Article
Nutrition & Dietetics
Avneet Oberoi, Caroline Giezenaar, Rachael S. Rigda, Kylie Lange, Michael Horowitz, Karen L. Jones, Ian Chapman, Stijn Soenen
Summary: The ingestion of dietary protein with carbohydrates reduces postprandial hyperglycemia in older men and may be a useful strategy for the prevention and management of type 2 diabetes in older people.
Article
Multidisciplinary Sciences
Christoph Ahlgrim, Philipp Birkner, Florian Seiler, Sebastian Grundmann, Christoph Bode, Torben Pottgiesser
Summary: Plasma volume excess is a relevant predictor of clinical outcomes in heart failure patients. Estimation of plasma volume status based on prediction formulas may not accurately predict true plasma volume excess, with the Kaplan formula showing more reliability than the Hakim formula. Therefore, using these formulas for plasma volume status estimation may not be suitable for clinical decision making.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Toshiko Tanaka, Jayanta K. Das, Yichen Jin, Qu Tian, Ruin Moaddel, Ann Zenobia Moore, Katherine L. Tucker, Sameera A. Talegawkar, Luigi Ferrucci
Summary: This study explores the role of circulating metabolites in mediating the relationship between dietary protein and frailty. The results suggest that higher intake of plant protein is associated with lower levels of frailty, while animal protein does not show such association. The study also identifies specific metabolites, such as lipid metabolites and tryptophan-related metabolites, that mediate the protective effect of plant protein on frailty.
Article
Cardiac & Cardiovascular Systems
Emilia A. A. Hermann, Amin Motahari, Eric A. A. Hoffman, Norrina Allen, Alain G. G. Bertoni, David A. A. Bluemke, Ali Eskandari, Sarah E. E. Gerard, Junfeng Guo, Grant T. T. Hiura, David W. W. Kaczka, Erin D. D. Michos, Prashant Nagpal, Jim Pankow, Sanjiv Shah, Benjamin M. M. Smith, Karen Hinckley Stukovsky, Yifei Sun, Karol Watson, R. Graham Barr
Summary: The study found that pulmonary blood volume decreases substantially with advanced age in older adults, and this is independently associated with greater symptom scores.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Review
Pharmacology & Pharmacy
Leila Hosseini, Parviz Shahabi, Ali Fakhari, Hamid Soltani Zangbar, Fatemehsadat Seyedaghamiri, Jafar Sadeghzadeh, Nasrin Abolhasanpour
Summary: Aging is accompanied by changes in the body that lead to a decline in physiological integrity and functionality, making individuals more susceptible to diseases and death. Biomarkers associated with age have been observed in red blood cells, and plasma proteins play a critical role in rejuvenating the aging process and age-related disorders. Advanced age is a risk factor for various diseases and disorders, such as cardiovascular diseases, musculoskeletal disorders, liver and chronic kidney disease, neurodegenerative diseases, and cancer, due to a loss of regenerative capacity, reduced systemic factors, and increased pro-inflammatory cytokines. Studies have shown that systemic factors in young blood or plasma can protect against age-related diseases in different tissues by restoring autophagy, increasing neurogenesis, and reducing oxidative stress, inflammation, and apoptosis. This article focuses on the current advances in using young plasma or blood as a therapeutic approach to combat aging and age-related diseases, and summarizes the experimental and clinical evidence supporting this approach.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Geriatrics & Gerontology
Lucas Melo Neves, Raphael Ritti-Dias, Valeria Juday, Raquel Marquesini, Aline Mendes Gerage, Gilberto Candido Laurentino, Renato Hoffmann Nunes, Brendon Stubbs, Carlos Ugrinowitsch
Summary: Brain atrophy, a decrease in brain volume, is associated with cognitive health in older adults. Insufficient moderate and vigorous physical activity (MVPA) has been linked to lower brain volume. This study found that meeting weekly MVPA recommendations helps preserve the volume of over 30 brain areas and structures in older adults. Additionally, cardiorespiratory fitness is an important predictor of brain volume preservation.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Nutrition & Dietetics
Ester Parada-Ricart, Natalia Ferre, Veronica Luque, Dariusz Gruszfeld, Kinga Gradowska, Ricardo Closa-Monasterolo, Berthold Koletzko, Veit Grote, Joaquin Escribano Subias
Summary: This study aimed to assess the persistent effect of higher protein ingestion early in life on kidney volume and blood pressure at 11 years of age. The results showed that infants fed with a higher-protein formula had larger kidney volume and higher systolic blood pressure at 11 years of age. This suggests that increased protein ingestion early in life may impact kidney volume and blood pressure in later childhood.
Article
Nutrition & Dietetics
Avneet Oberoi, Caroline Giezenaar, Kylie Lange, Karen L. Jones, Michael Horowitz, Ian Chapman, Stijn Soenen
Summary: This study found that even with relatively low intake of whey protein, there is a risk of blood pressure decrease in older men.
Article
Medicine, Research & Experimental
Devin Kepchia, Ling Huang, Antonio Currais, Zhibin Liang, Wolfgang Fischer, Pamela Maher
Summary: J147 targets liver cells to activate the AMPK/ACC1 signaling pathway by reducing plasma free fatty acid levels, enhancing cellular bioenergetics at the expense of inhibiting FFA synthesis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemical Research Methods
Na Wu, Fuchuan Xiao, Jing Zhang, Yafei Chi, Yanan Zhai, Baian Chen, Jing Lu
Summary: Aging is a serious social issue, and its underlying mechanisms are not clear. Through the study of proteins in the blood, we found differential expression of 257 proteins in plasma and 1183 proteins in blood cells between old and young rhesus monkeys. These differentially expressed proteins are involved in various biological pathways related to immune response, metabolism, and cellular function. We identified certain target proteins, such as C2, C3, C4BPB, and ARPC2, which may be important for anti-aging research.
Article
Peripheral Vascular Disease
Isabel J. Sible, Daniel A. Nation
Summary: This study found that blood pressure variability (BPV) in older adults is related to tau accumulation in brain regions vulnerable to Alzheimer's disease, independent of average blood pressure levels. The relationship is modified by APOE ε4 carrier status. BPV may serve as a marker of vascular dysfunction contributing to early-stage tau pathology in Alzheimer's disease.
Article
Cell Biology
Jerome Salignon, Omid R. Faridani, Tasso Miliotis, Georges E. Janssens, Ping Chen, Bader Zarrouki, Rickard Sandberg, Pia Davidsson, Christian G. Riedel
Summary: By analyzing proteins and small RNAs in human blood plasma samples, it was found that combining protein and miRNA data can result in more accurate age-predictive models, possibly capturing a broader range of age-related physiological changes.
Article
Multidisciplinary Sciences
Nourhen Ghazel, Amine Souissi, Iyed Salhi, Ismail Dergaa, Hugo Cesar Martins-Costa, Sarah Musa, Helmi Ben Saad, Abderraouf Ben Abderrahman
Summary: This study evaluated the effects of mat Pilates training on hematological parameters in healthy, active women. The results showed that Pilates training increased plasma volume variations and decreased white blood cell count, neutrophils, hematocrit, and hemoglobin levels.
Article
Geriatrics & Gerontology
Avneet Oberoi, Caroline Giezenaar, Kylie Lange, Karen L. Jones, Michael Horowitz, Ian Chapman, Stijn Soenen
Summary: This study aimed to determine the effects of whey-protein, alone and mixed with other macronutrients, on blood pressure and heart rate in older men. The results showed that whey-protein drinks can significantly lower blood pressure and increase heart rate, and these effects are primarily dependent on the energy content rather than the macronutrient composition. These effects can persist for at least 3 hours after ingestion.
Article
Neurosciences
Andrew L. Zhou, Nidhi Sharda, Vidur V. Sarma, Kristen M. Ahlschwede, Geoffry L. Curran, Xiaojia Tang, Joseph F. Poduslo, Krishna R. Kalari, Val J. Lowe, Karunya K. Kandimalla
Summary: Age-related changes in the plasma pharmacokinetics and brain influx of A beta isoforms and insulin may potentially increase the risk of Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Physiology
Eriko Kawai, Ryosuke Takeda, Akemi Ota, Emiko Morita, Daiki Imai, Yuta Suzuki, Hisayo Yokoyama, Shin-ya Ueda, Hidehiro Nakahara, Tadayoshi Miyamoto, Kazunobu Okazaki
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2020)
Article
Physiology
Masahiro Horiuchi, Kazunobu Okazaki, Katsumi Asano, Alexander T. Friend, Gabriella M. K. Rossetti, Samuel J. Oliver
Summary: Orthostasis at sea level and high altitude have different effects on cerebral and leg oxygenation. High altitude preferentially maintains cerebral oxygenation post-orthostasis, indicating different vascular regulation between cerebral and peripheral circulations.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Clinical Neurology
Chueh-Lung Hwang, Kazunobu Okazaki, Shigeki Shibata, Yu-Lun Liu, Qi Fu
Summary: This study investigated the effects of the menstrual cycle on muscle sympathetic nerve activity burst amplitude distribution during an orthostatic challenge in young women. The results showed that the mean and median values of relative burst amplitude increased from supine to upright position, regardless of menstrual cycle phases. However, the skewness and kurtosis of burst amplitude distribution varied between the early follicular phase and mid-luteal phase.
CLINICAL AUTONOMIC RESEARCH
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Yutaka Igarashi, Atsuya Toya, Kazunobu Okazaki
Article
Physiology
Daichi Sumi, Haruna Nagatsuka, Kaori Matsuo, Kazunobu Okazaki, Kazushige Goto
Summary: Endurance training under hot conditions improves thermoregulation, but does not attenuate exercise-induced hepcidin elevation.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Daichi Sumi, Haruna Nagatsuka, Kaori Matsuo, Kazunobu Okazaki, Kazushige Goto
Summary: The study aimed to investigate the effects of heat acclimation on gastrointestinal damage and gastric emptying rate following endurance exercise. The results showed that endurance training in a hot environment improved thermoregulation, but did not further attenuate exercise-induced GI damage and delay in gastric emptying rate compared to training in a cool environment.
Article
Health Care Sciences & Services
Hisayo Yokoyama, Daiki Imai, Yuta Suzuki, Akira Ogita, Hitoshi Watanabe, Haruka Kawabata, Takaaki Miyake, Izumi Yoshii, Shinji Tsubouchi, Yoshimasa Matsuura, Kazunobu Okazaki
Summary: This study evaluated the current state of health literacy (HL) among college students and explored the factors influencing HL, as well as the relationship between HL and health conditions. The majority of participants had problematic or unsatisfactory HL levels. Those with healthy lifestyles scored higher on HL, and higher HL levels were associated with better subjective health. Educational intervention programs for college students should be established to improve their HL levels.
Meeting Abstract
Sport Sciences
Daichi Sumi, Haruna Nagatsuka, Kaori Matsuo, Kazunobu Okazaki, Kazushige Goto
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Meeting Abstract
Sport Sciences
Hisayo Yokoyama, Miwako Deguchi, Nobuko Hongu, Hitoshi Watanabe, Akira Ogita, Daiki Imai, Yuta Suzuki, Kazunobu Okazaki
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Nutrition & Dietetics
Miwako Deguchi, Hisayo Yokoyama, Nobuko Hongu, Hitoshi Watanabe, Akira Ogita, Daiki Imai, Yuta Suzuki, Kazunobu Okazaki
Summary: This study aimed to investigate the dietary practices of para-athletes and identified factors such as nutrition knowledge and body image that may hinder their nutrition practices. Results showed para-athletes had lower nutrition knowledge compared to collegiate student athletes and unique eating perceptions. Future interventions should focus on providing tailored nutritional support and education, highlighting the crucial role of dietitians in the process.
Meeting Abstract
Biochemistry & Molecular Biology
Daiki Imai, Ryosuke Takeda, Eriko Kawai, Kosuke Saho, Akemi Ota, Emiko Morita, Yuta Suzuki, Hisayo Yokoyama, Kazunobu Okazaki
Meeting Abstract
Biochemistry & Molecular Biology
Ryosuke Takeda, Daiki Imai, Eriko Kawai, Akemi Ota, Kosuke Saho, Emiko Morita, Yuta Suzuki, Hisayo Yokoyama, Hideya Takahashi, Hideshi Hayashi, Tasuku Kimura, Kazunobu Okazaki
Meeting Abstract
Biochemistry & Molecular Biology
Kazunobu Okazaki, Ryosuke Takeda, Daiki Imai, Eriko Kawai, Akemi Ota, Kosuke Saho, Emiko Morita, Yuta Suzuki, Kazushige Goto, Hisayo Yokoyama
Meeting Abstract
Biochemistry & Molecular Biology
Akemi Ota, Ryosuke Takeda, Daiki Imai, Eriko Kawai, Kosuke Saho, Emiko Morita, Yuta Suzuki, Hisayo Yokoyama, Kazunobu Okazaki
Meeting Abstract
Biochemistry & Molecular Biology
Eriko Kawai, Ryosuke Takeda, Kosuke Saho, Akemi Ota, Emiko Morita, Daiki Imai, Yuta Suzuki, Hisayo Yokoyama, Kazunobu Okazaki