Review
Biochemistry & Molecular Biology
Jingwei Shi, Xujun Song, Benno Traub, Michael Luxenhofer, Marko Kornmann
Summary: IL-4 and IL-13 are pleiotropic Th2 cytokines involved in immune responses and have been found to play a role in oncogenesis and tumor progression. Their effects on tumor cells are mediated through specific receptors, with IL-4R alpha/IL-13R alpha 1 being the main target in tumors. Understanding the implications of these cytokines and their receptors in pancreatic cancer helps in developing potential new diagnostic and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Allergy
Archana Shankar, Jaclyn W. McAlees, Ian P. Lewkowich
Summary: Abnormal activation of CD4 T(H)2 cells and excessive production of T(H)2 cytokines IL-4 and IL-13 are implicated in the development of allergic diseases. IL-4 and IL-13 utilize JAK/STAT signaling pathways for induction of inflammatory gene expression and disease pathology. However, there are alternative signaling cascades activated by IL-4 and IL-13, contributing to specific aspects of IL-4/IL-13-associated responses. A better understanding of these signaling pathways is important for designing targeted therapies for uncommon disease endotypes.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Biology
Mimmi L. E. Lundahl, Morgane Mitermite, Dylan Gerard Ryan, Sarah Case, Niamh C. Williams, Ming Yang, Roisin Lynch, Eimear Lagan, Filipa M. Lebre, Aoife L. Gorman, Bojan Stojkovic, Adrian P. Bracken, Christian Frezza, Frederick J. Sheedy, Eoin M. Scanlan, Luke A. J. O'Neill, Stephen Gordon, Ed C. Lavelle, Simon Yona
Summary: This study provides new and unexpected insights into alternative macrophage activation states in the context of mycobacterial infection. Activation with IL-4 and IL-13 induces protective innate memory against mycobacterial challenge and enhances the killing capacity of macrophages. IL-4/13 trained macrophages retain heightened oxidative phosphorylation metabolism and impede heightened pro-inflammatory cytokine responses by inhibiting oxidative phosphorylation.
Review
Immunology
Zachary J. J. Bernstein, Anjali Shenoy, Amy Chen, Nicola M. M. Heller, Jamie B. B. Spangler
Summary: IL-4 and IL-13 cytokines play important roles in immune activity, especially in T helper 2 cell-mediated inflammation, immune regulation, antibody production, and fibrosis. Manipulating the IL-4/IL-13 axis through cytokine engineering, fusion protein formulation, antagonist development, cell engineering, and biosensor design can lead to the discovery of new immunotherapies targeting allergy, autoimmune diseases, and cancer.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Dermatology
Xiuju Dai, Ryo Utsunomiya, Ken Shiraishi, Hideki Mori, Jun Muto, Masamoto Murakami, Koji Sayama
Summary: IL-33 is highly expressed in atopic dermatitis (AD) lesions, potentially participating in the pathogenesis of AD by inhibiting keratinocyte differentiation and skin barrier function.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Medicine, Research & Experimental
Florian Sicklinger, Ingmar Soren Meyer, Xue Li, Daniel Radtke, Severin Dicks, Moritz P. Kornadt, Christina Mertens, Julia K. Meier, Kory J. Lavine, Yunhang Zhang, Tim Christian Kuhn, Tobias Terzer, Jyoti Patel, Melanie Boerries, Gabriele Schramm, Norbert Frey, Hugo A. Katus, David Voehringer, Florian Leuschner
Summary: The study show that basophils play a crucial role in promoting tissue repair after myocardial infarction by increasing levels of IL-4 and IL-13 in the heart. Depletion of basophils leads to an increase in inflammatory response, scar thinning, and deterioration of cardiac function post-MI.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Quentin D'Arcy, Mehrnaz Gharaee-Kermani, Alisa Zhilin-Roth, Jill A. Macoska
Summary: The IL-4/IL-13 signaling axis plays a crucial role in the development of lower urinary tract symptoms. IL-4 and IL-13 promote the activation of prostate fibroblasts and the secretion of extracellular matrix, leading to fibrosis. These findings have important clinical implications for the treatment of lower urinary tract symptoms.
Article
Biochemistry & Molecular Biology
Kyunghee Kim, Hyeju Kim, Gun Yong Sung
Summary: The study indicates that short-term use of I3LA for approximately one week can effectively suppress the progression of atopic dermatitis and impact the expression of major constituent proteins of the skin barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Nicholas N. Jarjour, Kelsey M. Wanhainen, Changwei Peng, Noah V. Gavil, Nicholas J. Maurice, Henrique Borges da Silva, Ryan J. Martinez, Talia S. Dalzell, Matthew A. Huggins, David Masopust, Sara E. Hamilton, Stephen C. Jameson
Summary: Interleukin-15 (IL-15) is a central regulator of memory CD8+ T cells and can stimulate their proliferation and expansion. IL-15 sensitivity is an important feature of memory CD8+ T cell populations, with therapeutic potential.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Lilli Arndt, Andreas Lindhorst, Julia Neugebauer, Anne Hoffmann, Constance Hobusch, Vasileia-Ismini Alexaki, Adhideb Ghosh, Matthias Blueher, Christian Wolfrum, Markus Glass, Martin Gericke
Summary: White adipose tissue fibrosis is strongly associated with inflammation and dysfunction due to obesity. IL-13 and IL-4 have been identified as critical mediators in fibrotic diseases, but their role in WAT fibrosis is still unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Dayvson Mauricio da Silva, Juliana Prado Goncales, Jose Valter Joaquim Silva Junior, Thaisa Regina Rocha Lopes, Luan Araujo Bezerra, Virginia Maria Barros de Lorena, Maria Rosangela Cunha Duarte Coelho
Summary: In HIV/HHV-8 coinfection, levels of cytokines IL-4, IL-6, and IL-10 are higher in patients compared to those infected with only HIV, potentially indicating the development of HHV-8-related diseases. On the other hand, levels of IL-2, TNF-alpha, and IFN-gamma show no significant difference between the two groups.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Cell Biology
Milena Iwaszko, Sylwia Bialy, Katarzyna Bogunia-Kubik
Summary: IL-4 and IL-13 are key mediators of allergic inflammation and have been implicated in the development of autoimmune diseases. Recent studies suggest that they may play a significant role in downregulating inflammatory processes underlying rheumatoid arthritis pathogenesis.
Article
Hematology
Johanna Melo-Cardenas, Lavanya Bezavada, Jeremy Chase Crawford, Sandeep Gurbuxani, Anitria Cotton, Guolian Kang, Jeffrey Gossett, Christian Marinaccio, Rona Weinberg, Ronald Hoffman, Anna Rita Migliaccio, Yan Zheng, Marta Derecka, Ciro R. Rinaldi, John D. Crispino
Summary: This study analyzed MF mouse models and samples from MF patients, and found that high levels of IL-13 are associated with MF progression and fibrosis. Inhibition of the IL-13/IL-4 signaling pathway may serve as a novel therapeutic target for treating MF.
Review
Immunology
Judith E. Allen
Summary: Type 2 immunity plays a crucial role in protecting against parasites and responding to allergens, as well as maintaining tissue integrity and promoting wound repair. IL-4 and IL-13, key type 2 cytokines, are involved in suppressing the initial inflammatory response to injury and modulating extracellular matrix changes for effective repair. However, the exact contribution of IL-4R alpha signaling in wound repair is still not fully understood due to redundancy and other signaling pathways.
ANNUAL REVIEW OF IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Eva Conde, Romain Bertrand, Bianca Balbino, Jonathan Bonnefoy, Julien Stackowicz, Noemie Caillot, Fabien Colaone, Samir Hamdi, Raissa Houmadi, Alexia Loste, Jasper B. J. Kamphuis, Francois Huetz, Laurent Guilleminault, Nicolas Gaudenzio, Aurelie Mougel, David Hardy, John N. Snouwaert, Beverly H. Koller, Vincent Serra, Pierre Bruhns, Geraldine Grouard-Vogel, Laurent L. Reber
Summary: The study developed vaccines targeting IL-4 and IL-13, demonstrating promising prophylactic and therapeutic effects in mouse models of asthma. Vaccines specific for human IL-4 and IL-13 also showed efficient neutralization of these cytokines in mice, suggesting a potential long-term therapeutic strategy for allergic asthma.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Tadayoshi Kanao, Naruki Hase, Hisayuki Nakayama, Kyoya Yoshida, Kazumi Nishiura, Megumi Kosaka, Kazuo Kamimura, Yu Hirano, Taro Tamada
Summary: Tetrathionate hydrolase (4THase) is crucial in acidophilic iron- and sulfur-oxidizing bacterium Acidithiobacillus ferrooxidans, with Asp325 playing a key role in the reaction process. The reaction occurs only under acidic conditions, and the polymerized sulfur atoms in the active site cavity may serve as intermediate products in the subsequent steps.
Article
Chemistry, Applied
Takeshi Hiromoto, Koji Nishikawa, Taro Tamada, Yoshiki Higuchi
Summary: X-ray crystallography is a powerful tool for obtaining structural information of protein molecules, but it cannot accurately determine the positions of hydrogen atoms. Neutron crystallography, on the other hand, enables direct identification of hydrogen positions, aiding in understanding the physiological functions of enzymes and catalytic reaction mechanisms.
TOPICS IN CATALYSIS
(2021)
Article
Oncology
Tatsuhito Matsuo, Kazuma Nakatani, Taiki Setoguchi, Koichi Matsuo, Taro Tamada, Yusuke Suenaga
Summary: NCYM, a newly evolved gene from non-genic regions specific to Homininae, has been shown to promote human tumor aggressiveness. The secondary structure of NCYM was determined using vacuum-ultraviolet circular dichroism, revealing that the Homininae-specific domain is responsible for MYCN stabilization. This study provides insights into the oncogenic functions of NCYM and potential strategies for cancer therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Respiratory System
Yasuo To, Yurie Taguchi, Tatsuya Shimazaki, Kazuhiko Arima, Eric Yu, Demiya Sven, Takashi Iwanaga
Summary: This study aimed to investigate healthcare resource use among adult asthma patients in Japan, focusing on severe asthma patients. The results showed that treating severe asthma incurred higher costs compared to mild/moderate asthma, with a higher annual asthma exacerbation rate. Additionally, longer oral corticosteroid use was associated with increased risks of secondary adrenal insufficiency, osteoporosis, and pneumonia in the following year.
RESPIRATORY INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Toshiaki Nakano, Ken Akamatsu, Masataka Tsuda, Ayane Tujimoto, Ryoichi Hirayama, Takeshi Hiromoto, Taro Tamada, Hiroshi Ide, Naoya Shikazono
Summary: This study established a method to evaluate the yield and complexity of clustered DNA damage in irradiated cells using atomic force microscopy. It was found that clustered DNA damage is a signature of ionizing radiation, and Fe ion beams produce clustered DNA damage with high complexity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medical Laboratory Technology
Masayuki Takai, Junya Ono, Masaki Okamoto, Kiminori Fujimoto, Ayami Kamei, Satoshi Nunomura, Yasuhiro Nanri, Shoichiro Ohta, Tomoaki Hoshino, Arata Azuma, Kenji Izuhara
Summary: The formation of an IgA complex affects the measurement of periostin. The EMI and R1 domains of periostin contribute to the formation of the complex with IgA. A novel ELISA system that combines the R3 and R4 domains allows for independent measurement of periostin.
ANNALS OF CLINICAL BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Yuya Hanazono, Yu Hirano, Kazuki Takeda, Katsuhiro Kusaka, Taro Tamada, Kunio Miki
Summary: The planarity of the peptide bond is crucial for protein stability and structure formation. However, it has been observed that peptide bonds can be distorted. A high-resolution neutron structure analysis revealed that the position of the amide proton deviates from the peptide plane and shifts towards the acceptors. The planarity of the peptide bond depends on the pyramidalization of the nitrogen atom.
Review
Dermatology
El-Bdaoui Haddad, Sonya L. Cyr, Kazuhiko Arima, Robert A. McDonald, Noah A. Levit, Frank O. Nestle
Summary: Type 2 immunity is an immune response evolved to combat helminth infections by orchestrating a combined protective response of innate and adaptive immune cells, promoting parasite destruction or expulsion, wound repair, and barrier function. Aberrant type 2 immune responses are associated with chronic tissue inflammation in allergic conditions, such as atopic dermatitis and asthma. Key cytokines of type 2 immunity include IL-4, IL-5, IL-9, IL-13, and IL-31, as well as IL-25, IL-33, and thymic stromal lymphopoietin. These cytokines play important roles in regulating inflammation, barrier function, and sensory nerve sensitization. Various therapeutic strategies targeting type 2 pathways have emerged to suppress type 2 inflammation.
DERMATOLOGY AND THERAPY
(2022)
Article
Dermatology
Norito Katoh, Hidehisa Saeki, Yoko Kataoka, Takafumi Etoh, Satoshi Teramukai, Hiroki Takagi, Hiroyuki Fujita, Marius Ardeleanu, Elena Rizova, Kazuhiko Arima
Summary: The study in Japan showed that atopic dermatitis is a common chronic skin disease among adults, with most patients using topical corticosteroids for treatment. Some patients may require systemic treatment options for inadequately controlled moderate-to-severe AD.
JOURNAL OF DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Takeshi Hiromoto, Teikichi Ikura, Eijiro Honjo, Michael Blaber, Ryota Kuroki, Taro Tamada
Summary: In this study, protein crystals are rigidified through the introduction of disulfide cross-links, resulting in improved stability and mechanical strength. The cross-linked crystals maintain diffraction in various solutions and can withstand soaking in high concentrations of organic solvents.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Medicine, General & Internal
Hidehisa Saeki, Yukihiro Ohya, Hisakatsu Nawata, Kazuhiko Arima, Miho Inukai, Ana B. Rossi, Gaelle Bego-Le-Bagousse
Summary: This study investigated the impact of pediatric atopic dermatitis (AD) on family quality of life in Japanese patients. The results showed that the severity of AD was negatively correlated with family quality of life, especially in families with children under the age of 6, where sleep and tiredness were the most affected aspects. The study also found that family and household environments, such as family history of allergic conditions, residency, second-hand smoke exposure, and household pets, can influence AD prevalence and severity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Allergy
Hidehisa Saeki, Hiroyuki Fujita, Katsuhisa Suzuki, Kazuhiko Arima
Summary: This study investigated the safety and effectiveness of dupilumab in adult atopic dermatitis (AD) patients in Japan. The data from 600 patients demonstrated that dupilumab significantly improved disease severity and was well tolerated, with no new safety signals or new-onset asthma.
JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY
(2023)
Letter
Dermatology
Takeshi Nakahara, Hiroyuki Fujita, Yuki Tajima, Kazuhiko Arima
Summary: An online questionnaire assessed the patient-reported outcome measures of atopic dermatitis (AD) in 5546 patients and found that the Atopic Dermatitis Control Tool (ADCT) scores had strong correlations with established AD assessment tools. This demonstrates that ADCT scores effectively characterize the disease burden of AD.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Yukihiro Ohya, Hidehisa Saeki, Hisakatsu Nawata, Kazuhiko Arima, Miho Inukai, Ana B. Rossi, Gaelle Le-Bagousse-Bego
Summary: This study investigated the impact of atopic dermatitis (AD) severity on disease burden in Japanese pediatric patients. The results showed that as AD severity increased, patients experienced more severe symptoms, frequent flares, other atopic comorbidities, increased healthcare resource utilization, higher school absences, and worsened health-related quality of life.
PEDIATRIC DERMATOLOGY
(2023)
Review
Biophysics
Fumiaki Kono, Kazuo Kurihara, Taro Tamada
Summary: This review explores the application of neutron crystallography in protein research, specifically its observation of hydrogen bonding and catalytic reactions. While there are limitations to neutron crystallography in protein studies, the increasing availability of diffraction instruments and advancements in sample preparation have made it more popular.
BIOPHYSICS AND PHYSICOBIOLOGY
(2022)