Article
Gastroenterology & Hepatology
Mengli Yu, Xinjue He, Xin Song, Jianguo Gao, Jiaqi Pan, Tianyu Zhou, Qinqiu Wang, Wei Zhu, Huijian Ma, Hang Zeng, Chengfu Xu, Chaohui Yu
Summary: This study reveals that BGN plays a significant role in liver fibrosis by regulating ECM deposition and HSC activation through an HSP47-dependent mechanism. BGN may serve as a potential biomarker and therapeutic target for hepatic fibrosis.
LIVER INTERNATIONAL
(2023)
Article
Chemistry, Medicinal
Daisuke Okuno, Noriho Sakamoto, Mohammed S. O. Tagod, Yoshiko Akiyama, Sakiko Moriyama, Takuto Miyamura, Atsuko Hara, Takashi Kido, Hiroshi Ishimoto, Yuji Ishimatsu, Takashi Tanaka, Jun Ishihara, Kohsuke Takeda, Yoshimasa Tanaka, Hiroshi Mukae
Summary: The study prepared human HSP47 and established an inhibitor screening system. Among the compounds screened, three were found to effectively inhibit the function of HSP47, with epigallocatechin-3-O-gallate from tea leaves being one of them.
Review
Cell Biology
Willy Roque
Summary: This review examines the roles of specific heat shock proteins (HSPs), including HSP90, HSP70, and HSP47, in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Understanding the functions of these HSPs in the development of IPF can provide valuable insights for the future treatment and prevention of IPF.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Noriho Sakamoto, Daisuke Okuno, Takatomo Tokito, Hirokazu Yura, Takashi Kido, Hiroshi Ishimoto, Yoshimasa Tanaka, Hiroshi Mukae
Summary: Idiopathic pulmonary fibrosis is a chronic lung disease characterized by a decline in lung function and poor prognosis. Type I collagen, a major component of the extracellular matrix, is a potential target for fibrosis treatment. HSP47, a collagen-binding protein, is increased in pulmonary fibrosis and has implications in the development of therapeutic strategies.
Review
Pharmacology & Pharmacy
Pierre-Simon Bellaye, Olivier Burgy, Philippe Bonniaud, Martin Kolb
Summary: As a collagen-specific chaperon, HSP47 shows promising therapeutic potential in fibrosis. Preclinical models have demonstrated encouraging anti-fibrotic effects. Further evaluation of anti-HSP47 strategies in clinical trials is warranted.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2021)
Article
Respiratory System
Keishi Sugino, Hirotaka Ono, Natsumi Watanabe, Masahiro Ando, Eiyasu Tsuboi, Sakae Homma, Kazuma Kishi
Summary: The study compared the survival and disease progression of early-stage IPF patients with and without oxygen desaturation on the 6-minute walk test or increased GAP staging. The results showed that antifibrotic drugs have a beneficial effect on slowing the decline in forced vital capacity in early-stage IPF patients who exhibit oxygen desaturation or increased GAP staging.
BMC PULMONARY MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Young Jo Yoo, Seulgi Jeon, Hee Jin, Hee Yeon Won, Mi Gyeong Jeong, Yeseul Cho, Eun Sook Hwang, Younghwa Na, Jaeho Cho, Yun-Sil Lee
Summary: This study evaluated the anti-fibrotic effects of a novel HSP27 inhibitor, NA49, in preclinical models of pulmonary fibrosis. NA49 effectively suppressed fibrosis development in radiation and bleomycin-induced models, reduced fibrosis, inhibited EMT-related signaling pathways, and showed improved safety profiles compared to previous HSP27 inhibitors. These findings highlight the potential of NA49 as a promising candidate for the treatment of pulmonary fibrosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hanjing Sheng, Gang Lin, Shengxian Zhao, Weibin Li, Zhaolin Zhang, Weidong Zhang, Li Yun, Xiaoyang Yan, Hongyu Hu
Summary: This study evaluated the anti-fibrotic role of Piceatannol (PIC) in a mouse model of pulmonary fibrosis and found that PIC reduces the number of activated myofibroblasts by promoting autophagy. The study demonstrates for the first time the protective effects of PIC against pulmonary fibrosis and suggests its potential as a candidate compound for pulmonary fibrosis therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Yuji Iwanami, Kento Ebihara, Keiko Nakao, Naofumi Sato, Midori Miyagi, Yasuhiko Nakamura, Susumu Sakamoto, Kazuma Kishi, Sakae Homma, Satoru Ebihara
Summary: This study investigated the effect of pulmonary rehabilitation (PR) on patients with idiopathic pulmonary fibrosis (IPF) receiving antifibrotic drugs (AFDs). The results showed that PR can improve dyspnea and exercise tolerance, and may prevent or mitigate the side effects of AFDs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Panagiotis Paliogiannis, Sara Solveig Fois, Alessandro Giuseppe Fois, Antonio Cossu, Giuseppe Palmieri, Gianfranco Pintus
Summary: Idiopathic pulmonary fibrosis (IPF) and lung cancer share similarities in molecular, pathophysiological, and clinical aspects, with high mortality rates. Anti-fibrotic drugs like Nintedanib and Pirfenidone have potential for treating lung cancer, while novel targeted agents and immunotherapies may have anti-fibrotic properties. This suggests the possibility of using anti-fibrotic and anti-neoplastic drugs in combination for the treatment of these deadly diseases.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Benjamin Seeliger, Alfonso Carleo, Pedro David Wendel-Garcia, Jan Fuge, Ana Montes-Warboys, Sven Schuchardt, Maria Molina-Molina, Antje Prasse
Summary: This study characterized the metabolic and lipidomic changes in patients with idiopathic pulmonary fibrosis (IPF) compared to healthy volunteers and analyzed the changes in metabolomic profiles following treatment with nintedanib and pirfenidone. The results showed that specific lipidic metabolite signatures may serve as biomarkers for disease progression or favorable treatment response to nintedanib.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Respiratory System
Benjamin E. Decato, Diana Julie Leeming, Jannie Marie Bulow Sand, Aryeh Fischer, Shuyan Du, Scott M. Palmer, Morten Karsdal, Yi Luo, Anne Minnich
Summary: This study elucidated the antifibrotic mechanism of action for pharmacological LPA(1) blockade in IPF. BMS-986020 reduced serum ECM-neoepitope biomarkers and inhibited LPA(1)-induced fibrogenesis.
RESPIRATORY RESEARCH
(2022)
Article
Respiratory System
Hyogo Naoi, Yuzo Suzuki, Kazutaka Mori, Yuya Aono, Masato Kono, Hirotsugu Hasegawa, Koshi Yokomura, Yusuke Inoue, Hironao Hozumi, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Hidenori Nakamura, Takafumi Suda
Summary: Antifibrotic therapy may reduce the risk of lung cancer development in patients with idiopathic pulmonary fibrosis (IPF) and potentially prolong their survival.
Article
Biochemistry & Molecular Biology
Rong Zhou, Chaomei Jin, Linlin Jiao, Siyu Zhang, Mei Tian, Jiamin Liu, Songtai Yang, Wu Yao, Fang Zhou
Summary: This study found that HSP70 promoted the transition of BEAS-2B cells from epithelial to mesenchymal cells through the NF-kB/NOX4/ROS signaling pathway and reduced apoptosis of BEAS-2B cells induced by TGF-81. Furthermore, HSP70 attenuated pulmonary fibrosis progression in mice. These findings suggest that HSP70 could be a potential therapeutic strategy for lung fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Critical Care Medicine
Bhavika Kaul, Joyce S. Lee, Laura A. Petersen, Charles McCulloch, Ivan O. Rosas, Venkata D. Bandi, Ning Zhang, Alison M. DeDent, Harold R. Collard, Mary A. Whooley
Summary: Among 14,792 veterans with IPF, 17% received antifibrotic medications. Factors associated with lower uptake include female sex, Black race, rural residence, and receiving IPF diagnosis outside the VA healthcare system. Interventions to address these disparities in antifibrotic utilization rates among veterans with IPF warrant further investigation.
Article
Respiratory System
Maki Asami-Noyama, Misa Harada, Kaori Murakawa, Junki Suizu, Keita Murakawa, Ayumi Chikumoto, Kazuki Hamada, Yoriyuki Murata, Keiji Oishi, Yoshikazu Yamaji, Nobutaka Edakuni, Tsunahiko Hirano, Tomoyuki Kakugawa, Kazuto Matsunaga
Summary: In immunocompromised patients familiar with gardening, careful medical interviews and attention to sputum color and gardening habits are crucial for diagnosing and providing targeted therapy for non-pneumophila Legionella species pneumonia, even if the urine Legionella antigen test is negative.
RESPIROLOGY CASE REPORTS
(2021)
Article
Respiratory System
Masatoshi Hanada, Noriho Sakamoto, Hiroshi Ishimoto, Takashi Kido, Takuto Miyamura, Masato Oikawa, Hiroki Nagura, Rina Takeuchi, Yurika Kawazoe, Shuntaro Sato, S. Ahmed Hassan, Yuji Ishimatsu, Hideaki Takahata, Hiroshi Mukae, Ryo Kozu
Summary: This study assessed the accuracy of three sarcopenia screening tools in patients with interstitial lung disease. The study found that CalF is the most suitable tool for screening sarcopenia in these patients, while SARC-F and SARC-CalF are not.
BMC PULMONARY MEDICINE
(2022)
Article
Respiratory System
Hiroshi Ishimoto, Noriho Sakamoto, Hirokazu Yura, Atsuko Hara, Takashi Kido, Hiroyuki Yamaguchi, Kazuko Yamamoto, Yasushi Obase, Yuji Ishimatsu, Minoru Satoh, Hiroshi Mukae
Summary: This article presents a case of exacerbation of respiratory failure in a patient diagnosed with anti-ARS antibody-positive interstitial pneumonia due to treatment with steroids and immunosuppressive agents. Further examination revealed misdiagnosis of this patient and a subsequent diagnosis of autoimmune pulmonary alveolar proteinosis. Therefore, physicians should reconsider the diagnosis and include pulmonary alveolar proteinosis in the differential diagnosis when interstitial pneumonia worsens with immunosuppressive treatment.
BMC PULMONARY MEDICINE
(2022)
Article
Biology
Lingyun Feng, Jun Weng, Chenguang Yao, Ruyuan Wang, Ning Wang, Yilei Zhang, Yoshimasa Tanaka, Li Su
Summary: In this study, we found that high expression of SIPA1 in breast cancer can enhance macrophage infiltration through extracellular vesicles (EVs) enriched with myosin-9, leading to increased malignancy of the tumor.
Article
Respiratory System
Koki Fukushima, Atsuko Hara, Takashi Kido, Rika Ono, Yoshiaki Zaizen, Yusuke Yamane, Hiroshi Ishimoto, Noriho Sakamoto, Junya Fukuoka, Hiroshi Mukae
Summary: We present a rare case of idiopathic pulmonary hemosiderosis recurrence in a 20-year-old Japanese man with childhood onset. This type of recurrence is uncommon in adults, and there is limited information available. Only five cases of this adult recurrent form have been reported, with features that are intermediary between childhood- and adult-onset IPH in terms of age and frequency of smoking history. Additionally, it was found that the anemia in this type of idiopathic pulmonary hemosiderosis is usually not severe, and a positive response to corticosteroid therapy is expected.
RESPIRATORY INVESTIGATION
(2022)
Article
Multidisciplinary Sciences
Masahiro Tahara, Noriho Sakamoto, Minoru Satoh, Hiroshi Ishimoto, Hirokazu Yura, Kei Yamasaki, Takashi Kido, Yoshihisa Fujino, Tomoko Hasegawa, Shin Tanaka, Kazuhiro Yatera, Hiroshi Mukae
Summary: Antibodies to Ro52, known as anti-Ro52, are commonly found in patients with idiopathic interstitial pneumonias (IIPs), and they are often present alongside other autoantibodies. Patients with anti-Ro52 have a higher likelihood of meeting the criteria for interstitial pneumonia with autoimmune features (IPAF), and they also frequently exhibit serological abnormalities and Raynaud's phenomenon.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Respiratory System
Maki Asami-Noyama, Misa Harada, Yukari Hisamoto, Taiga Kobayashi, Keiji Oishi, Nobutaka Edakuni, Tsunahiko Hirano, Tomoyuki Kakugawa, Kazuto Matsunaga
Summary: SARS-CoV-2 infection causes excessive vasodilation in the vascular endothelium, leading to increased blood flow in lung lesions at the base of the lung, resulting in V/Q mismatch and the platypnea-orthodeoxia syndrome.
RESPIROLOGY CASE REPORTS
(2022)
Article
Medicine, General & Internal
Yasuhiro Tanaka, Kazuko Yamamoto, Shimpei Morimoto, Takeshi Nabeshima, Kayoko Matsushima, Hiroshi Ishimoto, Nobuyuki Ashizawa, Tatsuro Hirayama, Kazuaki Takeda, Hiroshi Gyotoku, Naoki Iwanaga, Shinnosuke Takemoto, Susumu Fukahori, Takahiro Takazono, Hiroyuki Yamaguchi, Takashi Kido, Noriho Sakamoto, Naoki Hosogaya, Shogo Akabame, Takashi Sugimoto, Hirotomo Yamanashi, Kosuke Matsui, Mai Izumida, Ayumi Fujita, Masato Tashiro, Takeshi Tanaka, Koya Ariyoshi, Akitsugu Furumoto, Kouichi Morita, Koichi Izumikawa, Katsunori Yanagihara, Hiroshi Mukae
Summary: This study investigated the outcomes of Japanese patients with mild COVID-19 and identified risk factors associated with hospitalization during isolation. The findings suggest that 80% of mild COVID-19 patients can safely isolate at home.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Lingyun Feng, Lijuan Guo, Yoshimasa Tanaka, Li Su
Summary: sEVs are important mediators in cell-to-cell communication and play a crucial role in cancer development and progression. Tumor-derived sEVs regulate processes such as proliferation, metastasis, drug resistance, and immunosuppression, and have a significant impact on the tumor microenvironment. They have the potential to be used as biomarkers and therapeutic targets for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Yoshikazu Yamaji, Tsunahiko Hirano, Hiromasa Ogawa, Ayumi Fukatsu-Chikumoto, Kazuki Matsuda, Kazuki Hamada, Shuichiro Ohata, Ryo Suetake, Yoriyuki Murata, Keiji Oishi, Maki Asami-Noyama, Nobutaka Edakuni, Tomoyuki Kakugawa, Kazuto Matsunaga
Summary: Sedentary behavior has been found to predict mortality in patients with COPD. However, assessing activity levels in these patients can be challenging due to their avoidance of shortness of breath. The SOBDA-Q, a modified questionnaire, offers a measure of shortness of breath by assessing low-intensity activities in daily life. This study found that CAT and all domains of the SOBDA-Q were significantly correlated with physical activity levels in COPD patients, and combining these domains helped identify patients with sedentary COPD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Yoriyuki Murata, Tsunahiko Hirano, Keiko Doi, Ayumi Fukatsu-Chikumoto, Kazuki Hamada, Keiji Oishi, Tomoyuki Kakugawa, Masafumi Yano, Kazuto Matsunaga
Summary: Physical inactivity is associated with poor prognosis in COPD and is related to lung hyperinflation. This study examined the association between physical activity and the E/I ratio of MLD, the imaging biomarker of resting lung hyperinflation. The results showed that COPD patients had higher E/I-MLD than healthy subjects, and sedentary COPD patients had higher E/I-MLD than non-sedentary patients. E/I-MLD > 0.980 can predict sedentary behavior in COPD patients. In conclusion, higher E/I-MLD scores are associated with sedentary behavior and can be a useful imaging biomarker for the early detection of physical inactivity in COPD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Tomoyuki Kakugawa, Keiko Doi, Yuichi Ohteru, Hiroyuki Kakugawa, Keiji Oishi, Masahiro Kakugawa, Tsunahiko Hirano, Yusuke Mimura, Kazuto Matsunaga
Summary: This study investigated the immune response of long-term care facility (LTCF) residents following COVID-19 vaccination and found that factors such as older age, poor performance status, and hypoalbuminemia were associated with a lower humoral immune response. LTCF residents had lower anti-spike IgG levels and neutralizing activity compared to other participants over 24 weeks after vaccination, but booster vaccination helped improve their immune response.
Review
Microbiology
Ryo Ogata, Takashi Kido, Kazuaki Takeda, Kazuki Nemoto, Riko Heima, Mami Takao, Ritsuko Miyashita, Mutsumi Ozasa, Takatomo Tokito, Daisuke Okuno, Yuya Ito, Hirokazu Yura, Tomohiro Koga, Kunio Hashimoto, Shinnosuke Takemoto, Takahiro Takazono, Hiroshi Ishimoto, Noriho Sakamoto, Kazumasa Fukuda, Yuka Sasaki, Yasushi Obase, Yuji Ishimatsu, Kazuhiro Yatera, Koichi Izumikawa, Hiroshi Mukae
Summary: This article presents a case of disseminated Mycobacterium genavense infection initially diagnosed as sarcoidosis. The study reveals that M. genavense infection mimics systemic inflammatory diseases like sarcoidosis and is challenging to identify. The lack of standard treatment protocols highlights the limited understanding of this rare disease.
Review
Biochemistry & Molecular Biology
Noriho Sakamoto, Daisuke Okuno, Takatomo Tokito, Hirokazu Yura, Takashi Kido, Hiroshi Ishimoto, Yoshimasa Tanaka, Hiroshi Mukae
Summary: Idiopathic pulmonary fibrosis is a chronic lung disease characterized by a decline in lung function and poor prognosis. Type I collagen, a major component of the extracellular matrix, is a potential target for fibrosis treatment. HSP47, a collagen-binding protein, is increased in pulmonary fibrosis and has implications in the development of therapeutic strategies.
Review
Immunology
Yoshimasa Tanaka, Megumi Nishikawa, Kaho Kamisaki, Saki Hachiya, Moeka Nakamura, Takahiro Kuwazuru, Susumu Tanimura, Kiyoshi Soyano, Kohsuke Takeda
Summary: Marine-derived biomolecules from Nagasaki prefecture are receiving increasing attention as potential therapeutics for autoimmune diseases. The development of an original marine microbial extract library and shark nanobodies holds promise for highly specific, stable, effective, and inexpensive biotherapeutics.
INFLAMMATION AND REGENERATION
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
