期刊
ONCOIMMUNOLOGY
卷 4, 期 8, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2015.1009299
关键词
Aurora kinase; apoptosis; melanoma; p53; senescence
资金
- NATIONAL CANCER INSTITUTE [R01CA116021, R01CA034590] Funding Source: NIH RePORTER
- Veterans Affairs [I01BX002301] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA116021, R01 CA034590] Funding Source: Medline
- BLRD VA [I01 BX002301, IK6 BX005225] Funding Source: Medline
We recently demonstrated that dual therapy combining AURKA and MDM2 antagonists is effective against melanoma in preclinical settings. Notably, besides inducing apoptosis, this regimen led to tumor senescence and stimulated the host's antitumor immune defenses. Treatments leveraging both cancer cell-intrinsic and extrinsic antitumor mechanisms can improve melanoma therapeutic outcomes.
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