Review
Biochemistry & Molecular Biology
Yansui Mai, Jiyan Su, Chuan Yang, Chenglai Xia, Liwu Fu
Summary: Cancer stem-like cells, with their remarkable capabilities, are crucial in tumor progression and metastasis. Targeting CSC biomarkers, stemness-associated pathways, tumor microenvironment, and immunoevasion can improve cancer treatment outcomes.
Article
Oncology
Jae-Il Choi, Sung Ill Jang, Jaehyun Hong, Chul Hoon Kim, Soon Sung Kwon, Joon Seong Park, Jong-Baeck Lim
Summary: In this study, it was demonstrated that CD44(+), CD24(+) and EpCAM(+) cancer-initiating cells (CICs) were enriched in patient-derived organoids of PDAC. CD44-expressing CICs formed lumen structures within the organoids. Additionally, CD44(-) cancer cells from the organoids could re-form organoids and be re-programed as CD44-expressing CICs. The study also showed that the maintenance of CICs in PDAC organoids was mediated by interactions with endothelial cells through Wnt and Notch signaling pathways.
Article
Biotechnology & Applied Microbiology
Yan Hu, Chao Wan, Xiao Yang, Yu Tian, Suke Deng, Dandan An, Yijun Wang, Jiacheng Wang, Zhiyun Liao, Jingshu Meng, You Qin, Yajie Sun, Kunyu Yang
Summary: Stem-like tumor cells (SLTCs) are resistant to traditional cancer treatments and are responsible for tumor recurrence and metastasis. In this study, researchers cultured low-serum-cultured tumor cells and confirmed their quiescent state and chemotherapy resistance, consistent with SLTC features. They found SLTCs had high levels of reactive oxygen species (ROS) and used radiated tumor cell-derived microparticles (RT-MPs), which contained ROS, to kill SLTCs both in vivo and in vitro. This study provides a new method for eliminating SLTCs.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Health Care Sciences & Services
Eva Obermayr, Nina Koppensteiner, Nicole Heinzl, Eva Schuster, Barbara Holzer, Hannah Fabikan, Christoph Weinlinger, Oliver Illini, Maximilian Hochmair, Robert Zeillinger
Summary: This study highlighted the importance of molecular characterization of circulating tumor cells (CTCs) in NSCLC patients. The analysis found that cancer stem cell-related transcripts were significantly associated with overall survival at both primary diagnosis and disease progression.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Genetics & Heredity
Olalekan H. Usman, Liting Zhang, Gengqiang Xie, Hemant M. Kocher, Chang-il Hwang, Yue Julia Wang, Xian Mallory, Jerome Irianto
Summary: The establishment of patient-derived pancreatic cancer organoid culture has provided an important tool to study genomic heterogeneity and stability in cancer cells. Research has shown the presence of clonal populations with similar copy number profiles in pancreatic cancer organoids, and the proportion of these clones changes with extended culture, indicating the growth advantage of certain clones. However, sub-clonal genomic heterogeneity is also observed within each clonal population, suggesting the genomic instability of pancreatic cancer cells. Additionally, gene expression regulation is influenced by copy number alterations.
NPJ GENOMIC MEDICINE
(2022)
Article
Biology
Yoichiro Harada, Yu Mizote, Takehiro Suzuki, Akiyoshi Hirayama, Satsuki Ikeda, Mikako Nishida, Toru Hiratsuka, Ayaka Ueda, Yusuke Imagawa, Kento Maeda, Yuki Ohkawa, Junko Murai, Hudson H. Freeze, Eiji Miyoshi, Shigeki Higashiyama, Heiichiro Udono, Naoshi Dohmae, Hideaki Tahara, Naoyuki Taniguchi
Summary: Mannose has anticancer activity by regulating cell metabolism and inducing dNTP loss, affecting cell cycle and chemotherapy efficacy.
Article
Multidisciplinary Sciences
Juliann Shih, Shahab Sarmashghi, Nadja Zhakula-Kostadinova, Shu Zhang, Yohanna Georgis, Stephanie H. Hoyt, Michael S. S. Cuoco, Galen F. F. Gao, Liam F. F. Spurr, Ashton C. C. Berger, Gavin Ha, Veronica Rendo, Hui Shen, Matthew Meyerson, Andrew D. D. Cherniack, Alison M. M. Taylor, Rameen Beroukhim
Summary: A method called BISCUT was developed to identify loci with fitness advantages or disadvantages by analyzing length distributions of telomere- or centromere-bounded copy-number events. These loci were enriched for known cancer driver genes and often specific to certain cell lineages. The study also found that the impact of copy-number alterations on cellular fitness is highly correlated with the frequency of whole-chromosome or whole-arm imbalances.
Article
Biochemistry & Molecular Biology
Chunfeng Xie, Chunhua Liang, Rong Wang, Kefan Yi, Xu Zhou, Xiaoting Li, Yue Chen, Dengshun Miao, Caiyun Zhong, Jianyun Zhu
Summary: Increasing evidence suggests that cancer stem cells (CSCs) play a crucial role in tumor initiation and recurrence. Targeting CSCs and the tumor microenvironment (TME) is a novel anti-cancer approach. Resveratrol (RES) inhibits lung cancer by targeting lung cancer stem-like cells (LCSCs) and IL-6 in the TME.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Editorial Material
Multidisciplinary Sciences
Craig M. Bielski, Barry S. Taylor
Summary: Genomic instability is a characteristic of cancer, but exploiting this feature to selectively target cancer cells remains a major challenge in cancer biology with significant implications for drug development.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Chen-Chi Liu, Hsin-Hsien Li, Jiun-Han Lin, Ming-Chen Chiang, Tien-Wei Hsu, Anna Fen-Yau Li, David Hung-Tsang Yen, Han-Shui Hsu, Shih-Chieh Hung
Summary: Cancer stem cells (CSCs) in esophageal squamous cell carcinoma are more susceptible to ferroptosis-inducing agents, but can be rescued from cell death by activating Hsp27 to upregulate GPX4. Targeting Hsp27 or GPX4 to block this protective mechanism against ferroptosis may be a potential treatment strategy for eradicating CSCs in this type of cancer.
Article
Biochemistry & Molecular Biology
Yushi Abe, Daigo Ochiai, Masako Taguchi, Seiji Kanzaki, Satoru Ikenoue, Yoshifumi Kasuga, Mamoru Tanaka
Summary: Human amniotic fluid stem cells (hAFSCs) can form aggregates with host immune cells and alleviate inflammation. Additionally, hAFSCs can increase regulatory T cells in the acquired immune system. Therefore, hAFSCs play an important role in the treatment of inflammation-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Juliane Strietz, Stella S. Stepputtis, Marie Follo, Peter Bronsert, Elmar Stickeler, Jochen Maurer
Summary: Primary breast cancer stem cell (BCSC) cultures isolated from TNBC specimens have been established and shown to grow as tumor spheres under anchorage-independent culture conditions in vitro, while reliably forming tumors in mice when transplanted in limiting dilutions in vivo. Additionally, these BCSC xenograft tumors exhibit similar architecture and gene expression to the original patient tumor, suggesting a promising model for researching BCSC biology and testing new treatment options for TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Guoxiang Rong, Zhongjun Pan, Ming Ding, Lihui Wang
Summary: The study revealed that the expression of RNF168 is positively correlated with survival in lung adenocarcinoma patients but not in squamous cell carcinoma patients. RNF168 suppresses cancer stem cell traits in NSCLC cells by promoting the ubiquitination and degradation of RhoC, suggesting a potential therapeutic target for NSCLC treatment.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Oncology
Atsushi Shiozaki, Hiroyuki Inoue, Hiroki Shimizu, Toshiyuki Kosuga, Kenichi Takemoto, Michihiro Kudou, Takuma Ohashi, Tomohiro Arita, Hirotaka Konishi, Shuhei Komatsu, Takeshi Kubota, Hitoshi Fujiwara, Eigo Otsuji
Summary: This study found that TRPV2 and SLC12A2 are involved in the maintenance of esophageal adenocarcinoma stem cells (CSCs), and their specific inhibitors, tranilast and furosemide, respectively, have potential as targeted therapeutic agents for esophageal adenocarcinoma (EAC).
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Toxicology
Onat Kadioglu, Mohamed Saeed, Nuha Mahmoud, Shaymaa Azawi, Kristin Mrasek, Thomas Liehr, Thomas Efferth
Summary: In this study, colon cancer cells with TP53 deletion were characterized, and multiple genes were found to be overexpressed, potentially influencing multidrug resistance. The research sheds light on unknown drug resistance mechanisms and may impact future treatment strategies.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Medicine, Research & Experimental
Gang Wang, Jianjun Tang, Weixiang Zhan, Ruhua Zhang, Meifang Zhang, Dan Liao, Xin Wang, Yuanzhong Wu, Tiebang Kang
Article
Medicine, Research & Experimental
Xinchun Li, Li Zhong, Zhuo Wang, Huiming Chen, Dan Liao, Ruhua Zhang, Hongyu Zhang, Tiebang Kang
Article
Oncology
Li Zhong, Dan Liao, Meifang Zhang, Cuiling Zeng, Xinchun Li, Ruhua Zhang, Haiqing Ma, Tiebang Kang
Article
Medicine, Research & Experimental
Yujiao Han, Heng Feng, Jun Sun, Xiaoting Liang, Zhuo Wang, Wenhui Xing, Qinggang Dai, Yang Yang, Anjia Han, Zhanying Wei, Qing Bi, Hongbin Ji, Tiebang Kang, Weiguo Zou
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Multidisciplinary Sciences
Xin Wang, Ge Qin, Xiaoting Liang, Wen Wang, Zhuo Wang, Dan Liao, Li Zhong, Ruhua Zhang, Yi-Xin Zeng, Yuanzhong Wu, Tiebang Kang
NATURE COMMUNICATIONS
(2020)
Article
Cell Biology
Dan Liao, Li Zhong, Junqiang Yin, Cuiling Zeng, Xin Wang, Xingchuan Huang, Jinna Chen, Hong Zhang, Ruhua Zhang, Xin-Yuan Guan, Xintao Shuai, Jianhua Sui, Song Gao, Wuguo Deng, Yi-Xin Zeng, Jing-Nan Shen, Jian Chen, Tiebang Kang
NATURE CELL BIOLOGY
(2020)
Article
Cell Biology
Denghui Wei, Weixiang Zhan, Ying Gao, Liyan Huang, Run Gong, Wen Wang, Ruhua Zhang, Yuanzhong Wu, Song Gao, Tiebang Kang
Summary: RAB31 plays a dual role in exosome biogenesis by driving ILVs formation and suppressing the fusion of MVEs with lysosomes, providing a better understanding of the exosome biogenesis process.
Article
Biochemistry & Molecular Biology
Xianchong Zheng, Zefu Liu, Jianliang Zhong, Liwen Zhou, Jiawei Chen, Lisi Zheng, Zhiyong Li, Ruhua Zhang, Jingxuan Pan, Yuanzhong Wu, Zhuowei Liu, Tiebang Kang
Summary: The downregulation of histone H4 transcription factor (HINFP) is associated with cell senescence in bladder cancer tissues, and lower HINFP expression predicts an unfavorable outcome in bladder cancer patients. Knockout of HINFP inhibits the transcription of H1F0 and H1FX, leading to DNA damage and cell senescence, which suppresses the proliferation and growth of bladder cancer cells. However, the senescence-associated secretory phenotype enhances the invasion and metastasis of non-senescent bladder cancer cells. Histone deacetylase inhibitors can effectively eliminate the senescent cells induced by HINFP knockout, thereby suppressing the invasion and metastasis of bladder cancer cells.
Article
Chemistry, Multidisciplinary
Cuiling Zeng, Li Zhong, Wenqiang Liu, Yu Zhang, Xinhao Yu, Xin Wang, Ruhua Zhang, Tiebang Kang, Dan Liao
Summary: The Rab22a-NeoF1 fusion protein undergoes lysosomal degradation mediated by the autophagy receptor NDP52 and the E3 ligase STUB1. The degradation is facilitated by the phosphorylation of Rab22a-NeoF1 by PINK1 kinase. Sorafenib and Regorafenib can inhibit osteosarcoma lung metastasis induced by Rab22a-NeoF1 by upregulating PINK1. These findings suggest that targeting the lysosomal degradation of the Rab22a-NeoF1 fusion protein may be beneficial for osteosarcoma patients.
Article
Biochemistry & Molecular Biology
Xiaodan Huang, Lanqing Huo, Beibei Xiao, Yi Ouyang, Foping Chen, Junyun Li, Xueping Zheng, Denghui Wei, Yuanzhong Wu, Ruhua Zhang, Xinping Cao, Tiebang Kang, Ying Gao
Summary: This study reveals that activation of the STING-TBK1 pathway can suppress cervical cancer growth by promoting the degradation of E7 oncoproteins. This finding provides new insights into the host innate immune defense against oncoviruses and suggests that activating STING/TBK1 could be a promising strategy for treating HPV-positive cervical cancer.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Cell Biology
Ying Gao, Xueping Zheng, Boyang Chang, Yujie Lin, Xiaodan Huang, Wen Wang, Shirong Ding, Weixiang Zhan, Shang Wang, Beibei Xiao, Lanqing Huo, Youhui Yu, Yilin Chen, Run Gong, Yuanzhong Wu, Ruhua Zhang, Li Zhong, Xin Wang, Qiuyan Chen, Song Gao, Zhengfan Jiang, Denghui Wei, Tiebang Kang
Summary: Activated STING can be transferred between cells to promote antitumor immunity, a process triggered by non-canonical autophagy mediated by RAB22A. RAB22A induces the fusion of non-canonical autophagosomes with early endosomes, forming a new organelle called Rafeesome, and suppresses fusion with lysosomes. The inner vesicle of non-canonical autophagosome, containing activated STING, is secreted as R-EV, which induces the release of IFN beta from recipient cells and promotes antitumor immunity.
Article
Biochemistry & Molecular Biology
Li Zhong, Dan Liao, Jingjing Li, Wenqiang Liu, Jingxuan Wang, Cuiling Zeng, Xin Wang, Zhiliang Cao, Ruhua Zhang, Miao Li, Kuntai Jiang, Yi-Xin Zeng, Jianhua Sui, Tiebang Kang
Summary: The study revealed that the Rab22a-NeoF1 fusion protein in osteosarcoma promotes the formation of pulmonary pre-metastatic niche by exosomes and subsequently enhances lung metastasis. Additionally, exosomal PYK2 activates signaling pathways in recipient macrophages and osteosarcoma cells, leading to an increase in the M2 phenotype.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Medicine, Research & Experimental
Xiaoting Liang, Xin Wang, Yaohui He, Yuanzhong Wu, Li Zhong, Wen Liu, Dan Liao, Tiebang Kang
Article
Biochemistry & Molecular Biology
Liwen Zhou, Lisi Zheng, Kaishun Hu, Xin Wang, Ruhua Zhang, Yezi Zou, Li Zhong, Shang Wang, Yuanzhong Wu, Tiebang Kang
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2020)
Article
Medicine, Research & Experimental
Shang Wang, Li Zhong, Yin Li, Desheng Xiao, Ruhua Zhang, Dan Liao, Dongming Lv, Xin Wang, Juanfei Wang, Xianbiao Xie, Jing Chen, Yuanzhong Wu, Tiebang Kang