Article
Biology
Vesna Benkovic, Nikola Borojevic, Dunja Sikic, Anica Horvat Knezevic, Mirta Milic
Summary: In a study on 185 healthy Swiss albino mice, it was found that halothane exposure after 1 or 2 Gy of IR caused higher levels of DNA damage, while sevoflurane and isoflurane demonstrated a protective effect. Despite this, none of the exposures reached control levels even after 24 hours, indicating that halothane may increase radiation-induced DNA damage levels.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Bilal Onur, Kultrgin Cavusoglu, Emine Yalcin, Ali Acar
Summary: This study investigated the toxicity of Paraquat herbicide in Swiss albino mice. The results showed that the dose of Paraquat was closely associated with changes in physiological, biochemical, oxidative stress and genetic parameters.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Baran Seven, Cavusoglu Kultigin, Emine Yalcin, Ali Acar
Summary: In this study, the toxicity of cypermethrin was investigated using various parameters, molecular docking, and the comet assay technique. The results showed that cypermethrin caused toxicity in different cell types and promoted DNA damage, as evidenced by the formation of micronucleus and chromosomal aberrations. The study also demonstrated the interaction between cypermethrin and DNA through molecular docking and spectral measurements.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Vesna Benkovic, Mirta Milic, Nada Orsolic, Anica Horvat Knezevic, Gordana Brozovic, Nikola Borojevic
Summary: With the increasing use of general volatile anaesthesia (VA) in radiotherapy and radiology diagnostic procedures, there is a need to understand the combined effects of VA and ionising radiation (IR) on DNA damage and repair. This study evaluated DNA damage in liver tissue of mice exposed to different VA agents alone or in combination with IR using the comet assay. The results showed that halothane alone or in combination with IR caused the highest DNA damage, while sevoflurane and isoflurane had protective effects against lower doses of IR.
ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY
(2023)
Review
Medicine, Research & Experimental
Santiago Alonso Tobar Leitao, Douglas Dos Santos Soares, Nelson Carvas Junior, Rafael Zimmer, Nataniel Floriano Ludwig, Michael Andrades
Summary: The study found that different anesthetics have varying effects on the biological outcomes of laboratory animals before euthanasia. However, the data did not conclusively support the use of one specific anesthetic over others, or the omission of anesthesia during euthanasia.
Article
Pharmacology & Pharmacy
Hiroyuki Saito, Ryuichi Kambayashi, Ai Goto, Mihoko Hagiwara-Nagasawa, Kiyotaka Hoshiai, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Yasuki Akie, Yoshinori Takei, Akio Matsumoto, Atsushi Sugiyama
Summary: In intact beagle dogs, increasing the concentration of inhaled halothane or isoflurane decreased mean blood pressure and prolonged QRS width without significant effects on heart rate, PR interval, or QT interval. These effects were reversible upon cessation of anesthesia, suggesting a counterbalancing mechanism involving reflex-mediated increase in sympathetic tone.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Article
Microbiology
Mohammed Alrouji, Fahd A. Kuriri, Mohammed Hussein Alqasmi, Hamood AlSudais, Mohammed Alissa, Meshari A. Alsuwat, Mohammed Asad, Babu Joseph, Yasir Almuhanna
Summary: The study developed a simple and inexpensive method to induce biofilm formation in-vivo using Swiss albino mice for the evaluation of the antibiofilm activity of pharmacological agents. Preformed biofilm and MRSA culture were introduced into excision wounds of diabetic mice. The method successfully developed biofilm after 24 hours of incubation, which was confirmed by microscopic examination and a crystal violet assay. It was also effective in inducing profound infection and biofilm formation in the excision wounds within 72 hours.
Article
Biology
Munevver Baran, Arzu Yay, Gozde Ozge Onder, Fazile Canturk Tan, Betul Yalcin, Esra Balcioglu, Oguz Galip Yildiz
Summary: This study investigated the potential protective effects of quercetin on radiation-induced liver and kidney damage in rats. The results showed that quercetin could alleviate the histopathological and immunohistochemical changes in liver and kidney tissues caused by radiation, as well as reduce DNA damage and oxidative stress.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Pankaj Yadav, Hina Iqbal, Kapil Kumar, Parmanand Kumar, Divya Mishra, Arjun Singh, Anirban Pal, Pradipto Mukhopadhyay, Beena Vamadevan, Dhirendra Singh, Arvind Singh Negi, Debabrata Chanda
Summary: LT-9 exhibited potent biological activity against sepsis in CLP mice by reversing vascular hyporeactivity and enhancing contraction response to norepinephrine through opening of L-type VDCC. Oral administration of LT-9 for 15 days significantly improved survival time, hemodynamic and ECG profile in CLP mice.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Doaa Mohamed El-Nagar, Badr Abdullah Al-Dahmash, Saad Alkahtani, Areej Ahmed Kalu, Ahmed Rady
Summary: This study aimed to investigate the effect of dandelion seed extract in reducing hypercholesterolemia and its hazardous effects on the liver. The results showed that dandelion seed extract significantly reduced the weight of mice and improved liver function while reducing pathological changes.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Jorid B. Sorlia, Alexander C. O. Jensen, Alicja Mortensen, Jozef Szarek, Claudia A. T. Gutierrez, Lucas Givelet, Katrin Loeschner, Charis Loizides, Iosif Hafez, George Biskos, Ulla Vogel, Niels Hadrup
Summary: By conducting nose-only inhalation tests on mice, we found that the air concentration of molybdenum disulphide particles has no observed adverse effect on body weight gain and genotoxicity below 13mg/m³, while the effects on respiratory function suggest this level as the lowest observed adverse effect concentration.
Article
Pharmacology & Pharmacy
Hossam El Din H. Abdelhafez, Amr A. Abdallah, Asmaa A. El-Dahshan, Yasser A. Abd El-Baset, Osama M. Morsy, Mohamed Bedair M. Ahmed
Summary: The study found that fipronil induces various health risks in vivo, while date extract can alleviate the toxic effects of fipronil but failed to reduce genotoxicity.
Article
Multidisciplinary Sciences
Madhu Bala, Shilpa S. Shetty, Ranjit Singh Sangwan, Satheesh Kumar Bhandary, P. G. Roopashree, P. C. Suhasini, N. Suchetha Kumari
Summary: Ganoderma lucidum (GL) mycelium powder has radioprotective efficacy against gamma radiation-induced damage, mitigating hematological and oxidative stress changes caused by radiation.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Biology
Avelyno H. D'Costa, Soorambail K. Shyama, Praveen M. K. Kumar, Vidhyadatta S. Verenkar, Rudraji B. Tangsali
Summary: This study assessed the genotoxic effect of Manganese and Nickel doped Zinc Ferrite (MNZF) nanoparticle in Swiss albino mice, revealing a significant dose-dependent increase in genetic damage. It is important to take proper precautions to avoid contact with this nanoparticle.
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Jorid B. Sorli, Alexander C. o. Jensen, Alicja Mortensen, Jozef Szarek, Eleni Chatzigianelli, Claudia A. T. Gutierrez, Nicklas R. Jacobsen, Sarah S. Poulsen, Iosif Hafez, Charis Loizides, George Biskos, Karin S. Hougaard, Ulla Vogel, Niels Hadrup
Summary: This study evaluated the pulmonary toxicity of tungsten by exposing male mice to tungsten particles and found increased genotoxicity at certain exposure levels. However, no adverse effects were observed on body weight, inflammation, or organ pathology. The study suggests that tungsten exhibits non-dose dependent genotoxicity without inflammation.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Biology
Marko Milisa, Domagoj Dikic, Tvrtko Mandic, Dino Grozic, Ivan Colic, Ana Ostojic
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2017)
Article
Fisheries
D. Dikic, I. Landeka, D. Franjevic, D. Skaramuca, R. Fuchs, S. Matic Skoko, P. Tutman, I. Lukic, B. Skaramuca
JOURNAL OF APPLIED ICHTHYOLOGY
(2017)
Review
Public, Environmental & Occupational Health
Kristina Dominko, Domagoj Dikic
ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY
(2018)
Article
Biotechnology & Applied Microbiology
K. Jurica, I. Brcic Karaconji, A. Mikolic, D. Milojkovic-Opsenica, V. Benkovic, N. Kopjar
Article
Chemistry, Multidisciplinary
Karlo Jurica, Vesna Benkovic, Suncana Sikiric, Nevenka Kopjar, Irena Brcic Karaconji
DRUG AND CHEMICAL TOXICOLOGY
(2020)
Article
Environmental Sciences
Davor Zeljezic, Suzana Zunec, Marija Bjelis, Vesna Benkovic, Marin Mladinic, Blanka Lovakovic Tariba, Ivan Pavicic, Ana Marija Marjanovic Cermak, Vilena Kasuba, Mirta Milic, Alica Pizent, Ana Lucic Vrdoljak, Nevenka Kopjar
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2018)
Article
Plant Sciences
Karlo Jurica, Irena Brcic Karaconji, Nevenka Kopjar, Ana Shek-Vugrovecki, Tihana Cikac, Vesna Benkovic
JOURNAL OF ETHNOPHARMACOLOGY
(2018)
Article
Neurosciences
Kristina Dominko, Domagoj Dikic, Silva Hecimovic
NUTRITIONAL NEUROSCIENCE
(2020)
Article
Environmental Sciences
Dimitrija Savic-Zdravkovic, Djuradj Milosevic, Ezgi Uluer, Hatice Duran, Sanja Matic, Snezna Stanic, Janja Vidmar, Janez Scancar, Domagoj Dikic, Boris Jovanovic
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2020)
Article
Food Science & Technology
Vedran Balta, Domagoj Dikic, Irena Crnic, Dyna Odeh, Nada Orsolic, Ivana Kmetic, Teuta Murati, Verica Dragovic Uzelac, Irena Landeka Jurcevic
POLISH JOURNAL OF FOOD AND NUTRITION SCIENCES
(2020)
Article
Infectious Diseases
Zenon Pogorelic, Ana Marija Luksic, Jakov Mihanovic, Domagoj Dikic, Vedran Balta
Summary: This study found that elevated levels of total serum bilirubin may serve as an indicator of perforated appendicitis in children. Multivariable logistic regression analysis identified serum bilirubin concentration, serum sodium concentration, body temperature, and duration of symptoms as risk factors for perforated appendicitis. Serum bilirubin levels are a useful and affordable laboratory marker that should be considered in the initial evaluation of pediatric patients with acute appendicitis.
SURGICAL INFECTIONS
(2021)
Article
Biotechnology & Applied Microbiology
Irena Crnic, Tajana Francic, Petar Dragicevic, Vedran Balta, Verica Dragovic-Uzelac, Domagoj Dikic, Irena Landeka Jurcevic
Summary: The study aimed to investigate the effects of blackthorn flower extract on blood glucose levels in normoglycaemic and hyperglycaemic mice models. The results showed that the extract increased glucose concentrations in normoglycaemic mice but reduced serum blood glucose in hyperglycaemic mice. Additionally, the extract enhanced insulin secretion and lowered serum alpha-amylase activity in the hyperglycaemic group.
FOOD TECHNOLOGY AND BIOTECHNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Teuta Murati, Marina Miletic, Josipa Kolaric, Vanja Lovric, Danijela Bursac Kovacevic, Predrag Putnik, Irena Landeka Jurcevic, Domagoj Dikic, Verica Dragovic-Uzelac, Ivana Kmetic
ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Nada Orsolic, Irena Landeka Jurcevic, Domagoj Dikic, Dunja Rogic, Dyana Odeh, Vedran Balta, Eleonora Perak Junakovic, Svjetlana Terzic, David Jutric
Article
Fisheries
Domagoj Dikic, Irena Landeka, Radovan Fuchs, Daria Skaramuca, Sanja Matic-Skoko, Pero Tutman, Zdenko Franic, Ivona Cvetkovic, Bosko Skaramuca
ACTA ICHTHYOLOGICA ET PISCATORIA
(2017)