Signaling pathways leading to ischemic mitochondrial neuroprotection

Cardiac Mitochondria and Reactive Oxygen Species Generation

(2014) Yeong-Renn Chen et al.   CIRCULATION RESEARCH

Protein Kinase C Epsilon Regulates Mitochondrial Pools of Nampt and NAD Following Resveratrol and Ischemic Preconditioning in the Rat Cortex

(2014) Kahlilia C Morris-Blanco et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Epigenetic control and the circadian clock: Linking metabolism to neuronal responses

(2014) R. Orozco-Solis et al.   NEUROSCIENCE

Nicotinamide Mononucleotide, an Intermediate of NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion

(2014) Takanobu Yamamoto et al.   PLoS One

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A Novel Role of the STAT3 Pathway in Brain Inflammation-induced Human Neural Progenitor Cell Differentiation

(2013) E. Chen et al.   CURRENT MOLECULAR MEDICINE

Ischemic Preconditioning Alters the Epigenetic Profile of the Brain from Ischemic Intolerance to Ischemic Tolerance

(2013) John W. Thompson et al.   Neurotherapeutics

Epsilon PKC Increases Brain Mitochondrial SIRT1 Protein Levels via Heat Shock Protein 90 following Ischemic Preconditioning in Rats

(2013) John W. Thompson et al.   PLoS One

The Yin and Yang of redox regulation

(2013) Lars Folke Olsen et al.   REDOX REPORT

Role of sirtuins in ischemia-reperfusion injury

(2013) Eirini Pantazi   WORLD JOURNAL OF GASTROENTEROLOGY

Mitochondrial Pathways, Permeability Transition Pore, and Redox Signaling in Cardioprotection: Therapeutic Implications

(2012) Claudia Penna et al.   ANTIOXIDANTS & REDOX SIGNALING

Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia

(2012) Pei Wang et al.   Autophagy

Redox Signaling Pathways Involved in Neuronal Ischemic Preconditioning

(2012) John W. Thompson et al.   Current Neuropharmacology

Antioxidant-induced INrf2 (Keap1) tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2–Cul3–Rbx1 complex to allow normal Nrf2 activation and repression

(2012) James W. Kaspar et al.   JOURNAL OF CELL SCIENCE

Novel Mitochondrial Targets for Neuroprotection

(2012) Miguel A Perez-Pinzon et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: Novel therapeutic strategies for neurodegenerative disorders

(2012) Dénes Zádori et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome

(2012) Alexander S. Hebert et al.   MOLECULAR CELL

NAD+ administration decreases ischemic brain damage partially by blocking autophagy in a mouse model of brain ischemia

(2012) Chaobo Zheng et al.   NEUROSCIENCE LETTERS

Overexpression of Mitochondrial Uncoupling Protein 2 Inhibits Inflammatory Cytokines and Activates Cell Survival Factors after Cerebral Ischemia

(2012) Bryan Haines et al.   PLoS One

Human neuronal uncoupling proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation, and physiological role in protection against oxidative stress and mitochondrial dysfunction

(2012) David B. Ramsden et al.   Brain and Behavior

Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway

(2011) Pei Wang et al.   ANNALS OF NEUROLOGY

Caloric Restriction Primes Mitochondria for Ischemic Stress by Deacetylating Specific Mitochondrial Proteins of the Electron Transport Chain

(2011) Ken Shinmura et al.   CIRCULATION RESEARCH

Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage

(2011) Bing Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

NMNAT suppresses Tau-induced neurodegeneration by promoting clearance of hyperphosphorylated Tau oligomers in a Drosophila model of tauopathy

(2011) Yousuf O. Ali et al.   HUMAN MOLECULAR GENETICS

Acetylation-Deacetylation of the Transcription Factor Nrf2 (Nuclear Factor Erythroid 2-related Factor 2) Regulates Its Transcriptional Activity and Nucleocytoplasmic Localization

(2011) Yumiko Kawai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathways for Ischemic Cytoprotection: Role of Sirtuins in Caloric Restriction, Resveratrol, and Ischemic Preconditioning

(2011) Kahlilia C Morris et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pre-B-cell colony-enhancing factor exerts a neuronal protection through its enzymatic activity and the reduction of mitochondrial dysfunction in in vitro ischemic models

(2011) Jing Bi et al.   JOURNAL OF NEUROCHEMISTRY

Resveratrol Restores Nrf2 Level and Prevents Ethanol-Induced Toxic Effects in the Cerebellum of a Rodent Model of Fetal Alcohol Spectrum Disorders

(2011) A. Kumar et al.   MOLECULAR PHARMACOLOGY

Nitric oxide activates Nrf2 through S-nitrosylation of Keap1 in PC12 cells

(2011) Han-Cheon Um et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Protective effects and mechanisms of sirtuins in the nervous system

(2011) Feng Zhang et al.   PROGRESS IN NEUROBIOLOGY

Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion

(2010) Kerstin Boengler et al.   BASIC RESEARCH IN CARDIOLOGY

Lysine deacetylation in ischaemic preconditioning: the role of SIRT1

(2010) Sergiy M. Nadtochiy et al.   CARDIOVASCULAR RESEARCH

Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α) and Sirtuin 1 (SIRT1) Reside in Mitochondria

(2010) Katia Aquilano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of Mitochondrial Uncoupling Protein-2 Increases Ischemic Brain Damage after Transient Focal Ischemia by Altering Gene Expression Patterns and Enhancing Inflammatory Cytokines

(2010) Bryan A Haines et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Disruption of Astrocyte STAT3 Signaling Decreases Mitochondrial Function and Increases Oxidative Stress In Vitro

(2010) Theodore A. Sarafian et al.   PLoS One

Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway

(2010) R. E. Haskew-Layton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for proteasome inhibitor-mediated cardioprotection

(2009) H. Dreger et al.   CARDIOVASCULAR RESEARCH

Absolute levels of transcripts for mitochondrial uncoupling proteins UCP2, UCP3, UCP4, and UCP5 show different patterns in rat and mice tissues

(2009) Lukáš Alán et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Nicotinamide Mononucleotide Adenylyl Transferase-Mediated Axonal Protection Requires Enzymatic Activity But Not Increased Levels of Neuronal Nicotinamide Adenine Dinucleotide

(2009) Y. Sasaki et al.   JOURNAL OF NEUROSCIENCE

Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1–uncoupling protein 2 pathway

(2009) D. Della-Morte et al.   NEUROSCIENCE

Lipopolysaccharide Preconditioning Reduces Neuroinflammation Against Hypoxic Ischemia and Provides Long-Term Outcome of Neuroprotection in Neonatal Rat

(2009) Hsiang-Yin Lin et al.   PEDIATRIC RESEARCH

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

Nrf2-Mediated Transcriptional Induction of Antioxidant Response in Mouse Embryos Exposed to Ethanol in vivo: Implications for the Prevention of Fetal Alcohol Spectrum Disorders

(2008) Jian Dong et al.   ANTIOXIDANTS & REDOX SIGNALING

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

(2008) Marcella Fulco et al.   DEVELOPMENTAL CELL

Preconditioning Mediated by Sublethal Oxygen—Glucose Deprivation-Induced Cyclooxygenase-2 Expression via the Signal Transducers and Activators of Transcription 3 Phosphorylation

(2008) Eun J Kim et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Overexpression of UCP2 Protects Thalamic Neurons following Global Ischemia in the Mouse

(2008) Tomas Deierborg Olsson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration

(2008) R. Grace Zhai et al.   NATURE

Endogenous neuroprotection: Mitochondria as gateways to cerebral preconditioning?

(2008) Ulrich Dirnagl et al.   NEUROPHARMACOLOGY

Cellular NAD Replenishment Confers Marked Neuroprotection Against Ischemic Cell Death

(2008) Suping Wang et al.   STROKE

NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences

(2007) Weihai Ying   ANTIOXIDANTS & REDOX SIGNALING