuses on the role of the purinergic system in diabetes and hypertension, highlighting changes in the expression of P1 and P2 receptors, as well as the activities of CD39, CD73, and ADA. It suggests that manipulating the purinergic axis at various levels could potentially prevent or exacerbate the development of diabetes and hypertension as a compensatory mechanism.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Immunology
Yanzhi Jiang, Jianxin Lin, Haiyun Zheng, Ping Zhu
Summary: This review examines the role of purinergic signaling in ischemia-reperfusion injury and rejection after heart transplantation, as well as its clinical applications and prospects.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Shanu Jain, Kenneth A. Jacobson
Summary: Research has shown that purinergic receptors play a vital role in regulating liver function and the development of liver diseases, suggesting potential therapeutic strategies by targeting adenosine, P2Y, and P2X receptors.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Maria Luiza Mukai Franciosi, Millena Daher Medeiros Lima, Maria Rosa Chitolina Schetinger, Andreia Machado Cardoso
Summary: This review explores the potential role of purinergic signaling in COVID-19, focusing on purinergic receptors and components such as ATP, CD39, and CD73. It suggests therapeutic combination or association possibilities targeting purinergic system components as a useful tool for future research, aiming to unveil a novel option to treat COVID-19 patients.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Review
Oncology
Jasmeet Kaur, Sanchit Dora
Summary: Cancer is a complex disease with diverse characteristics, and there is a need to discover new therapeutic targets to improve treatment outcomes.
FRONTIERS IN ONCOLOGY
(2023)
Review
Endocrinology & Metabolism
Larissa Berloffa Belardin, Keliane Brochu, Christine Legare, Maria Agustina Battistone, Sylvie Breton
Summary: Purinergic receptors are widely expressed throughout the body and play a role in regulating cell function. They activate specific receptors and trigger different signaling pathways to regulate various cellular responses. Purinergic signaling is important for the physiological and pathophysiological processes in the male reproductive system, but our understanding of this is limited.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Bernhard Wernly, David Erlinge, John Pernow, Zhichao Zhou
Summary: Cardiometabolic diseases can lead to vascular complications globally, with altered purinergic signaling being a key mechanism. Ticagrelor, a successful drug, targets purinergic signaling by affecting platelet aggregation and RBCs to potentially provide cardiovascular benefits in patients with acute coronary syndrome.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Immunology
Gabriel Espinosa, Ivan Conejeros, Lisbeth Rojas-Baron, Carlos Rodrigo Hermosilla, Anja Taubert
Summary: This study investigated a new immune response mechanism in cattle called neutrophil extracellular trap (NET) formation caused by bovine besnoitiosis. The study found that ATP plays a critical role in regulating polymorphonuclear neutrophils (PMN) through the nucleotide P2 receptor family for NET formation. Additionally, the study identified the P2X1 purinergic receptor as a key molecule in B. besnoiti-induced PMN clustering and anchored NET formation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Eric R. Barros Lamus, Valentina Carotti, Christine R. S. de Vries, Femke Witsel, Onno J. Arntz, Fons A. J. van de Loo, Cristian A. Carvajal, Rene J. M. Bindels, Joost G. J. Hoenderop, Juan P. Rigalli
Summary: This study investigates the regulatory effect of EVs from renal proximal tubule and collecting duct cells on extracellular ATP levels and the expression of the alpha subunit of the epithelial sodium channel. The findings reveal that EVs can modulate purinergic signaling through mechanisms such as miRNA regulation and ATPase activity, impacting renal physiological and pathophysiological processes. Further research on EV release and cargo content may shed light on the role of EVs in renal purinergic signaling.
Article
Neurosciences
Matthias Ollivier, Juline Beudez, Nathalie Linck, Thomas Grutter, Vincent Compan, Francois Rassendren
Summary: Biosensors based on P2X receptors and GECIs have been developed, capable of detecting nanomolar ATP concentrations and tracking P2X receptor activity. These sensors have successfully dynamically tracked ATP release in mouse neurons.
Article
Neurosciences
Cristian Saquel, Romina J. Catalan, Rodrigo Lopez-Leal, Ramon A. Ramirez, David Necunir, Ursula Wyneken, Christophe Lamaze, Felipe A. Court
Summary: Functional recovery after peripheral nerve injuries relies on axonal regeneration, which is regulated by both autonomous and non-cell autonomous processes. This study demonstrates that neuronal activity enhances the release of repair Schwann cell-derived extracellular vesicles (EVs) and their transfer to neurons. This effect is mediated by the ATP-P2Y signaling pathway and leads to increased content of miRNA-21 in the EVs. These findings highlight the importance of neuron to glia communication in regulating axonal elongation through the transfer of EVs.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Melih Acar, Kiranmai S. Kocherlakota, Malea M. Murphy, James G. Peyer, Hideyuki Oguro, Christopher N. Inra, Christabel Jaiyeola, Zhiyu Zhao, Katherine Luby-Phelps, Sean J. Morrison
Article
Multidisciplinary Sciences
George Dalton, Sung-Wan An, Saif I. Al-Juboori, Nicole Nischan, Joonho Yoon, Evgenia Dobrinskikh, Donald W. Hilgemann, Jian Xie, Kate Luby-Phelps, Jennifer J. Kohler, Lutz Birnbaumer, Chou-Long Huang
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Cell Biology
Eunmyong Lee, Yeon Koo, Aylwin Ng, Yongjie Wei, Kate Luby-Phelps, Amy Juraszek, Ramnik J. Xavier, Ondine Cleaver, Beth Levine, James F. Amatruda
Article
Biochemistry & Molecular Biology
Samarpita Sengupta, Szu-Wei Tu, Kyle Wedin, Svetlana Earnest, Steve Stippec, Katherine Luby-Phelps, Melanie H. Cobb
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Shanica Pompey, Zhenze Zhao, Kate Luby-Phelps, Peter Michaely
JOURNAL OF LIPID RESEARCH
(2013)
Article
Cell Biology
Dorothy I. Mundy, Wei Ping Li, Katherine Luby-Phelps, Richard G. W. Anderson
MOLECULAR BIOLOGY OF THE CELL
(2012)
Article
Cell Biology
Kate Luby-Phelps
MOLECULAR BIOLOGY OF THE CELL
(2013)
Article
Multidisciplinary Sciences
Yuying Zhang, Meredith L. Akins, Kartikeya Murari, Jiefeng Xi, Ming-Jun Li, Katherine Luby-Phelps, Mala Mahendroo, Xingde Li
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2012)
Article
Endocrinology & Metabolism
Kai Sun, Christine M. Kusminski, Kate Luby-Phelps, Stephen B. Spurgin, Yu A. An, Qiong A. Wang, William L. Holland, Philipp E. Scherer
MOLECULAR METABOLISM
(2014)
Article
Multidisciplinary Sciences
Linzhang Huang, Ken L. Chambliss, Xiaofei Gao, Ivan S. Yuhanna, Erica Behling-Kelly, Sonia Bergaya, Mohamed Ahmed, Peter Michaely, Kate Luby-Phelps, Anza Darehshouri, Lin Xu, Edward A. Fisher, Woo-Ping Ge, Chieko Mineo, Philip W. Shaul
Article
Biochemistry & Molecular Biology
Sahba Kasiri, Baozhi Chen, Alexandra N. Wilson, Annika Reczek, Simbarashe Mazambani, Jashkaran Gadhvi, Evan Noel, Ummay Marriam, Barbara Mino, Wei Lu, Luc Girard, Luisa M. Solis, Katherine Luby-Phelps, Justin Bishop, Jung-Whan Kim, James Kim
Article
Cell Biology
Parker S. Tirrell, Kailey N. Nguyen, Katherine Luby-Phelps, Jonathan R. Friedman
JOURNAL OF CELL BIOLOGY
(2020)
Article
Reproductive Biology
Shanmugasundaram Nallasamy, Meredith Akins, Breanna Tetreault, Kate Luby-Phelps, Mala Mahendroo
BIOLOGY OF REPRODUCTION
(2018)
Article
Developmental Biology
Lei Gao, Zhufeng Yang, Chitkale Hiremath, Susan E. Zimmerman, Blake Long, Paul R. Brakeman, Keith E. Mostov, David M. Bryant, Katherine Luby-Phelps, Denise K. Marciano
Proceedings Paper
Engineering, Biomedical
Shuo Li, Kate Luby-Phelps, Baoju Zhang, Xiaorong Wu, Jean Gao
2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
(2011)