期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 19, 期 4, 页码 1371-1376出版社
IOS PRESS
DOI: 10.3233/JAD-2010-1332
关键词
A beta Autoantibody; Alzheimer's disease; biomarker; cholesterol; type 2 diabetes mellitus
资金
- 21C Frontier Functional Proteomics Project [FPR08K1301-002210]
- WCU [R11-2002-097-08001]
- Basic Research Program [2008-05943]
- Ministry of Health, Welfare and Family Affair, Korea [00-PJ3-PG6-GN07-001]
Increasing evidence suggests that type 2 diabetes mellitus (T2DM) is strongly correlated with Alzheimer's disease (AD). To examine the relationship between T2DM and AD, autoantibodies against amyloid-A beta were measured in the serum of T2DM patients and age-matched controls. Levels of A beta autoantibody were measured by ELISA in serum samples of T2DM patients (n = 92) and age-matched control group (n = 106). A beta autoantibody levels were increased in T2DM compared with age-matched controls by 45.4 +/- 8.1% (p < 0.001). Females had higher A beta autoantibody levels than males in both T2DM and control group. A beta autoantibody levels in the T2DM group were positively correlated with the levels of cholesterol (p = 0.011), low density lipoprotein cholesterol (p = 0.020), and triglycerides (p = 0.039). In conclusion, the level of A beta autoantibody is dramatically elevated in patient serum of T2DM, and, as such, might be used as a possible biomarker for T2DM.
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