Article
Biochemistry & Molecular Biology
Takuto Miyamura, Noriho Sakamoto, Tomoyuki Kakugawa, Hirokazu Taniguchi, Yoshiko Akiyama, Daisuke Okuno, Sakiko Moriyama, Atsuko Hara, Takashi Kido, Hiroshi Ishimoto, Hiroyuki Yamaguchi, Taiga Miyazaki, Yasushi Obase, Yuji Ishimatsu, Yoshimasa Tanaka, Hiroshi Mukae
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Shoichi Fukui, Shimpei Morimoto, Kunihiro Ichinose, Shota Nakashima, Hiroshi Ishimoto, Atsuko Hara, Tomoyuki Kakugawa, Noriho Sakamoto, Yoshika Tsuji, Toshiyuki Aramaki, Tomohiro Koga, Shin-ya Kawashiri, Naoki Iwamoto, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Yukitaka Ueki, Shino Suzuki, Hiroshi Mukae, Atsushi Kawakami
SCIENTIFIC REPORTS
(2020)
Article
Medicine, General & Internal
Daisuke Okuno, Takashi Kido, Keiji Muramatsu, Kei Tokutsu, Sakiko Moriyama, Takuto Miyamura, Atsuko Hara, Hiroshi Ishimoto, Hiroyuki Yamaguchi, Taiga Miyazaki, Noriho Sakamoto, Yasushi Obase, Yuji Ishimatsu, Yoshihisa Fujino, Kazuhiro Yatera, Shinya Matsuda, Hiroshi Mukae
Summary: The study found that early corticosteroid therapy for severe influenza pneumonia patients does not significantly improve survival rates, but may lead to an increased in-hospital mortality rate.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Medicinal
Daisuke Okuno, Noriho Sakamoto, Mohammed S. O. Tagod, Yoshiko Akiyama, Sakiko Moriyama, Takuto Miyamura, Atsuko Hara, Takashi Kido, Hiroshi Ishimoto, Yuji Ishimatsu, Takashi Tanaka, Jun Ishihara, Kohsuke Takeda, Yoshimasa Tanaka, Hiroshi Mukae
Summary: The study prepared human HSP47 and established an inhibitor screening system. Among the compounds screened, three were found to effectively inhibit the function of HSP47, with epigallocatechin-3-O-gallate from tea leaves being one of them.
Article
Cardiac & Cardiovascular Systems
Noriho Sakamoto, Hiroshi Ishimoto, Masahiro Tahara, Takashi Kido, Atsuko Hara, Takuto Miyamura, Daisuke Okuno, Takatomo Tokito, Sumako Yoshioka, Shimpei Morimoto, Takahiro Takazono, Kazuko Yamamoto, Hiroyuki Yamaguchi, Yasushi Obase, Yuji Ishimatsu, Kazuhiro Yatera, Hiroshi Mukae
Summary: The study indicates a significant association between HLA-B54 positivity and the incidence of pneumonia in Japanese patients with ILD, and it is also an important risk factor for death, especially in patients with idiopathic pulmonary fibrosis.
RESPIRATORY MEDICINE
(2021)
Article
Multidisciplinary Sciences
Takashi Kido, Hiroshi Ishimoto, Hiroshi Ishii, Kanako Hara, Mutsumi Ozasa, Hiroki Kawabata, Toshinori Kawanami, Yu Suzuki, Hiroki Yoshikawa, Atsuko Hara, Noriho Sakamoto, Nobuhiro Matsumoto, Chiharu Yoshii, Junya Fukuoka, Masaki Fujita, Masamitsu Nakazato, Junichi Kadota, Hiroshi Mukae, Kazuhiro Yatera
Summary: The study evaluated the diagnostic potential of combined detection of MALT1 translocations and clonality using BALF for patients with clinically suspected pulmonary lymphomas. The sensitivity and specificity of detecting IGH rearrangements for diagnosing B-cell lymphoma were high. The combined detection of lymphocyte clonality and MALT1 translocations using BALF is suitable for screening and diagnosing B-cell lymphomas.
SCIENTIFIC REPORTS
(2021)
Article
Respiratory System
Masatoshi Hanada, Noriho Sakamoto, Hiroshi Ishimoto, Takashi Kido, Takuto Miyamura, Masato Oikawa, Hiroki Nagura, Rina Takeuchi, Yurika Kawazoe, Shuntaro Sato, S. Ahmed Hassan, Yuji Ishimatsu, Hideaki Takahata, Hiroshi Mukae, Ryo Kozu
Summary: This study assessed the accuracy of three sarcopenia screening tools in patients with interstitial lung disease. The study found that CalF is the most suitable tool for screening sarcopenia in these patients, while SARC-F and SARC-CalF are not.
BMC PULMONARY MEDICINE
(2022)
Article
Respiratory System
Hiroshi Ishimoto, Noriho Sakamoto, Sakiko Moriyama, Mayako Murata, Nana Nakada, Atsuko Hara, Takashi Kido, Hiroyuki Yamaguchi, Kazuko Yamamoto, Yasushi Obase, Yuji Ishimatsu, Hiroshi Mukae
Summary: This case report describes a successful removal of an airway foreign body using a cryoprobe in an 88-year-old patient with obstructive pneumonia caused by a foreign object. The success of using a cryoprobe for removal of airway foreign bodies depends on the nature of the foreign body, and long-term airway foreign bodies should also be considered for removal using a cryoprobe, regardless of the water content of the material.
RESPIROLOGY CASE REPORTS
(2021)
Article
Respiratory System
Hiroshi Ishimoto, Noriho Sakamoto, Hirokazu Yura, Atsuko Hara, Takashi Kido, Hiroyuki Yamaguchi, Kazuko Yamamoto, Yasushi Obase, Yuji Ishimatsu, Minoru Satoh, Hiroshi Mukae
Summary: This article presents a case of exacerbation of respiratory failure in a patient diagnosed with anti-ARS antibody-positive interstitial pneumonia due to treatment with steroids and immunosuppressive agents. Further examination revealed misdiagnosis of this patient and a subsequent diagnosis of autoimmune pulmonary alveolar proteinosis. Therefore, physicians should reconsider the diagnosis and include pulmonary alveolar proteinosis in the differential diagnosis when interstitial pneumonia worsens with immunosuppressive treatment.
BMC PULMONARY MEDICINE
(2022)
Article
Respiratory System
Koki Fukushima, Atsuko Hara, Takashi Kido, Rika Ono, Yoshiaki Zaizen, Yusuke Yamane, Hiroshi Ishimoto, Noriho Sakamoto, Junya Fukuoka, Hiroshi Mukae
Summary: We present a rare case of idiopathic pulmonary hemosiderosis recurrence in a 20-year-old Japanese man with childhood onset. This type of recurrence is uncommon in adults, and there is limited information available. Only five cases of this adult recurrent form have been reported, with features that are intermediary between childhood- and adult-onset IPH in terms of age and frequency of smoking history. Additionally, it was found that the anemia in this type of idiopathic pulmonary hemosiderosis is usually not severe, and a positive response to corticosteroid therapy is expected.
RESPIRATORY INVESTIGATION
(2022)
Article
Multidisciplinary Sciences
Masahiro Tahara, Noriho Sakamoto, Minoru Satoh, Hiroshi Ishimoto, Hirokazu Yura, Kei Yamasaki, Takashi Kido, Yoshihisa Fujino, Tomoko Hasegawa, Shin Tanaka, Kazuhiro Yatera, Hiroshi Mukae
Summary: Antibodies to Ro52, known as anti-Ro52, are commonly found in patients with idiopathic interstitial pneumonias (IIPs), and they are often present alongside other autoantibodies. Patients with anti-Ro52 have a higher likelihood of meeting the criteria for interstitial pneumonia with autoimmune features (IPAF), and they also frequently exhibit serological abnormalities and Raynaud's phenomenon.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Yasuhiro Tanaka, Kazuko Yamamoto, Shimpei Morimoto, Takeshi Nabeshima, Kayoko Matsushima, Hiroshi Ishimoto, Nobuyuki Ashizawa, Tatsuro Hirayama, Kazuaki Takeda, Hiroshi Gyotoku, Naoki Iwanaga, Shinnosuke Takemoto, Susumu Fukahori, Takahiro Takazono, Hiroyuki Yamaguchi, Takashi Kido, Noriho Sakamoto, Naoki Hosogaya, Shogo Akabame, Takashi Sugimoto, Hirotomo Yamanashi, Kosuke Matsui, Mai Izumida, Ayumi Fujita, Masato Tashiro, Takeshi Tanaka, Koya Ariyoshi, Akitsugu Furumoto, Kouichi Morita, Koichi Izumikawa, Katsunori Yanagihara, Hiroshi Mukae
Summary: This study investigated the outcomes of Japanese patients with mild COVID-19 and identified risk factors associated with hospitalization during isolation. The findings suggest that 80% of mild COVID-19 patients can safely isolate at home.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Microbiology
Ryo Ogata, Takashi Kido, Kazuaki Takeda, Kazuki Nemoto, Riko Heima, Mami Takao, Ritsuko Miyashita, Mutsumi Ozasa, Takatomo Tokito, Daisuke Okuno, Yuya Ito, Hirokazu Yura, Tomohiro Koga, Kunio Hashimoto, Shinnosuke Takemoto, Takahiro Takazono, Hiroshi Ishimoto, Noriho Sakamoto, Kazumasa Fukuda, Yuka Sasaki, Yasushi Obase, Yuji Ishimatsu, Kazuhiro Yatera, Koichi Izumikawa, Hiroshi Mukae
Summary: This article presents a case of disseminated Mycobacterium genavense infection initially diagnosed as sarcoidosis. The study reveals that M. genavense infection mimics systemic inflammatory diseases like sarcoidosis and is challenging to identify. The lack of standard treatment protocols highlights the limited understanding of this rare disease.
Review
Biochemistry & Molecular Biology
Noriho Sakamoto, Daisuke Okuno, Takatomo Tokito, Hirokazu Yura, Takashi Kido, Hiroshi Ishimoto, Yoshimasa Tanaka, Hiroshi Mukae
Summary: Idiopathic pulmonary fibrosis is a chronic lung disease characterized by a decline in lung function and poor prognosis. Type I collagen, a major component of the extracellular matrix, is a potential target for fibrosis treatment. HSP47, a collagen-binding protein, is increased in pulmonary fibrosis and has implications in the development of therapeutic strategies.
Article
Respiratory System
Hiroshi Ishimoto, Noriho Sakamoto, Mutsumi Ozasa, Shin Tsutsui, Atsuko Hara, Takashi Kido, Hiroyuki Yamaguchi, Kazuko Yamamoto, Yasushi Obase, Yuji Ishimatsu, Hiroshi Mukae
Summary: A 60-year-old Japanese man with a history of heavy smoking presented to the hospital with gradually worsening dyspnea, and was diagnosed with desquamative interstitial pneumonia using transbronchial lung cryobiopsy. This is the first detailed report of such diagnosis.
RESPIRATORY MEDICINE CASE REPORTS
(2021)