Article
Allergy
Rajarshi Ghosh, Marita Bosticardo, Sunita Singh, Morgan Similuk, Ottavia M. Delmonte, Francesca Pala, Christine Peng, Colleen Jodarski, Michael D. Keller, Ivan K. Chinn, Andrew K. Groves, Luigi D. Notarangelo, Magdalena A. Walkiewicz, Javier Chinen, Vanessa Bundy
Summary: This study identified heterozygous loss-of-function variants in the FOXI3 gene as a possible genetic basis for nonsevere T-cell lymphopenia. Understanding the genetic etiology of this condition is crucial for clinical management and family planning.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Anna Soderstrom, Sofie Vonlanthen, Kerstin Jonsson-Videsater, Stephan Mielke, Hannes Lindahl, Johan Torlen, Michael Uhlin
Summary: This study found that measuring TREC levels can predict the prognosis of adult AML patients after bone marrow transplantation, especially overall survival. Lower TREC levels were associated with viral infections and CMV reactivation. KREC levels were not associated with clinical outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Luxin Qiao, Xiao Cui, Lin Jia, Yuxue Gao, Wenjing Wang, Feili Wei, Zhili Zhang, Dexi Chen, Yingmin Ma, Yulin Zhang
Summary: This study used mass cytometry and high-throughput sequencing to analyze the immune response characteristics of patients with Pneumocystis pneumonia (PCP). The results showed that the proportions of immune cells and cytokines in PCP patients changed, and these changes were alleviated after anti-PCP treatment.
CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Nidal Muvarak, Haishan Li, Tyler Lahusen, Jeffrey A. Galvin, Princy N. Kumar, C. David Pauza, Jose Bordon
Summary: AGT103-T, a cell and gene therapy product, is designed to restore immune response in HIV patients under antiretroviral therapy. In a clinical trial, AGT103-T has shown to be safe and effective in improving host T cell immunity to HIV. Further studies are needed to evaluate its efficacy in HIV disease.
FRONTIERS IN MEDICINE
(2022)
Article
Biophysics
A. K. M. Arifuzzman, Norh Asmare, Tevhide Ozkaya-Ahmadov, Ozgun Civelekoglu, Ningquan Wang, A. Fatih Sarioglu
Summary: Characterization and identification of cell populations using surface markers are crucial in various applications. However, conventional techniques are limited by the need for immunolabeling, expensive instruments, and skilled operators. This study introduces an autonomous microchip that can electronically quantify the immunophenotypical composition of a cell suspension. The microchip captures different cell subtypes in separate microfluidic chambers and electrically monitors all on-chip activity, allowing real-time determination of subpopulation fractions. The capability to analyze immune cells without labels has the potential to enable remote testing and quality control in cell manufacturing.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Cell Biology
Lianfeng Lu, Xiaodi Li, Xiaosheng Liu, Zhifeng Qiu, Yang Han, Xiaojing Song, Yanling Li, Xiaoxia Li, Wei Cao, Wei Lv, Zhihui Dou, Taisheng Li
Summary: The extent and speed of T cell subset retrieval after long-term antiretroviral treatment in HIV-infected patients were studied. Results showed that robust immune restoration occurred after 2-3 years of ART, and significant changes in CD4 and CD4+T cells could persist until 6-8 years. The expression of activation antigens on CD8 lymphocytes declined during the first 2 years, and the proportion of CD4 cells expressing CD28 reached normal levels in the second year. Overall, the immune response was influenced by age and time of antiretroviral treatment.
Article
Biology
Mariona Baliu-Pique, Vera van Hoeven, Julia Drylewicz, Lotte E. van der Wagen, Anke Janssen, Sigrid A. Otto, Menno C. van Zelm, Rob J. de Boer, Jurgen Kuball, Jose A. M. Borghans, Kiki Tesselaar
Summary: The study found that in patients after autologous hematopoietic stem cell transplantation (autoHSCT), the production rates of most T- and B-cell subsets increased significantly, but accompanied by an increase in cell loss rates, which persisted even after cell numbers normalized.
Article
Immunology
Katrine Schou Sandgaard, Triantafylia Gkouleli, Teresa Attenborough, Stuart Adams, Deena Gibbons, Mette Holm, Sarah Eisen, Helen Baxendale, Anita De Rossi, Savita Pahwa, Benny Chain, Athina S. Gkazi, Nigel Klein
Summary: Current ART guidelines recommend treating all children with HIV-1 infection to improve morbidity and minimize mortality. This study provides new insights into the unique pediatric immune system and immunological changes when HIV-1 replication is ongoing.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Xian Li, Xinyi Zhu, Xiaohong Zhang, Weiqin Wang
Summary: This report presents a case of an elderly patient with pure red-cell aplasia (PRCA) associated with autoimmune disorder rather than malignancy. The patient exhibited significantly proliferated gamma delta T cells and clonal T-cell receptor (TCR) gene rearrangement. Despite previous reports suggesting poor response to cyclosporin A (CsA) in patients with TCR clonal rearrangement, this patient showed sensitivity to CsA. The case provides valuable clinical findings for the future diagnosis and management of PRCA caused by autoimmune conditions and further research on gamma delta T cells' autoimmune pathophysiology and gene rearrangement.
FRONTIERS IN IMMUNOLOGY
(2023)
Letter
Oncology
Chenchen Zhao, Matthew Bartock, Bei Jia, Neal Shah, David F. Claxton, Baldeep Wirk, Kevin L. Rakszawski, Myles S. Nickolich, Seema G. Naik, Witold B. Rybka, W. Christopher C. Ehmann, Raymond J. Hohl, Jessica Valentin, Michelle Bernas-Peterson, Emily M. Gerber, Michele Zimmerman, Joseph A. Mierski, Shin Mineishi, Hong Zheng
Summary: This study investigates the impact of post-transplant cyclophosphamide (PTCy) on immune reconstitution post-allogeneic hematopoietic stem cell transplantation (allo-HSCT), with a focus on T cells. The results show that PTCy significantly delays T cell reconstitution and affects T cell subsets, increasing regulatory T cells (Treg) and reducing naive T cells. It also leads to the upregulation of inhibitory receptors on CD4(+) and CD8(+) T cells, resulting in less functional CD8 T cells. The findings provide critical information for understanding the mechanism of PTCy's effect on immune reconstitution and optimizing clinical practices.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Virology
Bin Su, Deshenyue Kong, Xiaodong Yang, Tong Zhang, Yi-Qun Kuang
Summary: The decreased number of MAIT cells in HIV-infected individuals affects intestinal barrier integrity and microbial homeostasis, which in turn further compromises immune reconstitution.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Cell Biology
Martijn Cordes, Karin Pike-Overzet, Erik B. B. Van Den Akker, Frank J. T. Staal, Kirsten Cante-Barrett
Summary: Flow cytometry has traditionally been used to characterize immune cells and their markers. Single-cell RNA-sequencing has revolutionized the study of immune development, allowing for the analysis of heterogenous tissues and the integration of omics data at the single-cell level. This integration contributes to our understanding of the immune system by revealing the heterogeneity within cell populations identified by surface markers and the correlation between RNA and protein data.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Immunology
Constantin Aschauer, Kira Jelencsics, Karin Hu, Mariella Gregorich, Roman Reindl-Schwaighofer, Sabine Wenda, Thomas Wekerle, Andreas Heinzel, Rainer Oberbauer
Summary: Longitudinal monitoring of kidney transplant recipients receiving different induction therapies showed increased donor-reactive T-cell repertoire in both ATLG and basiliximab groups, with no significant differences in overall TCR repertoire diversity and turnover.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Daniel D. Murray, John Zaunders, Samuel T. Milliken, C. Mee Ling Munier, Carole Ford, C. Orla Morrissey, Malini Visweswaran, Sharon Avery, Joseph Sasadeusz, John Kwan, Shrinivas Desai, Matthew Law, Kersten K. Koelsch, Sharon R. Lewin, John Moore, Anthony D. Kelleher, Mark N. Polizzotto
Summary: Individuals with HIV who undergo ASCT have a higher number of CD8+ T-cells post-transplant compared to HIV-negative individuals, despite similar CD4+ T-cell levels. The antigen specificity and markers of these reconstituting T-cells varied among participants, suggesting that preexisting HIV infection and post-transplant antigen exposure can impact immune reconstitution in this group.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Oncology
Julie D. Gibbs, Sophia Ma, Anna Kim, Lucia Seminario-Vidal, Lubomir Sokol, Hailing Zhang, Xiaohui Zhang, Elizabeth Sagatys, Pei-Ling Chen, Jane L. Messina
Summary: Cutaneous T-cell lymphoma (CTCL) is challenging to diagnose early, with diagnostic tools including clinical examination, histomorphologic analysis, immunohistochemistry, flow cytometry, and gene rearrangement analysis. A study compared the performance of different diagnostic modalities, with high-throughput sequencing (HTS) showing high specificity in identifying CTCL. Further research is needed to find more sensitive tests for early-stage CTCL.
Meeting Abstract
Psychology, Developmental
Diane M. Straub, Elizabeth Enriquez Bruce, Bernard Washington, Carina Rodriguez, Patricia Emmanuel
JOURNAL OF ADOLESCENT HEALTH
(2017)
Article
Microbiology
Daniel M. Cohen, Jennifer Kline, Larissa S. May, Glenn Eric Harnett, Jane Gibson, Stephen Y. Liang, Zubaid Rafique, Carina A. Rodriguez, Kevin M. McGann, Charlotte A. Gaydos, Donna Mayne, David Phillips, Jason Cohenl
JOURNAL OF CLINICAL MICROBIOLOGY
(2018)
Article
Clinical Neurology
Tiffany Chenneville, Kemesha Gabbidon, Hunter Drake, Carina Rodriguez
JOURNAL OF AFFECTIVE DISORDERS
(2019)
Article
Nursing
Courtney Lynn, Tiffany Chenneville, Kathy Bradley-Klug, Audra St John Walsh, Robert F. Dedrick, Carina A. Rodriguez
JANAC-JOURNAL OF THE ASSOCIATION OF NURSES IN AIDS CARE
(2020)
Article
Pediatrics
Ellen Gould Chadwick, Echezona Edozie Ezeanolue
Article
Medicine, General & Internal
C. Buddy Creech, Evan Anderson, Vladimir Berthaud, Inci Yildirim, Andrew M. Atz, Ivan Melendez Baez, Daniel Finkelstein, Paul Pickrell, Judith Kirstein, Clifford Yut, Ronald Blair, Robert A. Clifford, Michael Dunn, James D. Campbell, David C. Montefiori, Joanne E. Tomassini, Xiaoping Zhao, Weiping Deng, Honghong Zhou, Daniela Ramirez Schrempp, Kelly Hautzinger, Bethany Girard, Karen Slobod, Roderick McPhee, Rolando Pajon, Rituparna Das, Jacqueline M. Miller, Sabine Schnyder Ghamloush
Summary: The study demonstrated that two 50-mu g doses of the mRNA-1273 vaccine are safe and effective in inducing immune responses and preventing Covid-19 in children aged 6 to 11 years, with noninferior responses compared to young adults.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
E. J. Anderson, C. B. Creech, V Berthaud, A. Piramzadian, K. A. Johnson, M. Zervos, F. Garner, C. Griffin, K. Palanpurwala, M. Turner, J. Gerber, R. L. Bennett, K. Ali, M. Ampajwala, G. Berman, J. Nayak, C. Chronis, B. Rizzardi, W. J. Muller, C. A. Smith, G. Fuchs, D. Hsia, J. E. Tomassini, D. DeLucia, C. Reuter, B. Kuter, X. Zhao, W. Deng, H. Zhou, D. Ramirez Schrempp, K. Hautzinger, B. Girard, K. Slobod, R. McPhee, R. Pajon, A. Aunins, R. Das, J. M. Miller, S. Schnyder Ghamloush
Summary: This study evaluated the safety and immunogenicity of the mRNA-1273 vaccine in young children aged 6 months to 5 years. The results showed that two doses of 25 μg mRNA-1273 vaccine were safe in children and elicited immune responses comparable to those in young adults.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Anne-Marie Rick, Matthew B. Laurens, Ying Huang, Chenchen Yu, Thomas C. S. Martin, Carina A. Rodriguez, Christina A. Rostad, Rebone M. Maboa, Lindsey R. Baden, Hana M. El Sahly, Beatriz Grinsztejn, Glenda E. Gray, Cynthia L. Gay, Peter B. Gilbert, Holly E. Janes, James G. Kublin, Yunda Huang, Brett Leav, Ian Hirsch, Frank Struyf, Lisa M. Dunkle, Kathleen M. Neuzil, Lawrence Corey, Paul A. Goepfert, Stephen R. Walsh, Dean Follmann, Karen L. Kotloff
Summary: This study found that previous infection, hybrid immunity, and vaccination all provide substantial protection against symptomatic and severe COVID-19 during the early Delta period. Hybrid immunity, which combines previous infection with vaccination, is more effective than vaccination alone. Vaccination, previous infection, and hybrid immunity all offer near-complete protection against severe disease.
Article
Infectious Diseases
Sabah Kalyoussef, Amin Hakim, Ambuj Kumar, Sergio Fanella, Sindhu Mohandas, Claudia Gaviria-Agudelo, PIDS Telehlth Work Grp
Summary: The usage of telehealth by pediatric infectious disease specialists increased during the COVID-19 pandemic, and there was an improvement in their comfort and satisfaction with telehealth. It is anticipated that telehealth will continue to be used after the pandemic.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2023)
Meeting Abstract
Infectious Diseases
Victoria A. Salinas, Lisa I. Sanders, Carina E. Rodriguez
SEXUALLY TRANSMITTED DISEASES
(2022)
Article
Health Policy & Services
Courtney Lynn, Tiffany Chenneville, Kathy Bradley-Klug, Audra St John Walsh, Robert F. Dedrick, Carina A. Rodriguez
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2019)
Article
Health Policy & Services
Tiffany Chenneville, Kemesha Gabbidon, Courtney Lynn, Carina Rodriguez
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2018)
Meeting Abstract
Immunology
M. Cotton, A. Liberty, C. A. Rodriguez, K. Chokephaibulkit, P. Kosalaraksa, E. Hellstrom, E. Natukunda, P. Wong, S. R. Majeed, E. Quirk, H. Graham, C. Pikora
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2018)
Meeting Abstract
Oncology
Elissa Engel, Mary Soliman, Juan Rico, Carina Rodriguez
PEDIATRIC BLOOD & CANCER
(2018)
Article
Health Policy & Services
Audra St John Walsh, Katherine L. Wesley, Sim Yin Tan, Courtney Lynn, Kimberly O'Leary, Yan Wang, Diep Nguyen, Tiffany Chenneville, Carina A. Rodriguez
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2017)