Article
Cell Biology
Jing Ouyang, Yaosheng Xiao, Qun Ren, Jishang Huang, Qingluo Zhou, Shanshan Zhang, Linfu Li, Weimei Shi, Zhixi Chen, Longhuo Wu
Summary: This study found that 7KC can inhibit osteogenic differentiation of MC3T3-E1 cells by inducing oxiapoptophagy. Pretreatment with the antioxidant NAC can alleviate the oxidative stress and cell apoptosis induced by 7KC, and restore the osteogenic differentiation of MC3T3-E1 cells.
Article
Environmental Sciences
Pengli Liu, Yilong Cui, Menglin Liu, Bonan Xiao, Jian Zhang, Wanyue Huang, Xuliang Zhang, Miao Song, Yanfei Li
Summary: The study revealed that activation of mitophagy can protect MC3T3-E1 cells from Al-induced functional damage, as evidenced by improved cell viability, cellular calcium and phosphorus contents, and gene expression of collagen I, osteocalcin, and bone alkaline phosphatase.
Article
Endocrinology & Metabolism
Yu Chen, Yuwei Cai, Chunxiang Chen, Mengting Li, Lingdan Lu, Zhongxiang Yu, Shuqiang Wang, Lei Fang, Shengming Xu
Summary: This study evaluated the osteotoxicity of polychlorinated biphenyls in murine osteoblastic cells and found that oxidative stress plays a crucial role. The results showed that exposure to polychlorinated biphenyls reduced calcium homeostasis, osteoblast differentiation, and bone formation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Bin-Feng Cheng, Xiao Feng, Yao-Xin Gao, Shao-Qin Jian, Shi-Rao Liu, Mian Wang, Yun-Fei Xie, Lei Wang, Zhi-Wei Feng, Hai-Jie Yang
Summary: NCAM regulates osteoblast differentiation through activation of the Wnt/β-catenin and PI3K-Akt signaling pathways, with its silencing inhibiting osteoblastic differentiation in various cell lines.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Orthopedics
Wei Bing Jing, Hongjuan Ji, Rui Jiang, Jinlong Wang
Summary: This study confirmed that Astragaloside can promote osteogenic differentiation of MC3T3-E1 cells, possibly through regulating the PI3K/Akt signaling pathway.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Multidisciplinary Sciences
Claudia Medeiros, Joseph M. Wallace
Summary: Diabetes has a global impact on health and is associated with bone quality deterioration. This study demonstrates that high glucose levels inhibit mineralization and induce mitochondrial impairment in bone cells, affecting bone matrix formation.
Article
Chemistry, Medicinal
Seung-Hong Lee, Mihyang Kim, Mi Hwa Park
Summary: The study demonstrated that DPHC from Ishige okamurae has protective effects against oxidative damage in osteoblastic cells induced by H2O2 through the BMP2/Runx2 signaling pathway, improving cellular functions and promoting osteoblast differentiation. DPHC also reduced the expression levels of bone resorption-promoting factors and inhibited the generation of reactive oxygen species induced by oxidative stress.
Article
Multidisciplinary Sciences
Sirirak Mukem, Tipsuda Thongbuakaew, Kanjana Khornchatri
Summary: This study aimed to investigate the neuroprotective effects of MitoTempo on glutamate-induced neurotoxicity and found that MitoTempo can improve neuronal properties against glutamate cytotoxicity through its direct free radical scavenging activity and inhibit excessive autophagy signaling pathway.
Article
Medicine, General & Internal
Pei Zhang, Jing Liao, Xiaoju Wang, Zhengping Feng
Summary: The present study compared the effects of high glucose and glucose fluctuation on apoptosis and autophagy in MC3T3-E1 osteoblasts. The results showed that high glucose and glucose fluctuation decreased cell proliferation and activated autophagy. They also induced oxidative stress, mitochondrial damage, and apoptosis, with more significant differences observed in the glucose fluctuation group. Antioxidant treatment eliminated reactive oxygen species, inhibited autophagy and apoptosis, while autophagy inhibition enhanced apoptosis in the osteoblasts.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Anatomy & Morphology
Xiaocong Liu, Yuanyuan Zhang, Xiaoyan Yang, Yan Zhang, Yulan Liu, Li Wang, Ting Yi, Jing Yuan, Wu Wen, Yi Jian
Summary: The study reveals the anti-tumor potential of mitochondrial transplantation by regulating cellular oxidative stress in cholangiocarcinoma through the PTEN/PI3K/AKT signaling pathway.
Article
Toxicology
Karolina Kowalska, Marta Justyna Koziel, Dominika Ewa Habrowska-Gorczynska, Kinga Anna Urbanek, Kamila Dominska, Agnieszka Wanda Piastowska-Ciesielska
Summary: The PI3K/Akt signaling pathway is one of the most deregulated pathways in prostate cancer, and DON can affect apoptosis and autophagy in normal prostate epithelial cells by modulating this pathway. High concentrations of DON induce apoptosis, while low concentrations induce autophagy.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zhen Qi, Renrong Wang, Rongheng Liao, Song Xue, Yongyi Wang
Summary: Neferine can protect the heart from lipopolysaccharide-induced damage, improve cardiac function, increase survival rate, and alleviate apoptosis and oxidative stress by activating the PI3K/AKT/mTOR signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Xiaoya Li, Huali Chen, Zelin Zhang, Jiaxin Duan, Rongmao Hua, Xiaodi Li, Li Yang, Jianyong Cheng, Qingwang Li
Summary: This study investigated the therapeutic effect of isorhamnetin on ZEA-induced damage in porcine ovarian granulosa cells and elucidated its molecular mechanism. The results showed that isorhamnetin protected ovarian granulosa cells from ZEA-induced damage, promoting proliferation and alleviating apoptosis, endoplasmic reticulum stress, oxidative stress, and steroidogenesis disorder.
Article
Biochemistry & Molecular Biology
Jun Bai, Jun Li, Ning Liu, Hai Jia, Xuemeng Si, Yusong Zhou, Zhian Zhai, Ying Yang, Fazheng Ren, Zhenlong Wu
Summary: This study found that glucosamine can protect porcine trophectoderm (pTr) cells from apoptosis and oxidative damage induced by zearalenone. Further research suggests that glucosamine exerts its protective effect by activating the PI3K/AKT signaling pathway. These findings provide a theoretical basis for the application of glucosamine in alleviating impaired early embryo development.
Article
Biochemistry & Molecular Biology
Tong Pei, Guanyue Su, Jie Yang, Wenbo Gao, Xinrui Yang, Yaojia Zhang, Jie Ren, Yang Shen, Xiaoheng Liu
Summary: This study reveals a previously unknown relationship between FSS-induced osteogenic differentiation and autophagy, and identifies AnxA6 as a key mediator of autophagy in response to FSS. This may provide a new target for the treatment of osteoporosis and other diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)