Article
Chemistry, Medicinal
Tatsuki Koike, Masato Yoshikawa, Haruhi Kamisaki Ando, William Farnaby, Toshiya Nishi, Etsurou Watanabe, Jason Yano, Maki Miyamoto, Shigeru Kondo, Tsuyoshi Ishii, Takanobu Kuroita
Summary: The study reports the development of novel CH24H inhibitors through structure-based drug design, with 3v identified as a highly potent, selective, and brain-penetrant inhibitor. This compound is currently under clinical investigation as a novel drug class for epilepsy treatment.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Yasuomi Urano, Shoya Osaki, Ren Chiba, Noriko Noguchi
Summary: The accumulation of 24S-OHC esters caused phosphorylation of eIF2 alpha, dissociation of polysomes, and formation of stress granules (SG), resulting in robust downregulation of global protein de novo synthesis in human neuroblastoma SH-SY5Y cells.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Wassim Guidara, Meriam Messedi, Manel Maalej, Manel Naifar, Walid Khrouf, Sahar Grayaa, Mohamed Maalej, Dominique Bonnefont-Rousselot, Foudil Lamari, Fatma Ayadi
Summary: The study found that patients with bipolar disorder showed altered levels of specific oxysterols in plasma, with a significant decrease in 24-hydroxycholesterol. Additionally, 24-OHC was negatively correlated with MAS subscale score and age in patients. Multivariate analysis revealed that acute decompensation in BD was independently associated with elevated plasma 24-OHC levels. However, further investigation is needed to determine the relevance of 24-OHC as a biomarker for this disease.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alejandro O. Sodero
Summary: The production and elimination of 24S-HC in the brain is discussed, followed by a focus on how this oxysterol affects various aspects of cellular function and disease progression at the cellular level.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Yuqin Wang, Eylan Yutuc, William J. Griffiths
Summary: The brain is rich in cholesterol and oxysterols, which interact with various receptors to transmit biological signals, playing important roles during development and in later life.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gabriella Testa, Serena Giannelli, Barbara Sottero, Erica Staurenghi, Giorgio Giaccone, Paola Caroppo, Paola Gamba, Gabriella Leonarduzzi
Summary: The study suggests that 24-OHC contributes to the degradation of tau protein through the up-regulation of the SIRT1/PGC1 alpha/Nrf2 axis, highlighting the potential role of these factors in neuroprotection and the importance of avoiding 24-OHC loss in the AD brain.
Article
Biochemistry & Molecular Biology
Felix Oestereich, Noosha Yousefpour, Ethan Yang, Jasmine Phenix, Zari Saadati Nezhad, Albert Nitu, Antonio Vazquez Coba, Alfredo Ribeiro-da-Silva, Pierre Chaurand, Lisa Marie Munter
Summary: CETP activity affects brain health by modulating cholesterol distribution and clearance. CETPtg mice provide a valuable research tool for investigating the impact of cholesterol metabolism on brain function.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Clinical Neurology
Nicholas M. Vogt, Jack F. Hunt, Yue Ma, Carol A. Van Hulle, Nagesh Adluru, Richard J. Chappell, Karen K. Lazar, Laura E. Jacobson, Benjamin P. Austin, Sanjay Asthana, Sterling C. Johnson, Barbara B. Bendlin, Cynthia M. Carlsson
Summary: Treatment with simvastatin in healthy middle-aged adults resulted in preserved white matter microstructure and volume at 18 months. The reduction in serum total cholesterol partially mediated the effect, suggesting both peripheral and central mechanisms are involved. Further studies are needed to determine the persistence of these effects and potential cognitive outcomes.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Pharmacology & Pharmacy
Anthony W. Harrington, Changlu Liu, Naomi Phillips, Diane Nepomuceno, Chester Kuei, Joseph Chang, Weixuan Chen, Steven W. Sutton, Daniel O'Malley, Ly Pham, Xiang Yao, Siquan Sun, Pascal Bonaventure
Summary: The study suggests that oxysterols, including 24S-HC, could be physiological activators for GPR17, regulating oligodendrocyte progenitor cell differentiation and myelination through receptor activation.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Neurosciences
Gabriela L. L. Martins, Claudia N. Ferreira, Andras Palotas, Natalia P. Rocha, Helton J. J. Reis
Summary: Alzheimer's disease (AD) is a complex clinical condition with multifactorial origin that poses a major burden to health care systems worldwide. Both central and peripheral inflammation, particularly the activation of the NLRP3 inflammasome, has been implicated in AD. Dyslipidemia, as a risk factor for dementia, and its association with cholesterol and oxysterols are also speculated to be involved in AD pathology. This review explores the potential role of NLRP3 activation by nuclear receptors, mediated by oxysterols, as a pharmacological avenue in dementia.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Daniela Rojas, Serine Benachenhou, Asma Laroui, Amira Abdourahim Aden, Armita Abolghasemi, Luc Galarneau, Taratibu Janviere Irakoze, Rosalie Plantefeve, Sophie Bouhour, Amanda Toupin, Francois Corbin, Guy Fink, Pierre-Luc Mallet, Artuela Caku
Summary: Accurate quantification of 24(S)-hydroxycholesterol and 27-hydroxycholesterol is of significant biological importance due to their involvement in crucial cellular processes and their potential as disease biomarkers. By developing and validating a liquid chromatography coupled to tandem mass spectrometry method, we have successfully overcome the challenges of low concentrations and similarities in molecular structures, allowing consistent and reliable quantification of these oxysterols in human plasma.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jie Du, Xiaodong Chen, Yongshun Zhao, Tingting Zhao, Dalong Wang, Zujia Chen, Changyuan Wang, Qiang Meng, Jialin Yao, Huijun Sun, Kexin Liu, Jingjing Wu
Summary: This study investigated the inhibitory effects of sesame lignans on CYP46A1 activity. The results showed that sesamin and sesamolin competitively inhibited CYP46A1, while sesamol produced non-competitive inhibition. Additionally, sesame lignans could reduce cholesterol levels and regulate protein expression, indicating their potential therapeutic role in treating excitatory neurotoxicity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pediatrics
Amanda M. Dave, Eric S. Peeples
Summary: Neonatal encephalopathy (NE) may involve aberrations in cholesterol metabolism, similar to certain adult diseases. The cholesterol pathways have potential as targets for novel therapeutic interventions, with cholesterol metabolites possibly serving as biomarkers for injury. Gaps in current literature were identified for future studies to explore the interactions between cholesterol pathways and NE.
PEDIATRIC RESEARCH
(2021)
Article
Neurosciences
Emanuele Porru, Erik Edstrom, Lisa Arvidsson, Adrian Elmi-Terander, Alexander Fletcher-Sandersjoo, Anita Lovgren Sandblom, Magnus Hansson, Frida Duell, Ingemar Bjorkhem
Summary: This study investigates the potential use of oxysterols as biomarkers in iNPH. The results show that VP-shunt treatment significantly increases the levels of 7HOCA and 24S-hydroxycholesterol in CSF. The study also suggests that CSF drainage may alleviate the inhibitory effect of transiently increased pressure on the metabolic capacity of neuronal cells in the brain.
Article
Endocrinology & Metabolism
Lucia Baila-Rueda, Ana Cenarro, Itziar Lamiquiz-Moneo, Victoria Marco-Benedi, Irene Gracia-Rubio, Maria Carmen Casamayor-Franco, Jose M. Arbones-Mainar, Fernando Civeira, Martin Laclaustra
Summary: This study found that cholesterol and oxidized metabolites in adipose tissue are associated with metabolic characteristics. Insulin is positively correlated with hydroxycholesterol, and leptin is also positively correlated with hydroxycholesterol. There is a positive correlation between tissue cholesterol and hydroxycholesterol.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Geriatrics & Gerontology
Manuel Montero-Odasso, Quincy J. Almeida, Louis Bherer, Amer M. Burhan, Richard Camicioli, Julien Doyon, Sarah Fraser, Susan Muir-Hunter, Karen Z. H. Li, Teresa Liu-Ambrose, William McIlroy, Laura Middleton, Jose A. Morais, Ryota Sakurai, Mark Speechley, Akshya Vasudev, Olivier Beauchet, Jeffrey M. Hausdorff, Caterina Rosano, Stephanie Studenski, Joe Verghese
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2019)
Article
Neurosciences
Andrea L. Rosso, Andrea L. Metti, Kimberly Faulkner, Mark Redfern, Kristine Yaffe, Lenore Launer, C. Elizabeth Shaaban, Neelesh K. Nadkarni, Caterina Rosano
JOURNAL OF ALZHEIMERS DISEASE
(2019)
Article
Sport Sciences
C. Elizabeth Shaaban, Howard Jay Aizenstein, Dana R. Jorgensen, Rebecca L. M. Mahbubani, Nicole A. Meckes, Kirk Erickson, Nancy W. Glynn, Joseph Mettenburg, Jack Guralnik, Anne B. Newman, Tamer S. Ibrahim, Paul J. Laurienti, Abbe N. Vallejo, Caterina Rosano
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2019)
Article
Geriatrics & Gerontology
Cindy K. Barha, John R. Best, Caterina Rosano, Kristine Yaffe, Janet M. Catov, Teresa Liu-Ambrose
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2020)
Article
Geriatrics & Gerontology
Stephen F. Smagula, Lana Chahine, Andrea Metti, Anusha Rangarajan, Howard J. Aizenstein, Qu Tian, Caterina Rosano
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2020)
Article
Geriatrics & Gerontology
Marco Inzitari, Andrea Metti, Caterina Rosano, Cristina Udina, Laura M. Perez, Gabriela Carrizo, Joe Verghese, Anne B. Newman, Stephanie Studenski, Andrea L. Rosso
EXPERIMENTAL GERONTOLOGY
(2019)
Article
Geriatrics & Gerontology
Caterina Rosano, Andrea L. Metti, Andrea L. Rosso, Stephanie Studenski, Nicolaas Bohnen
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2020)
Editorial Material
Geriatrics & Gerontology
Caterina Rosano
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2020)
Article
Geriatrics & Gerontology
Nikki L. DiSalvio, Caterina Rosano, Howard J. Aizenstein, Mark S. Redfern, Joseph M. Furman, J. Richard Jennings, Susan L. Whitney, Patrick J. Sparto
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2020)
Article
Clinical Neurology
Patrick J. Sparto, Andrea L. Rosso, Ayushi A. Divecha, Andrea L. Metti, Caterina Rosano
ALZHEIMERS & DEMENTIA
(2020)
Article
Clinical Neurology
Cameron Miller-Patterson, Jennifer Han, Kristine Yaffe, Andrea L. Rosso, Lenore J. Launer, Stephen B. Kritchevsky, Robert M. Boudreau, Caterina Rosano
PARKINSONISM & RELATED DISORDERS
(2020)
Article
Geriatrics & Gerontology
Tiffany F. Hughes, Joanne C. Beer, Erin Jacobsen, Mary Ganguli, Chung-Chou H. Chang, Caterina Rosano
EXPERIMENTAL GERONTOLOGY
(2020)
Letter
Geriatrics & Gerontology
Qu Tian, Nancy W. Glynn, Rebecca C. Ehrenkranz, Briana N. Sprague, Andrea L. Rosso, Caterina Rosano
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2020)
Article
Medicine, General & Internal
Qu Tian, Susan M. Resnick, Michelle M. Mielke, Kristine Yaffe, Lenore J. Launer, Palmi V. Jonsson, Giulia Grande, Anna-Karin Welmer, Erika J. Laukka, Stefania Bandinelli, Antonio Cherubini, Caterina Rosano, Stephen B. Kritchevsky, Eleanor M. Simonsick, Stephanie A. Studenski, Luigi Ferrucci
Article
Geriatrics & Gerontology
Robyn E. Massa, Andrea Rosso, Andrea L. Metti, Patrick J. Sparto, Howard Aizenstein, Luigi Ferrucci, Ayushi Divecha, Caterina Rosano
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2019)