Article
Plant Sciences
Pin Gong, Xuyang Xiao, Shuang Wang, Fuxiong Shi, Ni Liu, Xuefeng Chen, Wenjuan Yang, Lan Wang, Fuxin Chen
Summary: Astragaloside IV (AS-IV) significantly reversed abnormalities in diabetic mice, protected cellular architecture, and regulated intestinal flora. Its anti-diabetic effects are mediated through modulating the AMPK/SIRT1 and PI3K/AKT signaling pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell Biology
Bingkun Zhao, Qian Peng, Dan Wang, Rong Zhou, Raorao Wang, Yizhun Zhu, Shengcai Qi
Summary: This study found that leonurine can protect the proliferation and differentiation of rat BMSCs under oxidative stress by activating mitophagy, which depends on the PI3K/Akt/mTOR pathway. These findings suggest that leonurine may have potential usage in osteoporosis and bone defect repair.
Article
Medicine, Research & Experimental
Miao Li, Zhaofeng Pan, Qi He, Jiacong Xiao, Baihao Chen, Fanchen Wang, Pan Kang, Haoran Luo, Jianliang Li, Jiaxu Zeng, Shaocong Li, Junzheng Yang, Haibin Wang, Chi Zhou
Summary: In this study, arctiin (ARC) was found to have potential as a therapeutic agent for iron overload-induced osteoporosis (IOOP). ARC improved bone microarchitecture and biochemical parameters in a mouse model of iron overload by modulating the PI3K/Akt pathway and exhibiting anti-apoptotic, antioxidant, and osteogenic properties.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Junwen Han, Li Li, Chen Zhang, Qianqian Huang, Shanglong Wang, Wenyu Li, Jiancheng Zong, Lijie Li, Zhen Zhao, Zengliang Zhang, Zimin Liu, Qi Wang, Yuanyuan Shi
Summary: Osteoporosis is a common and burdensome disease that poses a public health threat. This study found that a combination of Eucommia, Cuscuta, and Drynaria, traditional Chinese medicine ingredients, can effectively treat glucocorticoid-induced osteoporosis by inhibiting osteoclast differentiation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Bingkun Zhao, Qian Peng, Enoch Hin Lok Poon, Fubo Chen, Rong Zhou, Guangwei Shang, Dan Wang, Yuanzhi Xu, Raorao Wang, Shengcai Qi
Summary: The study showed that Leonurine promotes the proliferation and osteoblastic differentiation of rat BMSCs by activating autophagy dependent on the PI3K/Akt/mTOR pathway. Results suggest that Leonurine may be a potential treatment for osteoporosis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Food Science & Technology
Ming Chen, Siqi Zhou, Kai Sun, Yongjun Hu, Haiyan Wen, Geliang Ren
Summary: Osteoporosis is a common metabolic disease in the elderly, causing a significant socioeconomic burden. This study investigated the protective effect of andrographolide (AGP) on glucocorticoid-induced osteoporosis (GIOP). The results showed that AGP alleviated the negative effects of glucocorticoid on BMSCs and promoted osteogenic differentiation through the activation of the PI3K/AKT pathway. In a GIOP mice model, AGP was also found to alleviate bone loss.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Pharmacology & Pharmacy
Yongxiang Xu, Shichun Chen, Linxuan Huang, Weichao Han, Yingying Shao, Minyi Chen, Yusheng Zhang, Ruirong He, Baocheng Xie
Summary: In this research, the protective impacts of epimedin C on the osteogenic inhibition impact of MC3T3-E1 cells and zebrafish larvae mediated by DEX were examined. The results showed that epimedin C could alleviate the suppressive impact of DEX on the osteogenesis of MC3T3-E1 cells and zebrafish larvae by triggering the PI3K and AKT signaling pathways. This suggests that epimedin C has significant potential in the development of innovative drugs for the treatment of glucocorticoid-mediated osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Fujiang Zhao, Yier Xu, Yulong Ouyang, Zhexu Wen, Guihao Zheng, Ting Wan, Guicai Sun
Summary: The study identified that miR-483-5p inhibits SATB2 and activates the PI3K/AKT pathway to contribute to the pathogenesis of PMOP. MiR-483-5p/SATB2 axis could be a potential therapeutic target for PMOP.
Review
Biochemistry & Molecular Biology
Maricedes Acosta-Martinez, Maria Zulema Cabail
Summary: Obesity is a global epidemic and a major risk factor for cardiovascular disease, stroke, and mortality. Meta-inflammation, characterized by immune cell accumulation, dysregulation of adipokine synthesis, and increased production of proinflammatory factors, is believed to contribute to obesity's negative health consequences. The crosstalk between macrophages and adipocytes and the impairment of the PI3K/Akt signaling pathway play crucial roles in the development of meta-inflammation and insulin resistance associated with obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Lu Zhang, Junsheng Gao, Zhentao Li, Jun Liu, Chong Zhang, Jie Liu, Hui Dong, Wei Mei
Summary: This study found that Astragaloside IV can inhibit IL-1β-induced apoptosis, inflammation, and extracellular matrix degeneration in human nucleus pulposus cells by activating the PI3K/Akt signaling pathway, making it an effective drug to reduce disc degeneration.
Review
Medicine, Research & Experimental
Martina S. Savova, Liliya Mihaylova, Daniel Tews, Martin Wabitsch, Milen I. Georgiev
Summary: Obesity is a growing disorder that damages patients' quality of life and increases healthcare costs. Developing safe and innovative prevention strategies and treatments for obesity is crucial. The pathophysiology of obesity is complex and involves multiple signaling pathways, including the PI3K/AKT pathway, which plays a critical role in metabolic homeostasis. Natural compounds have been shown to target the PI3K/AKT signaling pathway and have potential for managing obesity. This paper evaluates the druggability of PI3K as a target and suggests perspectives on using natural compounds to modulate the PI3K/AKT pathway for obesity management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Integrative & Complementary Medicine
Rui-jiao Ma, Maharajan Kannan, Qing Xia, Shan-shan Zhang, Peng-fei Tu, Ke-chun Liu, Yun Zhang
Summary: This study aimed to investigate the anti-angiogenic activity of the KX extract in zebrafish. The results showed that the KX extract significantly inhibited the formation of intersegmental vessels and the sub-intestinal vein in zebrafish larvae. Furthermore, the extract down-regulated the expressions of PI3K and AKT, as well as the downstream signaling cascade involving ERKs, MAPK, VEGF, and FGF-2.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Medicine, Research & Experimental
Keda Yang, Lei Pei, Siming Zhou, Lin Tao, Yue Zhu
Summary: The study shows that metformin can repair mitochondrial damage and inhibit H2O2-induced osteoblast apoptosis, reversing bone mass loss in ovariectomized mice. SIRT3 plays a key role in producing antioxidant enzymes and metformin can reverse H2O2-induced osteoblast apoptosis by upregulating SIRT3 expression.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jianliang Li, Jiale Mai, Meng Zhang, Yanhuai Ma, Qi He, Dawei Gong, Jiacong Xiao, Miao Li, Weijian Chen, Zhen Li, Shuai Chen, Zhaofeng Pan, Shaocong Li, Haibin Wang
Summary: This study aimed to investigate the effect of myricitrin on osteoblast differentiation in imBMSCs and bone trabecular loss in OVX mice. The study found that myricitrin enhanced osteogenic differentiation and calcium deposition in imBMSCs, and upregulated the PI3K/AKT signaling pathway. In vivo, myricitrin attenuated bone trabecular loss and upregulated osteopontin, osteoprotegerin, p-PI3K, and p-AKT. These findings suggest that myricitrin has therapeutic potential as an antiosteoporosis drug.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Jian Hao, Jiaxin Bei, Zhenhan Li, Mingyuan Han, Boyuan Ma, Pengyi Ma, Xianhu Zhou
Summary: In this study, the potential molecular mechanism of Qing'e Pill (QEP) in treating osteoporosis was investigated using network analysis and experimental verification. The results demonstrated that QEP exerts therapeutic effects on osteoporosis by inhibiting ferroptosis and promoting cell survival via the PI3K/AKT pathway and ATM. This study provides an efficient method to validate the molecular mechanism of QEP on osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2022)