The CorA Mg2+ channel is required for the virulence of Salmonella enterica serovar Typhimurium

CorA is the primary Mg2+ channel in Salmonella enterica serovar Typhimurium. A corA mutant is attenuated in mice and defective for invasion of and replication within epithelial cells. Microarray studies show that several virulence effectors are repressed in a corA mutant strain, which ultimately manifests itself as a decrease in virulence.