Article
Critical Care Medicine
Ryan C. Murphy, Ying Lai, Matthew Liu, Taha Al-Shaikhly, Matthew C. Altman, William A. Altemeier, Charles W. Frevert, Jason S. Debley, Adrian M. Piliponsky, Steven F. Ziegler, Sina A. Gharib, Teal S. Hallstrand
Summary: This study identified differentially expressed genes associated with exercise-induced bronchoconstriction in individuals with asthma using RNA-sequencing analysis. Experiments suggested that the interactions between airway epithelial cells, mast cells, and eosinophils are closely associated with indirect airway hyperresponsiveness and play a critical role in modulating airway inflammation.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Medicine, General & Internal
Shih-Lung Cheng
Summary: Despite advancements in understanding asthma pathophysiology, a subgroup of patients remains unresponsive to standard treatments. Omalizumab, a monoclonal antibody targeting IgE, has shown efficacy in treating moderate-to-severe asthma and chronic idiopathic urticaria. Future research may focus on optimal treatment duration and predicting treatment response through biomarkers.
Article
Pharmacology & Pharmacy
Brandon W. Lewis, Maria L. Ford, Aiman Q. Khan, Joshua Walum, Rodney D. Britt
Summary: Type 2-high severe asthma is a distinct subtype characterized by Th2 inflammation, high eosinophil lung infiltration, impaired lung function, and reduced corticosteroid sensitivity. Acute and chronic allergen models induce type 2 inflammation, but the differences in corticosteroid sensitivity remain unclear. This study found that chronic allergen exposure is associated with more persistent type 2 immune responses and corticosteroid insensitivity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Luigino Calzetta, Marina Aiello, Annalisa Frizzelli, Giuseppina Bertorelli, Beatrice Ludovica Ritondo, Paola Rogliani, Alfredo Chetta
Summary: AHR is a central pathophysiological feature of asthma, involving ASM with pro-inflammatory and immunomodulatory actions. mAbs target various inflammatory mediators to modulate ASM contractility, showing potential in treating severe asthma by preventing AHR.
Review
Pharmacology & Pharmacy
Mojdeh Matloubi, Latifa Koussih, Lianyu Shan, Chelsea Lukawy, Abdelilah S. Gounni
Summary: Asthma is a heterogeneous airway disease characterized by airway inflammation and remodeling, affecting more than 300 million people worldwide and posing a significant burden on society. Semaphorin3E, a critical molecule in lung pathophysiology, plays a role in both lung development and homeostasis. Recent studies have demonstrated that the Semaphorin3E-plexinD1 axis is implicated in asthma, impacting inflammatory and structural cells associated with airway inflammation, tissue remodeling, and airway hyperresponsiveness. This review highlights the potential role of the Semaphorin3E-plexinD1 axis as a therapeutic target in airway allergic diseases.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Chi-Chien Lin, Kai-Cheng Chuang, Shih-Wei Chen, Ya-Hsuan Chao, Chih-Ching Yen, Shang-Hsun Yang, Wei Chen, Kuang-Hsi Chang, Yu-Kang Chang, Chuan-Mu Chen
Summary: Lactoferrin exhibits anti-inflammation and immunoregulation activities in OVA-induced allergic asthma, ameliorating lung injury, decreasing Th2 cytokines and allergen-specific antibodies production, and influencing the functions of dendritic cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wei Li, Lu Xue, Changsi Peng, Ping Zhao, Yongbo Peng, Weiwei Chen, Wenyi Wang, Jinhua Shen
Summary: PP121 exerts dual anti-contractile and anti-inflammatory effects in asthma treatment by blocking specific ion channels and downregulating inflammatory factors, mucins, and the MAPK/Akt signaling pathway in asthmatic mice, suggesting it as a promising therapeutic compound for asthma therapy.
MOLECULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Jorge Reyes-Garcia, Abril Carbajal-Garcia, Luis M. Montano
Summary: Transient receptor potential (TRP) ion channels, particularly TRPV1, TRPV2, and TRPV4, play critical roles in the development of asthma. These channels contribute to environmental sensitization, airway inflammation, airway hyperresponsiveness, and remodeling, and may serve as novel therapeutic targets for asthma.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Allergy
Morten Hvidtfeldt, Asger Sverrild, Alexis Pulga, Laurits Frossing, Alexander Silberbrandt, Morten Hostrup, Martin Thomassen, Caroline Sanden, Carl Magnus Clausson, Premkumar Siddhuraj, Daisy Bornesund, Juan Jose Nieto-Fontarigo, Lena Uller, Jonas Erjefalt, Celeste Porsbjerg
Summary: This study investigated the relationship between airway hyperresponsiveness and infiltrating mast cells, as well as the effectiveness of inhaled corticosteroid treatment. The results showed that inhaled corticosteroid treatment significantly improved airway hyperresponsiveness in both patients with high fractional exhaled nitric oxide (FENO) and patients with low FENO. However, there were differences in mast cell phenotypes and distribution between the two groups.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Plamen Bokov, Donies Jallouli-Masmoudi, Flore Amat, Veronique Houdouin, Christophe Delclaux
Summary: The study found that parameters related to small airway dysfunction are linked to asthma probability, but are unable to differentiate wheezing phenotypes. Lung function parameters obtained from impulse oscillometry and asthma probability belong to independent dimensions of the wheezing disease.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Immunology
Cancan Zhang, Huisha Xu, Keilah G. Netto, Leon A. Sokulsky, Yiyan Miao, Zhongyuan Mo, Yan Meng, Yingying Du, Chengyong Wu, Liyou Han, Lirong Zhang, Chi Liu, Guojun Zhang, Fuguang Li, Ming Yang
Summary: In this study, the therapeutic potential of GGsTop, a γ-glutamyl transferase inhibitor, on acute asthma exacerbations was investigated using a murine model. The results showed that GGsTop significantly attenuated hallmark features of asthma exacerbation, including airway hyperresponsiveness, mucus hypersecretion, collagen deposition, and expression of inflammatory cytokines. Furthermore, GGsTop restored the level of glutathione and inhibited the activation of the LPS/NFκB signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Amlan Chakraborty, Anita A. Pinar, Maggie Lam, Jane E. Bourke, Simon G. Royce, Cordelia Selomulya, Chrishan S. Samuel
Summary: This study conjugated relaxin to nanoparticles and delivered them intranasally to a preclinical rodent model of chronic allergic airways disease and collagen gel contraction from asthma patient-derived myofibroblasts, showing potential anti-remodeling and anti-inflammatory effects, which could be important for treating the central features of asthma.
Article
Pediatrics
Francois Galode, O. Ladipo, A. Andrieux, H. Feghali, S. Bui, Michael Fayon
Summary: The study found that wheezing and a positive bronchodilatory response are common in children with CF, with wheezing potentially impacting lung function negatively. Predictive markers of wheezing and differences in respiratory function affect bronchodilatory responses in children of different age groups.
FRONTIERS IN PEDIATRICS
(2022)
Article
Physiology
Ryan C. Murphy, Ying Lai, James D. Nolin, Robier A. Aguillon Prada, Arindam Chakrabarti, Michael Novotny, Michael C. Seeds, William A. Altemeier, Michael H. Gelb, Robert Duncan Hite, Teal S. Hallstrand
Summary: Exercise challenge induces alterations in airway phospholipid structure and eicosanoid release in asthma, promoting bronchoconstriction, particularly in individuals with EIB who have higher basal levels of phospholipid turnover.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Respiratory System
Oliver Djurhuus Tupper, Charlotte Suppli Ulrik
Summary: This study aimed to explore long-term predictors of severe exacerbations and mortality in adults with well-characterised asthma. The results showed that increasing age, smoking history, decreased lung function, high blood eosinophils, prolonged symptom duration, and frequent use of reliever medication were predictors of asthma-related death and repeated severe exacerbations. Improving asthma control, including lung function and reducing the use of reliever medication, is crucial for enhancing the long-term outcome of asthma.
RESPIRATORY RESEARCH
(2021)
Editorial Material
Medicine, General & Internal
T. Horino, S. Inotani, K. Takamatsu, H. Ohnishi, M. Komori, Y. Terada
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2022)
Editorial Material
Medicine, General & Internal
T. Horino, S. Inotani, H. Nakajima, H. Ohnishi, M. Komori, Y. Terada
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2022)
Editorial Material
Rheumatology
Taro Horino, Satoko Ohmi, Satoshi Inotani, Hideki Nakajima, Hiroshi Ohnishi, Masahiro Komori, Osamu Ichii, Yoshio Terada
Editorial Material
Rheumatology
Taro Horino, Satoshi Inotani, Hideki Nakajima, Hiroshi Ohnishi, Masahiro Komori, Osamu Ichii, Yoshio Terada
LANCET RHEUMATOLOGY
(2023)
Letter
Allergy
Mayuka Yamane, Hiroshi Ohnishi, Kimiko Tsuji, Kazuki Anabuki, Akihito Yokoyama
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
Editorial Material
Critical Care Medicine
Yu Nakatani, Hiroshi Ohnishi, Junki Terada, Akihito Yokoyama
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Editorial Material
Rheumatology
Taro Horino, Hiroshi Ohnishi, Masahiro Komori, Yoshio Terada
Article
Respiratory System
Hiroshi Ohnishi, Masafumi Okazaki, Kazuki Anabuki, Shin Akita, Shigeo Kawase, Kimiko Sakai Tsuji, Mitsuhiko Miyamura, Akihito Yokoyama
Summary: This study retrospectively assessed the electronic medical records of 161 patients and found that 24.2% of patients had incorrect use of a pMDI. Advanced age and decreased lung capacity were associated with the incorrect use. A large-scale prospective study is needed to confirm these findings.
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY
(2023)
Letter
Rheumatology
Taro Horino, Hiroshi Ohnishi, Masahiro Komori, Yoshio Terada
Editorial Material
Medicine, General & Internal
Hiroshi Ohnishi, Yu Arakawa, Kazuki Anabuki, Akihito Yokoyama
Article
Medicine, General & Internal
Yuichi Baba, Toru Kubo, Yuri Ochi, Takayoshi Hirota, Naohito Yamasaki, Hiroshi Ohnishi, Tetsuya Kubota, Akihito Yokoyama, Hiroaki Kitaoka
Summary: This study retrospectively evaluated the prognostic factors associated with cardiovascular events in patients with systemic sarcoidosis. The results showed that high-sensitivity cardiac troponin T (hs-cTnT) is a useful biomarker for predicting cardiovascular events, even if cardiac involvement is not detected at the initial evaluation.
Article
Multidisciplinary Sciences
Kensuke Kataoka, Keishi Oda, Hajime Takizawa, Takashi Ogura, Atsushi Miyamoto, Yoshikazu Inoue, Shinobu Akagawa, Seishu Hashimoto, Tomoo Kishaba, Koji Sakamoto, Naoki Hamada, Kazuyoshi Kuwano, Masayuki Nakayama, Masahito Ebina, Noriyuki Enomoto, Yasunari Miyazaki, Kenichiro Atsumi, Shinyu Izumi, Yoshinori Tanino, Hiroshi Ishii, Hiroshi Ohnishi, Takafumi Suda, Yasuhiro Kondoh
Summary: While high-level evidence is lacking, supplemental oxygen has been shown to have value in improving the clinical course and survival of patients with idiopathic pulmonary fibrosis and other interstitial lung diseases. Factors such as low BMI, low pulmonary function, low oxygen saturation, short walking distance, and severe patient-reported symptoms are associated with poor prognosis.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Taro Horino, Hiroshi Ohnishi, Masahiro Komori, Yoshio Terada
Summary: This article reports a case of allergic reaction induced by clopidogrel, a widely prescribed anticoagulant drug. Through detailed medical history, chest CT, and gastroscopy, the patient was diagnosed with clopidogrel-induced hypereosinophilic syndrome.
ROMANIAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Taro Horino, Mitsuharu Yoshida, Satoshi Inotani, Kazuki Anabuki, Hiroshi Ohnishi, Masahiro Komori, Osamu Ichii, Yoshio Terada
Summary: This is a case of rheumatoid arthritis with anti-cyclic citrullinated peptide antibody-positive in a patient with Sjogren's syndrome, possibly related to bacterial organizing pneumonia.
ROMANIAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Medicine, General & Internal
Taro Horino, Masami Ogasawara, Takeshi Kashio, Satoshi Inotani, Masayuki Ishihara, Hiroshi Ohnishi, Masahiro Komori, Osamu Ichii, Yoshio Terada
Summary: Lupus-related protein-losing enteropathy and pseudo-pseudo Meigs' syndrome are rare complications in patients with systemic lupus erythematosus, sharing similar clinical features but having slight differences in treatment. This case presents a potential overlap between the two conditions, highlighting the importance of considering both in differential diagnosis for patients with marked ascites and elevated CA 125 levels.
ROMANIAN JOURNAL OF INTERNAL MEDICINE
(2022)