Endoplasmic reticulum aminopeptidases: biochemistry, physiology and pathology

Puromycin-Sensitive Aminopeptidase Limits MHC Class I Presentation in Dendritic Cells but Does Not Affect CD8 T Cell Responses during Viral Infections

(2014) C. F. Towne et al.   JOURNAL OF IMMUNOLOGY

Endoplasmic reticulum aminopeptidase 2 haplotypes play a role in modulating susceptibility to HIV infection

(2013) Mara Biasin et al.   AIDS

Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1

(2013) Yohei Kirino et al.   NATURE GENETICS

Exon 10 Coding Sequence Is Important for Endoplasmic Reticulum Retention of Endoplasmic Reticulum Aminopeptidase 1

(2012) Akira Hattori et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

A Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen Processing

(2012) I. Evnouchidou et al.   JOURNAL OF IMMUNOLOGY

Functional Interaction of the Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 1 Polymorphism and HLA-B27in Vivo

(2012) Noel García-Medel et al.   MOLECULAR & CELLULAR PROTEOMICS

A Functional Variant in ERAP1 Predisposes to Multiple Sclerosis

(2012) Franca Rosa Guerini et al.   PLoS One

Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides

(2011) Efthalia Zervoudi et al.   BIOCHEMICAL JOURNAL

The Crystal Structure of Human Endoplasmic Reticulum Aminopeptidase 2 Reveals the Atomic Basis for Distinct Roles in Antigen Processing

(2011) James R. Birtley et al.   BIOCHEMISTRY

Secretion of Endoplasmic Reticulum Aminopeptidase 1 Is Involved in the Activation of Macrophages Induced by Lipopolysaccharide and Interferon-γ

(2011) Yoshikuni Goto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Coding Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 Can Affect Antigenic Peptide Generation In Vitro by Influencing Basic Enzymatic Properties of the Enzyme

(2011) I. Evnouchidou et al.   JOURNAL OF IMMUNOLOGY

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Human cytomegalovirus microRNA miR-US4-1 inhibits CD8+ T cell responses by targeting the aminopeptidase ERAP1

(2011) Sungchul Kim et al.   NATURE IMMUNOLOGY

Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1

(2011) Tina T Nguyen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

(2011) G. Kochan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetics of ankylosing spondylitis

(2010) Matthew A Brown   CURRENT OPINION IN RHEUMATOLOGY

Genetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infection

(2010) R. Cagliani et al.   HUMAN MOLECULAR GENETICS

ABC proteins in antigen translocation and viral inhibition

(2010) David Parcej et al.   Nature Chemical Biology

Association analyses identify six new psoriasis susceptibility loci in the Chinese population

(2010) Liang-Dan Sun et al.   NATURE GENETICS

Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci

(2010) John D Reveille et al.   NATURE GENETICS

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

(2010) Amy Strange et al.   NATURE GENETICS

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Endoplasmic reticulum aminopeptidases: biology and pathogenic potential

(2010) Nigil Haroon et al.   Nature Reviews Rheumatology

Balancing Selection Maintains a Form of ERAP2 that Undergoes Nonsense-Mediated Decay and Affects Antigen Presentation

(2010) Aida M. Andrés et al.   PLoS Genetics

Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis

(2009) F. W. L. Tsui et al.   ANNALS OF THE RHEUMATIC DISEASES

The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations

(2009) Matthew P. Johnson et al.   HUMAN GENETICS

Intramembrane-cleaving Proteases

(2009) Michael S. Wolfe   JOURNAL OF BIOLOGICAL CHEMISTRY

Intramembrane Proteolysis by Signal Peptide Peptidases: A Comparative Discussion of GXGD-type Aspartyl Proteases

(2009) Regina Fluhrer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of the Role of Tripeptidyl Peptidase II in MHC Class I Antigen Presentation In Vivo

(2009) M. Kawahara et al.   JOURNAL OF IMMUNOLOGY

Structural basis for the inhibition of the essentialPlasmodium falciparumM1 neutral aminopeptidase

(2009) Sheena McGowan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRAP Identifies an Endosomal Compartment Required for MHC Class I Cross-Presentation

(2009) L. Saveanu et al.   SCIENCE

An association between RBMX, a heterogeneous nuclear ribonucleoprotein, and ARTS-1 regulates extracellular TNFR1 release

(2008) Barbara Adamik et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glutamine-181 is crucial in the enzymatic activity and substrate specificity of human endoplasmic-reticulum aminopeptidase-1

(2008) Yoshikuni Goto et al.   BIOCHEMICAL JOURNAL

Structural Basis for the Unusual Specificity of Escherichia coli Aminopeptidase N

(2008) Anthony Addlagatta et al.   BIOCHEMISTRY

The Internal Sequence of the Peptide-Substrate Determines Its N-Terminus Trimming by ERAP1

(2008) Irini Evnouchidou et al.   PLoS One