Article
Biochemistry & Molecular Biology
Hojun Choi, Hwayoung Yim, Cheolhyoung Park, So-Hee Ahn, Yura Ahn, Areum Lee, Heekyoung Yang, Chulhee Choi
Summary: Exosomes have the potential to serve as efficient therapeutic vehicles for delivering anti-cancer drugs, but challenges remain in improving loading efficiency and establishing monitoring methods.
Article
Biochemistry & Molecular Biology
Martha Baydoun, Lea Boidin, Bertrand Leroux, Anne-Sophie Vignion-Dewalle, Alexandre Quilbe, Guillaume Paul Grolez, Henri Azais, Celine Frochot, Olivier Morales, Nadira Delhem
Summary: A targeted photodynamic therapy using a photosensitizer coupled with folic acid was applied in an in vivo mouse model of peritoneal ovarian carcinomatosis. The treatment showed effective tumor growth reduction and induced an immune response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Adrianne Wallace-Povirk, Zhanjun Hou, Md. Junayed Nayeen, Aleem Gangjee, Larry H. Matherly
Summary: New therapies are urgently needed for ovarian cancer, and this review discusses the remarkable advances in identifying metabolic vulnerabilities and strategies for targeted therapy. The development of tumor-selective approaches, such as folate receptors and the proton-coupled folate transporter, as well as the discovery of drugs targeting key metabolic processes, show extraordinary potential for improving the lives of women with this devastating disease.
Review
Chemistry, Multidisciplinary
Bethany M. Cooper, Jessica Iegre, Daniel H. O' Donovan, Maria Olwegard Halvarsson, David R. Spring
Summary: Peptides offer versatility in oncology drug discovery, with peptide-drug conjugates showing promise in targeting tumors. Despite limitations such as slow progress and limited oral bioavailability, new approaches have enhanced peptide stability, leading to two molecules on the market and various variations in clinical trials.
CHEMICAL SOCIETY REVIEWS
(2021)
Review
Chemistry, Multidisciplinary
Ali Shakeri-Zadeh, Abolhasan Rezaeyan, Abolfazl Sarikhani, Hamed Ghaffari, Hadi Samadian, Sara Khademi, Habib Ghaznavi, Jeff W. M. Bulte
Summary: Molecular imaging of cancer is a promising field for visualizing, characterizing, and quantifying cancer biology in vivo. Targeted nanoprobes designed for folate receptors show potential for early cancer detection, but face challenges such as non-specific uptake in the liver and spleen.
Article
Oncology
Sylvie Rottey, Jeffrey Clarke, Kyaw Aung, Jean-Pascal Machiels, Ben Markman, Kimberley M. Heinhuis, Michael Millward, Martijn Lolkema, Sandip Pravin Patel, Paul de Souza, Matteo Duca, Giuseppe Curigliano, Armando Santoro, Takafumi Koyama, Michelle Brown, Heather Vezina, Chunsheng He, Quincy Siu-Chung Chu
Summary: BMS-986148, a mesothelin-directed antibody-drug conjugate, showed acceptable safety and tolerability in patients and demonstrated preliminary clinical activity. This suggests that combining directed cytotoxic therapies with checkpoint inhibitors may be a potential multimodal therapeutic strategy in advanced solid tumors.
CLINICAL CANCER RESEARCH
(2022)
Review
Medicine, Research & Experimental
Ankit Banik, Rishika Sharma, Akansha Chauhan, Sandhya Singh
Summary: This article reviews the recent therapeutics developed to target cancer stem cells (CSCs) through multiple signaling cascades, altered metabolism, and the tumor microenvironment. It discusses the functioning of CSCs and their interaction with different cells in the tumor microenvironment, as well as possible strategies to disrupt this interaction for better treatment outcomes.
Review
Pharmacology & Pharmacy
Janani Indrakumar, Srivarshini Sankar, Harishkumar Madhyastha, Gothandam Kodiveri Muthukaliannan
Summary: The marine microenvironment is a rich source of compounds that can be used for the treatment of various diseases. The application of nanotechnology in medicine has opened up new possibilities for targeted therapies using marine biomolecules, ensuring minimal damage to healthy cells.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Review
Immunology
Lina S. M. Huang, Evan Y. Snyder, Robert T. Schooley
Summary: AIDS caused by HIV-1 has been a global public health challenge for decades. While drugs targeting CCR5-mediated entry or HIV-1 replication have been used clinically, drugs targeting CXCR4 have not yet reached clinical application. Research is ongoing on discovering novel molecules targeting CXCR4 for potential future anti-HIV therapeutic development.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Biotechnology & Applied Microbiology
Srividhya Venkataraman, Paul Apka, Erum Shoeb, Uzma Badar, Kathleen Hefferon
Summary: Plant virus nanoparticles (VNPs) are cost-effective, safe, and efficacious as treatments, showing potential as epitope carriers for vaccines and agents in cancer immunotherapy. Their highly immunogenic nature and ability to promote antigen presentation make them promising platforms for inducing robust immune responses.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Arijit Mondal, Amit Kumar Nayak, Prithviraj Chakraborty, Sabyasachi Banerjee, Bankim Chandra Nandy
Summary: Cancer is a common and deadly disease, and nanomedicine has emerged as a potential substitute for cancer treatment. The combination of natural bioactive compounds and nanotechnology has shown promise in improving chemotherapy effectiveness. Nanotechnology allows for targeted delivery of drugs, while natural bioactive compounds enhance the therapeutic outcomes.
Article
Biochemistry & Molecular Biology
Shuang Ju, Yu Zhang, Xijun Guo, Qinghui Yan, Siyi Liu, Bokai Ma, Mei Zhang, Jiaolin Bao, Sulan Luo, Ying Fu
Summary: Conotoxins from marine cone snail venom are valuable drug resources and potential candidates for ovarian cancer treatment.
Article
Oncology
Thaggikuppe Krishnamurthy Praveen, Hosahalli Veerabhadrappa Gangadharappa, Amr Selim Abu Lila, Afrasim Moin, Khalid Mehmood, Kamsagara Linganna Krishna, Talib Hussain, Ahmed Alafnan, Shazi Shakil, Syed Mohd Danish Rizvi
Summary: The study emphasizes the importance and challenges of nanotechnology in cancer treatment, highlighting the need to overcome issues in developing anti-inflammatory nanomedicines.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Madeeha Shahzad Lodhi, Fatima Khalid, Muhammad Tahir Khan, Zahoor Qadir Samra, Shabbir Muhammad, Yu-Juan Zhang, Kejie Mou
Summary: Therapeutic effects of anticancer medicines can be improved by targeting the specific receptors on cancer cells. In this research project, a novel formulation of targeting drug delivery was designed and its anticancer effects were analyzed. The results showed that the engineered nanomedicines demonstrated good cytotoxicity against cancer cells, indicating their potential in targeted drug delivery.
Review
Medicine, Research & Experimental
Preeti Ranjan, Vikash Kumar Dubey
Summary: Leishmaniasis is a parasitic disease that disproportionately affects impoverished and developing countries. The socioeconomic background of the affected region is a significant factor that influences the severity of the disease. The emergence of drug-resistant Leishmania poses a serious threat to current treatment options, necessitating a reevaluation of drug choices. Targeted therapy combined with immunotherapy appears to be a promising strategy for combating the disease.
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)