Article
Nanoscience & Nanotechnology
Francisco Ramirez-Cuevas, Kargal L. Gurunatha, Ivan P. Parkin, Ioannnis Papakonstantinou
Summary: This article presents a universal theory of averaged light scattering of randomly oriented objects, providing formulas for the absorption cross section, scattering cross section, and asymmetry parameter for objects of arbitrary shape. The proposed modeling framework is validated against optical measurements of polymer composite films. This work is important for understanding light-matter interactions in disordered systems and has applications in various fields.
Article
Optics
Jie Luo, Xun Li, Xinyuan Zhang, Jiajie Guo, Wei Liu, Yun Lai, Yaohui Zhan, Min Huang
Summary: The inverse design of nanoparticles is crucial for realizing cloaking, sensing, and functional devices. Traditional design processes are complex, but utilizing a well-trained deep-learning neural network can efficiently handle these issues, predict and inversely design the structure and material parameters of nanoparticles.
Article
Chemistry, Analytical
Federico Tommasi, Baptiste Auvity, Lorenzo Fini, Fabrizio Martelli, Stefano Cavalieri
Summary: Optical sensors research has been driven by the need for low-cost and non-invasive detection strategies. The invention of random lasers has provided opportunities for exploring new possibilities in sensing and amplification of signals. The improved setup using optical fibers, a reference sensor, and a peristaltic pump aims to enhance portability, stability, and ease of use in measuring liquid scattering.
Article
Chemistry, Multidisciplinary
Saurabh Kishen, Jinal Tapar, Naresh Kumar Emani
Summary: This study demonstrates through numerical simulations that electrically driven nano-strip tunnel junctions can achieve switchable and highly directional light emission. The emission can be tuned by changing the structure and periodicity of the sources, enabling wavelength-selective directional switching and paving the way for electrically driven, reconfigurable light sources.
NANOSCALE ADVANCES
(2022)
Article
Engineering, Multidisciplinary
Han Wu, Ji Xiong, Bing Han, ZiNan Wang, WeiLi Zhang, XinHong Jia, HouKun Liang
Summary: This paper proposes an ultra-high speed random bit generator based on a ytterbium-doped random fiber laser, achieving a physical random bit generation rate of 200 Gbps by utilizing chaotic signals and sampled signals. The combination of broadband emission and lack of time-delay signatures in random fiber lasers shows great potential for high performance random bit generation in cryptography and secure communication applications.
SCIENCE CHINA-TECHNOLOGICAL SCIENCES
(2021)
Article
Thermodynamics
Zhang Aoyu, Wang Fuqiang, Dong Yan, Yang Dongling, Xie Weixin
Summary: Spectral radiative transfer between particles of dispersed particulate medium involves dependent scattering effects, but traditional criteria have limitations. To address this, a multi-particle averaging clearance method is proposed to reduce errors and extend the range of dependent scattering criteria.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2022)
Article
Physics, Applied
Junichi Iwata, Masaru Sakai, Kosei Ohashi, Kazuhiko Hara, Tetsuya Kouno
Summary: The photoluminescence properties of ZnO disordered nanocrystals fabricated by mist-CVD were investigated, and random lasing behavior was observed under high optically pumped conditions, indicating the potential usefulness of this technique for fabricating optical microcavities.
JAPANESE JOURNAL OF APPLIED PHYSICS
(2021)
Article
Physics, Applied
A. N. Giakoumaki, G. Coccia, V. Bharadwaj, J. P. Hadden, A. J. Bennett, B. Sotillo, R. Yoshizaki, P. Olivero, O. Jedrkiewicz, R. Ramponi, S. M. Pietralunga, M. Bollani, A. Bifone, P. E. Barclay, A. Kubanek, S. M. Eaton
Summary: Integrated photonic circuits with the ability to confine and manipulate light show promise for applications in quantum information and sensing technologies. The negatively charged nitrogen vacancy (NV-) diamond color center is a leading candidate as a spin-active quantum emitter, with the capability of optically reading its ground spin state and long coherence times at room temperature. The use of femtosecond laser writing allows for the fabrication of optical waveguides and NV complexes. This Perspective reviews the physical mechanisms of laser fabrication in diamond, analyzes the properties of waveguides, single- and ensemble-NV centers, and discusses the potential for their integration into photonic devices for quantum information and sensing.
APPLIED PHYSICS LETTERS
(2022)
Article
Nanoscience & Nanotechnology
Kentaro Nishida, Koki Sasai, Rongyang Xu, Te-Hsin Yen, Yu-Lung Tang, Junichi Takahara, Shi-Wei Chu
Summary: In this paper, we demonstrated the photothermal nonlinearities of a quasi-perfect absorbing silicon-based metasurface with lambda/7 thickness through theoretical and experimental approaches. Laser irradiation efficiently heats up the metasurface, which modulates the scattering spectra via thermo-optical effect. By exciting the metasurface with a few milliwatts of continuous-wave laser at its resonance wavelength, the backward scattering cross-section doubles while the forward scattering cross-section is reduced by half. Our findings pave the way for all-optical dynamical control of scattering directionality in silicon photonic devices.
Article
Physics, Applied
Zhao Wang, Shanshan Wang, Rui Ma, Youwei Liu, Hongyang Zhu, Yong Zhang, Jun Liu, Yandong Mu, Yunjiang Rao, Weili Zhang
Summary: A self-reconfigurable speckle illumination method using a multimode fiber laser is proposed in this study, which utilizes the temporal-spectral randomness of a homemade coherent random-fiber laser and the spectral-sensitive output pattern of a multimode fiber. The proposed laser exhibits dynamically varying speckles within a moderate bandwidth, enabling applications in superresolution imaging and ghost imaging.
PHYSICAL REVIEW APPLIED
(2022)
Article
Engineering, Electrical & Electronic
Qian Yang, Hui Zou, Yu-Gang Shee, Zuxing Zhang
Summary: We propose a Brillouin-Raman random fiber laser with enhanced synergistic nonlinearity for ultra-wide bandwidth Brillouin comb generation. The augmented synergistic nonlinearity, including enhanced Rayleigh scattering (RS) effect, stimulated Brillouin scattering (SBS) and stimulated Raman scattering (SRS), is achieved in a hybrid fiber (a fiber combination of a 7.2-km dispersion compensation fiber and a 10-km single-mode fiber) under a strong Raman pumping condition. In the experiments, the multi-wavelength Brillouin comb with an ultra-wide bandwidth of 63.5 nm (1513 nm-1576.5 nm) with frequency spacing of double Brillouin frequency shift, which is the largest bandwidth from Brillouin fiber lasers, to the best of our knowledge, has been achieved. The proposed ultra-wide bandwidth Brillouin-Raman fiber laser has potential applications in optical communication, optical wavelength division multiplexing, and fiber sensing.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2023)
Article
Optics
Tiancheng Zheng, Xueyang Li, Xianglong Cai, Chencheng Shen, Juntao Li, Jinbo Liu, Jingwei Guo
Summary: Random laser and stimulated Raman scattering were studied in poly (melamine formaldehyde) foam with micro/nano-sized porous structures using Rhodamine 6G ethanol solution. Differences in the behavior of RL and SRS were observed at different dye concentrations, with shorter cavity lengths and only SRS peaks observed in the compressed state.
JOURNAL OF LUMINESCENCE
(2021)
Article
Optics
Xiaoyu Shi, Wanting Song, Ningning Liang, Dan Guo, Kaiyue Shen, Tianrui Zhai
Summary: This study reveals the crucial role of the pump boundary in the mode interaction and emission characteristics of diffusive random lasers. By increasing the ratio between the square root of the pump area and the circumference of the pump region, the strongly correlated nonresonant laser mode with a continuous spectral distribution is transformed into an independent resonant laser mode with a discrete frequency distribution. A critical ratio of 5.76 is demonstrated as the transition point for pump spots with arbitrary shapes. This pump strategy provides a universal guideline for regulating laser modes in diffusive RL systems that can be applied to multifunctional lasers to clarify the behavior of light in disordered structures.
LASER & PHOTONICS REVIEWS
(2023)
Article
Optics
S. F. Haddawi, N. Roostaei, S. M. Hamidi
Summary: This study demonstrates a flexible random laser based on a two-face double grating plasmonic structure made of PDMS. The experimental results confirm that thinner double grating structures can achieve higher efficiency in random lasing properties under certain conditions.
OPTICS AND LASER TECHNOLOGY
(2022)
Article
Optics
Jan Sperrhake, Matthias Falkner, Michael Steinert, Stefan Fasold, Thomas Pertsch
Summary: This study experimentally validates the effectiveness of the fundamental mode approximation (FMA) in the design of stacked metasurfaces, simplifying the design process. By using a semi-analytic method, it demonstrates the design of stacked periodic metasurfaces with arbitrary period ratios, bridging the existing gap in parameter space.
Article
Biochemistry & Molecular Biology
Chengbin Yang, Haoqiang Huang, Nishtha Manish Singh, Cheng Zhou, Guang Yang, Zhourui Xu, Haoming Lin, Gaixia Xu, Ken-Tye Yong, Guillermo C. Bazan
Summary: The conjugated oligoelectrolyte COE-S6 forms spherical nanoplexes with siRNA, which show protective effects, endosome escape, and transfection efficiencies comparable to commercial products. It can effectively silence the K-ras gene in pancreatic cancer cells, inhibit tumor growth, and has low toxicity. COE-S6-based nanoplexes have potential as nonviral vectors for gene delivery.
Article
Chemistry, Multidisciplinary
Zhourui Xu, Yihang Jiang, Yuanyuan Shen, Lele Tang, Zulu Hu, Guimiao Lin, Wing-Cheung Law, Mingze Ma, Biqin Dong, Ken-Tye Yong, Gaixia Xu, Ye Tao, Runfeng Chen, Chengbin Yang
Summary: This study combines phosphorescent materials with two-photon excitation to improve the generation of reactive oxygen species and precision of photodynamic therapy. A novel phosphorescent-based photosensitizer is successfully prepared, which exhibits high photoluminescence quantum yield and remarkable intersystem crossing efficiency. Encapsulated into a BSA matrix, the photosensitizer shows excellent biocompatibility, low dark toxicity, and high photostability, enabling efficient ROS generation and precise cell damage at the desired location.
MATERIALS HORIZONS
(2022)
Article
Materials Science, Multidisciplinary
Luyu Zhang, Caichao Wan, Jiahui Su, Chonghao Zhang, Song Wei, Wenyan Tian, Xinyi Liu, Wenjie Cheng, Xingong Li, Xianjun Li, Xin Guo, Ken-Tye Yong, Yiqiang Wu
Summary: This study presents a dual-crosslinked hydrogel obtained by infiltrating a flexible polyvinyl alcohol network into the rigid network of bamboo cellulose. The hydrogel exhibits superior flexibility, shape controllability, self-healing ability, high ionic conductivity, and sensing capabilities. It also demonstrates potential for use in wearable products and as a green platform for creating eco-friendly and powerful functional composites.
MATERIALS & DESIGN
(2022)
Review
Biochemical Research Methods
Shuangyang Kuang, Nishtha Manish Singh, Yichao Wu, Yan Shen, Weijia Ren, Liangcheng Tu, Ken-Tye Yong, Peiyi Song
Summary: This review focuses on the recent advances in space microfluidic technologies and their impact on the state-of-the-art space missions. It discusses the behavior of micro-sized fluid and microfluidic instruments in space conditions based on hydrodynamic theories. The review categorically investigates a series of successful space missions integrated with microfluidic technologies to outline the reasons why microfluidic components and operations have become crucial in recent missions. It provides a comprehensive technical analysis on the recently developed in-space microfluidic applications and presents insights on microfluidic technologies that hold considerable promise for the upcoming space missions.
Article
Biochemistry & Molecular Biology
Na Qiao, Yufan Zhang, Ying Fang, Heli Deng, Desuo Zhang, Hong Lin, Yuyue Chen, Ken Tye Yong, Jiaqing Xiong
Summary: A silk fabric-based medical dressing decorated by a thermo-responsive hydrogel is proposed for sustained release of paracetamol, effectively avoiding the drawbacks of oral ingestion.
MACROMOLECULAR BIOSCIENCE
(2022)
Review
Chemistry, Physical
Matthew Hadden, David Martinez-Martin, Ken-Tye Yong, Yogambha Ramaswamy, Gurvinder Singh
Summary: This review highlights the importance and applications of functional nanoporous materials, and provides recent advances in synthesis strategies and design approaches. It also discusses the working principles, challenges, and limitations associated with nanoporous material fabrication strategies, and explores the potential role of digitally controlled additive manufacturing in developing next-generation nanoporous materials.
Article
Materials Science, Multidisciplinary
Ying Fang, Na Qiao, Heli Deng, Meng Ren, Yufan Zhang, Desuo Zhang, Hong Lin, Yuyue Chen, Ken Tye Yong, Jiaqing Xiong
Summary: Transdermal drug delivery system (TDDS) is effective in alleviating patient's pain and reduces frequent administration. Realizing tunable drug release on fibers/fabrics is important for constructing TDDS platform with good skin affinity and long-term comfortability.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Review
Chemistry, Multidisciplinary
Arman Ahnood, Andre Chambers, Amy Gelmi, Ken-Tye Yong, Omid Kavehei
Summary: The advent of electronic technology for neural interfacing in the past 50 years has transformed medicine and biology. Devices like deep brain stimulators and cochlear implants have revolutionized the treatment of previously untreatable conditions. Semiconducting electrodes have advanced neural interfacing technologies, enabling high precision sensing and stimulation in electrical, biochemical, and optical domains. This emerging class of electrodes offers new opportunities for research and treatment.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Materials Science, Multidisciplinary
Yue Zhang, Jiahui Zhou, Heli Deng, Ying Fang, Na Qiao, Meng Ren, Yufan Zhang, Desuo Zhang, Hong Lin, Yuyue Chen, Ken Tye Yong, Jiaqing Xiong
Summary: Researchers have developed a fiber-based membrane with Janus wettability using alternating electrospinning-electrospraying technology, which can resist air pollution and inhibit bacteria proliferation. The membrane consists of silk fibroin nanofibers-substrate, polyurethane nanospheres-top layer, and in-situ grown silver nanoparticles middle layer, providing a self-cleaning physical barrier and a bio-barrier for sterilization. The membrane also has a high PM2.5 filtration efficiency of approximately 98.1%.
JOURNAL OF MATERIALS RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Shuo Li, Weiyao Han, Quan-Fu An, Ken-Tye Yong, Ming-Jie Yin
Summary: Metal-organic frameworks (MOFs) have great potential for membrane-based gas separation applications due to their unique properties. Defect engineering of MOFs has opened up new possibilities for enhancing membrane separation but more research is needed to fully understand its effects. This summary discusses recent developments in defect engineering of MOF-based membranes and outlines the challenges and future prospects in this field.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Yan Guo, Xianglong Su, Kaihua Wu, Ken-Tye Yong
Summary: In this study, a biosensor based on surface plasmon resonance (SPR) technique and nanodisk array was developed to enhance the sensitivity of virus detection. Through systematic optimization of all parameters, four optimal sensing configurations were achieved, leading to improved sensor performance and a smaller detection limit compared to bare gold-based sensors. The optimized sensors can clearly distinguish multi-jump resonance angle curves at tiny refractive index, which is important for accurate detection of trace substances.
Review
Chemistry, Multidisciplinary
Tian-Run Lv, Wen-Hai Zhang, Ya-Qiong Yang, Jia-Chen Zhang, Ming-Jie Yin, Zhigang Yin, Ken-Tye Yong, Quan-Fu An
Summary: With increasing demands for flexible organic electronic devices, conductive polymers have shown significant breakthroughs in the past decade due to their outstanding conductivity, solution-processing ability, and tailorability. However, commercialization of these devices still lags behind due to performance limitations and limited manufacturing techniques. This review comprehensively summarizes the state-of-the-art technologies for developing organic devices using conductive polymers, including synthesis methods, film fabrication techniques, nanostructure and microstructure tailoring, device applications, and future directions.
Article
Materials Science, Multidisciplinary
Miaozhuang Fan, Gang Feng, Lu Xia, Yibin Zhang, Maixian Liu, Zhengzheng Li, Yihang Jiang, Chengbin Yang, Wing-Cheung Law, Ken-Tye Yong, Yuanyuan Shen, Zhourui Xu, Gaixia Xu
Summary: Aggregation-induced emission luminogens (AIEgens) have gained significant attention in the research community as a new class of optical probes for two-photon imaging (2PI). However, their non-radiative energy dissipation affects their performance in 2PI. To address this, an organic doping method using TPE-Br and MeOTTMN is proposed, resulting in enhanced brightness but increased production of reactive oxygen species. The heavily organic-doped AIEgen (ODA) nanoparticles (NPs) enable ultradeep imaging depth of 1000 μm in a mouse brain, surpassing MeOTTMN NPs' imaging depth of 156 μm. The safety of ODA NPs is evaluated through toxicity assessment, providing a promising approach to control energy relaxation of AIEgen NPs in 2PI.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Yibin Zhang, Miaozhuang Fan, Zhourui Xu, Yihang Jiang, Huijun Ding, Zhengzheng Li, Kaixin Shu, Mingyan Zhao, Gang Feng, Ken-Tye Yong, Biqin Dong, Wei Zhu, Gaixia Xu
Summary: In this study, machine learning techniques were used to screen AIEgens with desired excitation and emission wavelength for biomedical fluorescence imaging. A database of various AIEgens was established and ML models were trained to predict molecular absorption and emission wavelength peaks. Three newly predicted AIEgens were successfully synthesized and applied for cellular fluorescence imaging and deep penetration imaging, demonstrating the great potential of ML in screening AIEgens with suitable wavelengths for novel organic fluorescent materials.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Engineering, Environmental
Hossein Moeinzadeh, Poogitha Jegakumaran, Ken-Tye Yong, Anusha Withana
Summary: Water quality is primarily assessed based on its visual acceptability, and this study proposes a deep learning-based approach to reconstruct seven heavy metal parameters from four parameters in order to estimate the water quality index. The proposed model effectively reconstructs these parameters with high accuracy and reliability, offering a cost-effective solution for understanding water quality.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Xintong Zhang, Yanhong Liu, Wei Liu, Liqing Chen, Mingji Jin, Zhonggao Gao, Wei Huang
Summary: This study developed a macrophage-hitchhiking gene delivery system for the treatment of rheumatoid arthritis. The system demonstrated excellent targeting ability and nuclear entry ability, leading to efficient transfection of interleukin-10 in macrophages and alleviation of inflammation symptoms. This research provides a novel strategy for gene therapy and gene delivery system design for rheumatoid arthritis and other similar inflammatory diseases.
Article
Chemistry, Multidisciplinary
Richard K. Cross, Dave Spurgeon, Claus Svendsen, Elma Lahive, Simon Little, Frank von der Kammer, Frederic Loosli, Marianne Matzke, Teresa F. Fernandes, Vicki Stone, Willie J. G. M. Peijnenburg, Eric A. J. Bleeker
Summary: Even small changes in physicochemical properties of nanoforms (NFs) can influence their environmental fate and hazard. Testing and characterizing each individual NF will not be feasible due to the large number of new materials being developed. Targeting the most relevant form of the NF for a given exposure is important for efficient risk assessment. In aquatic systems, functional fate processes play a key role in determining the exposure relevant form of NFs. Grouping of NFs and read-across based on functional fate pathways can be justified by considering the shared fate and hazard profile. A new Integrated Approaches to Testing and Assessment (IATA) is presented, focusing on dissolution, dispersion stability, chemical transformations, and the contribution to toxicity from particles and dissolved components. This IATA can be used as a template for future in vivo kinetic assessments.
Article
Chemistry, Multidisciplinary
Minhui Lu, Xiaoxuan Zhang, Lijun Cai, Jingjing Gan, Jinglin Wang, Yu Wang, Yuanjin Zhao
Summary: Researchers have proposed a novel black phosphorus-loaded hydrogel inverse opal microneedle patch that exhibits photothermal responsive capacity and vivid structural color screening for psoriasis treatment. With improved materials, structures, and functions, the microneedle patch enables intelligent drug delivery and enhances drug loading and controllable release.
Article
Chemistry, Multidisciplinary
Qianyun Tang, Dandan Wang, Jinhui Cui, Yiheng Zhang, Junyang Mei, Jing Du, Anyue Xia, Qian Sun, Dan Luo, Baosan Han, Mingzhe Gan, Peifeng Liu
Summary: This study presents a novel microfluidic platform for precise and flexible control of oxygen concentrations in microbial suspension culture. The platform demonstrates unique capabilities for spatiotemporal gas control and detection, allowing for applications in screening, studying, and culturing industrial or niche-specific environmental microbiomes.
Review
Chemistry, Multidisciplinary
Jiaen Wu, Hao Chen, Jiawei Xu, Muhammad Saif Ur Rahman, Shengmei Li, Jie Wang, Shifen Huang, Charles C. Han, Shanshan Xu, Ying Liu
Summary: This review categorizes the potential health risks of microplastic pollution by focusing on the three primary pollution sources. It provides an in-depth analysis of the pharmacokinetics, toxicity potential, and biological mechanism of microplastics in the human body. The review aims to fill knowledge gaps about the toxicity of microplastics on human health and provide ideas for repairing the damage caused by microplastics.
Article
Chemistry, Multidisciplinary
Fanshu Ma, Yi Cao, Jincong Yan, Zhongzhong Lu, Lina Sun, Zahid Hussain, Zheng Wang, Li Wang, Renjun Pei
Summary: This study proposes a simple yet powerful method to create multifunctional hybrid nanovesicles that combine the characteristics of oncolytic viruses and pyroptosis, leading to enhanced tumor targeting and improved immune response. The results demonstrate excellent tumor inhibition efficacy against melanoma and pulmonary metastasis.
Article
Chemistry, Multidisciplinary
Fangmian Wei, Johannes Karges, Siyuan Gao, Lili Wang, Xiting Zhang, Xing-Can Shen, Liangnian Ji, Hui Chao
Summary: This study presents the coordination of Ru(II) polypyridine complexes to graphitic carbon nitride nanosheets for oxygen-self-sufficient two-photon photodynamic immunotherapy. The conjugates were found with strong two-photon absorption and could generate reactive oxygen species (ROS) to induce cell death and inhibit tumor growth through immune system activation.
Article
Chemistry, Multidisciplinary
Weiwei Zheng, Shun-Yu Yao, Haijun Hu, Xiping Chen, Zhefeng Qian, Wenxing Liu, Yang Zhu, Zhengwei Mao, Dong-Sheng Guo, Changyou Gao
Summary: In this study, a hypoxia-responsive self-assembled peptide hydrogel was prepared for ischemic stroke treatment. The hydrogel showed the ability to release drugs and effectively improve motor function, reduce infarct volume, and alleviate inflammation.
Article
Chemistry, Multidisciplinary
Qianqian Qiao, Jinyu Wang, Kai Long, Linwei Li, Jiahao Chen, Yuhao Guo, Ziqiang Xu, Ying Kuang, Tianjiao Ji, Cao Li
Summary: This study developed a catalytic system using titanium-based MXene nanosheets to load enzymes and anticancer drugs. The nanosheets demonstrated catalase-like activity and photothermal capability, enabling enhanced cancer treatment through starvation therapy and alleviation of hypoxia. In vitro and in vivo studies confirmed the effective anticancer capability of this enzyme cascade system.
Article
Chemistry, Multidisciplinary
Shiyang Wu, Yan He, Ruiqi Zhou, Chunlin Chen, Dawei Chen, Haiyang Hu
Summary: In this research, LDHA@MIP-DSD nanoparticles were designed to enhance the effectiveness of immunogenic cell death (ICD) in cancer immunotherapy. LDHA@MIP-DSD improved the accessibility of nanodrugs to cancer cells by surface imprinting LDHA and induced autophagy with SLN. The combination of these two effects resulted in optimal immune stimulation and antitumor efficiency.
Article
Chemistry, Multidisciplinary
Xu Zhang, Kejian Shi, Jiahui Mao, Kerou Mao, Yangrui Jia, Jiakun Zhang, Qingzhen Wang, Ru Bai, Fene Gao, Shihui Liu, Mengyu Guo, Fenglan Qin, Shengmin Li, Chunying Chen, Huige Zhou, Jing Liu, Fulin Chen
Summary: Compared with vein injection, oral administration is a preferred non-invasive and self-help treatment option for cancer therapy. However, the harsh gastrointestinal tract and biological barriers limit the stability and efficiency of oral drug delivery systems. To overcome these challenges, researchers have developed Cyssome, a drug delivery platform that can maintain stability in harsh environments, penetrate biological barriers, and improve drug release and bioavailability.