Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products

X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis

(2015) Kristina Haslinger et al.   NATURE

β-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis

(2015) Nicole M. Gaudelli et al.   NATURE

Rapid access to glycopeptide antibiotic precursor peptides coupled with cytochrome P450-mediated catalysis: towards a biomimetic synthesis of glycopeptide antibiotics

(2015) Clara Brieke et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The Structure of a Transient Complex of a Nonribosomal Peptide Synthetase and a Cytochrome P450 Monooxygenase

(2014) Kristina Haslinger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antibiotic Resistance Mechanisms Inform Discovery: Identification and Characterization of a Novel Amycolatopsis Strain Producing Ristocetin

(2014) Andrew W. Truman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Overproduction of Ristomycin A by Activation of a Silent Gene Cluster in Amycolatopsis japonicum MG417-CF17

(2014) Marius Spohn et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Harnessing the Synthetic Capabilities of Glycopeptide Antibiotic Tailoring Enzymes: Characterization of the UK-68,597 Biosynthetic Cluster

(2014) Grace Yim et al.   CHEMBIOCHEM

Cytochrome P450 OxyBteiCatalyzes the First Phenolic Coupling Step in Teicoplanin Biosynthesis

(2014) Kristina Haslinger et al.   CHEMBIOCHEM

MBJ-0086 and MBJ-0087, new bicyclic depsipeptides, from Sphaerisporangium sp. 33226

(2014) Teppei Kawahara et al.   JOURNAL OF ANTIBIOTICS

Salinamide F, new depsipeptide antibiotic and inhibitor of bacterial RNA polymerase from a marine-derived Streptomyces sp.

(2014) Hossam M Hassan et al.   JOURNAL OF ANTIBIOTICS

Total Synthesis of [Ψ[C(═NH)NH]Tpg4]Vancomycin and its (4-Chlorobiphenyl)methyl Derivative: Impact of Peripheral Modifications on Vancomycin Analogues Redesigned for Dual d-Ala-d-Ala and d-Ala-d-Lac Binding

(2014) Akinori Okano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Epimerization and substrate gating by a TE domain in β-lactam antibiotic biosynthesis

(2014) Nicole M Gaudelli et al.   Nature Chemical Biology

Bis-chlorination of a hexapeptide–PCP conjugate by the halogenase involved in vancomycin biosynthesis

(2014) Patrick C. Schmartz et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate

(2014) Atsushi Nakayama et al.   ORGANIC LETTERS

The Antibiotics Dityromycin and GE82832 Bind Protein S12 and Block EF-G-Catalyzed Translocation

(2014) David Bulkley et al.   Cell Reports

Transcription inhibition by the depsipeptide antibiotic salinamide A

(2014) David Degen et al.   eLife

Structure of the epimerization domain of tyrocidine synthetase A

(2014) Stefan A. Samel et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Cytochrome P450sky Interacts Directly with the Nonribosomal Peptide Synthetase to Generate Three Amino Acid Precursors in Skyllamycin Biosynthesis

(2013) Stefanie Uhlmann et al.   ACS Chemical Biology

Alanine Scan of the Peptide Antibiotic Feglymycin: Assessment of Amino Acid Side Chains Contributing to Antimicrobial Activity

(2013) Anne Hänchen et al.   CHEMBIOCHEM

Cyclic lipodepsipeptides: a new class of antibacterial agents in the battle against resistant bacteria

(2013) Nina Bionda et al.   Future Medicinal Chemistry

Streptogramins – Two are better than one!

(2013) Yvonne Mast et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Glycopeptide antibiotic biosynthesis

(2013) Grace Yim et al.   JOURNAL OF ANTIBIOTICS

A new antibacterial lipopeptide found by UPLC-MS from an actinomyceteStreptomycessp. HCCB10043

(2013) Min Rao et al.   NATURAL PRODUCT RESEARCH

Identifying producers of antibacterial compounds by screening for antibiotic resistance

(2013) Maulik N Thaker et al.   NATURE BIOTECHNOLOGY

Substituent Effects on the Phenol Coupling Reaction Catalyzed by the Vancomycin Biosynthetic P450 Enzyme OxyB

(2012) Patrick C. Schmartz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanism of Action of the Arylomycin Antibiotics and Effects of Signal Peptidase I Inhibition

(2012) Peter A. Smith et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biosynthesis of new lipopentapeptides by an engineered strain of Streptomyces sp.

(2012) Xu Jin et al.   BIOTECHNOLOGY LETTERS

Structural and functional characterization of the bacterial translocation inhibitor GE82832

(2012) Letizia Brandi et al.   FEBS LETTERS

Racemisation of N-Fmoc phenylglycine under mild microwave-SPPS and conventional stepwise SPPS conditions: attempts to develop strategies for overcoming this

(2012) Mohamed A. Elsawy et al.   JOURNAL OF PEPTIDE SCIENCE

Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology

(2012) Gene H. Hur et al.   NATURAL PRODUCT REPORTS

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

Natural Product Disaccharide Engineering through Tandem Glycosyltransferase Catalysis Reversibility and Neoglycosylation

(2012) Pauline Peltier-Pain et al.   ORGANIC LETTERS

Sulfonation of glycopeptide antibiotics by sulfotransferase StaL depends on conformational flexibility of aglycone scaffold

(2012) R. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Feglymycin, a unique natural bacterial antibiotic peptide, inhibits HIV entry by targeting the viral envelope protein gp120

(2012) Geoffrey Férir et al.   VIROLOGY

Structural and mechanistic comparisons of the metal-binding members of the vicinal oxygen chelate (VOC) superfamily

(2011) Panqing He et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Initial Efforts toward the Optimization of Arylomycins for Antibiotic Activity

(2011) Tucker C. Roberts et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biosynthetic Origin of the 3-Amino-2,5,7,8-tetrahydroxy-10-methylundecanoic Acid Moiety and Absolute Configuration of Pahayokolides A and B

(2011) Li Liu et al.   JOURNAL OF NATURAL PRODUCTS

Synthesis and Biological Characterization of Arylomycin B Antibiotics

(2011) Tucker C. Roberts et al.   JOURNAL OF NATURAL PRODUCTS

Imaging Mass Spectrometry and Genome Mining via Short Sequence Tagging Identified the Anti-Infective Agent Arylomycin inStreptomyces roseosporus

(2011) Wei-Ting Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and Characterization of the Arylomycin Lipoglycopeptide Antibiotics and the Crystallographic Analysis of Their Complex with Signal Peptidase

(2011) Jian Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthetic Gene Cluster of the Non-ribosomally Synthesized Cyclodepsipeptide Skyllamycin: Deciphering Unprecedented Ways of Unusual Hydroxylation Reactions

(2011) Stefan Pohle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds

(2011) Yu-Chen Liu et al.   Nature Chemical Biology

NRPSpredictor2—a web server for predicting NRPS adenylation domain specificity

(2011) Marc Röttig et al.   NUCLEIC ACIDS RESEARCH

In VitroActivities of Arylomycin Natural-Product Antibiotics againstStaphylococcus epidermidisand Other Coagulase-Negative Staphylococci

(2010) Peter A. Smith et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Broad-Spectrum Antibiotic Activity of the Arylomycin Natural Products Is Masked by Natural Target Mutations

(2010) Peter A. Smith et al.   CHEMISTRY & BIOLOGY

Structural Characterization of OxyD, a Cytochrome P450 Involved in β-Hydroxytyrosine Formation in Vancomycin Biosynthesis

(2010) Max J. Cryle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and functional characterization of phenylglycine biosynthetic genes involved in pristinamycin biosynthesis in Streptomyces pristinaespiralis

(2010) Yvonne J. Mast et al.   JOURNAL OF BIOTECHNOLOGY

Enduracidin Analogues with Altered Halogenation Patterns Produced by Genetically Engineered Strains ofStreptomyces fungicidicus

(2010) Xihou Yin et al.   JOURNAL OF NATURAL PRODUCTS

Tailoring Enzyme-Rich Environmental DNA Clones: A Source of Enzymes for Generating Libraries of Unnatural Natural Products

(2010) Jacob J. Banik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of the ‘pristinamycin supercluster’ of Streptomyces pristinaespiralis

(2010) Yvonne Mast et al.   Microbial Biotechnology

Total Synthesis of the Antiviral Peptide Antibiotic Feglymycin

(2009) Frank Dettner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antibiotic susceptibility among Staphylococcus epidermidis isolated from prosthetic joint infections with special focus on rifampicin and variability of the rpoB gene

(2009) B. Hellmark et al.   CLINICAL MICROBIOLOGY AND INFECTION

Stereospecific Synthesis ofthreo- anderythro-β-Hydroxyglutamic Acid During Kutzneride Biosynthesis

(2009) Matthias Strieker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of Salinamide A: A Potent Anti-Inflammatory Bicyclic Depsipeptide

(2008) Li Tan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Two Roads Diverged:  The Structure of Hydroxymandelate Synthase fromAmycolatopsis orientalisin Complex with 4-Hydroxymandelate†,‡

(2008) June Brownlee et al.   BIOCHEMISTRY

Investigation into the Mechanism of Phenolic Couplings during the Biosynthesis of Glycopeptide Antibiotics

(2008) Andrew N. Holding et al.   CHEMBIOCHEM

Homotyrosine-Containing Cyanopeptolins 880 and 960 and Anabaenopeptins 908 and 915 fromPlanktothrix agardhiiCYA 126/8

(2008) Hilary S. Okumura et al.   JOURNAL OF NATURAL PRODUCTS

Exploring the substrate specificity of OxyB, a phenol coupling P450 enzyme involved in vancomycin biosynthesis

(2008) Katharina Woithe et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary

(2008) J. J. Banik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enantioselective Preparation of β²-Amino Acid Derivatives for β-Peptide Synthesis

(2008) Dieter Seebach et al.   SYNTHESIS-STUTTGART

New insights into the first oxidative phenol coupling reaction during vancomycin biosynthesis

(2007) Nina Geib et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The interaction of hydroxymandelate synthase with the 4-hydroxyphenylpyruvate dioxygenase inhibitor: NTBC

(2007) John A. Conrad et al.   INORGANICA CHIMICA ACTA